39S ribosomal protein L24, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9S7_LEIMA

TriTrypDb:

LmjF.25.1640 , LMJLV39_250023800 , LMJSD75_250023800

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005840	ribosome	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

Q4Q9S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9S7

PDB structure(s): 7aih_O , 7am2_O , 7ane_O

Function

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Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	7
GO:0006518	peptide metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009059	macromolecule biosynthetic process	4	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	7

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003735	structural constituent of ribosome	2	7
GO:0005198	structural molecule activity	1	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	459	463	PF00656	0.569
CLV_NRD_NRD_1	229	231	PF00675	0.402
CLV_NRD_NRD_1	279	281	PF00675	0.428
CLV_NRD_NRD_1	428	430	PF00675	0.574
CLV_PCSK_KEX2_1	229	231	PF00082	0.402
CLV_PCSK_KEX2_1	279	281	PF00082	0.428
CLV_PCSK_KEX2_1	38	40	PF00082	0.427
CLV_PCSK_KEX2_1	428	430	PF00082	0.574
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.427
CLV_PCSK_SKI1_1	315	319	PF00082	0.574

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I882	Leptomonas seymouri	73%	100%
A0A3Q8IDE3	Leishmania donovani	92%	100%
A4HEI0	Leishmania braziliensis	84%	100%
A4I1L0	Leishmania infantum	92%	100%
E9AXP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%

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