Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9U9_LEIMA

TriTrypDb:

LmjF.25.1440 , LMJLV39_250021400 , LMJSD75_250021200

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9U9

Function

Biological processes
Term	Name	Level	Count
GO:0000738	obsolete DNA catabolic process, exonucleolytic	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006308	DNA catabolic process	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004518	nuclease activity	4	10
GO:0004527	exonuclease activity	5	10
GO:0004529	DNA exonuclease activity	5	2
GO:0004536	DNA nuclease activity	4	2
GO:0005488	binding	1	10
GO:0008296	3'-5'-DNA exonuclease activity	7	2
GO:0008408	3'-5' exonuclease activity	6	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0097159	organic cyclic compound binding	2	10
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.737
CLV_NRD_NRD_1	10	12	PF00675	0.481
CLV_NRD_NRD_1	135	137	PF00675	0.261
CLV_NRD_NRD_1	231	233	PF00675	0.259
CLV_NRD_NRD_1	3	5	PF00675	0.497
CLV_NRD_NRD_1	462	464	PF00675	0.715
CLV_NRD_NRD_1	483	485	PF00675	0.626
CLV_PCSK_FUR_1	480	484	PF00082	0.617
CLV_PCSK_KEX2_1	10	12	PF00082	0.467
CLV_PCSK_KEX2_1	230	232	PF00082	0.242
CLV_PCSK_KEX2_1	3	5	PF00082	0.504
CLV_PCSK_KEX2_1	479	481	PF00082	0.708
CLV_PCSK_KEX2_1	482	484	PF00082	0.687
CLV_PCSK_KEX2_1	76	78	PF00082	0.403
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.724
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.709
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.403
CLV_PCSK_PC7_1	226	232	PF00082	0.242
CLV_PCSK_SKI1_1	185	189	PF00082	0.247
CLV_PCSK_SKI1_1	232	236	PF00082	0.242
CLV_PCSK_SKI1_1	302	306	PF00082	0.398
CLV_PCSK_SKI1_1	316	320	PF00082	0.369
CLV_PCSK_SKI1_1	42	46	PF00082	0.373
CLV_PCSK_SKI1_1	453	457	PF00082	0.649
CLV_PCSK_SKI1_1	504	508	PF00082	0.578
CLV_PCSK_SKI1_1	89	93	PF00082	0.405
DEG_MDM2_SWIB_1	160	168	PF02201	0.484
DEG_Nend_Nbox_1	1	3	PF02207	0.635
DEG_SPOP_SBC_1	339	343	PF00917	0.576
DEG_SPOP_SBC_1	443	447	PF00917	0.521
DOC_AGCK_PIF_1	88	93	PF00069	0.289
DOC_ANK_TNKS_1	135	142	PF00023	0.518
DOC_CKS1_1	171	176	PF01111	0.459
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.305
DOC_MAPK_gen_1	10	17	PF00069	0.573
DOC_MAPK_gen_1	230	236	PF00069	0.484
DOC_MAPK_gen_1	76	84	PF00069	0.478
DOC_MAPK_HePTP_8	74	86	PF00069	0.385
DOC_MAPK_MEF2A_6	77	86	PF00069	0.385
DOC_PP2B_LxvP_1	252	255	PF13499	0.448
DOC_PP2B_LxvP_1	84	87	PF13499	0.316
DOC_PP4_FxxP_1	97	100	PF00568	0.442
DOC_USP7_MATH_1	196	200	PF00917	0.450
DOC_USP7_MATH_1	330	334	PF00917	0.580
DOC_USP7_MATH_1	339	343	PF00917	0.540
DOC_USP7_MATH_1	359	363	PF00917	0.612
DOC_USP7_MATH_1	444	448	PF00917	0.561
DOC_USP7_MATH_1	467	471	PF00917	0.597
DOC_WW_Pin1_4	116	121	PF00397	0.442
DOC_WW_Pin1_4	170	175	PF00397	0.459
DOC_WW_Pin1_4	284	289	PF00397	0.356
DOC_WW_Pin1_4	32	37	PF00397	0.499
DOC_WW_Pin1_4	447	452	PF00397	0.581
LIG_14-3-3_CanoR_1	10	16	PF00244	0.541
LIG_14-3-3_CanoR_1	268	272	PF00244	0.525
LIG_14-3-3_CanoR_1	3	7	PF00244	0.530
LIG_14-3-3_CanoR_1	316	322	PF00244	0.460
LIG_14-3-3_CanoR_1	350	359	PF00244	0.639
LIG_14-3-3_CanoR_1	69	78	PF00244	0.437
LIG_14-3-3_CanoR_1	89	94	PF00244	0.172
LIG_AP2alpha_1	373	377	PF02296	0.631
LIG_BRCT_BRCA1_1	214	218	PF00533	0.484
LIG_BRCT_BRCA1_1	84	88	PF00533	0.330
LIG_Clathr_ClatBox_1	368	372	PF01394	0.656
LIG_Clathr_ClatBox_1	63	67	PF01394	0.359
LIG_deltaCOP1_diTrp_1	162	170	PF00928	0.484
LIG_FHA_1	107	113	PF00498	0.504
LIG_FHA_1	219	225	PF00498	0.466
LIG_FHA_1	322	328	PF00498	0.632
LIG_FHA_1	33	39	PF00498	0.479
LIG_FHA_1	364	370	PF00498	0.672
LIG_FHA_1	422	428	PF00498	0.545
LIG_FHA_1	444	450	PF00498	0.604
LIG_FHA_1	501	507	PF00498	0.650
LIG_FHA_1	73	79	PF00498	0.411
LIG_FHA_2	285	291	PF00498	0.342
LIG_LIR_Apic_2	94	100	PF02991	0.442
LIG_LIR_Gen_1	123	133	PF02991	0.448
LIG_LIR_Gen_1	162	171	PF02991	0.464
LIG_LIR_Gen_1	270	279	PF02991	0.484
LIG_LIR_Gen_1	370	377	PF02991	0.523
LIG_LIR_Gen_1	5	13	PF02991	0.546
LIG_LIR_Gen_1	81	91	PF02991	0.302
LIG_LIR_Nem_3	123	129	PF02991	0.473
LIG_LIR_Nem_3	162	167	PF02991	0.464
LIG_LIR_Nem_3	270	274	PF02991	0.484
LIG_LIR_Nem_3	343	349	PF02991	0.568
LIG_LIR_Nem_3	370	376	PF02991	0.526
LIG_LIR_Nem_3	5	9	PF02991	0.477
LIG_LIR_Nem_3	81	86	PF02991	0.317
LIG_PDZ_Class_2	504	509	PF00595	0.695
LIG_Pex14_1	271	275	PF04695	0.327
LIG_Pex14_2	160	164	PF04695	0.442
LIG_Pex14_2	373	377	PF04695	0.514
LIG_Pex14_2	93	97	PF04695	0.442
LIG_SH2_CRK	118	122	PF00017	0.542
LIG_SH2_CRK	275	279	PF00017	0.470
LIG_SH2_CRK	6	10	PF00017	0.406
LIG_SH2_STAP1	80	84	PF00017	0.429
LIG_SH2_STAT5	83	86	PF00017	0.312
LIG_SH3_3	168	174	PF00018	0.533
LIG_SH3_3	253	259	PF00018	0.427
LIG_SH3_3	33	39	PF00018	0.451
LIG_SUMO_SIM_anti_2	182	190	PF11976	0.525
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.384
LIG_SUMO_SIM_par_1	182	190	PF11976	0.451
LIG_SUMO_SIM_par_1	232	237	PF11976	0.484
LIG_SUMO_SIM_par_1	366	372	PF11976	0.607
LIG_TRAF2_1	388	391	PF00917	0.696
LIG_UBA3_1	186	194	PF00899	0.442
LIG_WRC_WIRS_1	90	95	PF05994	0.295
MOD_CDC14_SPxK_1	450	453	PF00782	0.578
MOD_CDK_SPK_2	284	289	PF00069	0.356
MOD_CDK_SPxK_1	447	453	PF00069	0.578
MOD_CK1_1	353	359	PF00069	0.601
MOD_CK1_1	417	423	PF00069	0.772
MOD_CK1_1	445	451	PF00069	0.667
MOD_CK1_1	468	474	PF00069	0.812
MOD_CK1_1	5	11	PF00069	0.523
MOD_CK2_1	177	183	PF00069	0.441
MOD_CK2_1	284	290	PF00069	0.355
MOD_Cter_Amidation	134	137	PF01082	0.259
MOD_Cter_Amidation	461	464	PF01082	0.598
MOD_GlcNHglycan	177	182	PF01048	0.241
MOD_GlcNHglycan	334	337	PF01048	0.601
MOD_GlcNHglycan	350	353	PF01048	0.614
MOD_GlcNHglycan	354	358	PF01048	0.590
MOD_GlcNHglycan	361	364	PF01048	0.732
MOD_GlcNHglycan	383	386	PF01048	0.611
MOD_GlcNHglycan	403	406	PF01048	0.690
MOD_GlcNHglycan	459	462	PF01048	0.627
MOD_GlcNHglycan	467	470	PF01048	0.797
MOD_GlcNHglycan	485	488	PF01048	0.618
MOD_GSK3_1	106	113	PF00069	0.540
MOD_GSK3_1	317	324	PF00069	0.659
MOD_GSK3_1	340	347	PF00069	0.675
MOD_GSK3_1	359	366	PF00069	0.603
MOD_GSK3_1	401	408	PF00069	0.681
MOD_GSK3_1	410	417	PF00069	0.716
MOD_GSK3_1	421	428	PF00069	0.537
MOD_GSK3_1	443	450	PF00069	0.621
MOD_GSK3_1	52	59	PF00069	0.483
MOD_NEK2_1	122	127	PF00069	0.531
MOD_NEK2_1	187	192	PF00069	0.442
MOD_NEK2_1	2	7	PF00069	0.500
MOD_NEK2_1	218	223	PF00069	0.457
MOD_NEK2_1	274	279	PF00069	0.463
MOD_NEK2_1	321	326	PF00069	0.706
MOD_NEK2_1	410	415	PF00069	0.725
MOD_NEK2_1	416	421	PF00069	0.761
MOD_NEK2_1	82	87	PF00069	0.437
MOD_NEK2_1	95	100	PF00069	0.430
MOD_PIKK_1	25	31	PF00454	0.370
MOD_PIKK_1	69	75	PF00454	0.397
MOD_PK_1	11	17	PF00069	0.549
MOD_PKA_1	11	17	PF00069	0.605
MOD_PKA_1	483	489	PF00069	0.699
MOD_PKA_2	2	8	PF00069	0.501
MOD_PKA_2	267	273	PF00069	0.549
MOD_PKA_2	483	489	PF00069	0.720
MOD_PKB_1	230	238	PF00069	0.484
MOD_Plk_1	122	128	PF00069	0.467
MOD_Plk_1	143	149	PF00069	0.457
MOD_Plk_1	196	202	PF00069	0.442
MOD_Plk_1	339	345	PF00069	0.670
MOD_Plk_1	425	431	PF00069	0.609
MOD_Plk_2-3	106	112	PF00069	0.442
MOD_Plk_4	11	17	PF00069	0.646
MOD_Plk_4	196	202	PF00069	0.467
MOD_Plk_4	212	218	PF00069	0.442
MOD_Plk_4	274	280	PF00069	0.470
MOD_Plk_4	321	327	PF00069	0.582
MOD_Plk_4	344	350	PF00069	0.741
MOD_ProDKin_1	116	122	PF00069	0.442
MOD_ProDKin_1	170	176	PF00069	0.459
MOD_ProDKin_1	284	290	PF00069	0.355
MOD_ProDKin_1	32	38	PF00069	0.495
MOD_ProDKin_1	447	453	PF00069	0.584
MOD_SUMO_rev_2	298	304	PF00179	0.426
MOD_SUMO_rev_2	386	394	PF00179	0.616
MOD_SUMO_rev_2	54	64	PF00179	0.391
TRG_DiLeu_BaEn_1	183	188	PF01217	0.442
TRG_DiLeu_BaEn_1	300	305	PF01217	0.383
TRG_DiLeu_BaEn_2	155	161	PF01217	0.472
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.525
TRG_ENDOCYTIC_2	118	121	PF00928	0.542
TRG_ENDOCYTIC_2	275	278	PF00928	0.344
TRG_ENDOCYTIC_2	6	9	PF00928	0.453
TRG_ENDOCYTIC_2	83	86	PF00928	0.312
TRG_ER_diArg_1	2	4	PF00400	0.538
TRG_ER_diArg_1	230	232	PF00400	0.442
TRG_ER_diArg_1	483	485	PF00400	0.539
TRG_ER_diArg_1	9	11	PF00400	0.501
TRG_NES_CRM1_1	143	156	PF08389	0.457
TRG_NLS_MonoExtN_4	479	486	PF00514	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P667	Leptomonas seymouri	65%	100%
A0A3R7N9L3	Trypanosoma rangeli	55%	100%
A0A3S7WZ67	Leishmania donovani	94%	100%
A4HEE6	Leishmania braziliensis	79%	100%
A4I1I8	Leishmania infantum	94%	100%
C9ZJX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AXM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B841	Trypanosoma cruzi	54%	100%