Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9Q4_LEIMA

TriTrypDb:

LmjF.25.1850 , LMJLV39_250026000 , LMJSD75_250026000

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	11
GO:0005840	ribosome	5	16
GO:0032991	protein-containing complex	1	16
GO:0043226	organelle	2	16
GO:0043228	non-membrane-bounded organelle	3	16
GO:0043229	intracellular organelle	3	16
GO:0043232	intracellular non-membrane-bounded organelle	4	16
GO:0071013	catalytic step 2 spliceosome	3	11
GO:0110165	cellular anatomical entity	1	16
GO:0140513	nuclear protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1990904	ribonucleoprotein complex	2	16
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0036064	ciliary basal body	3	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q9Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Q4

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.407
CLV_NRD_NRD_1	108	110	PF00675	0.652
CLV_NRD_NRD_1	220	222	PF00675	0.518
CLV_NRD_NRD_1	41	43	PF00675	0.709
CLV_NRD_NRD_1	59	61	PF00675	0.431
CLV_PCSK_FUR_1	106	110	PF00082	0.539
CLV_PCSK_KEX2_1	105	107	PF00082	0.557
CLV_PCSK_KEX2_1	108	110	PF00082	0.564
CLV_PCSK_KEX2_1	220	222	PF00082	0.518
CLV_PCSK_KEX2_1	40	42	PF00082	0.550
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.543
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.550
CLV_PCSK_SKI1_1	156	160	PF00082	0.416
CLV_PCSK_SKI1_1	184	188	PF00082	0.663
CLV_PCSK_SKI1_1	259	263	PF00082	0.416
CLV_PCSK_SKI1_1	336	340	PF00082	0.312
CLV_PCSK_SKI1_1	371	375	PF00082	0.248
CLV_PCSK_SKI1_1	442	446	PF00082	0.313
CLV_PCSK_SKI1_1	486	490	PF00082	0.498
CLV_PCSK_SKI1_1	507	511	PF00082	0.342
DEG_SPOP_SBC_1	203	207	PF00917	0.639
DOC_CKS1_1	7	12	PF01111	0.549
DOC_CYCLIN_yCln2_LP_2	499	505	PF00134	0.495
DOC_MAPK_gen_1	486	496	PF00069	0.492
DOC_PP1_RVXF_1	422	429	PF00149	0.483
DOC_PP2B_LxvP_1	159	162	PF13499	0.429
DOC_PP4_FxxP_1	158	161	PF00568	0.411
DOC_PP4_FxxP_1	187	190	PF00568	0.733
DOC_USP7_MATH_1	203	207	PF00917	0.675
DOC_USP7_MATH_1	271	275	PF00917	0.484
DOC_USP7_MATH_1	282	286	PF00917	0.426
DOC_USP7_MATH_1	417	421	PF00917	0.510
DOC_USP7_MATH_1	78	82	PF00917	0.626
DOC_USP7_UBL2_3	482	486	PF12436	0.512
DOC_WW_Pin1_4	385	390	PF00397	0.525
DOC_WW_Pin1_4	52	57	PF00397	0.549
DOC_WW_Pin1_4	6	11	PF00397	0.559
LIG_14-3-3_CanoR_1	252	262	PF00244	0.504
LIG_14-3-3_CanoR_1	379	385	PF00244	0.512
LIG_14-3-3_CanoR_1	41	49	PF00244	0.721
LIG_14-3-3_CanoR_1	453	459	PF00244	0.491
LIG_14-3-3_CanoR_1	463	470	PF00244	0.431
LIG_APCC_ABBA_1	425	430	PF00400	0.379
LIG_APCC_ABBAyCdc20_2	424	430	PF00400	0.384
LIG_CSL_BTD_1	499	502	PF09270	0.423
LIG_EVH1_1	63	67	PF00568	0.590
LIG_FHA_1	256	262	PF00498	0.536
LIG_FHA_1	267	273	PF00498	0.480
LIG_FHA_1	284	290	PF00498	0.473
LIG_FHA_1	402	408	PF00498	0.410
LIG_FHA_1	504	510	PF00498	0.508
LIG_FHA_2	306	312	PF00498	0.437
LIG_FHA_2	372	378	PF00498	0.456
LIG_FHA_2	409	415	PF00498	0.512
LIG_FHA_2	52	58	PF00498	0.525
LIG_FHA_2	7	13	PF00498	0.694
LIG_LIR_Apic_2	157	161	PF02991	0.407
LIG_LIR_Apic_2	383	389	PF02991	0.516
LIG_LIR_Nem_3	497	503	PF02991	0.386
LIG_PCNA_PIPBox_1	493	502	PF02747	0.475
LIG_PCNA_yPIPBox_3	486	500	PF02747	0.485
LIG_PDZ_Class_1	516	521	PF00595	0.472
LIG_PDZ_Wminus1_1	519	521	PF00595	0.416
LIG_SH2_CRK	386	390	PF00017	0.528
LIG_SH2_NCK_1	193	197	PF00017	0.578
LIG_SH2_NCK_1	53	57	PF00017	0.661
LIG_SH2_SRC	34	37	PF00017	0.543
LIG_SH2_STAP1	340	344	PF00017	0.354
LIG_SH2_STAT5	153	156	PF00017	0.528
LIG_SH2_STAT5	34	37	PF00017	0.679
LIG_SH2_STAT5	353	356	PF00017	0.452
LIG_SH2_STAT5	464	467	PF00017	0.470
LIG_SH2_STAT5	475	478	PF00017	0.470
LIG_SH2_STAT5	53	56	PF00017	0.442
LIG_SH3_1	61	67	PF00018	0.583
LIG_SH3_2	502	507	PF14604	0.429
LIG_SH3_3	133	139	PF00018	0.660
LIG_SH3_3	4	10	PF00018	0.721
LIG_SH3_3	407	413	PF00018	0.445
LIG_SH3_3	499	505	PF00018	0.411
LIG_SH3_3	61	67	PF00018	0.565
LIG_SUMO_SIM_par_1	48	55	PF11976	0.672
LIG_WRC_WIRS_1	262	267	PF05994	0.463
LIG_WW_1	235	238	PF00397	0.535
LIG_WW_3	178	182	PF00397	0.612
MOD_CK1_1	205	211	PF00069	0.683
MOD_CK1_1	285	291	PF00069	0.448
MOD_CK1_1	367	373	PF00069	0.558
MOD_CK2_1	154	160	PF00069	0.514
MOD_CK2_1	213	219	PF00069	0.732
MOD_CK2_1	371	377	PF00069	0.456
MOD_CK2_1	408	414	PF00069	0.514
MOD_CK2_1	51	57	PF00069	0.578
MOD_DYRK1A_RPxSP_1	6	10	PF00069	0.524
MOD_GlcNHglycan	119	122	PF01048	0.692
MOD_GlcNHglycan	200	203	PF01048	0.623
MOD_GlcNHglycan	215	218	PF01048	0.698
MOD_GlcNHglycan	225	228	PF01048	0.532
MOD_GlcNHglycan	243	246	PF01048	0.385
MOD_GlcNHglycan	449	452	PF01048	0.313
MOD_GlcNHglycan	466	469	PF01048	0.355
MOD_GlcNHglycan	96	99	PF01048	0.733
MOD_GSK3_1	192	199	PF00069	0.730
MOD_GSK3_1	271	278	PF00069	0.480
MOD_GSK3_1	285	292	PF00069	0.503
MOD_GSK3_1	305	312	PF00069	0.454
MOD_GSK3_1	367	374	PF00069	0.545
MOD_GSK3_1	445	452	PF00069	0.470
MOD_GSK3_1	503	510	PF00069	0.415
MOD_GSK3_1	79	86	PF00069	0.701
MOD_GSK3_1	89	96	PF00069	0.753
MOD_LATS_1	440	446	PF00433	0.376
MOD_N-GLC_1	254	259	PF02516	0.512
MOD_N-GLC_1	361	366	PF02516	0.256
MOD_N-GLC_1	367	372	PF02516	0.256
MOD_NEK2_1	116	121	PF00069	0.688
MOD_NEK2_1	154	159	PF00069	0.437
MOD_NEK2_1	253	258	PF00069	0.492
MOD_NEK2_1	261	266	PF00069	0.519
MOD_NEK2_1	275	280	PF00069	0.532
MOD_NEK2_1	361	366	PF00069	0.470
MOD_NEK2_1	484	489	PF00069	0.442
MOD_NEK2_1	494	499	PF00069	0.505
MOD_PIKK_1	266	272	PF00454	0.462
MOD_PIKK_1	408	414	PF00454	0.527
MOD_PK_1	42	48	PF00069	0.554
MOD_PKA_1	40	46	PF00069	0.507
MOD_PKA_2	40	46	PF00069	0.708
MOD_Plk_1	361	367	PF00069	0.494
MOD_Plk_1	377	383	PF00069	0.470
MOD_Plk_1	484	490	PF00069	0.494
MOD_Plk_4	154	160	PF00069	0.541
MOD_Plk_4	161	167	PF00069	0.608
MOD_Plk_4	205	211	PF00069	0.602
MOD_Plk_4	34	40	PF00069	0.542
MOD_Plk_4	356	362	PF00069	0.456
MOD_Plk_4	66	72	PF00069	0.770
MOD_ProDKin_1	385	391	PF00069	0.521
MOD_ProDKin_1	52	58	PF00069	0.547
MOD_ProDKin_1	6	12	PF00069	0.556
TRG_DiLeu_BaEn_1	325	330	PF01217	0.469
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.455
TRG_ENDOCYTIC_2	238	241	PF00928	0.459
TRG_ER_diArg_1	106	109	PF00400	0.606
TRG_ER_diArg_1	220	222	PF00400	0.401
TRG_ER_diArg_1	435	438	PF00400	0.400
TRG_NLS_MonoExtC_3	104	109	PF00514	0.642
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB3	Leptomonas seymouri	70%	98%
A0A1X0NZP7	Trypanosomatidae	51%	100%
A0A3Q8IDI9	Leishmania donovani	95%	100%
A0A3R7NW31	Trypanosoma rangeli	51%	100%
A0A3S7WR72	Leishmania donovani	23%	100%
A4H666	Leishmania braziliensis	23%	100%
A4HE87	Leishmania braziliensis	86%	100%
A4HUJ0	Leishmania infantum	23%	100%
A4I1N3	Leishmania infantum	95%	100%
C9ZK82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9AXR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QHD6	Leishmania major	22%	100%
V5BRZ9	Trypanosoma cruzi	51%	98%