DUF1935 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935), putative

Species:

Leishmania major

UniProt:

Q4Q9R4_LEIMA

TriTrypDb:

LmjF.25.1750 , LMJLV39_250025000 , LMJSD75_250025000

Length:

142

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: avilan@ula.ve
Publication title: Plasminogen binding proteins in secreted membrane vesicles of Leishmania mexicana
Publication 1st author(s): Figuera
Publication Identifier(s): 23178693
Host organism: -1
Interaction detection method(s): enzymatic linked imunosorbent assay
Interaction type: direct interaction
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: E9AUS1
ID(s) interactor B: P00747
Taxid interactor A: Leishmania mexicana
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 5
Forrest at al. (procyclic)	no	yes: 7
Silverman et al.	no	yes: 1
Pissara et al.	no	yes: 27

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 12

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 53
NetGPI	no	yes: 0, no: 53

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	1
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1

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Expansion

Sequence features

Q4Q9R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9R4

PDB structure(s): 1r75_A , 2fe0_A

Function

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Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044000	movement in host	4	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044409	entry into host	5	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.625
CLV_PCSK_KEX2_1	140	142	PF00082	0.657
CLV_PCSK_SKI1_1	27	31	PF00082	0.353
CLV_PCSK_SKI1_1	50	54	PF00082	0.431
DOC_MAPK_gen_1	34	41	PF00069	0.371
DOC_USP7_UBL2_3	129	133	PF12436	0.555
DOC_USP7_UBL2_3	30	34	PF12436	0.396
LIG_deltaCOP1_diTrp_1	49	53	PF00928	0.400
LIG_FHA_1	111	117	PF00498	0.456
LIG_FHA_2	79	85	PF00498	0.311

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Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y3	Leptomonas seymouri	39%	100%
A0A0N1HYV4	Leptomonas seymouri	35%	100%
A0A0N1I5S6	Leptomonas seymouri	39%	92%
A0A0N1I8U4	Leptomonas seymouri	32%	100%
A0A0N1P9P7	Leptomonas seymouri	36%	73%
A0A0N1PCZ0	Leptomonas seymouri	34%	100%
A0A0N1PE11	Leptomonas seymouri	94%	100%
A0A1X0NNW3	Trypanosomatidae	32%	100%
A0A1X0NW79	Trypanosomatidae	33%	72%
A0A1X0NW95	Trypanosomatidae	38%	100%

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