Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9U0_LEIMA

TriTrypDb:

LmjF.25.1510 , LMJLV39_250022500 , LMJSD75_250022500

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9U0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.800
CLV_C14_Caspase3-7	413	417	PF00656	0.702
CLV_C14_Caspase3-7	454	458	PF00656	0.557
CLV_C14_Caspase3-7	510	514	PF00656	0.603
CLV_NRD_NRD_1	227	229	PF00675	0.668
CLV_NRD_NRD_1	429	431	PF00675	0.737
CLV_NRD_NRD_1	432	434	PF00675	0.726
CLV_NRD_NRD_1	46	48	PF00675	0.592
CLV_NRD_NRD_1	486	488	PF00675	0.605
CLV_NRD_NRD_1	519	521	PF00675	0.609
CLV_PCSK_KEX2_1	229	231	PF00082	0.704
CLV_PCSK_KEX2_1	46	48	PF00082	0.592
CLV_PCSK_KEX2_1	486	488	PF00082	0.605
CLV_PCSK_KEX2_1	519	521	PF00082	0.609
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.630
CLV_PCSK_PC7_1	225	231	PF00082	0.684
CLV_PCSK_SKI1_1	47	51	PF00082	0.585
CLV_PCSK_SKI1_1	76	80	PF00082	0.383
DEG_APCC_DBOX_1	123	131	PF00400	0.744
DEG_COP1_1	489	501	PF00400	0.690
DEG_Nend_UBRbox_2	1	3	PF02207	0.632
DEG_SCF_FBW7_1	346	353	PF00400	0.780
DEG_SPOP_SBC_1	320	324	PF00917	0.836
DEG_SPOP_SBC_1	404	408	PF00917	0.816
DOC_CKS1_1	362	367	PF01111	0.804
DOC_MAPK_gen_1	430	440	PF00069	0.717
DOC_MAPK_HePTP_8	6	18	PF00069	0.362
DOC_MAPK_MEF2A_6	9	18	PF00069	0.579
DOC_PP2B_LxvP_1	72	75	PF13499	0.496
DOC_PP2B_PxIxI_1	392	398	PF00149	0.708
DOC_PP4_FxxP_1	11	14	PF00568	0.498
DOC_PP4_MxPP_1	348	351	PF00568	0.820
DOC_USP7_MATH_1	206	210	PF00917	0.643
DOC_USP7_MATH_1	299	303	PF00917	0.740
DOC_USP7_MATH_1	365	369	PF00917	0.696
DOC_USP7_MATH_1	371	375	PF00917	0.676
DOC_USP7_MATH_1	403	407	PF00917	0.813
DOC_USP7_MATH_1	456	460	PF00917	0.656
DOC_USP7_MATH_1	471	475	PF00917	0.803
DOC_USP7_MATH_1	61	65	PF00917	0.485
DOC_WW_Pin1_4	122	127	PF00397	0.680
DOC_WW_Pin1_4	284	289	PF00397	0.754
DOC_WW_Pin1_4	303	308	PF00397	0.839
DOC_WW_Pin1_4	346	351	PF00397	0.709
DOC_WW_Pin1_4	361	366	PF00397	0.742
DOC_WW_Pin1_4	389	394	PF00397	0.828
DOC_WW_Pin1_4	464	469	PF00397	0.692
LIG_14-3-3_CanoR_1	329	335	PF00244	0.725
LIG_14-3-3_CanoR_1	382	386	PF00244	0.766
LIG_14-3-3_CanoR_1	46	55	PF00244	0.582
LIG_AP2alpha_2	398	400	PF02296	0.724
LIG_BH_BH3_1	80	96	PF00452	0.560
LIG_BIR_III_2	279	283	PF00653	0.634
LIG_BIR_III_2	526	530	PF00653	0.689
LIG_EH1_1	81	89	PF00400	0.479
LIG_FHA_1	351	357	PF00498	0.643
LIG_FHA_1	435	441	PF00498	0.740
LIG_FHA_1	443	449	PF00498	0.622
LIG_FHA_1	477	483	PF00498	0.825
LIG_FHA_2	142	148	PF00498	0.583
LIG_FHA_2	409	415	PF00498	0.802
LIG_FHA_2	452	458	PF00498	0.674
LIG_FHA_2	92	98	PF00498	0.611
LIG_Integrin_isoDGR_2	108	110	PF01839	0.550
LIG_LIR_Apic_2	10	14	PF02991	0.511
LIG_LIR_Gen_1	259	270	PF02991	0.707
LIG_LIR_Nem_3	259	265	PF02991	0.702
LIG_LIR_Nem_3	512	518	PF02991	0.603
LIG_MAD2	47	55	PF02301	0.619
LIG_MYND_1	389	393	PF01753	0.740
LIG_SH2_NCK_1	262	266	PF00017	0.704
LIG_SH2_STAT3	182	185	PF00017	0.572
LIG_SH2_STAT5	140	143	PF00017	0.521
LIG_SH2_STAT5	194	197	PF00017	0.582
LIG_SH2_STAT5	532	535	PF00017	0.541
LIG_SH2_STAT5	65	68	PF00017	0.447
LIG_SH2_STAT5	70	73	PF00017	0.482
LIG_SH3_3	269	275	PF00018	0.773
LIG_SH3_3	278	284	PF00018	0.650
LIG_SH3_3	301	307	PF00018	0.691
LIG_SH3_3	383	389	PF00018	0.772
LIG_SH3_3	393	399	PF00018	0.637
LIG_SUMO_SIM_par_1	2	7	PF11976	0.458
LIG_SUMO_SIM_par_1	268	274	PF11976	0.784
LIG_TRAF2_1	234	237	PF00917	0.594
LIG_TRAF2_1	417	420	PF00917	0.769
LIG_WRC_WIRS_1	8	13	PF05994	0.521
MOD_CK1_1	287	293	PF00069	0.791
MOD_CK1_1	302	308	PF00069	0.759
MOD_CK1_1	408	414	PF00069	0.693
MOD_CK1_1	443	449	PF00069	0.665
MOD_CK1_1	466	472	PF00069	0.709
MOD_CK1_1	474	480	PF00069	0.747
MOD_CK1_1	490	496	PF00069	0.671
MOD_CK1_1	500	506	PF00069	0.683
MOD_CK1_1	7	13	PF00069	0.448
MOD_CK2_1	141	147	PF00069	0.509
MOD_CK2_1	168	174	PF00069	0.532
MOD_CK2_1	217	223	PF00069	0.623
MOD_CK2_1	334	340	PF00069	0.678
MOD_CK2_1	408	414	PF00069	0.724
MOD_CK2_1	53	59	PF00069	0.503
MOD_CK2_1	7	13	PF00069	0.607
MOD_CK2_1	91	97	PF00069	0.600
MOD_GlcNHglycan	136	139	PF01048	0.554
MOD_GlcNHglycan	144	147	PF01048	0.445
MOD_GlcNHglycan	219	222	PF01048	0.513
MOD_GlcNHglycan	325	328	PF01048	0.606
MOD_GlcNHglycan	368	371	PF01048	0.831
MOD_GlcNHglycan	383	386	PF01048	0.572
MOD_GlcNHglycan	469	472	PF01048	0.784
MOD_GlcNHglycan	489	493	PF01048	0.498
MOD_GlcNHglycan	499	502	PF01048	0.703
MOD_GlcNHglycan	55	58	PF01048	0.495
MOD_GSK3_1	196	203	PF00069	0.653
MOD_GSK3_1	287	294	PF00069	0.773
MOD_GSK3_1	299	306	PF00069	0.748
MOD_GSK3_1	315	322	PF00069	0.697
MOD_GSK3_1	330	337	PF00069	0.657
MOD_GSK3_1	346	353	PF00069	0.742
MOD_GSK3_1	361	368	PF00069	0.695
MOD_GSK3_1	404	411	PF00069	0.823
MOD_GSK3_1	463	470	PF00069	0.709
MOD_GSK3_1	471	478	PF00069	0.710
MOD_GSK3_1	487	494	PF00069	0.711
MOD_GSK3_1	497	504	PF00069	0.696
MOD_N-GLC_1	334	339	PF02516	0.786
MOD_N-GLC_2	115	117	PF02516	0.544
MOD_NEK2_1	141	146	PF00069	0.472
MOD_NEK2_1	168	173	PF00069	0.562
MOD_NEK2_1	217	222	PF00069	0.480
MOD_NEK2_1	315	320	PF00069	0.751
MOD_NEK2_1	451	456	PF00069	0.732
MOD_NEK2_1	91	96	PF00069	0.507
MOD_NEK2_2	458	463	PF00069	0.737
MOD_PIKK_1	159	165	PF00454	0.520
MOD_PKA_2	381	387	PF00069	0.767
MOD_Plk_1	334	340	PF00069	0.783
MOD_Plk_1	443	449	PF00069	0.665
MOD_Plk_4	371	377	PF00069	0.799
MOD_Plk_4	405	411	PF00069	0.825
MOD_Plk_4	434	440	PF00069	0.750
MOD_Plk_4	443	449	PF00069	0.614
MOD_Plk_4	7	13	PF00069	0.471
MOD_Plk_4	91	97	PF00069	0.520
MOD_ProDKin_1	122	128	PF00069	0.679
MOD_ProDKin_1	284	290	PF00069	0.754
MOD_ProDKin_1	303	309	PF00069	0.837
MOD_ProDKin_1	346	352	PF00069	0.713
MOD_ProDKin_1	361	367	PF00069	0.742
MOD_ProDKin_1	389	395	PF00069	0.826
MOD_ProDKin_1	464	470	PF00069	0.691
MOD_SUMO_for_1	102	105	PF00179	0.654
TRG_DiLeu_BaEn_1	239	244	PF01217	0.658
TRG_DiLeu_BaEn_1	460	465	PF01217	0.728
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.459
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.489
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.730
TRG_ENDOCYTIC_2	262	265	PF00928	0.703
TRG_ER_diArg_1	45	47	PF00400	0.591
TRG_ER_diArg_1	518	520	PF00400	0.604
TRG_NES_CRM1_1	13	27	PF08389	0.459
TRG_NLS_MonoExtC_3	429	434	PF00514	0.833
TRG_NLS_MonoExtN_4	427	434	PF00514	0.832
TRG_Pf-PMV_PEXEL_1	520	525	PF00026	0.740
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYY1	Leptomonas seymouri	37%	100%
A0A3Q8ICE6	Leishmania donovani	91%	100%
A4HEK1	Leishmania braziliensis	75%	100%
A4I1J7	Leishmania infantum	91%	100%
E9AXN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%