J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania major

UniProt:

Q4Q9S1_LEIMA

TriTrypDb:

LmjF.25.1690 , LMJLV39_250024300 , LMJSD75_250024300

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q9S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9S1

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016226	iron-sulfur cluster assembly	4	11
GO:0022607	cellular component assembly	4	11
GO:0031163	metallo-sulfur cluster assembly	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044571	[2Fe-2S] cluster assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0043933	protein-containing complex organization	4	4
GO:0051259	protein complex oligomerization	6	4
GO:0065003	protein-containing complex assembly	5	4

Molecular functions
Term	Name	Level	Count
GO:0001671	ATPase activator activity	3	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0051087	protein-folding chaperone binding	3	11
GO:0098772	molecular function regulator activity	1	11
GO:0140677	molecular function activator activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.494
CLV_NRD_NRD_1	41	43	PF00675	0.746
CLV_PCSK_KEX2_1	40	42	PF00082	0.749
CLV_PCSK_SKI1_1	12	16	PF00082	0.591
CLV_PCSK_SKI1_1	156	160	PF00082	0.552
CLV_PCSK_SKI1_1	183	187	PF00082	0.642
CLV_PCSK_SKI1_1	67	71	PF00082	0.436
DEG_Nend_Nbox_1	1	3	PF02207	0.643
DEG_SPOP_SBC_1	111	115	PF00917	0.606
DEG_SPOP_SBC_1	127	131	PF00917	0.581
DOC_MAPK_gen_1	67	76	PF00069	0.431
DOC_MAPK_MEF2A_6	67	76	PF00069	0.431
DOC_PP2B_LxvP_1	144	147	PF13499	0.424
DOC_PP4_FxxP_1	8	11	PF00568	0.621
DOC_USP7_MATH_1	111	115	PF00917	0.641
DOC_USP7_MATH_1	121	125	PF00917	0.530
DOC_USP7_MATH_1	127	131	PF00917	0.516
DOC_USP7_MATH_1	213	217	PF00917	0.547
DOC_USP7_MATH_1	243	247	PF00917	0.504
DOC_USP7_MATH_1	3	7	PF00917	0.577
DOC_USP7_MATH_1	51	55	PF00917	0.584
DOC_USP7_UBL2_3	241	245	PF12436	0.467
DOC_WW_Pin1_4	113	118	PF00397	0.611
DOC_WW_Pin1_4	46	51	PF00397	0.679
LIG_14-3-3_CanoR_1	222	228	PF00244	0.509
LIG_14-3-3_CanoR_1	40	46	PF00244	0.620
LIG_BRCT_BRCA1_1	196	200	PF00533	0.481
LIG_DLG_GKlike_1	41	49	PF00625	0.637
LIG_FHA_2	121	127	PF00498	0.659
LIG_LIR_Apic_2	6	11	PF02991	0.540
LIG_LIR_Gen_1	261	269	PF02991	0.379
LIG_LIR_Nem_3	261	265	PF02991	0.411
LIG_PTB_Apo_2	135	142	PF02174	0.390
LIG_PTB_Phospho_1	135	141	PF10480	0.388
LIG_REV1ctd_RIR_1	63	71	PF16727	0.431
LIG_SH2_CRK	83	87	PF00017	0.476
LIG_SH2_GRB2like	136	139	PF00017	0.392
LIG_SH2_GRB2like	83	86	PF00017	0.526
LIG_SH2_NCK_1	136	140	PF00017	0.403
LIG_SH2_SRC	136	139	PF00017	0.411
LIG_SH2_STAP1	136	140	PF00017	0.428
LIG_SH2_STAT5	153	156	PF00017	0.368
LIG_SH2_STAT5	239	242	PF00017	0.452
LIG_SH2_STAT5	264	267	PF00017	0.357
LIG_SH2_STAT5	62	65	PF00017	0.397
LIG_SH3_3	189	195	PF00018	0.601
LIG_SH3_3	47	53	PF00018	0.614
LIG_TRAF2_1	170	173	PF00917	0.431
MOD_CK1_1	44	50	PF00069	0.764
MOD_CK2_1	120	126	PF00069	0.574
MOD_CK2_1	166	172	PF00069	0.506
MOD_CK2_1	213	219	PF00069	0.438
MOD_GlcNHglycan	168	171	PF01048	0.610
MOD_GlcNHglycan	46	49	PF01048	0.726
MOD_GSK3_1	127	134	PF00069	0.548
MOD_GSK3_1	260	267	PF00069	0.488
MOD_GSK3_1	40	47	PF00069	0.660
MOD_NEK2_1	120	125	PF00069	0.687
MOD_NEK2_2	140	145	PF00069	0.411
MOD_NEK2_2	3	8	PF00069	0.568
MOD_PIKK_1	33	39	PF00454	0.522
MOD_PKA_1	40	46	PF00069	0.635
MOD_PKA_2	40	46	PF00069	0.769
MOD_PKB_1	150	158	PF00069	0.479
MOD_Plk_1	131	137	PF00069	0.453
MOD_Plk_1	260	266	PF00069	0.365
MOD_Plk_4	3	9	PF00069	0.686
MOD_ProDKin_1	113	119	PF00069	0.613
MOD_ProDKin_1	46	52	PF00069	0.673
MOD_SUMO_for_1	158	161	PF00179	0.502
MOD_SUMO_rev_2	124	130	PF00179	0.618
TRG_DiLeu_BaEn_1	172	177	PF01217	0.453
TRG_ENDOCYTIC_2	141	144	PF00928	0.378
TRG_ENDOCYTIC_2	62	65	PF00928	0.402
TRG_ENDOCYTIC_2	83	86	PF00928	0.400
TRG_ER_diArg_1	150	153	PF00400	0.400
TRG_ER_diArg_1	40	42	PF00400	0.728

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K0	Leptomonas seymouri	63%	100%
A0A1X0NZR6	Trypanosomatidae	40%	100%
A0A3S7WZD6	Leishmania donovani	95%	100%
A0A422NGH8	Trypanosoma rangeli	39%	100%
A4HEH4	Leishmania braziliensis	82%	100%
A4I1L6	Leishmania infantum	95%	100%
C9ZK58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AXQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	98%
V5BHV1	Trypanosoma cruzi	41%	88%