Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9Q7_LEIMA

TriTrypDb:

LmjF.25.1820 , LMJLV39_250025700 , LMJSD75_250025700

Length:

831

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0005930	axoneme	2	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q9Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Q7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.765
CLV_C14_Caspase3-7	294	298	PF00656	0.749
CLV_C14_Caspase3-7	395	399	PF00656	0.746
CLV_C14_Caspase3-7	492	496	PF00656	0.761
CLV_C14_Caspase3-7	551	555	PF00656	0.780
CLV_C14_Caspase3-7	565	569	PF00656	0.536
CLV_C14_Caspase3-7	660	664	PF00656	0.721
CLV_C14_Caspase3-7	674	678	PF00656	0.588
CLV_C14_Caspase3-7	781	785	PF00656	0.629
CLV_NRD_NRD_1	112	114	PF00675	0.449
CLV_NRD_NRD_1	115	117	PF00675	0.413
CLV_NRD_NRD_1	123	125	PF00675	0.505
CLV_NRD_NRD_1	130	132	PF00675	0.701
CLV_NRD_NRD_1	135	137	PF00675	0.610
CLV_NRD_NRD_1	145	147	PF00675	0.495
CLV_NRD_NRD_1	170	172	PF00675	0.762
CLV_NRD_NRD_1	179	181	PF00675	0.746
CLV_NRD_NRD_1	254	256	PF00675	0.787
CLV_NRD_NRD_1	725	727	PF00675	0.858
CLV_NRD_NRD_1	745	747	PF00675	0.536
CLV_NRD_NRD_1	98	100	PF00675	0.599
CLV_PCSK_FUR_1	113	117	PF00082	0.703
CLV_PCSK_KEX2_1	111	113	PF00082	0.610
CLV_PCSK_KEX2_1	115	117	PF00082	0.657
CLV_PCSK_KEX2_1	129	131	PF00082	0.706
CLV_PCSK_KEX2_1	135	137	PF00082	0.593
CLV_PCSK_KEX2_1	170	172	PF00082	0.737
CLV_PCSK_KEX2_1	254	256	PF00082	0.787
CLV_PCSK_KEX2_1	754	756	PF00082	0.843
CLV_PCSK_PC1ET2_1	754	756	PF00082	0.843
CLV_PCSK_PC7_1	107	113	PF00082	0.593
CLV_PCSK_PC7_1	131	137	PF00082	0.646
CLV_PCSK_SKI1_1	100	104	PF00082	0.518
CLV_PCSK_SKI1_1	130	134	PF00082	0.686
DEG_SPOP_SBC_1	229	233	PF00917	0.843
DEG_SPOP_SBC_1	314	318	PF00917	0.729
DEG_SPOP_SBC_1	759	763	PF00917	0.769
DOC_CDC14_PxL_1	61	69	PF14671	0.774
DOC_MAPK_MEF2A_6	3	10	PF00069	0.667
DOC_PP2B_PxIxI_1	5	11	PF00149	0.677
DOC_USP7_MATH_1	196	200	PF00917	0.781
DOC_USP7_MATH_1	235	239	PF00917	0.809
DOC_USP7_MATH_1	247	251	PF00917	0.712
DOC_USP7_MATH_1	314	318	PF00917	0.750
DOC_USP7_MATH_1	377	381	PF00917	0.778
DOC_USP7_MATH_1	494	498	PF00917	0.727
DOC_USP7_MATH_1	563	567	PF00917	0.646
DOC_USP7_MATH_1	672	676	PF00917	0.679
DOC_USP7_MATH_1	718	722	PF00917	0.792
DOC_USP7_MATH_1	759	763	PF00917	0.773
DOC_USP7_MATH_1	778	782	PF00917	0.589
DOC_USP7_MATH_1	790	794	PF00917	0.632
DOC_USP7_MATH_1	799	803	PF00917	0.667
DOC_WW_Pin1_4	315	320	PF00397	0.666
DOC_WW_Pin1_4	366	371	PF00397	0.737
DOC_WW_Pin1_4	46	51	PF00397	0.673
DOC_WW_Pin1_4	490	495	PF00397	0.741
DOC_WW_Pin1_4	741	746	PF00397	0.846
LIG_14-3-3_CanoR_1	12	17	PF00244	0.697
LIG_14-3-3_CanoR_1	310	319	PF00244	0.694
LIG_14-3-3_CanoR_1	37	45	PF00244	0.738
LIG_APCC_ABBA_1	390	395	PF00400	0.686
LIG_APCC_ABBA_1	82	87	PF00400	0.732
LIG_BIR_II_1	1	5	PF00653	0.783
LIG_BIR_III_2	530	534	PF00653	0.737
LIG_BIR_III_2	639	643	PF00653	0.685
LIG_BIR_III_4	439	443	PF00653	0.799
LIG_FHA_2	279	285	PF00498	0.765
LIG_FHA_2	412	418	PF00498	0.704
LIG_FHA_2	453	459	PF00498	0.760
LIG_FHA_2	490	496	PF00498	0.646
LIG_HCF-1_HBM_1	225	228	PF13415	0.850
LIG_KLC1_Yacidic_2	279	284	PF13176	0.763
LIG_LIR_Nem_3	55	61	PF02991	0.640
LIG_MYND_1	91	95	PF01753	0.677
LIG_REV1ctd_RIR_1	545	553	PF16727	0.729
LIG_REV1ctd_RIR_1	654	662	PF16727	0.674
LIG_SH2_STAP1	39	43	PF00017	0.845
LIG_SH2_STAP1	823	827	PF00017	0.774
LIG_SH2_STAT5	228	231	PF00017	0.683
LIG_SH2_STAT5	282	285	PF00017	0.659
LIG_SH2_STAT5	389	392	PF00017	0.686
LIG_SH2_STAT5	454	457	PF00017	0.859
LIG_SH3_1	170	176	PF00018	0.816
LIG_SH3_3	170	176	PF00018	0.816
LIG_SH3_3	267	273	PF00018	0.854
LIG_SH3_3	441	447	PF00018	0.847
LIG_SH3_3	62	68	PF00018	0.772
LIG_SH3_3	7	13	PF00018	0.609
LIG_SH3_3	772	778	PF00018	0.739
LIG_SH3_3	78	84	PF00018	0.680
LIG_TRAF2_1	276	279	PF00917	0.839
LIG_TRAF2_1	403	406	PF00917	0.819
LIG_TRAF2_1	410	413	PF00917	0.706
LIG_TRAF2_1	414	417	PF00917	0.714
LIG_TRAF2_1	455	458	PF00917	0.784
LIG_TRAF2_1	476	479	PF00917	0.851
LIG_TRAF2_1	587	590	PF00917	0.666
LIG_TRAF2_1	696	699	PF00917	0.622
LIG_TRAF2_1	76	79	PF00917	0.756
LIG_TRFH_1	72	76	PF08558	0.752
MOD_CDC14_SPxK_1	369	372	PF00782	0.736
MOD_CDC14_SPxK_1	744	747	PF00782	0.854
MOD_CDK_SPK_2	741	746	PF00069	0.776
MOD_CDK_SPxK_1	366	372	PF00069	0.737
MOD_CDK_SPxK_1	741	747	PF00069	0.848
MOD_CK1_1	23	29	PF00069	0.736
MOD_CK1_1	231	237	PF00069	0.850
MOD_CK1_1	240	246	PF00069	0.660
MOD_CK1_1	250	256	PF00069	0.686
MOD_CK1_1	306	312	PF00069	0.833
MOD_CK1_1	313	319	PF00069	0.722
MOD_CK1_1	355	361	PF00069	0.777
MOD_CK1_1	38	44	PF00069	0.611
MOD_CK1_1	380	386	PF00069	0.769
MOD_CK1_1	430	436	PF00069	0.851
MOD_CK1_1	489	495	PF00069	0.759
MOD_CK1_1	56	62	PF00069	0.693
MOD_CK1_1	599	605	PF00069	0.788
MOD_CK1_1	708	714	PF00069	0.853
MOD_CK1_1	725	731	PF00069	0.571
MOD_CK1_1	758	764	PF00069	0.840
MOD_CK1_1	773	779	PF00069	0.586
MOD_CK1_1	780	786	PF00069	0.745
MOD_CK1_1	802	808	PF00069	0.725
MOD_CK2_1	394	400	PF00069	0.687
MOD_CK2_1	411	417	PF00069	0.758
MOD_CK2_1	420	426	PF00069	0.683
MOD_CK2_1	452	458	PF00069	0.782
MOD_CK2_1	780	786	PF00069	0.839
MOD_DYRK1A_RPxSP_1	46	50	PF00069	0.826
MOD_GlcNHglycan	181	184	PF01048	0.828
MOD_GlcNHglycan	233	236	PF01048	0.853
MOD_GlcNHglycan	239	242	PF01048	0.708
MOD_GlcNHglycan	25	28	PF01048	0.717
MOD_GlcNHglycan	312	315	PF01048	0.727
MOD_GlcNHglycan	375	378	PF01048	0.861
MOD_GlcNHglycan	384	387	PF01048	0.695
MOD_GlcNHglycan	41	44	PF01048	0.593
MOD_GlcNHglycan	430	433	PF01048	0.782
MOD_GlcNHglycan	456	462	PF01048	0.652
MOD_GlcNHglycan	46	49	PF01048	0.809
MOD_GlcNHglycan	554	557	PF01048	0.825
MOD_GlcNHglycan	602	605	PF01048	0.723
MOD_GlcNHglycan	663	666	PF01048	0.738
MOD_GlcNHglycan	711	714	PF01048	0.835
MOD_GlcNHglycan	720	723	PF01048	0.720
MOD_GlcNHglycan	756	760	PF01048	0.812
MOD_GlcNHglycan	762	765	PF01048	0.772
MOD_GlcNHglycan	772	775	PF01048	0.596
MOD_GlcNHglycan	792	795	PF01048	0.530
MOD_GlcNHglycan	805	808	PF01048	0.618
MOD_GlcNHglycan	816	819	PF01048	0.615
MOD_GSK3_1	12	19	PF00069	0.756
MOD_GSK3_1	171	178	PF00069	0.747
MOD_GSK3_1	227	234	PF00069	0.847
MOD_GSK3_1	235	242	PF00069	0.673
MOD_GSK3_1	246	253	PF00069	0.706
MOD_GSK3_1	305	312	PF00069	0.813
MOD_GSK3_1	313	320	PF00069	0.688
MOD_GSK3_1	35	42	PF00069	0.684
MOD_GSK3_1	368	375	PF00069	0.855
MOD_GSK3_1	377	384	PF00069	0.697
MOD_GSK3_1	427	434	PF00069	0.776
MOD_GSK3_1	46	53	PF00069	0.675
MOD_GSK3_1	485	492	PF00069	0.714
MOD_GSK3_1	56	63	PF00069	0.738
MOD_GSK3_1	596	603	PF00069	0.721
MOD_GSK3_1	705	712	PF00069	0.840
MOD_GSK3_1	718	725	PF00069	0.630
MOD_GSK3_1	755	762	PF00069	0.842
MOD_GSK3_1	773	780	PF00069	0.538
MOD_GSK3_1	799	806	PF00069	0.686
MOD_LATS_1	753	759	PF00433	0.772
MOD_NEK2_1	1	6	PF00069	0.710
MOD_NEK2_1	166	171	PF00069	0.606
MOD_NEK2_1	427	432	PF00069	0.846
MOD_NEK2_1	760	765	PF00069	0.838
MOD_NEK2_1	801	806	PF00069	0.630
MOD_PIKK_1	53	59	PF00454	0.753
MOD_PK_1	12	18	PF00069	0.804
MOD_PKA_1	600	606	PF00069	0.731
MOD_PKA_1	709	715	PF00069	0.784
MOD_PKA_2	179	185	PF00069	0.847
MOD_PKA_2	23	29	PF00069	0.711
MOD_PKA_2	309	315	PF00069	0.780
MOD_PKA_2	718	724	PF00069	0.725
MOD_PKA_2	725	731	PF00069	0.738
MOD_Plk_1	278	284	PF00069	0.761
MOD_Plk_1	355	361	PF00069	0.847
MOD_Plk_1	70	76	PF00069	0.752
MOD_Plk_2-3	278	284	PF00069	0.833
MOD_Plk_2-3	420	426	PF00069	0.780
MOD_Plk_2-3	540	546	PF00069	0.783
MOD_Plk_2-3	649	655	PF00069	0.731
MOD_ProDKin_1	315	321	PF00069	0.667
MOD_ProDKin_1	366	372	PF00069	0.737
MOD_ProDKin_1	46	52	PF00069	0.671
MOD_ProDKin_1	490	496	PF00069	0.740
MOD_ProDKin_1	741	747	PF00069	0.848
MOD_SUMO_for_1	339	342	PF00179	0.780
MOD_SUMO_rev_2	177	182	PF00179	0.769
MOD_SUMO_rev_2	412	421	PF00179	0.794
MOD_SUMO_rev_2	529	534	PF00179	0.856
MOD_SUMO_rev_2	535	543	PF00179	0.755
MOD_SUMO_rev_2	573	581	PF00179	0.664
MOD_SUMO_rev_2	638	643	PF00179	0.803
MOD_SUMO_rev_2	644	652	PF00179	0.717
MOD_SUMO_rev_2	682	690	PF00179	0.627
TRG_DiLeu_BaEn_1	89	94	PF01217	0.682
TRG_DiLeu_BaEn_4	278	284	PF01217	0.763
TRG_DiLeu_BaEn_4	406	412	PF01217	0.747
TRG_ENDOCYTIC_2	564	567	PF00928	0.687
TRG_ENDOCYTIC_2	673	676	PF00928	0.738
TRG_ENDOCYTIC_2	85	88	PF00928	0.725
TRG_ER_diArg_1	111	113	PF00400	0.692
TRG_ER_diArg_1	114	116	PF00400	0.655
TRG_ER_diArg_1	129	131	PF00400	0.706
TRG_ER_diArg_1	170	172	PF00400	0.702
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.701
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WZ94	Leishmania donovani	86%	100%
A4HE84	Leishmania braziliensis	66%	98%
A4I1N0	Leishmania infantum	83%	98%
E9AXR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%