TPM_phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q9Q3_LEIMA

TriTrypDb:

LmjF.25.1860 , LMJLV39_250026100 , LMJSD75_250026100

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q9Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Q3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.502
CLV_NRD_NRD_1	41	43	PF00675	0.452
CLV_NRD_NRD_1	91	93	PF00675	0.397
CLV_PCSK_KEX2_1	107	109	PF00082	0.309
CLV_PCSK_KEX2_1	3	5	PF00082	0.502
CLV_PCSK_KEX2_1	378	380	PF00082	0.685
CLV_PCSK_KEX2_1	41	43	PF00082	0.452
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.304
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.680
CLV_PCSK_PC7_1	103	109	PF00082	0.386
CLV_PCSK_SKI1_1	103	107	PF00082	0.373
CLV_PCSK_SKI1_1	180	184	PF00082	0.352
CLV_PCSK_SKI1_1	206	210	PF00082	0.234
CLV_PCSK_SKI1_1	242	246	PF00082	0.393
CLV_PCSK_SKI1_1	311	315	PF00082	0.628
CLV_PCSK_SKI1_1	384	388	PF00082	0.511
CLV_PCSK_SKI1_1	397	401	PF00082	0.530
CLV_PCSK_SKI1_1	405	409	PF00082	0.599
DEG_APCC_DBOX_1	396	404	PF00400	0.347
DEG_Nend_Nbox_1	1	3	PF02207	0.731
DEG_SPOP_SBC_1	28	32	PF00917	0.717
DOC_CKS1_1	149	154	PF01111	0.444
DOC_CYCLIN_yClb3_PxF_3	33	41	PF00134	0.681
DOC_CYCLIN_yCln2_LP_2	403	409	PF00134	0.420
DOC_MAPK_gen_1	106	115	PF00069	0.555
DOC_MAPK_gen_1	239	247	PF00069	0.666
DOC_MAPK_MEF2A_6	136	143	PF00069	0.552
DOC_PP1_RVXF_1	250	256	PF00149	0.549
DOC_PP2B_LxvP_1	245	248	PF13499	0.577
DOC_PP4_FxxP_1	200	203	PF00568	0.474
DOC_USP7_MATH_1	154	158	PF00917	0.398
DOC_USP7_MATH_1	28	32	PF00917	0.717
DOC_USP7_UBL2_3	370	374	PF12436	0.335
DOC_WW_Pin1_4	148	153	PF00397	0.444
DOC_WW_Pin1_4	29	34	PF00397	0.743
DOC_WW_Pin1_4	47	52	PF00397	0.545
LIG_14-3-3_CanoR_1	108	116	PF00244	0.407
LIG_14-3-3_CanoR_1	3	9	PF00244	0.699
LIG_14-3-3_CanoR_1	405	410	PF00244	0.451
LIG_14-3-3_CanoR_1	92	100	PF00244	0.600
LIG_BRCT_BRCA1_1	156	160	PF00533	0.448
LIG_BRCT_BRCA1_1	34	38	PF00533	0.701
LIG_FHA_1	108	114	PF00498	0.552
LIG_FHA_1	181	187	PF00498	0.485
LIG_FHA_1	22	28	PF00498	0.704
LIG_FHA_1	220	226	PF00498	0.479
LIG_FHA_1	279	285	PF00498	0.325
LIG_FHA_1	351	357	PF00498	0.373
LIG_FHA_1	363	369	PF00498	0.288
LIG_FHA_2	83	89	PF00498	0.601
LIG_LIR_Apic_2	146	152	PF02991	0.444
LIG_LIR_Apic_2	197	203	PF02991	0.473
LIG_LIR_Gen_1	137	147	PF02991	0.436
LIG_LIR_Gen_1	79	86	PF02991	0.599
LIG_LIR_Nem_3	137	143	PF02991	0.436
LIG_LIR_Nem_3	207	212	PF02991	0.450
LIG_MLH1_MIPbox_1	157	161	PF16413	0.552
LIG_PDZ_Class_2	430	435	PF00595	0.465
LIG_Pex14_2	196	200	PF04695	0.450
LIG_RPA_C_Insects	54	69	PF08784	0.525
LIG_SH2_CRK	149	153	PF00017	0.270
LIG_SH2_CRK	404	408	PF00017	0.546
LIG_SH2_CRK	416	420	PF00017	0.430
LIG_SH2_NCK_1	388	392	PF00017	0.499
LIG_SH2_PTP2	140	143	PF00017	0.271
LIG_SH2_SRC	227	230	PF00017	0.307
LIG_SH2_STAP1	364	368	PF00017	0.335
LIG_SH2_STAP1	416	420	PF00017	0.482
LIG_SH2_STAT5	140	143	PF00017	0.284
LIG_SH2_STAT5	149	152	PF00017	0.309
LIG_SH2_STAT5	195	198	PF00017	0.307
LIG_SH2_STAT5	269	272	PF00017	0.310
LIG_SH2_STAT5	318	321	PF00017	0.336
LIG_SH2_STAT5	364	367	PF00017	0.355
LIG_SH3_3	139	145	PF00018	0.293
LIG_SH3_3	205	211	PF00018	0.436
LIG_SH3_3	30	36	PF00018	0.720
LIG_SH3_3	396	402	PF00018	0.443
LIG_SH3_3	8	14	PF00018	0.689
LIG_SUMO_SIM_par_1	140	146	PF11976	0.293
LIG_SUMO_SIM_par_1	243	249	PF11976	0.572
LIG_TRAF2_1	191	194	PF00917	0.317
LIG_UBA3_1	244	252	PF00899	0.512
LIG_UBA3_1	48	54	PF00899	0.543
LIG_WRC_WIRS_1	77	82	PF05994	0.500
MOD_CDK_SPK_2	148	153	PF00069	0.304
MOD_CDK_SPxxK_3	47	54	PF00069	0.545
MOD_CK1_1	188	194	PF00069	0.390
MOD_CK1_1	219	225	PF00069	0.323
MOD_CK1_1	31	37	PF00069	0.661
MOD_CK1_1	50	56	PF00069	0.595
MOD_CK2_1	188	194	PF00069	0.403
MOD_CK2_1	374	380	PF00069	0.460
MOD_CK2_1	82	88	PF00069	0.521
MOD_GlcNHglycan	18	21	PF01048	0.651
MOD_GlcNHglycan	187	190	PF01048	0.401
MOD_GlcNHglycan	429	432	PF01048	0.469
MOD_GSK3_1	130	137	PF00069	0.373
MOD_GSK3_1	143	150	PF00069	0.233
MOD_GSK3_1	27	34	PF00069	0.629
MOD_GSK3_1	422	429	PF00069	0.550
MOD_N-GLC_1	22	27	PF02516	0.709
MOD_N-GLC_2	323	325	PF02516	0.385
MOD_NEK2_1	155	160	PF00069	0.293
MOD_NEK2_1	275	280	PF00069	0.330
MOD_NEK2_1	288	293	PF00069	0.370
MOD_NEK2_1	37	42	PF00069	0.617
MOD_NEK2_1	386	391	PF00069	0.497
MOD_OFUCOSY	361	366	PF10250	0.362
MOD_PIKK_1	216	222	PF00454	0.436
MOD_PIKK_1	283	289	PF00454	0.507
MOD_PIKK_1	420	426	PF00454	0.538
MOD_PIKK_1	91	97	PF00454	0.508
MOD_PKA_1	107	113	PF00069	0.293
MOD_PKA_1	3	9	PF00069	0.602
MOD_PKA_1	384	390	PF00069	0.495
MOD_PKA_2	107	113	PF00069	0.316
MOD_PKA_2	3	9	PF00069	0.642
MOD_PKA_2	91	97	PF00069	0.446
MOD_Plk_1	180	186	PF00069	0.306
MOD_Plk_1	22	28	PF00069	0.751
MOD_Plk_1	305	311	PF00069	0.426
MOD_Plk_4	155	161	PF00069	0.293
MOD_Plk_4	338	344	PF00069	0.542
MOD_ProDKin_1	148	154	PF00069	0.285
MOD_ProDKin_1	29	35	PF00069	0.703
MOD_ProDKin_1	47	53	PF00069	0.426
MOD_SUMO_rev_2	58	67	PF00179	0.520
TRG_ENDOCYTIC_2	140	143	PF00928	0.271
TRG_ENDOCYTIC_2	318	321	PF00928	0.370
TRG_ENDOCYTIC_2	327	330	PF00928	0.383
TRG_ENDOCYTIC_2	404	407	PF00928	0.535
TRG_ENDOCYTIC_2	416	419	PF00928	0.415
TRG_ER_diArg_1	2	4	PF00400	0.649
TRG_ER_FFAT_2	360	369	PF00635	0.434
TRG_NLS_Bipartite_1	92	110	PF00514	0.433
TRG_NLS_MonoExtC_3	105	111	PF00514	0.399
TRG_NLS_MonoExtN_4	103	110	PF00514	0.401
TRG_Pf-PMV_PEXEL_1	405	410	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	59	64	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMC6	Leptomonas seymouri	83%	99%
A0A0S4JYA2	Bodo saltans	63%	100%
A0A1X0NZJ4	Trypanosomatidae	66%	88%
A0A3Q8IDD5	Leishmania donovani	97%	100%
A0A3R7N4K9	Trypanosoma rangeli	69%	94%
A4HE88	Leishmania braziliensis	89%	100%
A4I1N4	Leishmania infantum	97%	100%
C9ZK83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
C9ZK84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AXR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BHX3	Trypanosoma cruzi	67%	99%