EFP_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9S5_LEIMA

TriTrypDb:

LmjF.25.1650 , LMJLV39_250023900 , LMJSD75_250023900

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9S5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003746	translation elongation factor activity	4	4
GO:0005488	binding	1	4
GO:0008135	translation factor activity, RNA binding	3	4
GO:0045182	translation regulator activity	1	4
GO:0090079	translation regulator activity, nucleic acid binding	2	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	82	84	PF00675	0.255
CLV_PCSK_KEX2_1	6	8	PF00082	0.565
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.531
CLV_PCSK_SKI1_1	104	108	PF00082	0.255
CLV_PCSK_SKI1_1	184	188	PF00082	0.466
CLV_PCSK_SKI1_1	192	196	PF00082	0.321
CLV_PCSK_SKI1_1	35	39	PF00082	0.384
CLV_PCSK_SKI1_1	85	89	PF00082	0.242
DEG_Nend_Nbox_1	1	3	PF02207	0.523
DEG_SPOP_SBC_1	25	29	PF00917	0.592
DOC_CYCLIN_RxL_1	99	111	PF00134	0.354
DOC_MAPK_FxFP_2	118	121	PF00069	0.329
DOC_MAPK_gen_1	3	11	PF00069	0.624
DOC_MAPK_gen_1	41	50	PF00069	0.442
DOC_MAPK_gen_1	99	107	PF00069	0.357
DOC_MAPK_MEF2A_6	41	50	PF00069	0.473
DOC_MAPK_MEF2A_6	99	107	PF00069	0.357
DOC_MAPK_NFAT4_5	43	51	PF00069	0.455
DOC_PP1_RVXF_1	102	108	PF00149	0.349
DOC_PP4_FxxP_1	118	121	PF00568	0.329
DOC_USP7_MATH_1	134	138	PF00917	0.416
DOC_USP7_MATH_1	16	20	PF00917	0.684
DOC_USP7_MATH_1	25	29	PF00917	0.617
DOC_USP7_UBL2_3	184	188	PF12436	0.369
DOC_USP7_UBL2_3	216	220	PF12436	0.373
DOC_WW_Pin1_4	121	126	PF00397	0.544
LIG_FHA_1	10	16	PF00498	0.688
LIG_FHA_1	200	206	PF00498	0.486
LIG_FHA_2	193	199	PF00498	0.472
LIG_LIR_Gen_1	112	122	PF02991	0.372
LIG_LIR_Gen_1	167	175	PF02991	0.381
LIG_LIR_Gen_1	94	103	PF02991	0.391
LIG_LIR_Nem_3	112	118	PF02991	0.490
LIG_LIR_Nem_3	167	172	PF02991	0.392
LIG_LIR_Nem_3	94	98	PF02991	0.413
LIG_SH2_CRK	55	59	PF00017	0.455
LIG_SH2_STAT5	178	181	PF00017	0.333
LIG_SH3_3	12	18	PF00018	0.578
LIG_SH3_3	128	134	PF00018	0.454
LIG_SH3_3	215	221	PF00018	0.443
LIG_SUMO_SIM_par_1	200	207	PF11976	0.409
LIG_WRC_WIRS_1	193	198	PF05994	0.328
MOD_CK1_1	29	35	PF00069	0.585
MOD_CK2_1	134	140	PF00069	0.417
MOD_CK2_1	192	198	PF00069	0.373
MOD_CMANNOS	2	5	PF00535	0.557
MOD_GlcNHglycan	107	110	PF01048	0.369
MOD_GlcNHglycan	18	21	PF01048	0.643
MOD_GSK3_1	170	177	PF00069	0.429
MOD_GSK3_1	25	32	PF00069	0.623
MOD_GSK3_1	5	12	PF00069	0.692
MOD_GSK3_1	74	81	PF00069	0.473
MOD_NEK2_1	105	110	PF00069	0.333
MOD_PIKK_1	29	35	PF00454	0.618
MOD_PIKK_1	60	66	PF00454	0.442
MOD_Plk_1	170	176	PF00069	0.460
MOD_Plk_4	174	180	PF00069	0.474
MOD_Plk_4	192	198	PF00069	0.274
MOD_Plk_4	26	32	PF00069	0.643
MOD_ProDKin_1	121	127	PF00069	0.546
TRG_DiLeu_BaEn_1	101	106	PF01217	0.357
TRG_DiLeu_LyEn_5	101	106	PF01217	0.357
TRG_ENDOCYTIC_2	55	58	PF00928	0.471
TRG_ER_diArg_1	102	105	PF00400	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFC1	Leptomonas seymouri	82%	97%
A0A0S4IL43	Bodo saltans	68%	94%
A0A1X0NYW1	Trypanosomatidae	77%	100%
A0A3R7KDV7	Trypanosoma rangeli	77%	100%
A0A3S7WZ68	Leishmania donovani	99%	100%
A4HEH8	Leishmania braziliensis	89%	99%
A4I1L2	Leishmania infantum	99%	100%
C9ZK54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9AXP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%