MPN domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 3 subunit F

Species:

Leishmania major

UniProt:

Q4Q9T0_LEIMA

TriTrypDb:

LmjF.25.1610 , LMJLV39_250023500 , LMJSD75_250023500

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005852	eukaryotic translation initiation factor 3 complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9T0

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016310	phosphorylation	5	3
GO:0044237	cellular metabolic process	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008233	peptidase activity	3	2
GO:0008237	metallopeptidase activity	4	2
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.723
CLV_NRD_NRD_1	214	216	PF00675	0.785
CLV_NRD_NRD_1	22	24	PF00675	0.580
CLV_NRD_NRD_1	286	288	PF00675	0.635
CLV_NRD_NRD_1	305	307	PF00675	0.713
CLV_NRD_NRD_1	68	70	PF00675	0.689
CLV_NRD_NRD_1	73	75	PF00675	0.727
CLV_PCSK_KEX2_1	214	216	PF00082	0.790
CLV_PCSK_KEX2_1	22	24	PF00082	0.561
CLV_PCSK_KEX2_1	256	258	PF00082	0.782
CLV_PCSK_KEX2_1	286	288	PF00082	0.633
CLV_PCSK_KEX2_1	305	307	PF00082	0.573
CLV_PCSK_KEX2_1	67	69	PF00082	0.684
CLV_PCSK_KEX2_1	72	74	PF00082	0.609
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.561
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.831
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.670
CLV_PCSK_PC7_1	68	74	PF00082	0.662
CLV_PCSK_SKI1_1	145	149	PF00082	0.709
CLV_PCSK_SKI1_1	273	277	PF00082	0.632
CLV_PCSK_SKI1_1	69	73	PF00082	0.694
DEG_APCC_DBOX_1	152	160	PF00400	0.725
DEG_APCC_DBOX_1	184	192	PF00400	0.769
DEG_ODPH_VHL_1	156	168	PF01847	0.699
DOC_CKS1_1	8	13	PF01111	0.596
DOC_PP1_RVXF_1	128	134	PF00149	0.684
DOC_PP4_FxxP_1	139	142	PF00568	0.705
DOC_WW_Pin1_4	125	130	PF00397	0.790
DOC_WW_Pin1_4	7	12	PF00397	0.601
LIG_14-3-3_CanoR_1	153	157	PF00244	0.709
LIG_14-3-3_CanoR_1	73	83	PF00244	0.680
LIG_APCC_ABBA_1	115	120	PF00400	0.612
LIG_BIR_II_1	1	5	PF00653	0.699
LIG_BRCT_BRCA1_1	105	109	PF00533	0.594
LIG_BRCT_BRCA1_1	135	139	PF00533	0.655
LIG_BRCT_BRCA1_1	268	272	PF00533	0.731
LIG_eIF4E_1	75	81	PF01652	0.691
LIG_FHA_1	126	132	PF00498	0.707
LIG_FHA_1	170	176	PF00498	0.691
LIG_FHA_1	204	210	PF00498	0.742
LIG_FHA_1	41	47	PF00498	0.506
LIG_FHA_1	75	81	PF00498	0.584
LIG_FHA_2	240	246	PF00498	0.764
LIG_FHA_2	308	314	PF00498	0.876
LIG_FHA_2	47	53	PF00498	0.591
LIG_FHA_2	74	80	PF00498	0.683
LIG_FHA_2	92	98	PF00498	0.670
LIG_LIR_Apic_2	136	142	PF02991	0.682
LIG_LIR_Nem_3	245	250	PF02991	0.676
LIG_OCRL_FandH_1	108	120	PF00620	0.661
LIG_SH2_STAT3	75	78	PF00017	0.716
LIG_SH2_STAT5	196	199	PF00017	0.742
LIG_SH2_STAT5	30	33	PF00017	0.467
LIG_SH2_STAT5	75	78	PF00017	0.591
LIG_TRAF2_1	222	225	PF00917	0.807
MOD_CDK_SPK_2	125	130	PF00069	0.740
MOD_CK1_1	169	175	PF00069	0.722
MOD_CK2_1	239	245	PF00069	0.766
MOD_CK2_1	307	313	PF00069	0.867
MOD_GlcNHglycan	230	233	PF01048	0.700
MOD_GlcNHglycan	84	87	PF01048	0.603
MOD_GSK3_1	125	132	PF00069	0.782
MOD_GSK3_1	166	173	PF00069	0.667
MOD_GSK3_1	46	53	PF00069	0.564
MOD_N-GLC_1	307	312	PF02516	0.814
MOD_NEK2_2	143	148	PF00069	0.757
MOD_PIKK_1	266	272	PF00454	0.732
MOD_PIKK_1	74	80	PF00454	0.711
MOD_PKA_1	73	79	PF00069	0.697
MOD_PKA_2	152	158	PF00069	0.712
MOD_PKA_2	73	79	PF00069	0.676
MOD_PKB_1	257	265	PF00069	0.803
MOD_Plk_1	143	149	PF00069	0.698
MOD_Plk_4	103	109	PF00069	0.579
MOD_Plk_4	133	139	PF00069	0.588
MOD_Plk_4	170	176	PF00069	0.685
MOD_Plk_4	280	286	PF00069	0.736
MOD_Plk_4	294	300	PF00069	0.749
MOD_ProDKin_1	125	131	PF00069	0.778
MOD_ProDKin_1	7	13	PF00069	0.600
MOD_SUMO_rev_2	199	205	PF00179	0.756
TRG_DiLeu_BaEn_4	211	217	PF01217	0.791
TRG_DiLeu_BaEn_4	95	101	PF01217	0.653
TRG_ER_diArg_1	214	216	PF00400	0.807
TRG_ER_diArg_1	285	287	PF00400	0.661
TRG_ER_diArg_1	67	69	PF00400	0.663
TRG_ER_diArg_1	73	75	PF00400	0.727
TRG_NLS_MonoCore_2	21	26	PF00514	0.586
TRG_NLS_MonoExtN_4	22	27	PF00514	0.654
TRG_NLS_MonoExtN_4	69	76	PF00514	0.699
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.748
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X4	Leptomonas seymouri	73%	99%
A0A1X0NYA8	Trypanosomatidae	33%	94%
A0A3Q8IDI4	Leishmania donovani	99%	100%
A0A3R7MHX6	Trypanosoma rangeli	33%	99%
A4I1K7	Leishmania infantum	99%	100%
C9ZK49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	96%
E9AXP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5DIT1	Trypanosoma cruzi	30%	94%