Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q9Q2_LEIMA

TriTrypDb:

LmjF.25.1870 , LMJLV39_250026200 , LMJSD75_250026200

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Q2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.547
CLV_NRD_NRD_1	174	176	PF00675	0.505
CLV_NRD_NRD_1	231	233	PF00675	0.539
CLV_NRD_NRD_1	240	242	PF00675	0.529
CLV_NRD_NRD_1	425	427	PF00675	0.589
CLV_NRD_NRD_1	487	489	PF00675	0.638
CLV_NRD_NRD_1	49	51	PF00675	0.458
CLV_NRD_NRD_1	69	71	PF00675	0.508
CLV_NRD_NRD_1	89	91	PF00675	0.387
CLV_PCSK_FUR_1	423	427	PF00082	0.577
CLV_PCSK_FUR_1	69	73	PF00082	0.440
CLV_PCSK_KEX2_1	174	176	PF00082	0.505
CLV_PCSK_KEX2_1	230	232	PF00082	0.550
CLV_PCSK_KEX2_1	425	427	PF00082	0.589
CLV_PCSK_KEX2_1	487	489	PF00082	0.638
CLV_PCSK_KEX2_1	49	51	PF00082	0.458
CLV_PCSK_KEX2_1	69	71	PF00082	0.571
CLV_PCSK_KEX2_1	89	91	PF00082	0.401
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.583
CLV_PCSK_SKI1_1	425	429	PF00082	0.517
CLV_PCSK_SKI1_1	50	54	PF00082	0.441
CLV_PCSK_SKI1_1	506	510	PF00082	0.450
CLV_PCSK_SKI1_1	6	10	PF00082	0.510
DEG_APCC_DBOX_1	49	57	PF00400	0.439
DEG_APCC_DBOX_1	505	513	PF00400	0.448
DEG_APCC_DBOX_1	89	97	PF00400	0.433
DOC_CDC14_PxL_1	102	110	PF14671	0.499
DOC_CDC14_PxL_1	517	525	PF14671	0.469
DOC_CKS1_1	334	339	PF01111	0.565
DOC_CYCLIN_RxL_1	3	12	PF00134	0.500
DOC_MAPK_DCC_7	49	58	PF00069	0.438
DOC_MAPK_gen_1	239	248	PF00069	0.578
DOC_MAPK_HePTP_8	108	120	PF00069	0.487
DOC_MAPK_MEF2A_6	111	120	PF00069	0.485
DOC_MIT_MIM_1	418	427	PF04212	0.517
DOC_PP1_RVXF_1	142	148	PF00149	0.477
DOC_PP2B_LxvP_1	104	107	PF13499	0.498
DOC_PP2B_LxvP_1	56	59	PF13499	0.431
DOC_USP7_MATH_1	150	154	PF00917	0.584
DOC_USP7_MATH_1	156	160	PF00917	0.543
DOC_USP7_MATH_1	200	204	PF00917	0.547
DOC_USP7_MATH_1	213	217	PF00917	0.443
DOC_USP7_MATH_1	98	102	PF00917	0.468
DOC_WW_Pin1_4	247	252	PF00397	0.623
DOC_WW_Pin1_4	287	292	PF00397	0.583
DOC_WW_Pin1_4	320	325	PF00397	0.699
DOC_WW_Pin1_4	333	338	PF00397	0.561
DOC_WW_Pin1_4	51	56	PF00397	0.449
DOC_WW_Pin1_4	9	14	PF00397	0.492
LIG_14-3-3_CanoR_1	111	117	PF00244	0.482
LIG_14-3-3_CanoR_1	131	139	PF00244	0.504
LIG_14-3-3_CanoR_1	182	188	PF00244	0.589
LIG_14-3-3_CanoR_1	383	389	PF00244	0.633
LIG_14-3-3_CanoR_1	461	467	PF00244	0.427
LIG_14-3-3_CanoR_1	89	94	PF00244	0.421
LIG_Clathr_ClatBox_1	160	164	PF01394	0.495
LIG_FHA_1	113	119	PF00498	0.498
LIG_FHA_1	178	184	PF00498	0.621
LIG_FHA_1	224	230	PF00498	0.599
LIG_FHA_1	3	9	PF00498	0.501
LIG_FHA_1	346	352	PF00498	0.644
LIG_FHA_2	141	147	PF00498	0.464
LIG_FHA_2	350	356	PF00498	0.657
LIG_GBD_Chelix_1	44	52	PF00786	0.442
LIG_LIR_Gen_1	389	398	PF02991	0.500
LIG_LIR_Nem_3	209	214	PF02991	0.553
LIG_LIR_Nem_3	310	316	PF02991	0.608
LIG_LIR_Nem_3	389	395	PF02991	0.506
LIG_LYPXL_S_1	104	108	PF13949	0.502
LIG_LYPXL_yS_3	105	108	PF13949	0.505
LIG_NRBOX	423	429	PF00104	0.527
LIG_RPA_C_Fungi	177	189	PF08784	0.527
LIG_RPA_C_Fungi	226	238	PF08784	0.533
LIG_RPA_C_Plants	476	487	PF08784	0.460
LIG_SH2_CRK	211	215	PF00017	0.548
LIG_SH2_CRK	392	396	PF00017	0.506
LIG_SH2_SRC	401	404	PF00017	0.558
LIG_SH2_SRC	430	433	PF00017	0.601
LIG_SH2_STAP1	401	405	PF00017	0.518
LIG_SH2_STAP1	482	486	PF00017	0.448
LIG_SH2_STAP1	496	500	PF00017	0.478
LIG_SH2_STAP1	73	77	PF00017	0.424
LIG_SH2_STAT3	73	76	PF00017	0.429
LIG_SH3_1	288	294	PF00018	0.670
LIG_SH3_3	263	269	PF00018	0.627
LIG_SH3_3	288	294	PF00018	0.681
LIG_SH3_3	331	337	PF00018	0.582
LIG_SH3_3	97	103	PF00018	0.481
LIG_SUMO_SIM_anti_2	159	164	PF11976	0.560
LIG_SUMO_SIM_anti_2	16	25	PF11976	0.495
LIG_SUMO_SIM_anti_2	465	470	PF11976	0.426
LIG_SUMO_SIM_par_1	114	121	PF11976	0.487
LIG_SUMO_SIM_par_1	159	164	PF11976	0.523
LIG_SUMO_SIM_par_1	16	25	PF11976	0.481
LIG_SUMO_SIM_par_1	5	12	PF11976	0.503
LIG_TRAF2_1	14	17	PF00917	0.475
LIG_TRAF2_1	168	171	PF00917	0.557
LIG_TRAF2_1	437	440	PF00917	0.503
LIG_UBA3_1	118	123	PF00899	0.489
MOD_CDK_SPxK_1	333	339	PF00069	0.685
MOD_CK1_1	114	120	PF00069	0.490
MOD_CK1_1	140	146	PF00069	0.483
MOD_CK1_1	28	34	PF00069	0.478
MOD_CK1_1	333	339	PF00069	0.626
MOD_CK2_1	11	17	PF00069	0.481
MOD_CK2_1	218	224	PF00069	0.546
MOD_CK2_1	271	277	PF00069	0.620
MOD_CK2_1	349	355	PF00069	0.663
MOD_CK2_1	435	441	PF00069	0.466
MOD_GlcNHglycan	202	205	PF01048	0.578
MOD_GSK3_1	107	114	PF00069	0.498
MOD_GSK3_1	133	140	PF00069	0.495
MOD_GSK3_1	196	203	PF00069	0.579
MOD_GSK3_1	215	222	PF00069	0.492
MOD_GSK3_1	345	352	PF00069	0.650
MOD_GSK3_1	409	416	PF00069	0.613
MOD_LATS_1	109	115	PF00433	0.483
MOD_LATS_1	282	288	PF00433	0.636
MOD_N-GLC_1	25	30	PF02516	0.481
MOD_N-GLC_1	320	325	PF02516	0.647
MOD_NEK2_1	196	201	PF00069	0.579
MOD_PIKK_1	133	139	PF00454	0.504
MOD_PIKK_1	314	320	PF00454	0.660
MOD_PK_1	330	336	PF00069	0.588
MOD_PK_1	409	415	PF00069	0.514
MOD_PKA_1	89	95	PF00069	0.426
MOD_PKA_2	349	355	PF00069	0.608
MOD_PKA_2	80	86	PF00069	0.415
MOD_PKA_2	89	95	PF00069	0.409
MOD_PKB_1	129	137	PF00069	0.491
MOD_Plk_1	25	31	PF00069	0.479
MOD_Plk_4	114	120	PF00069	0.490
MOD_Plk_4	156	162	PF00069	0.649
MOD_Plk_4	330	336	PF00069	0.588
MOD_Plk_4	401	407	PF00069	0.570
MOD_Plk_4	89	95	PF00069	0.426
MOD_ProDKin_1	247	253	PF00069	0.622
MOD_ProDKin_1	287	293	PF00069	0.581
MOD_ProDKin_1	320	326	PF00069	0.700
MOD_ProDKin_1	333	339	PF00069	0.558
MOD_ProDKin_1	51	57	PF00069	0.447
MOD_ProDKin_1	9	15	PF00069	0.486
TRG_DiLeu_BaEn_3	16	22	PF01217	0.494
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.573
TRG_ENDOCYTIC_2	105	108	PF00928	0.505
TRG_ENDOCYTIC_2	211	214	PF00928	0.550
TRG_ENDOCYTIC_2	392	395	PF00928	0.513
TRG_ENDOCYTIC_2	482	485	PF00928	0.458
TRG_ER_diArg_1	173	175	PF00400	0.510
TRG_ER_diArg_1	229	232	PF00400	0.537
TRG_ER_diArg_1	423	426	PF00400	0.572
TRG_ER_diArg_1	48	50	PF00400	0.446
TRG_ER_diArg_1	486	488	PF00400	0.668
TRG_ER_diArg_1	69	72	PF00400	0.508
TRG_ER_diArg_1	79	82	PF00400	0.433
TRG_NLS_MonoExtN_4	69	74	PF00514	0.433
TRG_Pf-PMV_PEXEL_1	174	179	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	426	431	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1G6	Leptomonas seymouri	39%	100%
A0A3Q8IDF4	Leishmania donovani	89%	100%
A4HE89	Leishmania braziliensis	71%	100%
A4I1N5	Leishmania infantum	86%	100%
E9AXR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%