Cyclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cyclin

Gene product:

cyclin

Species:

Leishmania major

UniProt:

Q4Q9U4_LEIMA

TriTrypDb:

LmjF.25.1470 , LMJLV39_250022000 , LMJSD75_250022000

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	7	2
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2
GO:1902554	serine/threonine protein kinase complex	6	2
GO:1902911	protein kinase complex	5	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4Q9U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9U4

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	2
GO:0001932	regulation of protein phosphorylation	7	2
GO:0009987	cellular process	1	2
GO:0019220	regulation of phosphate metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0022402	cell cycle process	2	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031399	regulation of protein modification process	6	2
GO:0042325	regulation of phosphorylation	7	2
GO:0043549	regulation of kinase activity	5	2
GO:0044770	cell cycle phase transition	3	2
GO:0044772	mitotic cell cycle phase transition	4	2
GO:0045859	regulation of protein kinase activity	6	2
GO:0050789	regulation of biological process	2	2
GO:0050790	regulation of catalytic activity	3	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051174	regulation of phosphorus metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051338	regulation of transferase activity	4	2
GO:0051726	regulation of cell cycle	4	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0071900	regulation of protein serine/threonine kinase activity	7	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903047	mitotic cell cycle process	3	2
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	2
GO:0019207	kinase regulator activity	3	2
GO:0019887	protein kinase regulator activity	4	2
GO:0019899	enzyme binding	3	2
GO:0019900	kinase binding	4	2
GO:0030234	enzyme regulator activity	2	2
GO:0098772	molecular function regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	286	288	PF00675	0.262
CLV_NRD_NRD_1	75	77	PF00675	0.376
CLV_PCSK_KEX2_1	286	288	PF00082	0.262
CLV_PCSK_SKI1_1	106	110	PF00082	0.384
CLV_PCSK_SKI1_1	76	80	PF00082	0.268
DEG_APCC_DBOX_1	114	122	PF00400	0.262
DOC_CKS1_1	29	34	PF01111	0.494
DOC_MAPK_gen_1	115	123	PF00069	0.314
DOC_MAPK_gen_1	231	241	PF00069	0.222
DOC_PP1_RVXF_1	104	111	PF00149	0.395
DOC_PP4_FxxP_1	171	174	PF00568	0.329
DOC_WW_Pin1_4	247	252	PF00397	0.238
DOC_WW_Pin1_4	28	33	PF00397	0.564
LIG_14-3-3_CanoR_1	168	174	PF00244	0.322
LIG_14-3-3_CanoR_1	286	294	PF00244	0.282
LIG_14-3-3_CanoR_1	38	47	PF00244	0.379
LIG_14-3-3_CanoR_1	56	65	PF00244	0.138
LIG_14-3-3_CanoR_1	67	75	PF00244	0.339
LIG_APCC_ABBA_1	90	95	PF00400	0.262
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_BIR_III_1	1	5	PF00653	0.481
LIG_BIR_III_3	1	5	PF00653	0.481
LIG_BRCT_BRCA1_1	298	302	PF00533	0.314
LIG_CSL_BTD_1	135	138	PF09270	0.262
LIG_FHA_1	122	128	PF00498	0.239
LIG_FHA_1	13	19	PF00498	0.485
LIG_FHA_1	174	180	PF00498	0.340
LIG_FHA_1	263	269	PF00498	0.308
LIG_FHA_1	270	276	PF00498	0.259
LIG_FHA_1	47	53	PF00498	0.383
LIG_FHA_1	94	100	PF00498	0.278
LIG_FHA_2	137	143	PF00498	0.320
LIG_FHA_2	150	156	PF00498	0.244
LIG_KLC1_Yacidic_2	61	66	PF13176	0.168
LIG_LIR_Apic_2	20	25	PF02991	0.421
LIG_LIR_Gen_1	105	114	PF02991	0.262
LIG_LIR_Gen_1	158	169	PF02991	0.378
LIG_LIR_Gen_1	197	205	PF02991	0.345
LIG_LIR_Gen_1	291	302	PF02991	0.273
LIG_LIR_Gen_1	49	59	PF02991	0.256
LIG_LIR_Gen_1	95	104	PF02991	0.262
LIG_LIR_Nem_3	105	110	PF02991	0.262
LIG_LIR_Nem_3	158	164	PF02991	0.395
LIG_LIR_Nem_3	197	201	PF02991	0.317
LIG_LIR_Nem_3	291	297	PF02991	0.253
LIG_LIR_Nem_3	299	305	PF02991	0.438
LIG_LIR_Nem_3	49	54	PF02991	0.367
LIG_LIR_Nem_3	95	101	PF02991	0.262
LIG_LYPXL_yS_3	208	211	PF13949	0.376
LIG_PDZ_Class_1	304	309	PF00595	0.517
LIG_SH2_CRK	111	115	PF00017	0.376
LIG_SH2_CRK	22	26	PF00017	0.540
LIG_SH2_CRK	294	298	PF00017	0.273
LIG_SH2_NCK_1	294	298	PF00017	0.367
LIG_SH2_STAP1	294	298	PF00017	0.367
LIG_SH2_STAP1	59	63	PF00017	0.398
LIG_SH2_STAT5	151	154	PF00017	0.304
LIG_SH2_STAT5	50	53	PF00017	0.308
LIG_SH2_STAT5	64	67	PF00017	0.319
LIG_SH3_3	15	21	PF00018	0.600
LIG_SH3_3	26	32	PF00018	0.596
LIG_SH3_4	24	31	PF00018	0.465
LIG_Sin3_3	220	227	PF02671	0.273
LIG_SUMO_SIM_par_1	81	89	PF11976	0.450
LIG_TRFH_1	90	94	PF08558	0.262
MOD_CK1_1	12	18	PF00069	0.428
MOD_CK1_1	277	283	PF00069	0.311
MOD_CK1_1	69	75	PF00069	0.342
MOD_CK2_1	149	155	PF00069	0.262
MOD_CK2_1	287	293	PF00069	0.376
MOD_GlcNHglycan	202	205	PF01048	0.261
MOD_GlcNHglycan	276	279	PF01048	0.360
MOD_GSK3_1	109	116	PF00069	0.271
MOD_GSK3_1	169	176	PF00069	0.399
MOD_GSK3_1	34	41	PF00069	0.615
MOD_GSK3_1	42	49	PF00069	0.442
MOD_N-GLC_1	12	17	PF02516	0.515
MOD_N-GLC_1	232	237	PF02516	0.376
MOD_N-GLC_1	34	39	PF02516	0.442
MOD_N-GLC_2	141	143	PF02516	0.367
MOD_NEK2_1	109	114	PF00069	0.380
MOD_NEK2_1	169	174	PF00069	0.324
MOD_NEK2_1	183	188	PF00069	0.272
MOD_NEK2_1	200	205	PF00069	0.252
MOD_NEK2_1	304	309	PF00069	0.508
MOD_OFUCOSY	181	187	PF10250	0.273
MOD_PIKK_1	269	275	PF00454	0.366
MOD_PKA_1	287	293	PF00069	0.285
MOD_PKA_2	66	72	PF00069	0.376
MOD_Plk_1	34	40	PF00069	0.523
MOD_Plk_4	194	200	PF00069	0.345
MOD_Plk_4	46	52	PF00069	0.347
MOD_Plk_4	93	99	PF00069	0.273
MOD_ProDKin_1	247	253	PF00069	0.238
MOD_ProDKin_1	28	34	PF00069	0.565
MOD_SUMO_for_1	130	133	PF00179	0.245
MOD_SUMO_rev_2	85	92	PF00179	0.378
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.261
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.380
TRG_ENDOCYTIC_2	208	211	PF00928	0.294
TRG_ENDOCYTIC_2	294	297	PF00928	0.273
TRG_ER_diArg_1	285	287	PF00400	0.262
TRG_ER_diArg_1	5	8	PF00400	0.592
TRG_NES_CRM1_1	81	95	PF08389	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P242	Leptomonas seymouri	37%	73%
A0A0N1PCH1	Leptomonas seymouri	70%	100%
A0A0S4JB51	Bodo saltans	45%	89%
A0A0S4JDL7	Bodo saltans	37%	94%
A0A1X0NNN9	Trypanosomatidae	56%	93%
A0A1X0NS93	Trypanosomatidae	35%	77%
A0A3S7X632	Leishmania donovani	38%	100%
A0A422N0Z8	Trypanosoma rangeli	52%	93%
A0A422P2X2	Trypanosoma rangeli	38%	82%
A0MEB5	Arabidopsis thaliana	32%	94%
A2YH60	Oryza sativa subsp. indica	33%	74%
A4HE79	Leishmania braziliensis	85%	96%
A4HKX7	Leishmania braziliensis	38%	100%
A4I1J3	Leishmania infantum	97%	100%
A4I8F7	Leishmania infantum	38%	100%
E9AXM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B3B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
O48790	Arabidopsis thaliana	34%	80%
O77689	Bos taurus	28%	78%
O93229	Rana japonica	32%	79%
O95067	Homo sapiens	29%	78%
P04962	Spisula solidissima	35%	73%
P07818	Arbacia punctulata	34%	76%
P13350	Xenopus laevis	32%	78%
P13351	Xenopus laevis	33%	79%
P13952	Spisula solidissima	33%	72%
P14635	Homo sapiens	32%	71%
P15206	Marthasterias glacialis	31%	80%
P18606	Xenopus laevis	35%	74%
P20248	Homo sapiens	36%	72%
P24860	Mus musculus	31%	72%
P24861	Patella vulgata	33%	73%
P24862	Patella vulgata	33%	76%
P24865	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	74%
P24870	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	72%
P24871	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	67%
P25010	Daucus carota	35%	91%
P25011	Glycine max	34%	68%
P25012	Glycine max	37%	100%
P29332	Gallus gallus	31%	77%
P30183	Arabidopsis thaliana	33%	72%
P30274	Bos taurus	37%	72%
P30276	Mus musculus	29%	78%
P30277	Rattus norvegicus	31%	73%
P30278	Medicago sativa	31%	94%
P30281	Homo sapiens	28%	100%
P30282	Mus musculus	28%	100%
P30283	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	71%
P32943	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	81%
P34801	Antirrhinum majus	33%	70%
P36630	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	75%
P37881	Mesocricetus auratus	36%	73%
P37882	Mesocricetus auratus	32%	72%
P37883	Mesocricetus auratus	29%	78%
P42524	Dictyostelium discoideum	36%	71%
P42751	Arabidopsis thaliana	26%	91%
P43449	Gallus gallus	34%	78%
P46277	Medicago sativa subsp. varia	32%	72%
P46278	Medicago sativa subsp. varia	31%	71%
P48961	Rattus norvegicus	28%	100%
P49706	Gallus gallus	26%	100%
P49707	Gallus gallus	26%	76%
P51943	Mus musculus	35%	73%
P51986	Hydra viridissima	34%	74%
P51987	Hydra viridissima	32%	79%
P51988	Hydra vulgaris	32%	86%
P78396	Homo sapiens	36%	66%
Q01J96	Oryza sativa subsp. indica	34%	73%
Q08301	Cricetulus griseus	32%	72%
Q0D9C7	Oryza sativa subsp. japonica	33%	74%
Q0DH40	Oryza sativa subsp. japonica	32%	69%
Q0DJR9	Oryza sativa subsp. japonica	37%	87%
Q0JIF2	Oryza sativa subsp. japonica	35%	69%
Q0P5D3	Bos taurus	27%	100%
Q10654	Caenorhabditis elegans	26%	80%
Q10Q62	Oryza sativa subsp. japonica	29%	76%
Q10Q63	Oryza sativa subsp. japonica	34%	79%
Q147G5	Arabidopsis thaliana	36%	71%
Q1LZG6	Bos taurus	32%	72%
Q2QN26	Oryza sativa subsp. japonica	36%	80%
Q38819	Arabidopsis thaliana	32%	69%
Q39067	Arabidopsis thaliana	37%	69%
Q39068	Arabidopsis thaliana	35%	72%
Q39069	Arabidopsis thaliana	37%	75%
Q39070	Arabidopsis thaliana	32%	72%
Q39071	Arabidopsis thaliana	35%	70%
Q3ECW2	Arabidopsis thaliana	32%	84%
Q3MHH5	Bos taurus	28%	100%
Q4Q4U0	Leishmania major	38%	100%
Q4R7A8	Macaca fascicularis	29%	78%
Q5E9K7	Bos taurus	27%	76%
Q60FX9	Anguilla japonica	32%	78%
Q60FY0	Anguilla japonica	34%	77%
Q61456	Mus musculus	33%	73%
Q6AY13	Rattus norvegicus	37%	73%
Q77Q36	Human herpesvirus 8 type P (isolate GK18)	27%	100%
Q7XSJ6	Oryza sativa subsp. japonica	34%	74%
Q8MUA0	Leishmania donovani	96%	100%
Q8WNW2	Sus scrofa	27%	100%
Q92161	Carassius auratus	36%	79%
Q92162	Carassius auratus	35%	78%
Q9C6A9	Arabidopsis thaliana	32%	83%
Q9C6Y3	Arabidopsis thaliana	38%	67%
Q9C968	Arabidopsis thaliana	33%	67%
Q9DG96	Oryzias luzonensis	32%	80%
Q9DG97	Oryzias luzonensis	32%	77%
Q9DG99	Oryzias javanicus	32%	81%
Q9DGA0	Oryzias javanicus	34%	77%
Q9DGA3	Oryzias curvinotus	31%	80%
Q9DGA4	Oryzias curvinotus	35%	77%
Q9FMH5	Arabidopsis thaliana	35%	87%
Q9FVX0	Arabidopsis thaliana	35%	70%
Q9IBG0	Oryzias latipes	32%	80%
Q9IBG1	Oryzias latipes	32%	76%
Q9LDM4	Arabidopsis thaliana	34%	72%
Q9SFW6	Arabidopsis thaliana	32%	72%
V5BLA1	Trypanosoma cruzi	38%	82%