Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit, putative

Species:

Leishmania major

UniProt:

Q4Q9R5_LEIMA

TriTrypDb:

LmjF.25.1740 , LMJLV39_250024900 , LMJSD75_250024900

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9R5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009894	regulation of catabolic process	4	2
GO:0009895	negative regulation of catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010628	positive regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	2
GO:0016553	base conversion or substitution editing	6	2
GO:0016554	cytidine to uridine editing	7	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031329	regulation of cellular catabolic process	5	2
GO:0031330	negative regulation of cellular catabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043487	regulation of RNA stability	3	2
GO:0043488	regulation of mRNA stability	4	2
GO:0043489	RNA stabilization	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	2
GO:0046483	heterocycle metabolic process	3	2
GO:0048255	mRNA stabilization	5	2
GO:0048518	positive regulation of biological process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051253	negative regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0061013	regulation of mRNA catabolic process	6	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1902369	negative regulation of RNA catabolic process	7	2
GO:1902373	negative regulation of mRNA catabolic process	7	2
GO:1903311	regulation of mRNA metabolic process	6	2
GO:1903312	negative regulation of mRNA metabolic process	7	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	92	96	PF00656	0.592
CLV_NRD_NRD_1	156	158	PF00675	0.449
CLV_NRD_NRD_1	190	192	PF00675	0.531
CLV_NRD_NRD_1	195	197	PF00675	0.616
CLV_NRD_NRD_1	205	207	PF00675	0.535
CLV_NRD_NRD_1	210	212	PF00675	0.496
CLV_NRD_NRD_1	230	232	PF00675	0.636
CLV_NRD_NRD_1	264	266	PF00675	0.640
CLV_NRD_NRD_1	292	294	PF00675	0.633
CLV_PCSK_KEX2_1	195	197	PF00082	0.638
CLV_PCSK_KEX2_1	205	207	PF00082	0.574
CLV_PCSK_KEX2_1	210	212	PF00082	0.538
CLV_PCSK_KEX2_1	230	232	PF00082	0.636
CLV_PCSK_KEX2_1	264	266	PF00082	0.635
CLV_PCSK_KEX2_1	292	294	PF00082	0.633
CLV_PCSK_PC7_1	191	197	PF00082	0.548
CLV_PCSK_PC7_1	206	212	PF00082	0.536
CLV_PCSK_PC7_1	260	266	PF00082	0.572
CLV_PCSK_SKI1_1	103	107	PF00082	0.509
CLV_PCSK_SKI1_1	129	133	PF00082	0.432
CLV_PCSK_SKI1_1	151	155	PF00082	0.449
CLV_PCSK_SKI1_1	158	162	PF00082	0.410
DEG_Nend_UBRbox_1	1	4	PF02207	0.543
DOC_ANK_TNKS_1	283	290	PF00023	0.593
DOC_MAPK_gen_1	191	200	PF00069	0.547
DOC_PP4_FxxP_1	235	238	PF00568	0.567
DOC_PP4_FxxP_1	63	66	PF00568	0.570
DOC_PP4_FxxP_1	75	78	PF00568	0.604
DOC_USP7_MATH_1	296	300	PF00917	0.621
DOC_USP7_MATH_1	66	70	PF00917	0.539
DOC_WW_Pin1_4	234	239	PF00397	0.661
DOC_WW_Pin1_4	241	246	PF00397	0.593
LIG_14-3-3_CanoR_1	191	195	PF00244	0.536
LIG_14-3-3_CanoR_1	300	305	PF00244	0.597
LIG_14-3-3_CanoR_1	42	49	PF00244	0.627
LIG_14-3-3_CanoR_1	9	17	PF00244	0.593
LIG_14-3-3_CanoR_1	90	98	PF00244	0.462
LIG_FHA_1	112	118	PF00498	0.461
LIG_FHA_2	163	169	PF00498	0.538
LIG_Integrin_RGD_1	260	262	PF01839	0.576
LIG_LIR_Apic_2	61	66	PF02991	0.579
LIG_LIR_Apic_2	72	78	PF02991	0.602
LIG_LIR_Gen_1	130	139	PF02991	0.420
LIG_LIR_Gen_1	3	12	PF02991	0.517
LIG_LIR_Nem_3	130	135	PF02991	0.533
LIG_LIR_Nem_3	3	7	PF02991	0.507
LIG_SH2_SRC	173	176	PF00017	0.466
LIG_SH2_STAP1	36	40	PF00017	0.577
LIG_SH2_STAT5	173	176	PF00017	0.404
LIG_SH3_2	238	243	PF14604	0.634
LIG_SH3_3	235	241	PF00018	0.685
LIG_SH3_3	75	81	PF00018	0.595
LIG_TRAF2_2	268	273	PF00917	0.609
LIG_WRC_WIRS_1	1	6	PF05994	0.514
LIG_WRC_WIRS_1	150	155	PF05994	0.416
LIG_WW_1	246	249	PF00397	0.591
MOD_CK1_1	127	133	PF00069	0.422
MOD_CK1_1	236	242	PF00069	0.675
MOD_CK1_1	5	11	PF00069	0.734
MOD_CK1_1	50	56	PF00069	0.719
MOD_CK1_1	59	65	PF00069	0.601
MOD_CK1_1	69	75	PF00069	0.593
MOD_CK1_1	99	105	PF00069	0.460
MOD_CK2_1	149	155	PF00069	0.445
MOD_CK2_1	162	168	PF00069	0.501
MOD_Cter_Amidation	262	265	PF01082	0.700
MOD_GlcNHglycan	13	16	PF01048	0.619
MOD_GlcNHglycan	132	135	PF01048	0.420
MOD_GlcNHglycan	238	241	PF01048	0.689
MOD_GlcNHglycan	254	257	PF01048	0.613
MOD_GlcNHglycan	30	33	PF01048	0.453
MOD_GlcNHglycan	36	39	PF01048	0.529
MOD_GlcNHglycan	52	55	PF01048	0.747
MOD_GlcNHglycan	58	61	PF01048	0.800
MOD_GlcNHglycan	97	101	PF01048	0.517
MOD_GSK3_1	107	114	PF00069	0.414
MOD_GSK3_1	296	303	PF00069	0.602
MOD_GSK3_1	30	37	PF00069	0.530
MOD_GSK3_1	43	50	PF00069	0.555
MOD_N-GLC_1	280	285	PF02516	0.662
MOD_N-GLC_1	300	305	PF02516	0.750
MOD_N-GLC_1	90	95	PF02516	0.566
MOD_NEK2_2	124	129	PF00069	0.417
MOD_PK_1	107	113	PF00069	0.414
MOD_PK_1	2	8	PF00069	0.578
MOD_PKA_2	190	196	PF00069	0.542
MOD_PKA_2	50	56	PF00069	0.662
MOD_PKA_2	89	95	PF00069	0.474
MOD_Plk_1	107	113	PF00069	0.473
MOD_Plk_1	300	306	PF00069	0.641
MOD_Plk_4	107	113	PF00069	0.440
MOD_Plk_4	127	133	PF00069	0.389
MOD_ProDKin_1	234	240	PF00069	0.662
MOD_ProDKin_1	241	247	PF00069	0.590
TRG_ER_diArg_1	194	196	PF00400	0.658
TRG_ER_diArg_1	210	212	PF00400	0.581
TRG_ER_diArg_1	291	293	PF00400	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H0	Leptomonas seymouri	44%	96%
A0A3S7WZ80	Leishmania donovani	91%	100%
A4HEG8	Leishmania braziliensis	71%	99%
A4I1M2	Leishmania infantum	91%	100%
E9AXQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%