RMI1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9R3_LEIMA

TriTrypDb:

LmjF.25.1760 , LMJLV39_250025100 , LMJSD75_250025100

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016604	nuclear body	2	2
GO:0031422	RecQ family helicase-topoisomerase III complex	3	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4Q9R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9R3

Function

Biological processes
Term	Name	Level	Count
GO:0000712	resolution of meiotic recombination intermediates	4	2
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0022402	cell cycle process	2	2
GO:0022414	reproductive process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0061982	meiosis I cell cycle process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1903046	meiotic cell cycle process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004519	endonuclease activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.510
CLV_C14_Caspase3-7	168	172	PF00656	0.517
CLV_C14_Caspase3-7	278	282	PF00656	0.795
CLV_NRD_NRD_1	26	28	PF00675	0.707
CLV_NRD_NRD_1	485	487	PF00675	0.523
CLV_PCSK_KEX2_1	26	28	PF00082	0.707
CLV_PCSK_KEX2_1	485	487	PF00082	0.524
CLV_PCSK_SKI1_1	382	386	PF00082	0.639
DEG_ODPH_VHL_1	37	49	PF01847	0.643
DEG_SCF_FBW7_1	68	75	PF00400	0.530
DOC_ANK_TNKS_1	484	491	PF00023	0.521
DOC_CKS1_1	40	45	PF01111	0.577
DOC_CYCLIN_RxL_1	160	171	PF00134	0.482
DOC_CYCLIN_RxL_1	445	456	PF00134	0.497
DOC_MAPK_gen_1	96	104	PF00069	0.566
DOC_PP2B_LxvP_1	208	211	PF13499	0.449
DOC_PP4_FxxP_1	40	43	PF00568	0.607
DOC_USP7_MATH_1	283	287	PF00917	0.788
DOC_USP7_MATH_1	296	300	PF00917	0.759
DOC_USP7_MATH_1	72	76	PF00917	0.664
DOC_WW_Pin1_4	114	119	PF00397	0.535
DOC_WW_Pin1_4	303	308	PF00397	0.742
DOC_WW_Pin1_4	361	366	PF00397	0.619
DOC_WW_Pin1_4	39	44	PF00397	0.612
DOC_WW_Pin1_4	392	397	PF00397	0.448
DOC_WW_Pin1_4	407	412	PF00397	0.595
DOC_WW_Pin1_4	68	73	PF00397	0.733
LIG_14-3-3_CanoR_1	111	118	PF00244	0.576
LIG_14-3-3_CanoR_1	207	211	PF00244	0.526
LIG_14-3-3_CanoR_1	448	453	PF00244	0.461
LIG_14-3-3_CanoR_1	480	484	PF00244	0.516
LIG_APCC_ABBA_1	245	250	PF00400	0.537
LIG_APCC_ABBAyCdc20_2	63	69	PF00400	0.707
LIG_BRCT_BRCA1_1	169	173	PF00533	0.562
LIG_FHA_1	207	213	PF00498	0.532
LIG_FHA_1	350	356	PF00498	0.485
LIG_FHA_1	384	390	PF00498	0.530
LIG_FHA_1	42	48	PF00498	0.668
LIG_FHA_1	426	432	PF00498	0.522
LIG_FHA_1	461	467	PF00498	0.563
LIG_FHA_1	77	83	PF00498	0.572
LIG_LIR_Gen_1	170	179	PF02991	0.476
LIG_LIR_Gen_1	342	351	PF02991	0.367
LIG_LIR_Gen_1	386	393	PF02991	0.448
LIG_LIR_LC3C_4	299	304	PF02991	0.675
LIG_LIR_Nem_3	170	176	PF02991	0.471
LIG_LIR_Nem_3	342	348	PF02991	0.334
LIG_LIR_Nem_3	386	390	PF02991	0.456
LIG_LIR_Nem_3	445	450	PF02991	0.418
LIG_MYND_1	35	39	PF01753	0.623
LIG_SH2_CRK	387	391	PF00017	0.521
LIG_SH2_STAP1	387	391	PF00017	0.521
LIG_SH2_STAT5	12	15	PF00017	0.631
LIG_SH3_2	325	330	PF14604	0.566
LIG_SH3_3	151	157	PF00018	0.562
LIG_SH3_3	25	31	PF00018	0.653
LIG_SH3_3	301	307	PF00018	0.705
LIG_SH3_3	308	314	PF00018	0.715
LIG_SH3_3	322	328	PF00018	0.599
LIG_SH3_3	338	344	PF00018	0.501
LIG_SH3_3	437	443	PF00018	0.535
LIG_SUMO_SIM_anti_2	458	463	PF11976	0.519
LIG_SUMO_SIM_anti_2	79	84	PF11976	0.475
LIG_SUMO_SIM_par_1	175	181	PF11976	0.538
LIG_TRAF2_1	140	143	PF00917	0.541
MOD_CK1_1	106	112	PF00069	0.556
MOD_CK1_1	114	120	PF00069	0.537
MOD_CK1_1	183	189	PF00069	0.552
MOD_CK1_1	306	312	PF00069	0.779
MOD_CK1_1	55	61	PF00069	0.753
MOD_CK2_1	450	456	PF00069	0.577
MOD_GlcNHglycan	113	116	PF01048	0.381
MOD_GlcNHglycan	157	160	PF01048	0.351
MOD_GlcNHglycan	180	185	PF01048	0.362
MOD_GlcNHglycan	287	290	PF01048	0.803
MOD_GlcNHglycan	74	77	PF01048	0.717
MOD_GSK3_1	103	110	PF00069	0.510
MOD_GSK3_1	2	9	PF00069	0.642
MOD_GSK3_1	212	219	PF00069	0.582
MOD_GSK3_1	258	265	PF00069	0.654
MOD_GSK3_1	277	284	PF00069	0.682
MOD_GSK3_1	303	310	PF00069	0.771
MOD_GSK3_1	349	356	PF00069	0.474
MOD_GSK3_1	405	412	PF00069	0.687
MOD_GSK3_1	55	62	PF00069	0.759
MOD_GSK3_1	68	75	PF00069	0.672
MOD_NEK2_1	103	108	PF00069	0.581
MOD_NEK2_1	257	262	PF00069	0.655
MOD_NEK2_1	285	290	PF00069	0.723
MOD_NEK2_1	385	390	PF00069	0.524
MOD_NEK2_1	450	455	PF00069	0.480
MOD_PIKK_1	248	254	PF00454	0.513
MOD_PIKK_1	296	302	PF00454	0.706
MOD_PIKK_1	400	406	PF00454	0.597
MOD_PIKK_1	55	61	PF00454	0.695
MOD_PKA_2	110	116	PF00069	0.576
MOD_PKA_2	155	161	PF00069	0.520
MOD_PKA_2	206	212	PF00069	0.517
MOD_PKA_2	262	268	PF00069	0.692
MOD_PKA_2	33	39	PF00069	0.607
MOD_PKA_2	400	406	PF00069	0.572
MOD_PKA_2	479	485	PF00069	0.495
MOD_Plk_1	134	140	PF00069	0.487
MOD_Plk_1	213	219	PF00069	0.525
MOD_Plk_1	6	12	PF00069	0.675
MOD_Plk_1	90	96	PF00069	0.487
MOD_Plk_2-3	425	431	PF00069	0.433
MOD_Plk_2-3	6	12	PF00069	0.643
MOD_Plk_4	385	391	PF00069	0.560
MOD_Plk_4	78	84	PF00069	0.363
MOD_ProDKin_1	114	120	PF00069	0.535
MOD_ProDKin_1	303	309	PF00069	0.743
MOD_ProDKin_1	361	367	PF00069	0.628
MOD_ProDKin_1	39	45	PF00069	0.614
MOD_ProDKin_1	392	398	PF00069	0.449
MOD_ProDKin_1	407	413	PF00069	0.599
MOD_ProDKin_1	68	74	PF00069	0.729
MOD_SUMO_rev_2	493	501	PF00179	0.398
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.754
TRG_ENDOCYTIC_2	387	390	PF00928	0.525
TRG_ER_diArg_1	26	28	PF00400	0.518
TRG_ER_diArg_1	484	486	PF00400	0.431
TRG_ER_diArg_1	99	102	PF00400	0.581
TRG_NES_CRM1_1	168	181	PF08389	0.562
TRG_NES_CRM1_1	236	250	PF08389	0.562
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I876	Leptomonas seymouri	54%	100%
A0A0S4ILE1	Bodo saltans	26%	100%
A0A1X0NY87	Trypanosomatidae	30%	100%
A0A3S7WZC3	Leishmania donovani	94%	100%
A0A422NGJ8	Trypanosoma rangeli	30%	100%
A4HEG6	Leishmania braziliensis	78%	100%
A4I1M4	Leishmania infantum	94%	100%
C9ZK66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AXQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DIU3	Trypanosoma cruzi	34%	100%