Pyruvate dehydrogenase E1 component subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyruvate dehydrogenase E1 beta subunit, putative

Species:

Leishmania major

UniProt:

Q4Q9R8_LEIMA

TriTrypDb:

LmjF.25.1710 , LMJLV39_250024600 , LMJSD75_250024600

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005967	mitochondrial pyruvate dehydrogenase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0045254	pyruvate dehydrogenase complex	4	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990204	oxidoreductase complex	3	2

Expansion

Sequence features

Q4Q9R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9R8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006084	acetyl-CoA metabolic process	5	12
GO:0006085	acetyl-CoA biosynthetic process	6	12
GO:0006086	acetyl-CoA biosynthetic process from pyruvate	7	12
GO:0006090	pyruvate metabolic process	7	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006164	purine nucleotide biosynthetic process	6	12
GO:0006637	acyl-CoA metabolic process	4	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006790	sulfur compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009152	purine ribonucleotide biosynthetic process	7	12
GO:0009165	nucleotide biosynthetic process	6	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009260	ribonucleotide biosynthetic process	6	12
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0032787	monocarboxylic acid metabolic process	6	12
GO:0033865	nucleoside bisphosphate metabolic process	5	12
GO:0033866	nucleoside bisphosphate biosynthetic process	6	12
GO:0033875	ribonucleoside bisphosphate metabolic process	6	12
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	12
GO:0034032	purine nucleoside bisphosphate metabolic process	5	12
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0035383	thioester metabolic process	3	12
GO:0035384	thioester biosynthetic process	4	12
GO:0043436	oxoacid metabolic process	4	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0044272	sulfur compound biosynthetic process	4	12
GO:0044281	small molecule metabolic process	2	12
GO:0046390	ribose phosphate biosynthetic process	5	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071616	acyl-CoA biosynthetic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:0072521	purine-containing compound metabolic process	4	12
GO:0072522	purine-containing compound biosynthetic process	5	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901293	nucleoside phosphate biosynthetic process	5	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004738	pyruvate dehydrogenase activity	4	12
GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	5	12
GO:0016491	oxidoreductase activity	2	12
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	4	12
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.511
CLV_C14_Caspase3-7	308	312	PF00656	0.486
CLV_NRD_NRD_1	2	4	PF00675	0.560
CLV_PCSK_KEX2_1	2	4	PF00082	0.560
CLV_PCSK_KEX2_1	346	348	PF00082	0.425
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.530
CLV_PCSK_SKI1_1	19	23	PF00082	0.483
CLV_PCSK_SKI1_1	227	231	PF00082	0.339
CLV_PCSK_SKI1_1	280	284	PF00082	0.297
CLV_PCSK_SKI1_1	346	350	PF00082	0.459
CLV_PCSK_SKI1_1	7	11	PF00082	0.646
DEG_Nend_UBRbox_1	1	4	PF02207	0.565
DOC_CDC14_PxL_1	158	166	PF14671	0.486
DOC_CYCLIN_RxL_1	2	13	PF00134	0.721
DOC_MAPK_gen_1	221	231	PF00069	0.492
DOC_MAPK_gen_1	276	284	PF00069	0.511
DOC_MAPK_gen_1	71	79	PF00069	0.591
DOC_PP2B_LxvP_1	310	313	PF13499	0.486
DOC_PP4_FxxP_1	136	139	PF00568	0.486
DOC_PP4_FxxP_1	213	216	PF00568	0.410
DOC_USP7_MATH_1	119	123	PF00917	0.564
DOC_USP7_MATH_1	148	152	PF00917	0.486
DOC_USP7_MATH_1	30	34	PF00917	0.586
DOC_USP7_MATH_2	313	319	PF00917	0.486
DOC_USP7_UBL2_3	243	247	PF12436	0.572
DOC_WW_Pin1_4	321	326	PF00397	0.486
LIG_14-3-3_CanoR_1	19	27	PF00244	0.433
LIG_14-3-3_CanoR_1	280	285	PF00244	0.498
LIG_14-3-3_CanoR_1	316	323	PF00244	0.486
LIG_14-3-3_CanoR_1	7	16	PF00244	0.622
LIG_14-3-3_CterR_2	347	350	PF00244	0.441
LIG_BIR_III_4	174	178	PF00653	0.486
LIG_BRCT_BRCA1_1	150	154	PF00533	0.527
LIG_BRCT_BRCA1_1	198	202	PF00533	0.585
LIG_BRCT_BRCA1_1	303	307	PF00533	0.486
LIG_FHA_1	60	66	PF00498	0.488
LIG_FHA_2	24	30	PF00498	0.355
LIG_FHA_2	281	287	PF00498	0.493
LIG_LIR_Apic_2	210	216	PF02991	0.426
LIG_LIR_Gen_1	101	109	PF02991	0.486
LIG_LIR_Gen_1	304	314	PF02991	0.486
LIG_LIR_Nem_3	101	105	PF02991	0.527
LIG_LIR_Nem_3	304	310	PF02991	0.486
LIG_PCNA_yPIPBox_3	328	342	PF02747	0.498
LIG_Pex14_2	213	217	PF04695	0.408
LIG_SH2_CRK	158	162	PF00017	0.498
LIG_SH2_NCK_1	158	162	PF00017	0.498
LIG_SH2_SRC	309	312	PF00017	0.486
LIG_SH2_STAP1	198	202	PF00017	0.585
LIG_SH2_STAP1	326	330	PF00017	0.486
LIG_SH2_STAT5	309	312	PF00017	0.486
LIG_SH3_3	163	169	PF00018	0.478
LIG_SUMO_SIM_anti_2	228	233	PF11976	0.572
LIG_SUMO_SIM_par_1	188	193	PF11976	0.484
LIG_TRAF2_1	40	43	PF00917	0.536
LIG_UBA3_1	271	277	PF00899	0.527
LIG_WRC_WIRS_1	102	107	PF05994	0.527
MOD_CDK_SPxxK_3	321	328	PF00069	0.486
MOD_CK2_1	280	286	PF00069	0.493
MOD_GlcNHglycan	10	13	PF01048	0.578
MOD_GlcNHglycan	117	120	PF01048	0.286
MOD_GlcNHglycan	125	128	PF01048	0.284
MOD_GlcNHglycan	142	145	PF01048	0.241
MOD_GlcNHglycan	32	35	PF01048	0.372
MOD_GlcNHglycan	93	96	PF01048	0.310
MOD_GSK3_1	115	122	PF00069	0.564
MOD_GSK3_1	19	26	PF00069	0.559
MOD_GSK3_1	198	205	PF00069	0.532
MOD_GSK3_1	267	274	PF00069	0.491
MOD_GSK3_1	280	287	PF00069	0.475
MOD_N-GLC_1	23	28	PF02516	0.408
MOD_NEK2_1	10	15	PF00069	0.585
MOD_NEK2_1	115	120	PF00069	0.535
MOD_NEK2_1	123	128	PF00069	0.512
MOD_NEK2_2	119	124	PF00069	0.564
MOD_PIKK_1	148	154	PF00454	0.486
MOD_PIKK_1	331	337	PF00454	0.486
MOD_PKA_2	267	273	PF00069	0.496
MOD_PKA_2	315	321	PF00069	0.486
MOD_Plk_1	227	233	PF00069	0.511
MOD_Plk_1	23	29	PF00069	0.485
MOD_Plk_1	284	290	PF00069	0.496
MOD_Plk_2-3	303	309	PF00069	0.572
MOD_Plk_4	119	125	PF00069	0.564
MOD_Plk_4	267	273	PF00069	0.503
MOD_ProDKin_1	321	327	PF00069	0.486
MOD_SUMO_for_1	220	223	PF00179	0.486
MOD_SUMO_rev_2	223	229	PF00179	0.547
MOD_SUMO_rev_2	36	46	PF00179	0.520
TRG_DiLeu_BaEn_2	41	47	PF01217	0.536
TRG_ENDOCYTIC_2	158	161	PF00928	0.498
TRG_ER_diArg_1	1	3	PF00400	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M5	Leptomonas seymouri	32%	95%
A0A0N0P8J5	Leptomonas seymouri	88%	100%
A0A0S4J2J6	Bodo saltans	71%	100%
A0A1X0NJN2	Trypanosomatidae	34%	95%
A0A1X0NY97	Trypanosomatidae	76%	100%
A0A3Q8IJ06	Leishmania donovani	32%	96%
A0A3S7WZ91	Leishmania donovani	99%	100%
A0A422N7P1	Trypanosoma rangeli	31%	96%
A0A422NGI4	Trypanosoma rangeli	77%	100%
A2CI50	Chlorokybus atmophyticus	41%	100%
A4HEH1	Leishmania braziliensis	94%	100%
A4HM44	Leishmania braziliensis	32%	96%
A4I1L9	Leishmania infantum	99%	100%
A4IAQ6	Leishmania infantum	32%	96%
A6KXB3	Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC 11154)	25%	100%
A6VKQ3	Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z)	23%	100%
C9ZK62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
D0A2G0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	95%
E9AEI2	Leishmania major	31%	96%
E9AXQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B5P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	96%
G0RYE0	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	62%	92%
O34591	Bacillus subtilis (strain 168)	37%	100%
O44451	Caenorhabditis elegans	59%	99%
O64688	Arabidopsis thaliana	42%	86%
O66113	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	57%	76%
P09061	Pseudomonas putida	39%	100%
P0A0A1	Staphylococcus aureus (strain Mu50 / ATCC 700699)	36%	100%
P0A0A2	Staphylococcus aureus (strain MW2)	36%	100%
P0A0A3	Staphylococcus aureus	36%	100%
P11177	Homo sapiens	61%	97%
P11966	Bos taurus	60%	97%
P21839	Bos taurus	34%	89%
P21874	Geobacillus stearothermophilus	39%	100%
P21882	Bacillus subtilis (strain 168)	37%	100%
P21953	Homo sapiens	34%	89%
P26269	Ascaris suum	57%	97%
P27746	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	39%	100%
P32473	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	60%	96%
P35488	Acholeplasma laidlawii	34%	100%
P35738	Rattus norvegicus	33%	90%
P37941	Bacillus subtilis (strain 168)	38%	100%
P47515	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	32%	100%
P49432	Rattus norvegicus	60%	97%
P51266	Porphyra purpurea	44%	100%
P52904	Pisum sativum	62%	97%
P55573	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	23%	100%
P75391	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	32%	100%
P99063	Staphylococcus aureus (strain N315)	36%	100%
P9WF02	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	37%	75%
P9WIS0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	33%	100%
P9WIS1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	33%	100%
Q09171	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	61%	96%
Q0J0H4	Oryza sativa subsp. japonica	63%	93%
Q10G39	Oryza sativa subsp. japonica	43%	88%
Q1ACL0	Chara vulgaris	41%	100%
Q1RJX3	Rickettsia bellii (strain RML369-C)	54%	100%
Q1XDM1	Neopyropia yezoensis	43%	100%
Q2QM55	Oryza sativa subsp. japonica	41%	90%
Q32RM2	Zygnema circumcarinatum	42%	100%
Q32RS0	Staurastrum punctulatum	42%	100%
Q38799	Arabidopsis thaliana	62%	96%
Q4UKQ7	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	55%	100%
Q55FN7	Dictyostelium discoideum	38%	95%
Q5HGZ0	Staphylococcus aureus (strain COL)	36%	100%
Q5HQ75	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	37%	100%
Q5RE79	Pongo abelii	58%	97%
Q5SLR3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	41%	100%
Q68XA8	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	54%	100%
Q6ABX8	Leifsonia xyli subsp. xyli (strain CTCB07)	33%	100%
Q6B8T1	Gracilaria tenuistipitata var. liui	42%	100%
Q6GAC0	Staphylococcus aureus (strain MSSA476)	36%	100%
Q6GHZ1	Staphylococcus aureus (strain MRSA252)	36%	100%
Q6P3A8	Mus musculus	33%	90%
Q6Z1G7	Oryza sativa subsp. japonica	63%	94%
Q72GU2	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	41%	100%
Q7K5K3	Drosophila melanogaster	59%	96%
Q85FX1	Cyanidioschyzon merolae (strain NIES-3377 / 10D)	45%	100%
Q86HX0	Dictyostelium discoideum	63%	98%
Q8CPN2	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	37%	100%
Q8MA03	Chaetosphaeridium globosum	43%	100%
Q92IS2	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	56%	100%
Q9C6Z3	Arabidopsis thaliana	42%	86%
Q9D051	Mus musculus	59%	97%
Q9I1M1	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	38%	100%
Q9LDY2	Arabidopsis thaliana	33%	98%
Q9MUR4	Mesostigma viride	41%	100%
Q9R9N4	Rhizobium meliloti (strain 1021)	54%	76%
Q9SAV3	Arabidopsis thaliana	34%	99%
Q9TLS3	Cyanidium caldarium	41%	100%
Q9ZDR3	Rickettsia prowazekii (strain Madrid E)	54%	100%
V5BIR9	Trypanosoma cruzi	34%	95%
V5DIT8	Trypanosoma cruzi	75%	100%