Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CMGC/CLK family protein kinase, putative

Species:

Leishmania major

UniProt:

Q4Q9T5_LEIMA

TriTrypDb:

LmjF.25.1560 , LMJLV39_250023000 , LMJSD75_250023000

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9T5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.702
CLV_C14_Caspase3-7	44	48	PF00656	0.554
CLV_NRD_NRD_1	137	139	PF00675	0.561
CLV_NRD_NRD_1	404	406	PF00675	0.596
CLV_NRD_NRD_1	467	469	PF00675	0.654
CLV_NRD_NRD_1	784	786	PF00675	0.350
CLV_NRD_NRD_1	806	808	PF00675	0.479
CLV_PCSK_FUR_1	342	346	PF00082	0.654
CLV_PCSK_KEX2_1	137	139	PF00082	0.610
CLV_PCSK_KEX2_1	344	346	PF00082	0.673
CLV_PCSK_KEX2_1	404	406	PF00082	0.607
CLV_PCSK_KEX2_1	467	469	PF00082	0.653
CLV_PCSK_KEX2_1	475	477	PF00082	0.761
CLV_PCSK_KEX2_1	784	786	PF00082	0.314
CLV_PCSK_KEX2_1	793	795	PF00082	0.314
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.675
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.761
CLV_PCSK_PC1ET2_1	793	795	PF00082	0.406
CLV_PCSK_SKI1_1	138	142	PF00082	0.620
CLV_PCSK_SKI1_1	192	196	PF00082	0.381
CLV_PCSK_SKI1_1	216	220	PF00082	0.483
CLV_PCSK_SKI1_1	418	422	PF00082	0.314
CLV_PCSK_SKI1_1	521	525	PF00082	0.547
CLV_PCSK_SKI1_1	693	697	PF00082	0.350
CLV_PCSK_SKI1_1	784	788	PF00082	0.314
CLV_PCSK_SKI1_1	793	797	PF00082	0.314
DOC_ANK_TNKS_1	541	548	PF00023	0.667
DOC_CDC14_PxL_1	773	781	PF14671	0.406
DOC_CKS1_1	23	28	PF01111	0.721
DOC_CKS1_1	78	83	PF01111	0.651
DOC_MAPK_gen_1	501	510	PF00069	0.755
DOC_MAPK_MEF2A_6	452	460	PF00069	0.474
DOC_MAPK_MEF2A_6	626	634	PF00069	0.350
DOC_PP2B_LxvP_1	388	391	PF13499	0.487
DOC_PP2B_LxvP_1	412	415	PF13499	0.422
DOC_PP2B_LxvP_1	658	661	PF13499	0.406
DOC_PP2B_PxIxI_1	270	276	PF00149	0.665
DOC_PP4_FxxP_1	299	302	PF00568	0.373
DOC_SPAK_OSR1_1	298	302	PF12202	0.377
DOC_USP7_MATH_1	10	14	PF00917	0.652
DOC_USP7_MATH_1	338	342	PF00917	0.561
DOC_USP7_MATH_1	51	55	PF00917	0.716
DOC_USP7_MATH_1	516	520	PF00917	0.559
DOC_USP7_MATH_1	549	553	PF00917	0.679
DOC_USP7_MATH_1	88	92	PF00917	0.733
DOC_USP7_MATH_1	96	100	PF00917	0.685
DOC_WW_Pin1_4	138	143	PF00397	0.576
DOC_WW_Pin1_4	155	160	PF00397	0.458
DOC_WW_Pin1_4	199	204	PF00397	0.586
DOC_WW_Pin1_4	22	27	PF00397	0.768
DOC_WW_Pin1_4	267	272	PF00397	0.692
DOC_WW_Pin1_4	511	516	PF00397	0.591
DOC_WW_Pin1_4	561	566	PF00397	0.641
DOC_WW_Pin1_4	624	629	PF00397	0.380
DOC_WW_Pin1_4	77	82	PF00397	0.717
LIG_14-3-3_CanoR_1	155	159	PF00244	0.643
LIG_14-3-3_CanoR_1	263	273	PF00244	0.619
LIG_14-3-3_CanoR_1	345	352	PF00244	0.635
LIG_14-3-3_CanoR_1	367	376	PF00244	0.613
LIG_14-3-3_CanoR_1	704	710	PF00244	0.432
LIG_14-3-3_CanoR_1	71	79	PF00244	0.668
LIG_14-3-3_CanoR_1	794	801	PF00244	0.317
LIG_APCC_ABBA_1	219	224	PF00400	0.465
LIG_APCC_ABBAyCdc20_2	124	130	PF00400	0.593
LIG_APCC_ABBAyCdc20_2	434	440	PF00400	0.350
LIG_BIR_III_2	139	143	PF00653	0.591
LIG_deltaCOP1_diTrp_1	230	236	PF00928	0.482
LIG_EVH1_1	388	392	PF00568	0.584
LIG_EVH1_1	78	82	PF00568	0.652
LIG_FHA_1	158	164	PF00498	0.667
LIG_FHA_1	2	8	PF00498	0.786
LIG_FHA_1	283	289	PF00498	0.549
LIG_FHA_1	461	467	PF00498	0.539
LIG_FHA_1	556	562	PF00498	0.625
LIG_FHA_2	354	360	PF00498	0.792
LIG_FHA_2	598	604	PF00498	0.406
LIG_FHA_2	636	642	PF00498	0.410
LIG_FHA_2	675	681	PF00498	0.337
LIG_FHA_2	742	748	PF00498	0.455
LIG_FHA_2	766	772	PF00498	0.336
LIG_FHA_2	794	800	PF00498	0.314
LIG_LIR_Apic_2	20	26	PF02991	0.633
LIG_LIR_Apic_2	4	9	PF02991	0.768
LIG_LIR_Apic_2	622	628	PF02991	0.406
LIG_LIR_Apic_2	76	81	PF02991	0.655
LIG_LIR_Gen_1	141	150	PF02991	0.557
LIG_LIR_Gen_1	189	198	PF02991	0.393
LIG_LIR_Gen_1	230	239	PF02991	0.416
LIG_LIR_Gen_1	269	280	PF02991	0.607
LIG_LIR_Gen_1	359	369	PF02991	0.647
LIG_LIR_Gen_1	426	431	PF02991	0.381
LIG_LIR_Nem_3	122	128	PF02991	0.627
LIG_LIR_Nem_3	141	146	PF02991	0.546
LIG_LIR_Nem_3	170	176	PF02991	0.471
LIG_LIR_Nem_3	189	193	PF02991	0.407
LIG_LIR_Nem_3	230	236	PF02991	0.425
LIG_LIR_Nem_3	269	275	PF02991	0.610
LIG_LIR_Nem_3	426	430	PF02991	0.381
LIG_LIR_Nem_3	616	620	PF02991	0.346
LIG_LIR_Nem_3	702	706	PF02991	0.406
LIG_MAD2	192	200	PF02301	0.516
LIG_Pex14_2	597	601	PF04695	0.406
LIG_Pex14_2	703	707	PF04695	0.314
LIG_Pex14_2	716	720	PF04695	0.314
LIG_REV1ctd_RIR_1	803	809	PF16727	0.432
LIG_SH2_CRK	23	27	PF00017	0.700
LIG_SH2_CRK	409	413	PF00017	0.388
LIG_SH2_CRK	422	426	PF00017	0.162
LIG_SH2_CRK	617	621	PF00017	0.333
LIG_SH2_NCK_1	610	614	PF00017	0.439
LIG_SH2_NCK_1	617	621	PF00017	0.404
LIG_SH2_PTP2	272	275	PF00017	0.650
LIG_SH2_PTP2	576	579	PF00017	0.496
LIG_SH2_PTP2	6	9	PF00017	0.640
LIG_SH2_SRC	228	231	PF00017	0.484
LIG_SH2_SRC	6	9	PF00017	0.726
LIG_SH2_SRC	610	613	PF00017	0.416
LIG_SH2_STAP1	117	121	PF00017	0.707
LIG_SH2_STAP1	132	136	PF00017	0.392
LIG_SH2_STAP1	176	180	PF00017	0.494
LIG_SH2_STAP1	181	185	PF00017	0.495
LIG_SH2_STAP1	462	466	PF00017	0.568
LIG_SH2_STAT5	179	182	PF00017	0.375
LIG_SH2_STAT5	228	231	PF00017	0.484
LIG_SH2_STAT5	272	275	PF00017	0.650
LIG_SH2_STAT5	292	295	PF00017	0.249
LIG_SH2_STAT5	305	308	PF00017	0.506
LIG_SH2_STAT5	462	465	PF00017	0.475
LIG_SH2_STAT5	576	579	PF00017	0.496
LIG_SH2_STAT5	6	9	PF00017	0.748
LIG_SH2_STAT5	706	709	PF00017	0.327
LIG_SH2_STAT5	762	765	PF00017	0.314
LIG_SH3_3	160	166	PF00018	0.647
LIG_SH3_3	197	203	PF00018	0.607
LIG_SH3_3	241	247	PF00018	0.532
LIG_SH3_3	303	309	PF00018	0.451
LIG_SH3_3	315	321	PF00018	0.468
LIG_SH3_3	386	392	PF00018	0.668
LIG_SH3_3	574	580	PF00018	0.463
LIG_SH3_3	76	82	PF00018	0.721
LIG_SUMO_SIM_par_1	449	457	PF11976	0.406
LIG_SUMO_SIM_par_1	557	564	PF11976	0.626
LIG_SUMO_SIM_par_1	778	783	PF11976	0.406
LIG_TRAF2_1	250	253	PF00917	0.668
LIG_TRAF2_1	391	394	PF00917	0.482
LIG_TRAF2_1	751	754	PF00917	0.386
LIG_TRAF2_1	796	799	PF00917	0.386
LIG_TRAF2_2	565	570	PF00917	0.667
LIG_TRFH_1	707	711	PF08558	0.432
LIG_TYR_ITIM	407	412	PF00017	0.408
LIG_TYR_ITIM	420	425	PF00017	0.162
LIG_TYR_ITIM	615	620	PF00017	0.314
LIG_WRC_WIRS_1	424	429	PF05994	0.406
LIG_WRC_WIRS_1	598	603	PF05994	0.406
LIG_WRC_WIRS_1	675	680	PF05994	0.397
LIG_WRC_WIRS_1	700	705	PF05994	0.406
LIG_WW_2	83	86	PF00397	0.682
MOD_CDK_SPxxK_3	138	145	PF00069	0.582
MOD_CDK_SPxxK_3	561	568	PF00069	0.681
MOD_CK1_1	151	157	PF00069	0.722
MOD_CK1_1	274	280	PF00069	0.588
MOD_CK1_1	519	525	PF00069	0.641
MOD_CK1_1	54	60	PF00069	0.676
MOD_CK1_1	550	556	PF00069	0.693
MOD_CK1_1	64	70	PF00069	0.555
MOD_CK1_1	73	79	PF00069	0.627
MOD_CK1_1	738	744	PF00069	0.349
MOD_CK1_1	91	97	PF00069	0.584
MOD_CK1_1	98	104	PF00069	0.656
MOD_CK2_1	476	482	PF00069	0.704
MOD_CK2_1	493	499	PF00069	0.730
MOD_CK2_1	533	539	PF00069	0.758
MOD_CK2_1	793	799	PF00069	0.314
MOD_GlcNHglycan	12	15	PF01048	0.738
MOD_GlcNHglycan	150	153	PF01048	0.578
MOD_GlcNHglycan	163	166	PF01048	0.678
MOD_GlcNHglycan	209	212	PF01048	0.609
MOD_GlcNHglycan	369	372	PF01048	0.635
MOD_GlcNHglycan	380	383	PF01048	0.607
MOD_GlcNHglycan	478	481	PF01048	0.723
MOD_GlcNHglycan	53	56	PF01048	0.720
MOD_GlcNHglycan	638	641	PF01048	0.314
MOD_GlcNHglycan	685	688	PF01048	0.413
MOD_GlcNHglycan	737	740	PF01048	0.396
MOD_GlcNHglycan	94	97	PF01048	0.636
MOD_GSK3_1	10	17	PF00069	0.724
MOD_GSK3_1	151	158	PF00069	0.651
MOD_GSK3_1	18	25	PF00069	0.647
MOD_GSK3_1	234	241	PF00069	0.484
MOD_GSK3_1	263	270	PF00069	0.617
MOD_GSK3_1	448	455	PF00069	0.369
MOD_GSK3_1	476	483	PF00069	0.739
MOD_GSK3_1	50	57	PF00069	0.697
MOD_GSK3_1	511	518	PF00069	0.594
MOD_GSK3_1	547	554	PF00069	0.721
MOD_GSK3_1	58	65	PF00069	0.656
MOD_GSK3_1	620	627	PF00069	0.314
MOD_GSK3_1	67	74	PF00069	0.541
MOD_GSK3_1	683	690	PF00069	0.386
MOD_GSK3_1	761	768	PF00069	0.448
MOD_GSK3_1	88	95	PF00069	0.666
MOD_LATS_1	343	349	PF00433	0.625
MOD_N-GLC_1	17	22	PF02516	0.540
MOD_N-GLC_1	519	524	PF02516	0.694
MOD_N-GLC_1	636	641	PF02516	0.432
MOD_N-GLC_1	661	666	PF02516	0.406
MOD_N-GLC_2	355	357	PF02516	0.567
MOD_NEK2_1	1	6	PF00069	0.727
MOD_NEK2_1	175	180	PF00069	0.489
MOD_NEK2_1	281	286	PF00069	0.568
MOD_NEK2_1	447	452	PF00069	0.406
MOD_NEK2_1	493	498	PF00069	0.678
MOD_NEK2_1	508	513	PF00069	0.676
MOD_NEK2_1	533	538	PF00069	0.558
MOD_NEK2_1	551	556	PF00069	0.641
MOD_NEK2_1	597	602	PF00069	0.406
MOD_NEK2_1	60	65	PF00069	0.687
MOD_NEK2_1	752	757	PF00069	0.491
MOD_NEK2_1	780	785	PF00069	0.406
MOD_NEK2_1	92	97	PF00069	0.599
MOD_NEK2_2	271	276	PF00069	0.662
MOD_PIKK_1	204	210	PF00454	0.629
MOD_PIKK_1	25	31	PF00454	0.756
MOD_PIKK_1	563	569	PF00454	0.604
MOD_PIKK_1	58	64	PF00454	0.727
MOD_PK_1	452	458	PF00069	0.479
MOD_PKA_1	467	473	PF00069	0.608
MOD_PKA_1	484	490	PF00069	0.713
MOD_PKA_1	793	799	PF00069	0.314
MOD_PKA_2	154	160	PF00069	0.685
MOD_PKA_2	338	344	PF00069	0.630
MOD_PKA_2	467	473	PF00069	0.643
MOD_PKA_2	70	76	PF00069	0.650
MOD_PKA_2	793	799	PF00069	0.314
MOD_Plk_1	17	23	PF00069	0.797
MOD_Plk_1	181	187	PF00069	0.500
MOD_Plk_1	234	240	PF00069	0.435
MOD_Plk_1	519	525	PF00069	0.770
MOD_Plk_1	569	575	PF00069	0.565
MOD_Plk_1	602	608	PF00069	0.406
MOD_Plk_1	661	667	PF00069	0.409
MOD_Plk_1	752	758	PF00069	0.406
MOD_Plk_4	1	7	PF00069	0.614
MOD_Plk_4	175	181	PF00069	0.464
MOD_Plk_4	18	24	PF00069	0.592
MOD_Plk_4	319	325	PF00069	0.411
MOD_Plk_4	423	429	PF00069	0.406
MOD_Plk_4	533	539	PF00069	0.539
MOD_Plk_4	602	608	PF00069	0.350
MOD_Plk_4	722	728	PF00069	0.474
MOD_ProDKin_1	138	144	PF00069	0.562
MOD_ProDKin_1	155	161	PF00069	0.459
MOD_ProDKin_1	199	205	PF00069	0.584
MOD_ProDKin_1	22	28	PF00069	0.769
MOD_ProDKin_1	267	273	PF00069	0.686
MOD_ProDKin_1	511	517	PF00069	0.593
MOD_ProDKin_1	561	567	PF00069	0.643
MOD_ProDKin_1	624	630	PF00069	0.380
MOD_ProDKin_1	77	83	PF00069	0.715
MOD_SUMO_for_1	441	444	PF00179	0.314
MOD_SUMO_rev_2	487	493	PF00179	0.729
MOD_SUMO_rev_2	715	721	PF00179	0.422
TRG_DiLeu_BaLyEn_6	412	417	PF01217	0.463
TRG_ENDOCYTIC_2	125	128	PF00928	0.497
TRG_ENDOCYTIC_2	272	275	PF00928	0.673
TRG_ENDOCYTIC_2	409	412	PF00928	0.386
TRG_ENDOCYTIC_2	422	425	PF00928	0.162
TRG_ENDOCYTIC_2	576	579	PF00928	0.496
TRG_ENDOCYTIC_2	610	613	PF00928	0.350
TRG_ENDOCYTIC_2	617	620	PF00928	0.315
TRG_ENDOCYTIC_2	706	709	PF00928	0.350
TRG_ENDOCYTIC_2	789	792	PF00928	0.314
TRG_ER_diArg_1	136	138	PF00400	0.532
TRG_ER_diArg_1	466	468	PF00400	0.641
TRG_ER_diArg_1	784	786	PF00400	0.314
TRG_NES_CRM1_1	699	710	PF08389	0.432
TRG_NLS_MonoExtC_3	343	349	PF00514	0.662
TRG_NLS_MonoExtN_4	342	348	PF00514	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK2	Leptomonas seymouri	65%	92%
A0A3S7WZ58	Leishmania donovani	95%	94%
A0A422NL22	Trypanosoma rangeli	34%	100%
A4HEJ6	Leishmania braziliensis	81%	94%
A4I1K2	Leishmania infantum	95%	100%
E9AXN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B2C1	Trypanosoma cruzi	34%	100%