Putative casein kinase I

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase I, putative

Species:

Leishmania major

UniProt:

Q4Q9T3_LEIMA

TriTrypDb:

LmjF.25.1580 , LMJLV39_250023200 , LMJSD75_250023200

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0005737	cytoplasm	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

Q4Q9T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9T3

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	14
GO:0006793	phosphorus metabolic process	3	14
GO:0006796	phosphate-containing compound metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0006810	transport	3	4
GO:0006897	endocytosis	5	4
GO:0007165	signal transduction	2	4
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	14
GO:0016192	vesicle-mediated transport	4	4
GO:0016310	phosphorylation	5	14
GO:0018105	peptidyl-serine phosphorylation	6	4
GO:0018193	peptidyl-amino acid modification	5	4
GO:0018209	peptidyl-serine modification	6	4
GO:0019538	protein metabolic process	3	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0065007	biological regulation	1	4
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003824	catalytic activity	1	14
GO:0004672	protein kinase activity	3	14
GO:0004674	protein serine/threonine kinase activity	4	10
GO:0005488	binding	1	14
GO:0005524	ATP binding	5	14
GO:0016301	kinase activity	4	14
GO:0016740	transferase activity	2	14
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	14
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	14
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140096	catalytic activity, acting on a protein	2	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	378	382	PF00656	0.517
CLV_NRD_NRD_1	111	113	PF00675	0.505
CLV_NRD_NRD_1	156	158	PF00675	0.388
CLV_NRD_NRD_1	250	252	PF00675	0.399
CLV_NRD_NRD_1	328	330	PF00675	0.555
CLV_NRD_NRD_1	396	398	PF00675	0.618
CLV_NRD_NRD_1	53	55	PF00675	0.480
CLV_PCSK_KEX2_1	156	158	PF00082	0.377
CLV_PCSK_KEX2_1	250	252	PF00082	0.399
CLV_PCSK_KEX2_1	328	330	PF00082	0.526
CLV_PCSK_KEX2_1	336	338	PF00082	0.523
CLV_PCSK_KEX2_1	396	398	PF00082	0.618
CLV_PCSK_KEX2_1	434	436	PF00082	0.475
CLV_PCSK_KEX2_1	440	442	PF00082	0.526
CLV_PCSK_KEX2_1	490	492	PF00082	0.599
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.515
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.504
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.554
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.599
CLV_PCSK_PC7_1	332	338	PF00082	0.452
CLV_PCSK_SKI1_1	161	165	PF00082	0.328
CLV_PCSK_SKI1_1	185	189	PF00082	0.446
CLV_PCSK_SKI1_1	21	25	PF00082	0.396
CLV_PCSK_SKI1_1	229	233	PF00082	0.392
CLV_PCSK_SKI1_1	282	286	PF00082	0.377
CLV_PCSK_SKI1_1	290	294	PF00082	0.334
CLV_PCSK_SKI1_1	304	308	PF00082	0.400
CLV_PCSK_SKI1_1	328	332	PF00082	0.471
CLV_PCSK_SKI1_1	85	89	PF00082	0.565
DEG_APCC_DBOX_1	156	164	PF00400	0.377
DEG_APCC_DBOX_1	250	258	PF00400	0.416
DEG_SCF_FBW7_2	291	297	PF00400	0.292
DOC_CKS1_1	291	296	PF01111	0.434
DOC_CKS1_1	401	406	PF01111	0.601
DOC_CYCLIN_RxL_1	311	319	PF00134	0.463
DOC_CYCLIN_RxL_1	332	341	PF00134	0.384
DOC_CYCLIN_yCln2_LP_2	366	372	PF00134	0.608
DOC_MAPK_gen_1	197	205	PF00069	0.379
DOC_MAPK_gen_1	218	225	PF00069	0.322
DOC_MAPK_gen_1	336	342	PF00069	0.481
DOC_MAPK_gen_1	42	52	PF00069	0.447
DOC_MAPK_MEF2A_6	43	52	PF00069	0.442
DOC_PP1_RVXF_1	210	216	PF00149	0.377
DOC_PP1_RVXF_1	312	319	PF00149	0.456
DOC_PP2B_LxvP_1	340	343	PF13499	0.431
DOC_PP2B_LxvP_1	366	369	PF13499	0.574
DOC_PP4_FxxP_1	494	497	PF00568	0.588
DOC_USP7_MATH_1	360	364	PF00917	0.727
DOC_USP7_MATH_1	458	462	PF00917	0.629
DOC_USP7_MATH_1	486	490	PF00917	0.838
DOC_USP7_UBL2_3	300	304	PF12436	0.589
DOC_USP7_UBL2_3	51	55	PF12436	0.406
DOC_WW_Pin1_4	290	295	PF00397	0.438
DOC_WW_Pin1_4	400	405	PF00397	0.595
DOC_WW_Pin1_4	493	498	PF00397	0.626
LIG_14-3-3_CanoR_1	112	116	PF00244	0.511
LIG_14-3-3_CanoR_1	156	161	PF00244	0.387
LIG_14-3-3_CanoR_1	314	319	PF00244	0.471
LIG_14-3-3_CanoR_1	337	343	PF00244	0.433
LIG_14-3-3_CanoR_1	383	388	PF00244	0.622
LIG_14-3-3_CanoR_1	396	400	PF00244	0.553
LIG_14-3-3_CanoR_1	462	468	PF00244	0.543
LIG_AP2alpha_1	33	37	PF02296	0.428
LIG_APCC_ABBAyCdc20_2	180	186	PF00400	0.377
LIG_BRCT_BRCA1_1	255	259	PF00533	0.377
LIG_BRCT_BRCA1_1	314	318	PF00533	0.410
LIG_BRCT_BRCA1_1	348	352	PF00533	0.552
LIG_BRCT_BRCA1_1	483	487	PF00533	0.590
LIG_deltaCOP1_diTrp_1	426	432	PF00928	0.478
LIG_FHA_2	1	7	PF00498	0.555
LIG_FHA_2	291	297	PF00498	0.336
LIG_FHA_2	412	418	PF00498	0.667
LIG_FHA_2	9	15	PF00498	0.488
LIG_LIR_Apic_2	493	497	PF02991	0.527
LIG_LIR_Gen_1	132	142	PF02991	0.451
LIG_LIR_Gen_1	256	265	PF02991	0.321
LIG_LIR_Gen_1	323	331	PF02991	0.443
LIG_LIR_Gen_1	426	437	PF02991	0.485
LIG_LIR_Nem_3	211	217	PF02991	0.321
LIG_LIR_Nem_3	256	262	PF02991	0.421
LIG_LIR_Nem_3	305	309	PF02991	0.549
LIG_LIR_Nem_3	32	36	PF02991	0.552
LIG_LIR_Nem_3	323	327	PF02991	0.308
LIG_LIR_Nem_3	426	432	PF02991	0.501
LIG_LIR_Nem_3	66	72	PF02991	0.471
LIG_LYPXL_yS_3	59	62	PF13949	0.470
LIG_MYND_3	412	416	PF01753	0.580
LIG_Pex14_2	33	37	PF04695	0.560
LIG_PTB_Apo_2	27	34	PF02174	0.450
LIG_SH2_CRK	324	328	PF00017	0.508
LIG_SH2_CRK	69	73	PF00017	0.473
LIG_SH2_STAP1	425	429	PF00017	0.467
LIG_SH2_STAP1	64	68	PF00017	0.440
LIG_SH2_STAT5	128	131	PF00017	0.396
LIG_SH2_STAT5	153	156	PF00017	0.322
LIG_SH2_STAT5	176	179	PF00017	0.509
LIG_SH2_STAT5	204	207	PF00017	0.428
LIG_SH2_STAT5	237	240	PF00017	0.399
LIG_SH2_STAT5	263	266	PF00017	0.386
LIG_SH2_STAT5	309	312	PF00017	0.434
LIG_SH3_3	118	124	PF00018	0.451
LIG_SH3_3	359	365	PF00018	0.608
LIG_SH3_3	494	500	PF00018	0.595
LIG_SUMO_SIM_par_1	162	168	PF11976	0.448
LIG_SUMO_SIM_par_1	380	392	PF11976	0.755
LIG_TRAF2_1	294	297	PF00917	0.374
LIG_UBA3_1	330	336	PF00899	0.361
MOD_CK1_1	159	165	PF00069	0.399
MOD_CK1_1	386	392	PF00069	0.670
MOD_CK1_1	395	401	PF00069	0.588
MOD_CK1_1	461	467	PF00069	0.676
MOD_CK1_1	63	69	PF00069	0.384
MOD_CK1_1	93	99	PF00069	0.523
MOD_CK2_1	290	296	PF00069	0.368
MOD_CK2_1	8	14	PF00069	0.690
MOD_Cter_Amidation	334	337	PF01082	0.364
MOD_GlcNHglycan	104	107	PF01048	0.501
MOD_GlcNHglycan	348	351	PF01048	0.764
MOD_GlcNHglycan	456	459	PF01048	0.611
MOD_GlcNHglycan	484	487	PF01048	0.687
MOD_GSK3_1	111	118	PF00069	0.477
MOD_GSK3_1	286	293	PF00069	0.321
MOD_GSK3_1	312	319	PF00069	0.349
MOD_GSK3_1	370	377	PF00069	0.634
MOD_GSK3_1	379	386	PF00069	0.776
MOD_GSK3_1	388	395	PF00069	0.673
MOD_GSK3_1	454	461	PF00069	0.582
MOD_GSK3_1	482	489	PF00069	0.701
MOD_GSK3_1	90	97	PF00069	0.560
MOD_N-GLC_1	29	34	PF02516	0.453
MOD_N-GLC_1	355	360	PF02516	0.706
MOD_N-GLC_1	475	480	PF02516	0.663
MOD_N-GLC_1	93	98	PF02516	0.528
MOD_N-GLC_2	152	154	PF02516	0.318
MOD_N-GLC_2	308	310	PF02516	0.310
MOD_N-GLC_2	351	353	PF02516	0.568
MOD_NEK2_1	115	120	PF00069	0.445
MOD_NEK2_1	22	27	PF00069	0.441
MOD_NEK2_1	231	236	PF00069	0.446
MOD_NEK2_1	246	251	PF00069	0.266
MOD_NEK2_1	316	321	PF00069	0.466
MOD_NEK2_1	338	343	PF00069	0.579
MOD_NEK2_1	352	357	PF00069	0.598
MOD_NEK2_1	388	393	PF00069	0.574
MOD_NEK2_1	475	480	PF00069	0.736
MOD_PIKK_1	316	322	PF00454	0.383
MOD_PIKK_1	375	381	PF00454	0.520
MOD_PIKK_1	451	457	PF00454	0.605
MOD_PK_1	383	389	PF00069	0.622
MOD_PKA_1	156	162	PF00069	0.389
MOD_PKA_1	218	224	PF00069	0.321
MOD_PKA_1	490	496	PF00069	0.536
MOD_PKA_2	111	117	PF00069	0.508
MOD_PKA_2	156	162	PF00069	0.377
MOD_PKA_2	395	401	PF00069	0.635
MOD_PKA_2	461	467	PF00069	0.532
MOD_PKA_2	490	496	PF00069	0.536
MOD_Plk_1	115	121	PF00069	0.455
MOD_Plk_1	389	395	PF00069	0.594
MOD_Plk_4	115	121	PF00069	0.448
MOD_Plk_4	159	165	PF00069	0.458
MOD_Plk_4	383	389	PF00069	0.730
MOD_ProDKin_1	290	296	PF00069	0.438
MOD_ProDKin_1	400	406	PF00069	0.596
MOD_ProDKin_1	493	499	PF00069	0.627
MOD_SUMO_for_1	187	190	PF00179	0.357
MOD_SUMO_for_1	50	53	PF00179	0.458
MOD_SUMO_rev_2	283	292	PF00179	0.404
MOD_SUMO_rev_2	35	44	PF00179	0.377
MOD_SUMO_rev_2	63	68	PF00179	0.387
TRG_DiLeu_BaEn_2	254	260	PF01217	0.318
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.614
TRG_ENDOCYTIC_2	135	138	PF00928	0.403
TRG_ENDOCYTIC_2	214	217	PF00928	0.321
TRG_ENDOCYTIC_2	324	327	PF00928	0.439
TRG_ENDOCYTIC_2	59	62	PF00928	0.484
TRG_ENDOCYTIC_2	69	72	PF00928	0.484
TRG_ER_diArg_1	156	158	PF00400	0.377
TRG_ER_diArg_1	327	329	PF00400	0.462
TRG_NLS_Bipartite_1	42	59	PF00514	0.392
TRG_NLS_MonoExtN_4	54	59	PF00514	0.450
TRG_Pf-PMV_PEXEL_1	328	333	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H3	Leptomonas seymouri	33%	100%
A0A0N1IKB0	Leptomonas seymouri	32%	89%
A0A1X0NZS9	Trypanosomatidae	48%	100%
A0A1X0P176	Trypanosomatidae	37%	100%
A0A3Q8IJ66	Leishmania donovani	47%	100%
A0A3Q8ISA0	Leishmania donovani	44%	100%
A0A3S7WNZ6	Leishmania donovani	34%	100%
A0A3S7WZA2	Leishmania donovani	93%	97%
A0A422NL83	Trypanosoma rangeli	45%	100%
A4H436	Leishmania braziliensis	34%	100%
A4HEI6	Leishmania braziliensis	77%	98%
A4HFV0	Leishmania braziliensis	32%	90%
A4HIT6	Leishmania braziliensis	42%	100%
A4HMD0	Leishmania braziliensis	42%	100%
A4HMD1	Leishmania braziliensis	47%	100%
A4HSC0	Leishmania infantum	34%	100%
A4I1K4	Leishmania infantum	93%	97%
A4I638	Leishmania infantum	44%	100%
A4IAZ8	Leishmania infantum	47%	100%
C9ZK43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZM31	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	73%
E9AKA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AXN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	97%
E9B1C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B5Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
O96999	Leishmania major	33%	100%
P00521	Abelson murine leukemia virus	22%	68%
P39962	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	96%
P42168	Caenorhabditis elegans	44%	100%
Q09437	Caenorhabditis elegans	27%	70%
Q4Q6U1	Leishmania major	44%	100%
Q62761	Rattus norvegicus	43%	100%
Q86Y07	Homo sapiens	25%	99%
Q8BN21	Mus musculus	28%	100%
Q8BTH8	Mus musculus	43%	100%
Q8C4X2	Mus musculus	37%	100%
Q8VYK9	Arabidopsis thaliana	44%	100%
Q9NHE1	Leishmania major	47%	100%
V5BMQ3	Trypanosoma cruzi	39%	100%