Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9T8_LEIMA

TriTrypDb:

LmjF.25.1530 , LMJLV39_250022700 , LMJSD75_250022700

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9T8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.560
CLV_C14_Caspase3-7	380	384	PF00656	0.678
CLV_C14_Caspase3-7	423	427	PF00656	0.501
CLV_NRD_NRD_1	304	306	PF00675	0.668
CLV_NRD_NRD_1	308	310	PF00675	0.698
CLV_PCSK_FUR_1	302	306	PF00082	0.698
CLV_PCSK_KEX2_1	304	306	PF00082	0.632
CLV_PCSK_KEX2_1	308	310	PF00082	0.665
CLV_PCSK_PC7_1	304	310	PF00082	0.676
CLV_PCSK_SKI1_1	188	192	PF00082	0.596
CLV_PCSK_SKI1_1	284	288	PF00082	0.414
CLV_PCSK_SKI1_1	330	334	PF00082	0.566
DOC_ANK_TNKS_1	155	162	PF00023	0.543
DOC_CYCLIN_RxL_1	324	338	PF00134	0.574
DOC_MAPK_gen_1	186	195	PF00069	0.524
DOC_MAPK_gen_1	410	416	PF00069	0.587
DOC_PP1_RVXF_1	225	232	PF00149	0.456
DOC_PP1_RVXF_1	328	335	PF00149	0.583
DOC_USP7_MATH_1	23	27	PF00917	0.743
DOC_USP7_MATH_1	271	275	PF00917	0.434
DOC_USP7_MATH_1	318	322	PF00917	0.705
DOC_USP7_MATH_1	360	364	PF00917	0.677
DOC_USP7_MATH_1	424	428	PF00917	0.658
DOC_USP7_MATH_1	520	524	PF00917	0.785
DOC_WW_Pin1_4	162	167	PF00397	0.625
DOC_WW_Pin1_4	19	24	PF00397	0.614
DOC_WW_Pin1_4	389	394	PF00397	0.629
DOC_WW_Pin1_4	439	444	PF00397	0.764
LIG_14-3-3_CanoR_1	188	196	PF00244	0.597
LIG_14-3-3_CanoR_1	302	310	PF00244	0.682
LIG_14-3-3_CanoR_1	320	328	PF00244	0.587
LIG_14-3-3_CanoR_1	449	457	PF00244	0.502
LIG_14-3-3_CanoR_1	563	567	PF00244	0.679
LIG_APCC_ABBA_1	292	297	PF00400	0.352
LIG_BIR_II_1	1	5	PF00653	0.698
LIG_BIR_III_2	383	387	PF00653	0.632
LIG_eIF4E_1	327	333	PF01652	0.574
LIG_FHA_1	19	25	PF00498	0.488
LIG_FHA_1	276	282	PF00498	0.441
LIG_FHA_1	320	326	PF00498	0.515
LIG_FHA_1	402	408	PF00498	0.504
LIG_FHA_1	450	456	PF00498	0.551
LIG_FHA_1	46	52	PF00498	0.519
LIG_FHA_1	574	580	PF00498	0.671
LIG_FHA_2	115	121	PF00498	0.625
LIG_FHA_2	375	381	PF00498	0.795
LIG_FHA_2	578	584	PF00498	0.643
LIG_GBD_Chelix_1	465	473	PF00786	0.621
LIG_LIR_Gen_1	12	23	PF02991	0.624
LIG_LIR_Gen_1	351	362	PF02991	0.630
LIG_LIR_Gen_1	44	55	PF02991	0.539
LIG_LIR_Gen_1	559	568	PF02991	0.642
LIG_LIR_Nem_3	12	18	PF02991	0.547
LIG_LIR_Nem_3	133	138	PF02991	0.456
LIG_LIR_Nem_3	250	255	PF02991	0.495
LIG_LIR_Nem_3	351	357	PF02991	0.628
LIG_LIR_Nem_3	44	50	PF02991	0.493
LIG_LIR_Nem_3	66	72	PF02991	0.472
LIG_NRBOX	281	287	PF00104	0.448
LIG_PDZ_Class_1	585	590	PF00595	0.607
LIG_Pex14_2	398	402	PF04695	0.419
LIG_Rb_pABgroove_1	12	20	PF01858	0.670
LIG_Rb_pABgroove_1	289	297	PF01858	0.502
LIG_REV1ctd_RIR_1	558	567	PF16727	0.644
LIG_SH2_CRK	354	358	PF00017	0.490
LIG_SH2_CRK	47	51	PF00017	0.457
LIG_SH2_CRK	470	474	PF00017	0.678
LIG_SH2_STAP1	189	193	PF00017	0.552
LIG_SH2_STAP1	354	358	PF00017	0.490
LIG_SH2_STAP1	47	51	PF00017	0.485
LIG_SH2_STAP1	498	502	PF00017	0.593
LIG_SH2_STAT5	108	111	PF00017	0.395
LIG_SH2_STAT5	456	459	PF00017	0.478
LIG_SH2_STAT5	47	50	PF00017	0.440
LIG_SH2_STAT5	484	487	PF00017	0.683
LIG_SH3_1	156	162	PF00018	0.585
LIG_SH3_3	156	162	PF00018	0.646
LIG_SH3_3	235	241	PF00018	0.581
LIG_SH3_3	354	360	PF00018	0.469
LIG_SH3_3	383	389	PF00018	0.631
LIG_SH3_3	437	443	PF00018	0.754
LIG_SH3_3	497	503	PF00018	0.669
LIG_SUMO_SIM_par_1	165	171	PF11976	0.578
LIG_TRAF2_1	221	224	PF00917	0.520
LIG_TYR_ITIM	45	50	PF00017	0.576
LIG_TYR_ITIM	468	473	PF00017	0.640
LIG_UBA3_1	325	330	PF00899	0.576
MOD_CK1_1	199	205	PF00069	0.671
MOD_CK1_1	234	240	PF00069	0.497
MOD_CK1_1	335	341	PF00069	0.646
MOD_CK1_1	420	426	PF00069	0.654
MOD_CK1_1	434	440	PF00069	0.629
MOD_CK1_1	441	447	PF00069	0.563
MOD_CK1_1	515	521	PF00069	0.765
MOD_CK1_1	552	558	PF00069	0.575
MOD_CK1_1	82	88	PF00069	0.691
MOD_CK2_1	345	351	PF00069	0.630
MOD_CK2_1	374	380	PF00069	0.796
MOD_CK2_1	508	514	PF00069	0.707
MOD_CK2_1	520	526	PF00069	0.807
MOD_CK2_1	577	583	PF00069	0.623
MOD_CK2_1	58	64	PF00069	0.565
MOD_GlcNHglycan	25	28	PF01048	0.665
MOD_GlcNHglycan	261	264	PF01048	0.630
MOD_GlcNHglycan	305	308	PF01048	0.663
MOD_GlcNHglycan	313	316	PF01048	0.675
MOD_GlcNHglycan	347	350	PF01048	0.519
MOD_GlcNHglycan	422	425	PF01048	0.722
MOD_GlcNHglycan	516	520	PF01048	0.774
MOD_GlcNHglycan	522	526	PF01048	0.812
MOD_GlcNHglycan	81	84	PF01048	0.628
MOD_GSK3_1	184	191	PF00069	0.595
MOD_GSK3_1	19	26	PF00069	0.705
MOD_GSK3_1	271	278	PF00069	0.500
MOD_GSK3_1	416	423	PF00069	0.639
MOD_GSK3_1	431	438	PF00069	0.755
MOD_GSK3_1	508	515	PF00069	0.684
MOD_GSK3_1	573	580	PF00069	0.636
MOD_GSK3_1	75	82	PF00069	0.641
MOD_N-GLC_1	360	365	PF02516	0.650
MOD_N-GLC_1	508	513	PF02516	0.645
MOD_N-GLC_1	585	590	PF02516	0.657
MOD_NEK2_1	18	23	PF00069	0.668
MOD_NEK2_1	196	201	PF00069	0.626
MOD_NEK2_1	231	236	PF00069	0.460
MOD_NEK2_1	295	300	PF00069	0.591
MOD_NEK2_1	332	337	PF00069	0.547
MOD_NEK2_1	416	421	PF00069	0.624
MOD_NEK2_1	448	453	PF00069	0.608
MOD_NEK2_1	58	63	PF00069	0.593
MOD_OFUCOSY	549	556	PF10250	0.457
MOD_PIKK_1	319	325	PF00454	0.611
MOD_PIKK_1	424	430	PF00454	0.724
MOD_PIKK_1	88	94	PF00454	0.665
MOD_PKA_2	303	309	PF00069	0.632
MOD_PKA_2	311	317	PF00069	0.638
MOD_PKA_2	319	325	PF00069	0.615
MOD_PKA_2	420	426	PF00069	0.694
MOD_PKA_2	448	454	PF00069	0.523
MOD_PKA_2	562	568	PF00069	0.685
MOD_PKA_2	577	583	PF00069	0.556
MOD_PKB_1	186	194	PF00069	0.600
MOD_Plk_1	295	301	PF00069	0.562
MOD_Plk_1	350	356	PF00069	0.614
MOD_Plk_1	360	366	PF00069	0.613
MOD_Plk_1	508	514	PF00069	0.657
MOD_Plk_2-3	114	120	PF00069	0.639
MOD_Plk_2-3	510	516	PF00069	0.543
MOD_Plk_2-3	532	538	PF00069	0.713
MOD_Plk_2-3	554	560	PF00069	0.687
MOD_Plk_4	277	283	PF00069	0.469
MOD_Plk_4	480	486	PF00069	0.659
MOD_Plk_4	562	568	PF00069	0.620
MOD_ProDKin_1	162	168	PF00069	0.617
MOD_ProDKin_1	19	25	PF00069	0.618
MOD_ProDKin_1	389	395	PF00069	0.624
MOD_ProDKin_1	439	445	PF00069	0.756
MOD_SUMO_rev_2	406	413	PF00179	0.538
MOD_SUMO_rev_2	582	587	PF00179	0.703
MOD_SUMO_rev_2	82	91	PF00179	0.653
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.450
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.575
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.603
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.624
TRG_ENDOCYTIC_2	354	357	PF00928	0.613
TRG_ENDOCYTIC_2	47	50	PF00928	0.406
TRG_ENDOCYTIC_2	470	473	PF00928	0.670
TRG_ER_diArg_1	186	189	PF00400	0.563
TRG_ER_diArg_1	302	305	PF00400	0.701
TRG_ER_diArg_1	308	310	PF00400	0.624
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZM0	Leptomonas seymouri	46%	100%
A0A1X0NY83	Trypanosomatidae	25%	100%
A0A3S7WZ73	Leishmania donovani	91%	99%
A0A422NL47	Trypanosoma rangeli	28%	100%
A4HEJ9	Leishmania braziliensis	74%	99%
A4I1J9	Leishmania infantum	91%	99%
C9ZK33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AXN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	95%