Cytochrome c oxidase assembly protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase assembly protein, putative

Species:

Leishmania major

UniProt:

Q4Q9Q8_LEIMA

TriTrypDb:

LmjF.25.1810 , LMJLV39_250025600 , LMJSD75_250025600

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Q8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	240	242	PF00675	0.473
CLV_NRD_NRD_1	245	247	PF00675	0.470
CLV_NRD_NRD_1	26	28	PF00675	0.503
CLV_PCSK_KEX2_1	185	187	PF00082	0.423
CLV_PCSK_KEX2_1	240	242	PF00082	0.472
CLV_PCSK_KEX2_1	26	28	PF00082	0.505
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.452
CLV_PCSK_SKI1_1	182	186	PF00082	0.435
CLV_PCSK_SKI1_1	192	196	PF00082	0.433
CLV_PCSK_SKI1_1	264	268	PF00082	0.518
CLV_PCSK_SKI1_1	72	76	PF00082	0.393
DEG_Nend_UBRbox_1	1	4	PF02207	0.691
DOC_MAPK_RevD_3	226	241	PF00069	0.582
DOC_PP4_FxxP_1	166	169	PF00568	0.390
DOC_PP4_FxxP_1	248	251	PF00568	0.481
DOC_PP4_FxxP_1	9	12	PF00568	0.685
DOC_USP7_MATH_1	275	279	PF00917	0.564
DOC_USP7_MATH_1	76	80	PF00917	0.398
DOC_USP7_UBL2_3	188	192	PF12436	0.515
DOC_USP7_UBL2_3	221	225	PF12436	0.447
DOC_USP7_UBL2_3	24	28	PF12436	0.533
DOC_WW_Pin1_4	124	129	PF00397	0.541
LIG_14-3-3_CanoR_1	235	240	PF00244	0.589
LIG_14-3-3_CanoR_1	262	267	PF00244	0.602
LIG_BRCT_BRCA1_1	277	281	PF00533	0.557
LIG_deltaCOP1_diTrp_1	259	267	PF00928	0.520
LIG_EH1_1	37	45	PF00400	0.460
LIG_EVH1_2	168	172	PF00568	0.431
LIG_FHA_1	125	131	PF00498	0.515
LIG_FHA_1	142	148	PF00498	0.438
LIG_FHA_1	69	75	PF00498	0.443
LIG_FHA_1	91	97	PF00498	0.565
LIG_FHA_2	76	82	PF00498	0.472
LIG_LIR_Apic_2	163	169	PF02991	0.395
LIG_LIR_Apic_2	6	12	PF02991	0.642
LIG_LIR_Gen_1	113	124	PF02991	0.363
LIG_LIR_Gen_1	174	184	PF02991	0.473
LIG_LIR_Nem_3	113	119	PF02991	0.348
LIG_LIR_Nem_3	174	180	PF02991	0.415
LIG_LIR_Nem_3	242	248	PF02991	0.498
LIG_PCNA_PIPBox_1	227	236	PF02747	0.460
LIG_PCNA_yPIPBox_3	221	234	PF02747	0.428
LIG_Pex14_2	244	248	PF04695	0.461
LIG_SH2_NCK_1	177	181	PF00017	0.532
LIG_SH2_STAT3	233	236	PF00017	0.480
LIG_SH2_STAT3	273	276	PF00017	0.649
LIG_SH2_STAT5	203	206	PF00017	0.401
LIG_SH2_STAT5	223	226	PF00017	0.241
LIG_SH2_STAT5	89	92	PF00017	0.400
LIG_SH3_3	145	151	PF00018	0.440
LIG_SH3_3	269	275	PF00018	0.650
LIG_SUMO_SIM_anti_2	93	100	PF11976	0.354
LIG_SUMO_SIM_par_1	210	217	PF11976	0.406
LIG_TRAF2_1	79	82	PF00917	0.397
MOD_CDK_SPxxK_3	124	131	PF00069	0.542
MOD_CK2_1	75	81	PF00069	0.391
MOD_GlcNHglycan	13	16	PF01048	0.596
MOD_GlcNHglycan	156	159	PF01048	0.382
MOD_GlcNHglycan	204	207	PF01048	0.381
MOD_GlcNHglycan	3	6	PF01048	0.729
MOD_GlcNHglycan	46	49	PF01048	0.532
MOD_GSK3_1	235	242	PF00069	0.503
MOD_GSK3_1	275	282	PF00069	0.490
MOD_GSK3_1	49	56	PF00069	0.564
MOD_GSK3_1	64	71	PF00069	0.481
MOD_N-GLC_1	104	109	PF02516	0.416
MOD_N-GLC_2	104	106	PF02516	0.469
MOD_NEK2_1	202	207	PF00069	0.382
MOD_NEK2_1	239	244	PF00069	0.584
MOD_NEK2_1	44	49	PF00069	0.552
MOD_NEK2_1	54	59	PF00069	0.570
MOD_PK_1	262	268	PF00069	0.561
MOD_PKA_2	1	7	PF00069	0.592
MOD_PKA_2	239	245	PF00069	0.500
MOD_Plk_4	39	45	PF00069	0.477
MOD_ProDKin_1	124	130	PF00069	0.531
MOD_SUMO_for_1	187	190	PF00179	0.504
MOD_SUMO_rev_2	163	169	PF00179	0.376
MOD_SUMO_rev_2	181	187	PF00179	0.405
TRG_ENDOCYTIC_2	177	180	PF00928	0.399
TRG_ENDOCYTIC_2	245	248	PF00928	0.542
TRG_ER_diArg_1	239	241	PF00400	0.481
TRG_ER_diArg_1	261	264	PF00400	0.655
TRG_NLS_MonoExtC_3	184	190	PF00514	0.496
TRG_NLS_MonoExtN_4	182	189	PF00514	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8J2	Leptomonas seymouri	81%	100%
A0A0S4ITS5	Bodo saltans	60%	100%
A0A1X0NY80	Trypanosomatidae	70%	100%
A0A3S7WZA4	Leishmania donovani	96%	100%
A4HEI9	Leishmania braziliensis	89%	100%
A4I1M9	Leishmania infantum	96%	100%
C9ZK74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	99%
E9AXR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BHW7	Trypanosoma cruzi	68%	100%