Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania major

UniProt:

Q4Q9T9_LEIMA

TriTrypDb:

LmjF.25.1520 , LMJLV39_250022600 , LMJSD75_250022600

Length:

944

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9T9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9T9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.561
CLV_C14_Caspase3-7	289	293	PF00656	0.654
CLV_C14_Caspase3-7	367	371	PF00656	0.544
CLV_C14_Caspase3-7	37	41	PF00656	0.577
CLV_NRD_NRD_1	31	33	PF00675	0.615
CLV_NRD_NRD_1	425	427	PF00675	0.558
CLV_NRD_NRD_1	515	517	PF00675	0.312
CLV_NRD_NRD_1	923	925	PF00675	0.708
CLV_PCSK_KEX2_1	31	33	PF00082	0.615
CLV_PCSK_KEX2_1	515	517	PF00082	0.312
CLV_PCSK_KEX2_1	6	8	PF00082	0.668
CLV_PCSK_KEX2_1	723	725	PF00082	0.312
CLV_PCSK_KEX2_1	923	925	PF00082	0.662
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.668
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.291
CLV_PCSK_SKI1_1	541	545	PF00082	0.350
CLV_PCSK_SKI1_1	588	592	PF00082	0.327
CLV_PCSK_SKI1_1	593	597	PF00082	0.339
CLV_Separin_Metazoa	708	712	PF03568	0.340
DEG_APCC_DBOX_1	773	781	PF00400	0.539
DEG_Nend_UBRbox_3	1	3	PF02207	0.713
DEG_SPOP_SBC_1	72	76	PF00917	0.590
DEG_SPOP_SBC_1	815	819	PF00917	0.598
DEG_SPOP_SBC_1	862	866	PF00917	0.638
DOC_CYCLIN_RxL_1	538	548	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	238	241	PF00134	0.634
DOC_MAPK_DCC_7	606	614	PF00069	0.291
DOC_MAPK_gen_1	593	602	PF00069	0.312
DOC_MAPK_gen_1	606	614	PF00069	0.291
DOC_MAPK_gen_1	808	816	PF00069	0.588
DOC_MAPK_gen_1	923	929	PF00069	0.702
DOC_MAPK_JIP1_4	596	602	PF00069	0.312
DOC_MAPK_MEF2A_6	606	614	PF00069	0.291
DOC_PP2B_LxvP_1	238	241	PF13499	0.664
DOC_PP2B_LxvP_1	318	321	PF13499	0.543
DOC_PP2B_LxvP_1	877	880	PF13499	0.702
DOC_PP4_FxxP_1	536	539	PF00568	0.312
DOC_USP7_MATH_1	106	110	PF00917	0.674
DOC_USP7_MATH_1	113	117	PF00917	0.652
DOC_USP7_MATH_1	119	123	PF00917	0.657
DOC_USP7_MATH_1	231	235	PF00917	0.709
DOC_USP7_MATH_1	309	313	PF00917	0.622
DOC_USP7_MATH_1	366	370	PF00917	0.617
DOC_USP7_MATH_1	59	63	PF00917	0.648
DOC_USP7_MATH_1	698	702	PF00917	0.395
DOC_USP7_MATH_1	72	76	PF00917	0.613
DOC_WW_Pin1_4	176	181	PF00397	0.683
DOC_WW_Pin1_4	229	234	PF00397	0.657
DOC_WW_Pin1_4	298	303	PF00397	0.674
DOC_WW_Pin1_4	341	346	PF00397	0.620
DOC_WW_Pin1_4	38	43	PF00397	0.618
DOC_WW_Pin1_4	427	432	PF00397	0.682
DOC_WW_Pin1_4	434	439	PF00397	0.525
DOC_WW_Pin1_4	443	448	PF00397	0.544
DOC_WW_Pin1_4	45	50	PF00397	0.602
DOC_WW_Pin1_4	61	66	PF00397	0.706
DOC_WW_Pin1_4	730	735	PF00397	0.326
DOC_WW_Pin1_4	762	767	PF00397	0.601
DOC_WW_Pin1_4	785	790	PF00397	0.787
DOC_WW_Pin1_4	800	805	PF00397	0.692
DOC_WW_Pin1_4	868	873	PF00397	0.722
DOC_WW_Pin1_4	916	921	PF00397	0.620
LIG_14-3-3_CanoR_1	225	233	PF00244	0.734
LIG_14-3-3_CanoR_1	330	335	PF00244	0.606
LIG_14-3-3_CanoR_1	699	707	PF00244	0.291
LIG_14-3-3_CanoR_1	881	887	PF00244	0.767
LIG_Actin_WH2_2	475	492	PF00022	0.312
LIG_APCC_ABBAyCdc20_2	588	594	PF00400	0.312
LIG_BRCT_BRCA1_1	311	315	PF00533	0.621
LIG_CtBP_PxDLS_1	186	190	PF00389	0.677
LIG_eIF4E_1	341	347	PF01652	0.650
LIG_eIF4E_1	639	645	PF01652	0.312
LIG_EVH1_1	777	781	PF00568	0.534
LIG_EVH1_2	319	323	PF00568	0.648
LIG_FHA_1	189	195	PF00498	0.567
LIG_FHA_1	270	276	PF00498	0.669
LIG_FHA_1	281	287	PF00498	0.530
LIG_FHA_1	566	572	PF00498	0.316
LIG_FHA_1	580	586	PF00498	0.345
LIG_FHA_1	617	623	PF00498	0.312
LIG_FHA_1	632	638	PF00498	0.312
LIG_FHA_1	646	652	PF00498	0.312
LIG_FHA_1	911	917	PF00498	0.733
LIG_FHA_1	929	935	PF00498	0.587
LIG_FHA_2	35	41	PF00498	0.671
LIG_FHA_2	417	423	PF00498	0.703
LIG_FHA_2	555	561	PF00498	0.472
LIG_FHA_2	828	834	PF00498	0.681
LIG_FHA_2	849	855	PF00498	0.588
LIG_KLC1_Yacidic_2	556	560	PF13176	0.352
LIG_LIR_Apic_2	393	397	PF02991	0.643
LIG_LIR_Apic_2	535	539	PF02991	0.312
LIG_LIR_Apic_2	636	642	PF02991	0.312
LIG_LIR_Nem_3	178	184	PF02991	0.676
LIG_LIR_Nem_3	216	220	PF02991	0.771
LIG_LIR_Nem_3	297	303	PF02991	0.585
LIG_LIR_Nem_3	312	318	PF02991	0.579
LIG_LIR_Nem_3	468	472	PF02991	0.312
LIG_MLH1_MIPbox_1	311	315	PF16413	0.621
LIG_MYND_1	236	240	PF01753	0.661
LIG_MYND_1	45	49	PF01753	0.646
LIG_MYND_1	775	779	PF01753	0.534
LIG_PAM2_1	564	576	PF00658	0.312
LIG_REV1ctd_RIR_1	215	223	PF16727	0.614
LIG_SH2_CRK	181	185	PF00017	0.641
LIG_SH2_CRK	300	304	PF00017	0.544
LIG_SH2_CRK	469	473	PF00017	0.312
LIG_SH2_GRB2like	658	661	PF00017	0.312
LIG_SH2_NCK_1	549	553	PF00017	0.388
LIG_SH2_PTP2	394	397	PF00017	0.647
LIG_SH2_SRC	658	661	PF00017	0.388
LIG_SH2_STAP1	261	265	PF00017	0.609
LIG_SH2_STAP1	392	396	PF00017	0.596
LIG_SH2_STAT5	261	264	PF00017	0.721
LIG_SH2_STAT5	300	303	PF00017	0.732
LIG_SH2_STAT5	314	317	PF00017	0.466
LIG_SH2_STAT5	394	397	PF00017	0.647
LIG_SH2_STAT5	457	460	PF00017	0.312
LIG_SH2_STAT5	473	476	PF00017	0.312
LIG_SH2_STAT5	500	503	PF00017	0.312
LIG_SH2_STAT5	558	561	PF00017	0.330
LIG_SH2_STAT5	573	576	PF00017	0.323
LIG_SH2_STAT5	658	661	PF00017	0.348
LIG_SH2_STAT5	677	680	PF00017	0.316
LIG_SH3_1	251	257	PF00018	0.570
LIG_SH3_1	39	45	PF00018	0.661
LIG_SH3_1	876	882	PF00018	0.707
LIG_SH3_2	254	259	PF14604	0.559
LIG_SH3_3	142	148	PF00018	0.639
LIG_SH3_3	18	24	PF00018	0.632
LIG_SH3_3	208	214	PF00018	0.625
LIG_SH3_3	230	236	PF00018	0.588
LIG_SH3_3	251	257	PF00018	0.626
LIG_SH3_3	299	305	PF00018	0.748
LIG_SH3_3	39	45	PF00018	0.661
LIG_SH3_3	436	442	PF00018	0.610
LIG_SH3_3	772	778	PF00018	0.636
LIG_SH3_3	872	878	PF00018	0.790
LIG_SH3_3	899	905	PF00018	0.700
LIG_SH3_CIN85_PxpxPR_1	781	786	PF14604	0.625
LIG_SUMO_SIM_anti_2	841	848	PF11976	0.686
LIG_SUMO_SIM_par_1	185	192	PF11976	0.597
LIG_SUMO_SIM_par_1	333	340	PF11976	0.615
LIG_SUMO_SIM_par_1	812	820	PF11976	0.555
LIG_SUMO_SIM_par_1	850	857	PF11976	0.620
LIG_SUMO_SIM_par_1	931	938	PF11976	0.688
LIG_TRAF2_1	105	108	PF00917	0.590
LIG_TRAF2_1	242	245	PF00917	0.662
LIG_TRAF2_2	242	247	PF00917	0.631
LIG_TRFH_1	361	365	PF08558	0.680
LIG_TYR_ITIM	571	576	PF00017	0.312
LIG_UBA3_1	716	723	PF00899	0.326
LIG_UBA3_1	739	745	PF00899	0.526
LIG_WRC_WIRS_1	908	913	PF05994	0.546
LIG_WW_2	775	778	PF00397	0.534
LIG_WW_3	256	260	PF00397	0.563
LIG_WW_3	608	612	PF00397	0.312
LIG_WW_3	878	882	PF00397	0.701
MOD_CDC14_SPxK_1	921	924	PF00782	0.652
MOD_CDK_SPK_2	346	351	PF00069	0.661
MOD_CDK_SPK_2	800	805	PF00069	0.619
MOD_CDK_SPK_2	918	923	PF00069	0.644
MOD_CDK_SPxK_1	918	924	PF00069	0.646
MOD_CDK_SPxxK_3	176	183	PF00069	0.682
MOD_CDK_SPxxK_3	916	923	PF00069	0.646
MOD_CK1_1	176	182	PF00069	0.660
MOD_CK1_1	188	194	PF00069	0.547
MOD_CK1_1	278	284	PF00069	0.643
MOD_CK1_1	34	40	PF00069	0.698
MOD_CK1_1	378	384	PF00069	0.604
MOD_CK1_1	416	422	PF00069	0.716
MOD_CK1_1	432	438	PF00069	0.616
MOD_CK1_1	48	54	PF00069	0.584
MOD_CK1_1	551	557	PF00069	0.346
MOD_CK1_1	631	637	PF00069	0.321
MOD_CK1_1	71	77	PF00069	0.704
MOD_CK1_1	762	768	PF00069	0.691
MOD_CK1_1	817	823	PF00069	0.600
MOD_CK1_1	848	854	PF00069	0.572
MOD_CK1_1	864	870	PF00069	0.750
MOD_CK1_1	910	916	PF00069	0.620
MOD_CK1_1	96	102	PF00069	0.672
MOD_CK2_1	416	422	PF00069	0.696
MOD_CK2_1	523	529	PF00069	0.352
MOD_CK2_1	554	560	PF00069	0.472
MOD_CK2_1	827	833	PF00069	0.676
MOD_CK2_1	839	845	PF00069	0.550
MOD_Cter_Amidation	424	427	PF01082	0.563
MOD_GlcNHglycan	134	137	PF01048	0.680
MOD_GlcNHglycan	145	148	PF01048	0.572
MOD_GlcNHglycan	175	178	PF01048	0.669
MOD_GlcNHglycan	263	266	PF01048	0.605
MOD_GlcNHglycan	269	272	PF01048	0.622
MOD_GlcNHglycan	296	299	PF01048	0.714
MOD_GlcNHglycan	332	335	PF01048	0.734
MOD_GlcNHglycan	366	369	PF01048	0.623
MOD_GlcNHglycan	378	381	PF01048	0.597
MOD_GlcNHglycan	434	437	PF01048	0.615
MOD_GlcNHglycan	550	553	PF01048	0.312
MOD_GlcNHglycan	629	633	PF01048	0.324
MOD_GlcNHglycan	70	73	PF01048	0.788
MOD_GlcNHglycan	700	703	PF01048	0.466
MOD_GlcNHglycan	761	764	PF01048	0.657
MOD_GlcNHglycan	766	769	PF01048	0.686
MOD_GlcNHglycan	847	850	PF01048	0.681
MOD_GlcNHglycan	95	98	PF01048	0.552
MOD_GSK3_1	115	122	PF00069	0.591
MOD_GSK3_1	128	135	PF00069	0.533
MOD_GSK3_1	220	227	PF00069	0.624
MOD_GSK3_1	294	301	PF00069	0.683
MOD_GSK3_1	34	41	PF00069	0.672
MOD_GSK3_1	398	405	PF00069	0.721
MOD_GSK3_1	434	441	PF00069	0.625
MOD_GSK3_1	496	503	PF00069	0.388
MOD_GSK3_1	575	582	PF00069	0.427
MOD_GSK3_1	612	619	PF00069	0.351
MOD_GSK3_1	647	654	PF00069	0.396
MOD_GSK3_1	663	670	PF00069	0.309
MOD_GSK3_1	67	74	PF00069	0.625
MOD_GSK3_1	794	801	PF00069	0.667
MOD_GSK3_1	835	842	PF00069	0.658
MOD_GSK3_1	84	91	PF00069	0.688
MOD_GSK3_1	861	868	PF00069	0.735
MOD_GSK3_1	881	888	PF00069	0.754
MOD_GSK3_1	907	914	PF00069	0.598
MOD_LATS_1	30	36	PF00433	0.668
MOD_N-GLC_1	294	299	PF02516	0.706
MOD_N-GLC_1	376	381	PF02516	0.604
MOD_N-GLC_1	564	569	PF02516	0.340
MOD_N-GLC_1	868	873	PF02516	0.649
MOD_N-GLC_1	911	916	PF02516	0.629
MOD_NEK2_1	130	135	PF00069	0.590
MOD_NEK2_1	275	280	PF00069	0.645
MOD_NEK2_1	286	291	PF00069	0.649
MOD_NEK2_1	574	579	PF00069	0.318
MOD_NEK2_1	644	649	PF00069	0.388
MOD_NEK2_1	67	72	PF00069	0.655
MOD_NEK2_1	735	740	PF00069	0.487
MOD_NEK2_1	761	766	PF00069	0.641
MOD_NEK2_1	814	819	PF00069	0.588
MOD_NEK2_1	839	844	PF00069	0.624
MOD_NEK2_1	847	852	PF00069	0.606
MOD_NEK2_1	861	866	PF00069	0.646
MOD_NEK2_1	911	916	PF00069	0.625
MOD_PIKK_1	240	246	PF00454	0.724
MOD_PIKK_1	402	408	PF00454	0.660
MOD_PIKK_1	746	752	PF00454	0.529
MOD_PIKK_1	817	823	PF00454	0.713
MOD_PIKK_1	885	891	PF00454	0.668
MOD_PIKK_1	911	917	PF00454	0.603
MOD_PK_1	225	231	PF00069	0.633
MOD_PK_1	84	90	PF00069	0.556
MOD_PKA_1	31	37	PF00069	0.598
MOD_PKA_2	224	230	PF00069	0.700
MOD_PKA_2	278	284	PF00069	0.640
MOD_PKA_2	31	37	PF00069	0.704
MOD_PKA_2	465	471	PF00069	0.312
MOD_PKA_2	651	657	PF00069	0.343
MOD_PKA_2	698	704	PF00069	0.340
MOD_Plk_1	564	570	PF00069	0.340
MOD_Plk_1	746	752	PF00069	0.505
MOD_Plk_1	911	917	PF00069	0.579
MOD_Plk_2-3	794	800	PF00069	0.752
MOD_Plk_4	213	219	PF00069	0.683
MOD_Plk_4	319	325	PF00069	0.658
MOD_Plk_4	378	384	PF00069	0.673
MOD_Plk_4	390	396	PF00069	0.553
MOD_Plk_4	496	502	PF00069	0.331
MOD_Plk_4	523	529	PF00069	0.312
MOD_Plk_4	554	560	PF00069	0.456
MOD_Plk_4	73	79	PF00069	0.583
MOD_Plk_4	735	741	PF00069	0.418
MOD_Plk_4	848	854	PF00069	0.572
MOD_Plk_4	882	888	PF00069	0.751
MOD_ProDKin_1	176	182	PF00069	0.681
MOD_ProDKin_1	229	235	PF00069	0.658
MOD_ProDKin_1	298	304	PF00069	0.670
MOD_ProDKin_1	341	347	PF00069	0.621
MOD_ProDKin_1	38	44	PF00069	0.619
MOD_ProDKin_1	427	433	PF00069	0.681
MOD_ProDKin_1	434	440	PF00069	0.525
MOD_ProDKin_1	443	449	PF00069	0.538
MOD_ProDKin_1	45	51	PF00069	0.606
MOD_ProDKin_1	61	67	PF00069	0.709
MOD_ProDKin_1	730	736	PF00069	0.326
MOD_ProDKin_1	762	768	PF00069	0.605
MOD_ProDKin_1	785	791	PF00069	0.788
MOD_ProDKin_1	800	806	PF00069	0.692
MOD_ProDKin_1	868	874	PF00069	0.724
MOD_ProDKin_1	916	922	PF00069	0.616
MOD_SUMO_rev_2	828	836	PF00179	0.642
TRG_DiLeu_BaEn_1	708	713	PF01217	0.312
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.649
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.653
TRG_DiLeu_LyEn_5	708	713	PF01217	0.340
TRG_ENDOCYTIC_2	10	13	PF00928	0.733
TRG_ENDOCYTIC_2	181	184	PF00928	0.613
TRG_ENDOCYTIC_2	202	205	PF00928	0.793
TRG_ENDOCYTIC_2	300	303	PF00928	0.547
TRG_ENDOCYTIC_2	392	395	PF00928	0.642
TRG_ENDOCYTIC_2	469	472	PF00928	0.312
TRG_ENDOCYTIC_2	573	576	PF00928	0.312
TRG_ENDOCYTIC_2	677	680	PF00928	0.388
TRG_ER_diArg_1	31	33	PF00400	0.621
TRG_ER_diArg_1	514	516	PF00400	0.312
TRG_ER_diArg_1	922	924	PF00400	0.651
TRG_NES_CRM1_1	708	720	PF08389	0.312
TRG_NLS_MonoCore_2	722	727	PF00514	0.291
TRG_NLS_MonoExtN_4	721	727	PF00514	0.340
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	509	513	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	593	598	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	611	616	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I119	Leptomonas seymouri	48%	99%
A0A3Q8IFC6	Leishmania donovani	92%	100%
A4HEK0	Leishmania braziliensis	74%	100%
A4I1J8	Leishmania infantum	91%	100%
E9AXN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%