SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PUA domain/NOL1/NOP2/sun family, putative

Species:

Leishmania major

UniProt:

Q4Q9U1_LEIMA

TriTrypDb:

LmjF.25.1500 , LMJLV39_250022400 , LMJSD75_250022400

Length:

708

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9U1

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009451	RNA modification	5	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0032259	methylation	2	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0043414	macromolecule methylation	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0008168	methyltransferase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016741	transferase activity, transferring one-carbon groups	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	391	395	PF00656	0.434
CLV_C14_Caspase3-7	76	80	PF00656	0.492
CLV_NRD_NRD_1	156	158	PF00675	0.698
CLV_NRD_NRD_1	372	374	PF00675	0.511
CLV_NRD_NRD_1	501	503	PF00675	0.502
CLV_NRD_NRD_1	557	559	PF00675	0.264
CLV_PCSK_KEX2_1	372	374	PF00082	0.511
CLV_PCSK_KEX2_1	501	503	PF00082	0.510
CLV_PCSK_PC1ET2_1	501	503	PF00082	0.510
CLV_PCSK_SKI1_1	115	119	PF00082	0.480
CLV_PCSK_SKI1_1	309	313	PF00082	0.452
CLV_PCSK_SKI1_1	498	502	PF00082	0.458
CLV_PCSK_SKI1_1	558	562	PF00082	0.264
DEG_APCC_DBOX_1	304	312	PF00400	0.453
DEG_Nend_Nbox_1	1	3	PF02207	0.352
DEG_SPOP_SBC_1	323	327	PF00917	0.665
DOC_CKS1_1	98	103	PF01111	0.576
DOC_CYCLIN_RxL_1	157	170	PF00134	0.486
DOC_CYCLIN_RxL_1	305	315	PF00134	0.434
DOC_CYCLIN_RxL_1	552	563	PF00134	0.469
DOC_CYCLIN_yClb1_LxF_4	592	598	PF00134	0.505
DOC_MAPK_DCC_7	676	684	PF00069	0.450
DOC_MAPK_gen_1	112	121	PF00069	0.449
DOC_MAPK_gen_1	447	456	PF00069	0.481
DOC_MAPK_JIP1_4	162	168	PF00069	0.423
DOC_MAPK_MEF2A_6	115	123	PF00069	0.432
DOC_MAPK_MEF2A_6	158	167	PF00069	0.553
DOC_MAPK_MEF2A_6	402	409	PF00069	0.342
DOC_MAPK_NFAT4_5	402	410	PF00069	0.343
DOC_PP2B_LxvP_1	182	185	PF13499	0.505
DOC_PP2B_LxvP_1	465	468	PF13499	0.585
DOC_PP2B_LxvP_1	527	530	PF13499	0.437
DOC_PP4_FxxP_1	110	113	PF00568	0.541
DOC_USP7_MATH_1	111	115	PF00917	0.534
DOC_USP7_MATH_1	262	266	PF00917	0.519
DOC_USP7_MATH_1	323	327	PF00917	0.665
DOC_USP7_MATH_1	427	431	PF00917	0.513
DOC_USP7_MATH_1	466	470	PF00917	0.697
DOC_USP7_MATH_1	507	511	PF00917	0.573
DOC_USP7_MATH_1	54	58	PF00917	0.515
DOC_WW_Pin1_4	13	18	PF00397	0.493
DOC_WW_Pin1_4	132	137	PF00397	0.595
DOC_WW_Pin1_4	143	148	PF00397	0.736
DOC_WW_Pin1_4	295	300	PF00397	0.420
DOC_WW_Pin1_4	324	329	PF00397	0.744
DOC_WW_Pin1_4	364	369	PF00397	0.443
DOC_WW_Pin1_4	37	42	PF00397	0.590
DOC_WW_Pin1_4	383	388	PF00397	0.609
DOC_WW_Pin1_4	468	473	PF00397	0.601
DOC_WW_Pin1_4	474	479	PF00397	0.536
DOC_WW_Pin1_4	568	573	PF00397	0.505
DOC_WW_Pin1_4	90	95	PF00397	0.601
DOC_WW_Pin1_4	97	102	PF00397	0.546
LIG_14-3-3_CanoR_1	24	28	PF00244	0.465
LIG_14-3-3_CanoR_1	264	268	PF00244	0.528
LIG_14-3-3_CanoR_1	305	309	PF00244	0.405
LIG_14-3-3_CanoR_1	324	328	PF00244	0.541
LIG_14-3-3_CanoR_1	459	468	PF00244	0.533
LIG_14-3-3_CanoR_1	608	617	PF00244	0.464
LIG_Actin_WH2_2	356	374	PF00022	0.460
LIG_APCC_ABBA_1	682	687	PF00400	0.507
LIG_BRCT_BRCA1_1	190	194	PF00533	0.484
LIG_DCNL_PONY_1	1	4	PF03556	0.351
LIG_EVH1_1	329	333	PF00568	0.654
LIG_FHA_1	116	122	PF00498	0.525
LIG_FHA_1	129	135	PF00498	0.482
LIG_FHA_1	18	24	PF00498	0.473
LIG_FHA_1	264	270	PF00498	0.437
LIG_FHA_1	401	407	PF00498	0.353
LIG_FHA_1	475	481	PF00498	0.575
LIG_FHA_1	484	490	PF00498	0.493
LIG_FHA_1	582	588	PF00498	0.454
LIG_FHA_1	66	72	PF00498	0.399
LIG_FHA_1	667	673	PF00498	0.380
LIG_FHA_1	81	87	PF00498	0.520
LIG_FHA_2	16	22	PF00498	0.458
LIG_FHA_2	210	216	PF00498	0.582
LIG_FHA_2	274	280	PF00498	0.279
LIG_FHA_2	374	380	PF00498	0.555
LIG_FHA_2	389	395	PF00498	0.337
LIG_FHA_2	583	589	PF00498	0.441
LIG_GSK3_LRP6_1	97	102	PF00069	0.477
LIG_LIR_Apic_2	108	113	PF02991	0.538
LIG_LIR_Apic_2	59	65	PF02991	0.407
LIG_LIR_Gen_1	519	530	PF02991	0.465
LIG_LIR_Gen_1	683	693	PF02991	0.455
LIG_LIR_Nem_3	135	140	PF02991	0.619
LIG_LIR_Nem_3	240	245	PF02991	0.488
LIG_LIR_Nem_3	26	31	PF02991	0.434
LIG_LIR_Nem_3	279	283	PF02991	0.483
LIG_LIR_Nem_3	435	441	PF02991	0.454
LIG_LIR_Nem_3	5	10	PF02991	0.496
LIG_LIR_Nem_3	519	525	PF02991	0.440
LIG_LIR_Nem_3	600	604	PF02991	0.519
LIG_LIR_Nem_3	683	688	PF02991	0.498
LIG_LYPXL_yS_3	601	604	PF13949	0.464
LIG_MYND_1	538	542	PF01753	0.439
LIG_NRBOX	307	313	PF00104	0.467
LIG_NRBOX	405	411	PF00104	0.391
LIG_NRBOX	452	458	PF00104	0.401
LIG_NRBOX	81	87	PF00104	0.454
LIG_PCNA_PIPBox_1	454	463	PF02747	0.480
LIG_PCNA_yPIPBox_3	445	457	PF02747	0.419
LIG_PDZ_Class_1	703	708	PF00595	0.525
LIG_Pex14_2	696	700	PF04695	0.290
LIG_RPA_C_Fungi	605	617	PF08784	0.324
LIG_SH2_CRK	14	18	PF00017	0.493
LIG_SH2_CRK	62	66	PF00017	0.425
LIG_SH2_NCK_1	14	18	PF00017	0.477
LIG_SH2_NCK_1	62	66	PF00017	0.482
LIG_SH2_NCK_1	685	689	PF00017	0.500
LIG_SH2_SRC	12	15	PF00017	0.475
LIG_SH2_SRC	183	186	PF00017	0.374
LIG_SH2_SRC	685	688	PF00017	0.486
LIG_SH2_STAP1	353	357	PF00017	0.353
LIG_SH2_STAT3	10	13	PF00017	0.479
LIG_SH2_STAT3	626	629	PF00017	0.394
LIG_SH2_STAT5	205	208	PF00017	0.452
LIG_SH2_STAT5	484	487	PF00017	0.546
LIG_SH2_STAT5	7	10	PF00017	0.529
LIG_SH2_STAT5	705	708	PF00017	0.523
LIG_SH3_1	157	163	PF00018	0.575
LIG_SH3_1	569	575	PF00018	0.374
LIG_SH3_3	157	163	PF00018	0.645
LIG_SH3_3	24	30	PF00018	0.427
LIG_SH3_3	327	333	PF00018	0.739
LIG_SH3_3	477	483	PF00018	0.492
LIG_SH3_3	569	575	PF00018	0.374
LIG_SH3_3	91	97	PF00018	0.506
LIG_SUMO_SIM_anti_2	667	676	PF11976	0.468
LIG_SUMO_SIM_par_1	163	170	PF11976	0.317
LIG_SUMO_SIM_par_1	680	687	PF11976	0.402
LIG_TRAF2_1	414	417	PF00917	0.504
LIG_TRAF2_1	448	451	PF00917	0.476
LIG_TRAF2_1	586	589	PF00917	0.317
LIG_UBA3_1	311	316	PF00899	0.638
MOD_CDK_SPK_2	37	42	PF00069	0.587
MOD_CK1_1	143	149	PF00069	0.658
MOD_CK1_1	15	21	PF00069	0.457
MOD_CK1_1	273	279	PF00069	0.318
MOD_CK1_1	304	310	PF00069	0.473
MOD_CK1_1	35	41	PF00069	0.378
MOD_CK1_1	473	479	PF00069	0.637
MOD_CK1_1	511	517	PF00069	0.525
MOD_CK1_1	546	552	PF00069	0.385
MOD_CK1_1	571	577	PF00069	0.338
MOD_CK1_1	581	587	PF00069	0.244
MOD_CK1_1	635	641	PF00069	0.677
MOD_CK1_1	92	98	PF00069	0.633
MOD_CK2_1	148	154	PF00069	0.774
MOD_CK2_1	15	21	PF00069	0.450
MOD_CK2_1	209	215	PF00069	0.562
MOD_CK2_1	273	279	PF00069	0.276
MOD_CK2_1	332	338	PF00069	0.649
MOD_CK2_1	582	588	PF00069	0.292
MOD_DYRK1A_RPxSP_1	324	328	PF00069	0.559
MOD_GlcNHglycan	219	222	PF01048	0.588
MOD_GlcNHglycan	237	240	PF01048	0.442
MOD_GlcNHglycan	272	275	PF01048	0.438
MOD_GlcNHglycan	334	337	PF01048	0.702
MOD_GlcNHglycan	34	37	PF01048	0.685
MOD_GlcNHglycan	429	432	PF01048	0.508
MOD_GlcNHglycan	44	47	PF01048	0.538
MOD_GlcNHglycan	468	471	PF01048	0.649
MOD_GlcNHglycan	512	516	PF01048	0.659
MOD_GlcNHglycan	552	555	PF01048	0.292
MOD_GlcNHglycan	702	705	PF01048	0.442
MOD_GSK3_1	111	118	PF00069	0.548
MOD_GSK3_1	12	19	PF00069	0.430
MOD_GSK3_1	128	135	PF00069	0.589
MOD_GSK3_1	139	146	PF00069	0.599
MOD_GSK3_1	284	291	PF00069	0.515
MOD_GSK3_1	318	325	PF00069	0.652
MOD_GSK3_1	401	408	PF00069	0.368
MOD_GSK3_1	466	473	PF00069	0.673
MOD_GSK3_1	507	514	PF00069	0.524
MOD_GSK3_1	546	553	PF00069	0.350
MOD_GSK3_1	578	585	PF00069	0.317
MOD_GSK3_1	618	625	PF00069	0.336
MOD_GSK3_1	632	639	PF00069	0.543
MOD_GSK3_1	92	99	PF00069	0.648
MOD_N-GLC_1	217	222	PF02516	0.589
MOD_N-GLC_1	351	356	PF02516	0.331
MOD_N-GLC_1	474	479	PF02516	0.594
MOD_NEK2_1	139	144	PF00069	0.595
MOD_NEK2_1	23	28	PF00069	0.476
MOD_NEK2_1	284	289	PF00069	0.540
MOD_NEK2_1	312	317	PF00069	0.479
MOD_NEK2_1	405	410	PF00069	0.356
MOD_NEK2_1	560	565	PF00069	0.312
MOD_NEK2_1	597	602	PF00069	0.459
MOD_NEK2_1	700	705	PF00069	0.372
MOD_NEK2_2	619	624	PF00069	0.219
MOD_OFUCOSY	270	277	PF10250	0.263
MOD_PK_1	52	58	PF00069	0.605
MOD_PKA_1	502	508	PF00069	0.509
MOD_PKA_2	111	117	PF00069	0.469
MOD_PKA_2	177	183	PF00069	0.321
MOD_PKA_2	23	29	PF00069	0.461
MOD_PKA_2	263	269	PF00069	0.476
MOD_PKA_2	304	310	PF00069	0.596
MOD_PKA_2	323	329	PF00069	0.714
MOD_Plk_1	351	357	PF00069	0.329
MOD_Plk_1	416	422	PF00069	0.562
MOD_Plk_1	52	58	PF00069	0.605
MOD_Plk_2-3	686	692	PF00069	0.496
MOD_Plk_4	23	29	PF00069	0.454
MOD_Plk_4	263	269	PF00069	0.440
MOD_Plk_4	279	285	PF00069	0.365
MOD_Plk_4	352	358	PF00069	0.338
MOD_Plk_4	388	394	PF00069	0.475
MOD_Plk_4	401	407	PF00069	0.256
MOD_Plk_4	452	458	PF00069	0.479
MOD_ProDKin_1	13	19	PF00069	0.486
MOD_ProDKin_1	132	138	PF00069	0.598
MOD_ProDKin_1	143	149	PF00069	0.740
MOD_ProDKin_1	295	301	PF00069	0.420
MOD_ProDKin_1	324	330	PF00069	0.745
MOD_ProDKin_1	364	370	PF00069	0.440
MOD_ProDKin_1	37	43	PF00069	0.590
MOD_ProDKin_1	383	389	PF00069	0.594
MOD_ProDKin_1	468	474	PF00069	0.600
MOD_ProDKin_1	568	574	PF00069	0.375
MOD_ProDKin_1	90	96	PF00069	0.601
MOD_ProDKin_1	97	103	PF00069	0.541
MOD_SUMO_rev_2	273	283	PF00179	0.462
TRG_DiLeu_BaLyEn_6	668	673	PF01217	0.467
TRG_ENDOCYTIC_2	353	356	PF00928	0.355
TRG_ENDOCYTIC_2	601	604	PF00928	0.317
TRG_ENDOCYTIC_2	685	688	PF00928	0.486
TRG_ER_diArg_1	371	373	PF00400	0.498
TRG_ER_diArg_1	445	448	PF00400	0.486
TRG_NLS_MonoExtC_3	500	506	PF00514	0.508
TRG_NLS_MonoExtN_4	498	505	PF00514	0.426
TRG_Pf-PMV_PEXEL_1	502	506	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	558	562	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA86	Leptomonas seymouri	49%	99%
A0A0S4JUU1	Bodo saltans	30%	100%
A0A1X0NZU0	Trypanosomatidae	35%	100%
A0A3Q8IGM4	Leishmania donovani	92%	100%
A4HEK2	Leishmania braziliensis	78%	84%
A4I1J6	Leishmania infantum	92%	100%
Q84MA1	Arabidopsis thaliana	25%	100%