39S ribosomal protein L24, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9S7_LEIMA

TriTrypDb:

LmjF.25.1640 , LMJLV39_250023800 , LMJSD75_250023800

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005840	ribosome	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q9S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9S7

PDB structure(s): 7aih_O , 7am2_O , 7ane_O

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	7
GO:0006518	peptide metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009059	macromolecule biosynthetic process	4	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	7
GO:0043043	peptide biosynthetic process	5	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043603	amide metabolic process	3	7
GO:0043604	amide biosynthetic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003735	structural constituent of ribosome	2	7
GO:0005198	structural molecule activity	1	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	459	463	PF00656	0.569
CLV_NRD_NRD_1	229	231	PF00675	0.402
CLV_NRD_NRD_1	279	281	PF00675	0.428
CLV_NRD_NRD_1	428	430	PF00675	0.574
CLV_PCSK_KEX2_1	229	231	PF00082	0.402
CLV_PCSK_KEX2_1	279	281	PF00082	0.428
CLV_PCSK_KEX2_1	38	40	PF00082	0.427
CLV_PCSK_KEX2_1	428	430	PF00082	0.574
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.427
CLV_PCSK_SKI1_1	315	319	PF00082	0.574
CLV_PCSK_SKI1_1	42	46	PF00082	0.435
DEG_APCC_DBOX_1	77	85	PF00400	0.426
DEG_Kelch_Keap1_1	220	225	PF01344	0.521
DOC_MAPK_gen_1	161	168	PF00069	0.362
DOC_MAPK_gen_1	269	278	PF00069	0.445
DOC_MAPK_gen_1	76	83	PF00069	0.508
DOC_MAPK_MEF2A_6	269	278	PF00069	0.521
DOC_PP2B_LxvP_1	239	242	PF13499	0.431
DOC_PP2B_LxvP_1	54	57	PF13499	0.455
DOC_USP7_MATH_1	348	352	PF00917	0.726
DOC_USP7_MATH_1	401	405	PF00917	0.469
DOC_USP7_MATH_1	441	445	PF00917	0.530
DOC_USP7_MATH_1	469	473	PF00917	0.567
DOC_USP7_UBL2_3	217	221	PF12436	0.436
DOC_USP7_UBL2_3	38	42	PF12436	0.420
DOC_WW_Pin1_4	123	128	PF00397	0.429
DOC_WW_Pin1_4	47	52	PF00397	0.619
LIG_14-3-3_CanoR_1	16	22	PF00244	0.525
LIG_14-3-3_CanoR_1	229	234	PF00244	0.410
LIG_14-3-3_CanoR_1	381	389	PF00244	0.590
LIG_Actin_WH2_2	49	67	PF00022	0.448
LIG_CaM_IQ_9	307	322	PF13499	0.415
LIG_eIF4E_1	162	168	PF01652	0.357
LIG_FHA_1	139	145	PF00498	0.460
LIG_FHA_1	205	211	PF00498	0.552
LIG_FHA_1	221	227	PF00498	0.459
LIG_FHA_1	320	326	PF00498	0.442
LIG_FHA_1	363	369	PF00498	0.572
LIG_FHA_2	181	187	PF00498	0.454
LIG_HCF-1_HBM_1	98	101	PF13415	0.434
LIG_LIR_Apic_2	34	40	PF02991	0.429
LIG_LIR_Gen_1	400	406	PF02991	0.459
LIG_LIR_Nem_3	400	405	PF02991	0.459
LIG_PCNA_yPIPBox_3	163	177	PF02747	0.384
LIG_SH2_GRB2like	101	104	PF00017	0.427
LIG_SH2_NCK_1	21	25	PF00017	0.401
LIG_SH2_PTP2	402	405	PF00017	0.445
LIG_SH2_SRC	96	99	PF00017	0.441
LIG_SH2_STAT3	101	104	PF00017	0.427
LIG_SH2_STAT5	124	127	PF00017	0.475
LIG_SH2_STAT5	21	24	PF00017	0.405
LIG_SH2_STAT5	287	290	PF00017	0.427
LIG_SH2_STAT5	402	405	PF00017	0.445
LIG_SH2_STAT5	68	71	PF00017	0.429
LIG_SH3_3	173	179	PF00018	0.449
LIG_SH3_3	386	392	PF00018	0.664
LIG_SUMO_SIM_anti_2	140	146	PF11976	0.577
LIG_SUMO_SIM_anti_2	79	86	PF11976	0.502
LIG_SUMO_SIM_par_1	140	146	PF11976	0.384
LIG_SUMO_SIM_par_1	364	370	PF11976	0.516
LIG_TRAF2_1	243	246	PF00917	0.500
LIG_TRAF2_1	262	265	PF00917	0.489
LIG_TRAF2_1	444	447	PF00917	0.554
LIG_UBA3_1	53	60	PF00899	0.475
LIG_UBA3_1	63	72	PF00899	0.390
LIG_WRC_WIRS_1	310	315	PF05994	0.466
MOD_CK1_1	232	238	PF00069	0.443
MOD_CK1_1	346	352	PF00069	0.653
MOD_CK2_1	180	186	PF00069	0.454
MOD_CK2_1	401	407	PF00069	0.439
MOD_CK2_1	441	447	PF00069	0.539
MOD_GlcNHglycan	145	148	PF01048	0.439
MOD_GlcNHglycan	234	237	PF01048	0.444
MOD_GSK3_1	15	22	PF00069	0.451
MOD_GSK3_1	288	295	PF00069	0.458
MOD_GSK3_1	339	346	PF00069	0.645
MOD_N-GLC_1	47	52	PF02516	0.498
MOD_NEK2_1	19	24	PF00069	0.433
MOD_NEK2_1	254	259	PF00069	0.484
MOD_NEK2_1	288	293	PF00069	0.444
MOD_NEK2_1	83	88	PF00069	0.508
MOD_PIKK_1	19	25	PF00454	0.430
MOD_PIKK_1	339	345	PF00454	0.640
MOD_PIKK_1	349	355	PF00454	0.567
MOD_PKA_1	229	235	PF00069	0.413
MOD_PKA_2	15	21	PF00069	0.583
MOD_PKA_2	229	235	PF00069	0.413
MOD_PKA_2	319	325	PF00069	0.441
MOD_PKB_1	29	37	PF00069	0.434
MOD_Plk_1	244	250	PF00069	0.511
MOD_Plk_1	263	269	PF00069	0.476
MOD_Plk_1	409	415	PF00069	0.480
MOD_Plk_1	97	103	PF00069	0.437
MOD_Plk_2-3	263	269	PF00069	0.476
MOD_Plk_2-3	409	415	PF00069	0.618
MOD_Plk_2-3	447	453	PF00069	0.590
MOD_Plk_4	367	373	PF00069	0.529
MOD_Plk_4	401	407	PF00069	0.450
MOD_ProDKin_1	123	129	PF00069	0.426
MOD_ProDKin_1	47	53	PF00069	0.619
MOD_SUMO_for_1	376	379	PF00179	0.594
MOD_SUMO_rev_2	126	133	PF00179	0.424
TRG_DiLeu_BaEn_1	234	239	PF01217	0.428
TRG_DiLeu_BaEn_1	272	277	PF01217	0.437
TRG_DiLeu_BaEn_1	79	84	PF01217	0.500
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.479
TRG_ENDOCYTIC_2	122	125	PF00928	0.396
TRG_ENDOCYTIC_2	402	405	PF00928	0.457
TRG_ER_diArg_1	198	201	PF00400	0.497
TRG_ER_diArg_1	229	231	PF00400	0.402
TRG_ER_diArg_1	278	280	PF00400	0.439
TRG_ER_diArg_1	30	33	PF00400	0.431
TRG_ER_diArg_1	4	7	PF00400	0.489
TRG_NES_CRM1_1	209	222	PF08389	0.502
TRG_NES_CRM1_1	308	323	PF08389	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I882	Leptomonas seymouri	73%	100%
A0A3Q8IDE3	Leishmania donovani	92%	100%
A4HEI0	Leishmania braziliensis	84%	100%
A4I1L0	Leishmania infantum	92%	100%
E9AXP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%