Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U1 small nuclear ribonucleoprotein 24 kDa

Species:

Leishmania major

UniProt:

Q4Q9U8_LEIMA

TriTrypDb:

LmjF.25.1443 , LMJLV39_250021500 , LMJSD75_250021300

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005685	U1 snRNP	5	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q9U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9U8

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0045292	mRNA cis splicing, via spliceosome	9	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.499
CLV_NRD_NRD_1	217	219	PF00675	0.517
CLV_NRD_NRD_1	38	40	PF00675	0.351
CLV_NRD_NRD_1	83	85	PF00675	0.630
CLV_PCSK_KEX2_1	117	119	PF00082	0.552
CLV_PCSK_KEX2_1	217	219	PF00082	0.517
CLV_PCSK_KEX2_1	38	40	PF00082	0.404
CLV_PCSK_KEX2_1	82	84	PF00082	0.628
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.595
CLV_PCSK_SKI1_1	191	195	PF00082	0.548
CLV_PCSK_SKI1_1	39	43	PF00082	0.428
DOC_CKS1_1	154	159	PF01111	0.348
DOC_CYCLIN_yCln2_LP_2	75	81	PF00134	0.631
DOC_MAPK_DCC_7	99	108	PF00069	0.517
DOC_MAPK_JIP1_4	196	202	PF00069	0.471
DOC_MAPK_MEF2A_6	196	204	PF00069	0.469
DOC_PP1_RVXF_1	82	89	PF00149	0.595
DOC_USP7_MATH_1	61	65	PF00917	0.627
DOC_WW_Pin1_4	122	127	PF00397	0.621
DOC_WW_Pin1_4	153	158	PF00397	0.342
LIG_14-3-3_CanoR_1	118	126	PF00244	0.544
LIG_14-3-3_CanoR_1	191	200	PF00244	0.552
LIG_14-3-3_CanoR_1	217	224	PF00244	0.555
LIG_14-3-3_CanoR_1	82	87	PF00244	0.738
LIG_CtBP_PxDLS_1	105	109	PF00389	0.459
LIG_deltaCOP1_diTrp_1	242	248	PF00928	0.505
LIG_eIF4E_1	69	75	PF01652	0.595
LIG_FHA_1	217	223	PF00498	0.579
LIG_FHA_2	209	215	PF00498	0.478
LIG_LIR_Gen_1	30	36	PF02991	0.341
LIG_LIR_Gen_1	85	96	PF02991	0.584
LIG_LIR_Nem_3	12	17	PF02991	0.446
LIG_LIR_Nem_3	30	34	PF02991	0.233
LIG_LIR_Nem_3	85	91	PF02991	0.639
LIG_MYND_1	101	105	PF01753	0.508
LIG_PCNA_yPIPBox_3	68	82	PF02747	0.645
LIG_SH2_CRK	14	18	PF00017	0.421
LIG_SH2_GRB2like	201	204	PF00017	0.497
LIG_SH2_SRC	147	150	PF00017	0.378
LIG_SH2_SRC	176	179	PF00017	0.420
LIG_SH2_STAT5	113	116	PF00017	0.510
LIG_SH2_STAT5	147	150	PF00017	0.354
LIG_SH2_STAT5	16	19	PF00017	0.405
LIG_SH2_STAT5	161	164	PF00017	0.393
LIG_SH2_STAT5	201	204	PF00017	0.497
LIG_SH2_STAT5	69	72	PF00017	0.582
LIG_SH3_3	154	160	PF00018	0.347
LIG_SH3_3	184	190	PF00018	0.550
LIG_SH3_3	30	36	PF00018	0.460
LIG_SUMO_SIM_anti_2	167	173	PF11976	0.456
LIG_TRAF2_1	211	214	PF00917	0.506
LIG_TRAF2_1	236	239	PF00917	0.632
LIG_TYR_ITIM	199	204	PF00017	0.498
LIG_WRC_WIRS_1	223	228	PF05994	0.551
LIG_WRC_WIRS_1	93	98	PF05994	0.696
LIG_WW_3	188	192	PF00397	0.562
MOD_CDK_SPxK_1	153	159	PF00069	0.467
MOD_CK1_1	122	128	PF00069	0.492
MOD_CK1_1	225	231	PF00069	0.687
MOD_CK1_1	60	66	PF00069	0.572
MOD_CK1_1	95	101	PF00069	0.525
MOD_CK2_1	130	136	PF00069	0.522
MOD_CK2_1	208	214	PF00069	0.494
MOD_CK2_1	232	238	PF00069	0.641
MOD_CK2_1	45	51	PF00069	0.530
MOD_CMANNOS	245	248	PF00535	0.497
MOD_GlcNHglycan	140	143	PF01048	0.617
MOD_GlcNHglycan	191	194	PF01048	0.555
MOD_GlcNHglycan	234	237	PF01048	0.566
MOD_GlcNHglycan	47	50	PF01048	0.570
MOD_GlcNHglycan	59	62	PF01048	0.668
MOD_GSK3_1	122	129	PF00069	0.648
MOD_GSK3_1	222	229	PF00069	0.632
MOD_GSK3_1	45	52	PF00069	0.570
MOD_GSK3_1	57	64	PF00069	0.579
MOD_NEK2_1	226	231	PF00069	0.562
MOD_NEK2_1	250	255	PF00069	0.518
MOD_PIKK_1	191	197	PF00454	0.502
MOD_PIKK_1	253	259	PF00454	0.527
MOD_PIKK_1	69	75	PF00454	0.553
MOD_PK_1	130	136	PF00069	0.603
MOD_PKA_1	217	223	PF00069	0.548
MOD_PKA_1	82	88	PF00069	0.594
MOD_PKA_2	129	135	PF00069	0.660
MOD_PKA_2	216	222	PF00069	0.538
MOD_PKA_2	250	256	PF00069	0.645
MOD_PKA_2	82	88	PF00069	0.594
MOD_Plk_1	130	136	PF00069	0.651
MOD_Plk_4	6	12	PF00069	0.488
MOD_Plk_4	61	67	PF00069	0.612
MOD_ProDKin_1	122	128	PF00069	0.623
MOD_ProDKin_1	153	159	PF00069	0.351
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.389
TRG_ENDOCYTIC_2	14	17	PF00928	0.415
TRG_ENDOCYTIC_2	147	150	PF00928	0.413
TRG_ENDOCYTIC_2	201	204	PF00928	0.497
TRG_ER_diArg_1	116	119	PF00400	0.543
TRG_ER_diArg_1	216	218	PF00400	0.525
TRG_ER_diArg_1	81	84	PF00400	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN1	Leptomonas seymouri	56%	100%
A0A1X0NM21	Trypanosomatidae	27%	100%
A0A3S5H7E8	Leishmania donovani	94%	100%
A4HE80	Leishmania braziliensis	88%	100%
A4I1I9	Leishmania infantum	94%	100%
C9ZJX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AXM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BCP1	Trypanosoma cruzi	26%	100%