Putative DNA polymerase delta subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase delta subunit 2, putative

Species:

Leishmania major

UniProt:

Q4Q9V2_LEIMA

TriTrypDb:

LmjF.25.1410 , LMJLV39_250021100 , LMJSD75_250020900

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0042575	DNA polymerase complex	3	12
GO:0043625	delta DNA polymerase complex	3	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

Q4Q9V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9V2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006271	DNA strand elongation involved in DNA replication	6	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0022616	DNA strand elongation	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006260	DNA replication	5	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	8
GO:0003887	DNA-directed DNA polymerase activity	5	8
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0034061	DNA polymerase activity	4	8
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.377
CLV_C14_Caspase3-7	431	435	PF00656	0.499
CLV_NRD_NRD_1	76	78	PF00675	0.323
CLV_PCSK_KEX2_1	76	78	PF00082	0.325
CLV_PCSK_SKI1_1	185	189	PF00082	0.273
CLV_PCSK_SKI1_1	218	222	PF00082	0.386
CLV_PCSK_SKI1_1	25	29	PF00082	0.340
CLV_PCSK_SKI1_1	315	319	PF00082	0.278
CLV_PCSK_SKI1_1	510	514	PF00082	0.497
CLV_PCSK_SKI1_1	76	80	PF00082	0.323
CLV_PCSK_SKI1_1	95	99	PF00082	0.413
CLV_Separin_Metazoa	110	114	PF03568	0.273
DEG_APCC_DBOX_1	184	192	PF00400	0.255
DEG_APCC_DBOX_1	24	32	PF00400	0.365
DEG_APCC_DBOX_1	268	276	PF00400	0.385
DOC_CKS1_1	493	498	PF01111	0.377
DOC_CYCLIN_RxL_1	21	32	PF00134	0.376
DOC_MAPK_FxFP_2	480	483	PF00069	0.255
DOC_MAPK_gen_1	267	276	PF00069	0.273
DOC_MAPK_gen_1	291	300	PF00069	0.385
DOC_MAPK_gen_1	312	319	PF00069	0.240
DOC_MAPK_gen_1	352	361	PF00069	0.301
DOC_MAPK_gen_1	385	394	PF00069	0.259
DOC_MAPK_gen_1	426	432	PF00069	0.511
DOC_MAPK_gen_1	550	560	PF00069	0.331
DOC_MAPK_gen_1	74	81	PF00069	0.300
DOC_MAPK_HePTP_8	349	361	PF00069	0.255
DOC_MAPK_MEF2A_6	195	204	PF00069	0.385
DOC_MAPK_MEF2A_6	267	276	PF00069	0.256
DOC_MAPK_MEF2A_6	352	361	PF00069	0.255
DOC_MAPK_MEF2A_6	568	577	PF00069	0.360
DOC_MAPK_NFAT4_5	269	277	PF00069	0.299
DOC_PP1_RVXF_1	27	34	PF00149	0.381
DOC_PP2B_LxvP_1	381	384	PF13499	0.273
DOC_PP4_FxxP_1	480	483	PF00568	0.255
DOC_PP4_FxxP_1	525	528	PF00568	0.517
DOC_PP4_FxxP_1	589	592	PF00568	0.412
DOC_USP7_MATH_1	244	248	PF00917	0.332
DOC_USP7_MATH_1	254	258	PF00917	0.494
DOC_USP7_MATH_1	268	272	PF00917	0.293
DOC_USP7_MATH_1	332	336	PF00917	0.383
DOC_USP7_MATH_1	407	411	PF00917	0.376
DOC_USP7_MATH_1	450	454	PF00917	0.388
DOC_USP7_UBL2_3	312	316	PF12436	0.245
DOC_WW_Pin1_4	236	241	PF00397	0.415
DOC_WW_Pin1_4	492	497	PF00397	0.334
DOC_WW_Pin1_4	576	581	PF00397	0.327
LIG_14-3-3_CanoR_1	267	273	PF00244	0.276
LIG_14-3-3_CanoR_1	352	358	PF00244	0.307
LIG_14-3-3_CanoR_1	510	515	PF00244	0.510
LIG_AP2alpha_2	488	490	PF02296	0.240
LIG_BIR_II_1	1	5	PF00653	0.497
LIG_BRCT_BRCA1_1	29	33	PF00533	0.497
LIG_BRCT_BRCA1_1	368	372	PF00533	0.273
LIG_BRCT_BRCA1_1	395	399	PF00533	0.403
LIG_BRCT_BRCA1_1	480	484	PF00533	0.244
LIG_Clathr_ClatBox_1	111	115	PF01394	0.240
LIG_Clathr_ClatBox_1	572	576	PF01394	0.308
LIG_EH_1	396	400	PF12763	0.385
LIG_eIF4E_1	94	100	PF01652	0.273
LIG_FHA_1	196	202	PF00498	0.240
LIG_FHA_1	306	312	PF00498	0.251
LIG_FHA_1	354	360	PF00498	0.276
LIG_FHA_1	389	395	PF00498	0.373
LIG_FHA_1	48	54	PF00498	0.313
LIG_FHA_1	582	588	PF00498	0.400
LIG_FHA_2	346	352	PF00498	0.399
LIG_FHA_2	455	461	PF00498	0.264
LIG_FHA_2	511	517	PF00498	0.428
LIG_FHA_2	542	548	PF00498	0.627
LIG_LIR_Apic_2	478	483	PF02991	0.255
LIG_LIR_Apic_2	524	528	PF02991	0.509
LIG_LIR_Gen_1	224	235	PF02991	0.527
LIG_LIR_Gen_1	239	249	PF02991	0.358
LIG_LIR_Gen_1	508	517	PF02991	0.401
LIG_LIR_Nem_3	224	230	PF02991	0.514
LIG_LIR_Nem_3	239	245	PF02991	0.365
LIG_LIR_Nem_3	508	514	PF02991	0.326
LIG_MYND_1	380	384	PF01753	0.255
LIG_NRBOX	345	351	PF00104	0.385
LIG_Pex14_2	480	484	PF04695	0.255
LIG_PTAP_UEV_1	472	477	PF05743	0.240
LIG_SH2_CRK	205	209	PF00017	0.418
LIG_SH2_STAP1	49	53	PF00017	0.373
LIG_SH2_STAT5	242	245	PF00017	0.360
LIG_SH2_STAT5	49	52	PF00017	0.315
LIG_SH3_3	227	233	PF00018	0.389
LIG_SH3_3	371	377	PF00018	0.240
LIG_SH3_3	392	398	PF00018	0.251
LIG_SH3_3	470	476	PF00018	0.291
LIG_SH3_3	574	580	PF00018	0.327
LIG_SH3_3	80	86	PF00018	0.266
LIG_SUMO_SIM_anti_2	271	277	PF11976	0.277
LIG_SUMO_SIM_anti_2	358	363	PF11976	0.255
LIG_SUMO_SIM_par_1	355	360	PF11976	0.274
LIG_SUMO_SIM_par_1	463	468	PF11976	0.301
LIG_SUMO_SIM_par_1	571	576	PF11976	0.322
LIG_TRAF2_1	258	261	PF00917	0.511
LIG_TRAF2_1	513	516	PF00917	0.564
LIG_WRC_WIRS_1	563	568	PF05994	0.304
MOD_CK1_1	210	216	PF00069	0.361
MOD_CK1_1	335	341	PF00069	0.344
MOD_CK1_1	410	416	PF00069	0.515
MOD_CK1_1	532	538	PF00069	0.715
MOD_CK1_1	540	546	PF00069	0.647
MOD_CK2_1	170	176	PF00069	0.299
MOD_CK2_1	254	260	PF00069	0.469
MOD_CK2_1	345	351	PF00069	0.429
MOD_CK2_1	510	516	PF00069	0.429
MOD_CK2_1	541	547	PF00069	0.644
MOD_DYRK1A_RPxSP_1	236	240	PF00069	0.371
MOD_GlcNHglycan	122	127	PF01048	0.376
MOD_GlcNHglycan	14	17	PF01048	0.477
MOD_GlcNHglycan	172	175	PF01048	0.274
MOD_GlcNHglycan	180	185	PF01048	0.225
MOD_GlcNHglycan	221	224	PF01048	0.348
MOD_GlcNHglycan	246	249	PF01048	0.305
MOD_GlcNHglycan	3	6	PF01048	0.634
MOD_GlcNHglycan	338	341	PF01048	0.263
MOD_GlcNHglycan	409	412	PF01048	0.641
MOD_GlcNHglycan	441	444	PF01048	0.302
MOD_GlcNHglycan	467	470	PF01048	0.299
MOD_GlcNHglycan	50	53	PF01048	0.351
MOD_GlcNHglycan	531	534	PF01048	0.649
MOD_GlcNHglycan	539	542	PF01048	0.730
MOD_GlcNHglycan	568	571	PF01048	0.395
MOD_GSK3_1	219	226	PF00069	0.353
MOD_GSK3_1	27	34	PF00069	0.459
MOD_GSK3_1	280	287	PF00069	0.341
MOD_GSK3_1	301	308	PF00069	0.281
MOD_GSK3_1	332	339	PF00069	0.322
MOD_GSK3_1	450	457	PF00069	0.269
MOD_GSK3_1	471	478	PF00069	0.240
MOD_GSK3_1	506	513	PF00069	0.359
MOD_GSK3_1	523	530	PF00069	0.524
MOD_GSK3_1	537	544	PF00069	0.660
MOD_GSK3_1	562	569	PF00069	0.306
MOD_GSK3_1	578	585	PF00069	0.339
MOD_N-GLC_1	210	215	PF02516	0.377
MOD_N-GLC_1	284	289	PF02516	0.450
MOD_N-GLC_2	169	171	PF02516	0.230
MOD_NEK2_1	1	6	PF00069	0.439
MOD_NEK2_1	179	184	PF00069	0.318
MOD_NEK2_1	31	36	PF00069	0.398
MOD_NEK2_1	399	404	PF00069	0.370
MOD_NEK2_1	438	443	PF00069	0.241
MOD_NEK2_1	566	571	PF00069	0.305
MOD_NEK2_1	582	587	PF00069	0.302
MOD_NEK2_2	284	289	PF00069	0.259
MOD_PIKK_1	31	37	PF00454	0.361
MOD_PKA_2	254	260	PF00069	0.599
MOD_PKA_2	268	274	PF00069	0.327
MOD_PKA_2	450	456	PF00069	0.249
MOD_Plk_1	223	229	PF00069	0.466
MOD_Plk_1	284	290	PF00069	0.450
MOD_Plk_1	582	588	PF00069	0.399
MOD_Plk_4	204	210	PF00069	0.341
MOD_Plk_4	223	229	PF00069	0.246
MOD_Plk_4	345	351	PF00069	0.410
MOD_Plk_4	475	481	PF00069	0.323
MOD_Plk_4	582	588	PF00069	0.381
MOD_ProDKin_1	236	242	PF00069	0.403
MOD_ProDKin_1	492	498	PF00069	0.334
MOD_ProDKin_1	576	582	PF00069	0.322
MOD_SUMO_rev_2	304	313	PF00179	0.334
MOD_SUMO_rev_2	323	332	PF00179	0.334
MOD_SUMO_rev_2	543	552	PF00179	0.544
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.420
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.273
TRG_DiLeu_BaLyEn_6	556	561	PF01217	0.339
TRG_ENDOCYTIC_2	205	208	PF00928	0.418
TRG_ENDOCYTIC_2	242	245	PF00928	0.262
TRG_ENDOCYTIC_2	37	40	PF00928	0.257
TRG_ENDOCYTIC_2	511	514	PF00928	0.503
TRG_ENDOCYTIC_2	94	97	PF00928	0.260
TRG_ER_diArg_1	41	44	PF00400	0.320
TRG_ER_diArg_1	75	77	PF00400	0.288
TRG_NES_CRM1_1	347	360	PF08389	0.385
TRG_NLS_MonoExtC_3	313	318	PF00514	0.255
TRG_NLS_MonoExtC_3	425	431	PF00514	0.676
TRG_NLS_MonoExtN_4	312	319	PF00514	0.255
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.255
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.273
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P663	Leptomonas seymouri	71%	100%
A0A0S4IRV7	Bodo saltans	41%	100%
A0A1X0NMG0	Trypanosomatidae	47%	100%
A0A3Q8ING8	Leishmania donovani	94%	100%
A0A422P247	Trypanosoma rangeli	47%	100%
A4HEE9	Leishmania braziliensis	86%	100%
A4I1I5	Leishmania infantum	95%	100%
C9ZJY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AXM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O35654	Mus musculus	26%	100%
O48520	Arabidopsis thaliana	26%	100%
O93610	Xenopus laevis	26%	100%
P46957	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P49004	Bos taurus	26%	100%
P49005	Homo sapiens	26%	100%
P87324	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q6AXY4	Rattus norvegicus	26%	100%
Q9LRE5	Oryza sativa subsp. japonica	27%	100%
Q9W088	Drosophila melanogaster	27%	100%
V5B3K0	Trypanosoma cruzi	46%	100%