Putative DNA polymerase delta subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase delta subunit 2, putative

Species:

Leishmania major

UniProt:

Q4Q9V2_LEIMA

TriTrypDb:

LmjF.25.1410 , LMJLV39_250021100 , LMJSD75_250020900

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0042575	DNA polymerase complex	3	12
GO:0043625	delta DNA polymerase complex	3	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

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Expansion

Sequence features

Q4Q9V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9V2

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	10
GO:0006271	DNA strand elongation involved in DNA replication	6	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0022616	DNA strand elongation	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	8
GO:0003887	DNA-directed DNA polymerase activity	5	8
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0034061	DNA polymerase activity	4	8
GO:0097159	organic cyclic compound binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.377
CLV_C14_Caspase3-7	431	435	PF00656	0.499
CLV_NRD_NRD_1	76	78	PF00675	0.323
CLV_PCSK_KEX2_1	76	78	PF00082	0.325
CLV_PCSK_SKI1_1	185	189	PF00082	0.273
CLV_PCSK_SKI1_1	218	222	PF00082	0.386
CLV_PCSK_SKI1_1	25	29	PF00082	0.340
CLV_PCSK_SKI1_1	315	319	PF00082	0.278
CLV_PCSK_SKI1_1	510	514	PF00082	0.497
CLV_PCSK_SKI1_1	76	80	PF00082	0.323

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P663	Leptomonas seymouri	71%	100%
A0A0S4IRV7	Bodo saltans	41%	100%
A0A1X0NMG0	Trypanosomatidae	47%	100%
A0A3Q8ING8	Leishmania donovani	94%	100%
A0A422P247	Trypanosoma rangeli	47%	100%
A4HEE9	Leishmania braziliensis	86%	100%
A4I1I5	Leishmania infantum	95%	100%
C9ZJY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AXM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O35654	Mus musculus	26%	100%

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