Putative casein kinase I

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase I, putative

Species:

Leishmania major

UniProt:

Q4Q9T3_LEIMA

TriTrypDb:

LmjF.25.1580 , LMJLV39_250023200 , LMJSD75_250023200

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0005737	cytoplasm	2	4
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0043233	organelle lumen	3	1

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Expansion

Sequence features

Q4Q9T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9T3

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	14
GO:0006793	phosphorus metabolic process	3	14
GO:0006796	phosphate-containing compound metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0006810	transport	3	4
GO:0006897	endocytosis	5	4
GO:0007165	signal transduction	2	4
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	14
GO:0016192	vesicle-mediated transport	4	4

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003824	catalytic activity	1	14
GO:0004672	protein kinase activity	3	14
GO:0004674	protein serine/threonine kinase activity	4	10
GO:0005488	binding	1	14
GO:0005524	ATP binding	5	14
GO:0016301	kinase activity	4	14
GO:0016740	transferase activity	2	14
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	14
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	14

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	378	382	PF00656	0.517
CLV_NRD_NRD_1	111	113	PF00675	0.505
CLV_NRD_NRD_1	156	158	PF00675	0.388
CLV_NRD_NRD_1	250	252	PF00675	0.399
CLV_NRD_NRD_1	328	330	PF00675	0.555
CLV_NRD_NRD_1	396	398	PF00675	0.618
CLV_NRD_NRD_1	53	55	PF00675	0.480
CLV_PCSK_KEX2_1	156	158	PF00082	0.377
CLV_PCSK_KEX2_1	250	252	PF00082	0.399
CLV_PCSK_KEX2_1	328	330	PF00082	0.526

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2H3	Leptomonas seymouri	33%	100%
A0A0N1IKB0	Leptomonas seymouri	32%	89%
A0A1X0NZS9	Trypanosomatidae	48%	100%
A0A1X0P176	Trypanosomatidae	37%	100%
A0A3Q8IJ66	Leishmania donovani	47%	100%
A0A3Q8ISA0	Leishmania donovani	44%	100%
A0A3S7WNZ6	Leishmania donovani	34%	100%
A0A3S7WZA2	Leishmania donovani	93%	97%
A0A422NL83	Trypanosoma rangeli	45%	100%
A4H436	Leishmania braziliensis	34%	100%

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