Rho-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9S4_LEIMA

TriTrypDb:

LmjF.25.1660 , LMJLV39_250024000 , LMJSD75_250024000

Length:

960

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9S4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	432	436	PF00656	0.560
CLV_C14_Caspase3-7	485	489	PF00656	0.591
CLV_C14_Caspase3-7	542	546	PF00656	0.540
CLV_MEL_PAP_1	98	104	PF00089	0.414
CLV_NRD_NRD_1	309	311	PF00675	0.531
CLV_NRD_NRD_1	560	562	PF00675	0.627
CLV_NRD_NRD_1	776	778	PF00675	0.416
CLV_NRD_NRD_1	781	783	PF00675	0.435
CLV_NRD_NRD_1	888	890	PF00675	0.397
CLV_NRD_NRD_1	954	956	PF00675	0.632
CLV_NRD_NRD_1	958	960	PF00675	0.620
CLV_PCSK_KEX2_1	182	184	PF00082	0.555
CLV_PCSK_KEX2_1	259	261	PF00082	0.439
CLV_PCSK_KEX2_1	308	310	PF00082	0.505
CLV_PCSK_KEX2_1	335	337	PF00082	0.468
CLV_PCSK_KEX2_1	559	561	PF00082	0.625
CLV_PCSK_KEX2_1	776	778	PF00082	0.411
CLV_PCSK_KEX2_1	780	782	PF00082	0.418
CLV_PCSK_KEX2_1	888	890	PF00082	0.397
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.555
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.537
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.468
CLV_PCSK_PC7_1	776	782	PF00082	0.415
CLV_PCSK_SKI1_1	14	18	PF00082	0.586
CLV_PCSK_SKI1_1	171	175	PF00082	0.557
CLV_PCSK_SKI1_1	177	181	PF00082	0.668
CLV_PCSK_SKI1_1	192	196	PF00082	0.428
CLV_PCSK_SKI1_1	246	250	PF00082	0.477
CLV_PCSK_SKI1_1	343	347	PF00082	0.542
CLV_PCSK_SKI1_1	410	414	PF00082	0.521
CLV_PCSK_SKI1_1	46	50	PF00082	0.539
CLV_PCSK_SKI1_1	752	756	PF00082	0.532
CLV_PCSK_SKI1_1	844	848	PF00082	0.443
CLV_PCSK_SKI1_1	858	862	PF00082	0.437
DEG_APCC_DBOX_1	387	395	PF00400	0.445
DEG_APCC_DBOX_1	695	703	PF00400	0.468
DEG_MDM2_SWIB_1	465	473	PF02201	0.508
DEG_SPOP_SBC_1	624	628	PF00917	0.570
DOC_CKS1_1	172	177	PF01111	0.568
DOC_CYCLIN_RxL_1	212	223	PF00134	0.458
DOC_CYCLIN_RxL_1	406	418	PF00134	0.540
DOC_CYCLIN_RxL_1	749	758	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	313	319	PF00134	0.579
DOC_MAPK_gen_1	343	353	PF00069	0.513
DOC_MAPK_gen_1	843	849	PF00069	0.402
DOC_MAPK_gen_1	888	896	PF00069	0.450
DOC_MAPK_MEF2A_6	91	100	PF00069	0.399
DOC_MAPK_RevD_3	762	777	PF00069	0.304
DOC_PP1_RVXF_1	175	182	PF00149	0.544
DOC_PP1_RVXF_1	247	254	PF00149	0.530
DOC_PP1_RVXF_1	530	536	PF00149	0.672
DOC_PP2B_LxvP_1	313	316	PF13499	0.593
DOC_PP2B_LxvP_1	412	415	PF13499	0.510
DOC_PP2B_LxvP_1	579	582	PF13499	0.564
DOC_PP2B_LxvP_1	783	786	PF13499	0.467
DOC_PP2B_PxIxI_1	229	235	PF00149	0.529
DOC_PP4_FxxP_1	119	122	PF00568	0.410
DOC_PP4_FxxP_1	211	214	PF00568	0.389
DOC_PP4_FxxP_1	535	538	PF00568	0.682
DOC_PP4_FxxP_1	609	612	PF00568	0.449
DOC_USP7_MATH_1	387	391	PF00917	0.426
DOC_USP7_MATH_1	415	419	PF00917	0.455
DOC_USP7_MATH_1	501	505	PF00917	0.606
DOC_USP7_MATH_1	566	570	PF00917	0.537
DOC_USP7_MATH_1	617	621	PF00917	0.524
DOC_USP7_MATH_1	70	74	PF00917	0.572
DOC_USP7_MATH_1	942	946	PF00917	0.630
DOC_USP7_UBL2_3	10	14	PF12436	0.551
DOC_USP7_UBL2_3	752	756	PF12436	0.467
DOC_USP7_UBL2_3	956	960	PF12436	0.679
DOC_WW_Pin1_4	171	176	PF00397	0.564
DOC_WW_Pin1_4	218	223	PF00397	0.423
DOC_WW_Pin1_4	226	231	PF00397	0.480
DOC_WW_Pin1_4	527	532	PF00397	0.660
DOC_WW_Pin1_4	55	60	PF00397	0.667
DOC_WW_Pin1_4	689	694	PF00397	0.505
LIG_14-3-3_CanoR_1	101	105	PF00244	0.407
LIG_14-3-3_CanoR_1	177	182	PF00244	0.550
LIG_14-3-3_CanoR_1	281	289	PF00244	0.457
LIG_14-3-3_CanoR_1	388	392	PF00244	0.411
LIG_14-3-3_CanoR_1	410	415	PF00244	0.512
LIG_14-3-3_CanoR_1	428	434	PF00244	0.371
LIG_14-3-3_CanoR_1	618	622	PF00244	0.543
LIG_14-3-3_CanoR_1	743	749	PF00244	0.468
LIG_APCC_ABBA_1	351	356	PF00400	0.410
LIG_BIR_III_4	328	332	PF00653	0.548
LIG_BRCT_BRCA1_1	157	161	PF00533	0.487
LIG_Clathr_ClatBox_1	396	400	PF01394	0.430
LIG_deltaCOP1_diTrp_1	607	614	PF00928	0.469
LIG_EH1_1	391	399	PF00400	0.357
LIG_FHA_1	205	211	PF00498	0.415
LIG_FHA_1	429	435	PF00498	0.486
LIG_FHA_1	472	478	PF00498	0.416
LIG_FHA_1	50	56	PF00498	0.670
LIG_FHA_1	582	588	PF00498	0.482
LIG_FHA_1	626	632	PF00498	0.644
LIG_FHA_1	745	751	PF00498	0.470
LIG_FHA_1	811	817	PF00498	0.458
LIG_FHA_1	872	878	PF00498	0.420
LIG_FHA_1	903	909	PF00498	0.523
LIG_FHA_1	915	921	PF00498	0.492
LIG_FHA_2	259	265	PF00498	0.507
LIG_FHA_2	411	417	PF00498	0.689
LIG_FHA_2	430	436	PF00498	0.371
LIG_FHA_2	649	655	PF00498	0.689
LIG_FHA_2	859	865	PF00498	0.519
LIG_FHA_2	899	905	PF00498	0.494
LIG_FXI_DFP_1	345	349	PF00024	0.528
LIG_Integrin_isoDGR_2	953	955	PF01839	0.632
LIG_Integrin_RGD_1	605	607	PF01839	0.503
LIG_Integrin_RGDW_4	605	608	PF00362	0.465
LIG_IRF3_LxIS_1	319	326	PF10401	0.513
LIG_LIR_Apic_2	607	612	PF02991	0.461
LIG_LIR_Gen_1	110	119	PF02991	0.411
LIG_LIR_Gen_1	21	29	PF02991	0.555
LIG_LIR_Gen_1	768	775	PF02991	0.369
LIG_LIR_Gen_1	903	913	PF02991	0.583
LIG_LIR_Nem_3	110	116	PF02991	0.402
LIG_LIR_Nem_3	158	164	PF02991	0.423
LIG_LIR_Nem_3	21	26	PF02991	0.554
LIG_LIR_Nem_3	347	351	PF02991	0.499
LIG_LIR_Nem_3	376	382	PF02991	0.435
LIG_LIR_Nem_3	407	411	PF02991	0.485
LIG_LIR_Nem_3	584	589	PF02991	0.482
LIG_LIR_Nem_3	607	611	PF02991	0.458
LIG_LIR_Nem_3	768	772	PF02991	0.369
LIG_LIR_Nem_3	903	909	PF02991	0.588
LIG_LRP6_Inhibitor_1	337	343	PF00058	0.527
LIG_LYPXL_S_1	382	386	PF13949	0.472
LIG_LYPXL_yS_3	383	386	PF13949	0.465
LIG_MYND_2	785	789	PF01753	0.468
LIG_PCNA_APIM_2	750	756	PF02747	0.536
LIG_PCNA_PIPBox_1	846	855	PF02747	0.359
LIG_PCNA_yPIPBox_3	120	133	PF02747	0.468
LIG_Pex14_1	379	383	PF04695	0.457
LIG_Pex14_2	161	165	PF04695	0.399
LIG_Pex14_2	465	469	PF04695	0.514
LIG_SH2_CRK	29	33	PF00017	0.640
LIG_SH2_NCK_1	29	33	PF00017	0.640
LIG_SH2_NCK_1	327	331	PF00017	0.481
LIG_SH2_PTP2	113	116	PF00017	0.375
LIG_SH2_STAP1	269	273	PF00017	0.392
LIG_SH2_STAP1	875	879	PF00017	0.401
LIG_SH2_STAP1	916	920	PF00017	0.493
LIG_SH2_STAT3	737	740	PF00017	0.508
LIG_SH2_STAT3	916	919	PF00017	0.492
LIG_SH2_STAT5	113	116	PF00017	0.387
LIG_SH2_STAT5	29	32	PF00017	0.711
LIG_SH2_STAT5	586	589	PF00017	0.453
LIG_SH2_STAT5	737	740	PF00017	0.512
LIG_SH2_STAT5	753	756	PF00017	0.520
LIG_SH2_STAT5	763	766	PF00017	0.379
LIG_SH2_STAT5	793	796	PF00017	0.452
LIG_SH2_STAT5	875	878	PF00017	0.405
LIG_SH2_STAT5	895	898	PF00017	0.352
LIG_SH2_STAT5	916	919	PF00017	0.492
LIG_SH3_3	169	175	PF00018	0.549
LIG_SH3_3	381	387	PF00018	0.466
LIG_SH3_3	395	401	PF00018	0.425
LIG_SH3_3	663	669	PF00018	0.578
LIG_SH3_3	730	736	PF00018	0.572
LIG_SH3_3	829	835	PF00018	0.517
LIG_SH3_3	84	90	PF00018	0.440
LIG_SUMO_SIM_anti_2	103	108	PF11976	0.378
LIG_SUMO_SIM_anti_2	768	774	PF11976	0.421
LIG_SUMO_SIM_anti_2	92	98	PF11976	0.457
LIG_SUMO_SIM_par_1	367	373	PF11976	0.356
LIG_SUMO_SIM_par_1	410	416	PF11976	0.560
LIG_SUMO_SIM_par_1	664	670	PF11976	0.571
LIG_SUMO_SIM_par_1	707	714	PF11976	0.423
LIG_SUMO_SIM_par_1	845	850	PF11976	0.360
LIG_TRAF2_1	294	297	PF00917	0.411
LIG_TRAF2_1	710	713	PF00917	0.415
LIG_TYR_ITIM	111	116	PF00017	0.377
LIG_TYR_ITIM	587	592	PF00017	0.489
LIG_UBA3_1	111	118	PF00899	0.454
LIG_UBA3_1	196	201	PF00899	0.396
LIG_WW_2	87	90	PF00397	0.423
MOD_CDC14_SPxK_1	221	224	PF00782	0.512
MOD_CDK_SPK_2	226	231	PF00069	0.544
MOD_CDK_SPK_2	527	532	PF00069	0.660
MOD_CDK_SPxK_1	171	177	PF00069	0.515
MOD_CDK_SPxK_1	218	224	PF00069	0.433
MOD_CDK_SPxxK_3	226	233	PF00069	0.537
MOD_CDK_SPxxK_3	689	696	PF00069	0.498
MOD_CK1_1	166	172	PF00069	0.474
MOD_CK1_1	439	445	PF00069	0.587
MOD_CK1_1	504	510	PF00069	0.663
MOD_CK1_1	741	747	PF00069	0.542
MOD_CK1_1	765	771	PF00069	0.362
MOD_CK1_1	81	87	PF00069	0.479
MOD_CK1_1	932	938	PF00069	0.638
MOD_CK2_1	258	264	PF00069	0.522
MOD_CK2_1	291	297	PF00069	0.410
MOD_CK2_1	410	416	PF00069	0.520
MOD_CK2_1	596	602	PF00069	0.475
MOD_CK2_1	646	652	PF00069	0.592
MOD_CK2_1	858	864	PF00069	0.524
MOD_CK2_1	898	904	PF00069	0.483
MOD_Cter_Amidation	953	956	PF01082	0.677
MOD_GlcNHglycan	133	136	PF01048	0.607
MOD_GlcNHglycan	165	168	PF01048	0.542
MOD_GlcNHglycan	241	245	PF01048	0.592
MOD_GlcNHglycan	424	427	PF01048	0.460
MOD_GlcNHglycan	438	441	PF01048	0.553
MOD_GlcNHglycan	484	488	PF01048	0.587
MOD_GlcNHglycan	55	58	PF01048	0.534
MOD_GlcNHglycan	563	566	PF01048	0.595
MOD_GlcNHglycan	568	571	PF01048	0.619
MOD_GlcNHglycan	641	645	PF01048	0.602
MOD_GlcNHglycan	648	651	PF01048	0.571
MOD_GlcNHglycan	764	767	PF01048	0.437
MOD_GlcNHglycan	80	83	PF01048	0.475
MOD_GlcNHglycan	934	937	PF01048	0.654
MOD_GlcNHglycan	944	947	PF01048	0.587
MOD_GSK3_1	49	56	PF00069	0.716
MOD_GSK3_1	501	508	PF00069	0.649
MOD_GSK3_1	623	630	PF00069	0.503
MOD_GSK3_1	642	649	PF00069	0.659
MOD_GSK3_1	654	661	PF00069	0.572
MOD_GSK3_1	744	751	PF00069	0.406
MOD_GSK3_1	77	84	PF00069	0.502
MOD_GSK3_1	854	861	PF00069	0.541
MOD_GSK3_1	894	901	PF00069	0.525
MOD_GSK3_1	914	921	PF00069	0.396
MOD_GSK3_1	928	935	PF00069	0.493
MOD_GSK3_1	942	949	PF00069	0.542
MOD_LATS_1	856	862	PF00433	0.528
MOD_N-GLC_1	566	571	PF02516	0.670
MOD_N-GLC_1	929	934	PF02516	0.500
MOD_NEK2_1	100	105	PF00069	0.391
MOD_NEK2_1	133	138	PF00069	0.655
MOD_NEK2_1	374	379	PF00069	0.558
MOD_NEK2_1	429	434	PF00069	0.538
MOD_NEK2_1	555	560	PF00069	0.601
MOD_NEK2_1	631	636	PF00069	0.583
MOD_NEK2_1	702	707	PF00069	0.452
MOD_NEK2_1	725	730	PF00069	0.507
MOD_NEK2_1	748	753	PF00069	0.514
MOD_NEK2_1	762	767	PF00069	0.334
MOD_NEK2_1	78	83	PF00069	0.661
MOD_NEK2_1	854	859	PF00069	0.457
MOD_NEK2_1	902	907	PF00069	0.503
MOD_NEK2_1	922	927	PF00069	0.474
MOD_NEK2_2	387	392	PF00069	0.400
MOD_PIKK_1	374	380	PF00454	0.475
MOD_PIKK_1	46	52	PF00454	0.532
MOD_PIKK_1	642	648	PF00454	0.635
MOD_PIKK_1	70	76	PF00454	0.571
MOD_PKA_1	258	264	PF00069	0.522
MOD_PKA_1	560	566	PF00069	0.623
MOD_PKA_2	100	106	PF00069	0.395
MOD_PKA_2	387	393	PF00069	0.419
MOD_PKA_2	429	435	PF00069	0.478
MOD_PKA_2	560	566	PF00069	0.618
MOD_PKA_2	617	623	PF00069	0.534
MOD_PKB_1	559	567	PF00069	0.610
MOD_Plk_1	321	327	PF00069	0.464
MOD_Plk_1	415	421	PF00069	0.527
MOD_Plk_1	687	693	PF00069	0.502
MOD_Plk_1	741	747	PF00069	0.542
MOD_Plk_1	92	98	PF00069	0.461
MOD_Plk_2-3	291	297	PF00069	0.410
MOD_Plk_2-3	454	460	PF00069	0.581
MOD_Plk_2-3	812	818	PF00069	0.494
MOD_Plk_2-3	873	879	PF00069	0.420
MOD_Plk_4	387	393	PF00069	0.419
MOD_Plk_4	429	435	PF00069	0.542
MOD_Plk_4	477	483	PF00069	0.488
MOD_Plk_4	581	587	PF00069	0.499
MOD_Plk_4	725	731	PF00069	0.477
MOD_Plk_4	744	750	PF00069	0.570
MOD_Plk_4	765	771	PF00069	0.554
MOD_Plk_4	784	790	PF00069	0.443
MOD_Plk_4	92	98	PF00069	0.426
MOD_ProDKin_1	171	177	PF00069	0.569
MOD_ProDKin_1	218	224	PF00069	0.433
MOD_ProDKin_1	226	232	PF00069	0.472
MOD_ProDKin_1	527	533	PF00069	0.661
MOD_ProDKin_1	55	61	PF00069	0.665
MOD_ProDKin_1	689	695	PF00069	0.501
MOD_SUMO_for_1	232	235	PF00179	0.448
MOD_SUMO_for_1	755	758	PF00179	0.527
MOD_SUMO_rev_2	921	927	PF00179	0.570
TRG_DiLeu_BaEn_1	93	98	PF01217	0.456
TRG_DiLeu_BaEn_4	296	302	PF01217	0.417
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.538
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.542
TRG_ENDOCYTIC_2	113	116	PF00928	0.387
TRG_ENDOCYTIC_2	29	32	PF00928	0.643
TRG_ENDOCYTIC_2	383	386	PF00928	0.465
TRG_ENDOCYTIC_2	589	592	PF00928	0.492
TRG_ER_diArg_1	308	310	PF00400	0.508
TRG_ER_diArg_1	427	430	PF00400	0.478
TRG_ER_diArg_1	559	561	PF00400	0.605
TRG_ER_diArg_1	780	782	PF00400	0.434
TRG_ER_diArg_1	887	889	PF00400	0.388
TRG_NES_CRM1_1	676	688	PF08389	0.468
TRG_NLS_MonoExtC_3	13	18	PF00514	0.656
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	598	602	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I315	Leptomonas seymouri	57%	100%
A0A3Q8IBU0	Leishmania donovani	94%	100%
A4HEH7	Leishmania braziliensis	78%	99%
A4I1L3	Leishmania infantum	94%	100%
E9AXP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%