Vacuolar protein sorting 55

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar protein sorting 55, putative

Species:

Leishmania major

UniProt:

Q4Q9Q1_LEIMA

TriTrypDb:

LmjF.25.1880 , LMJLV39_250026400 , LMJSD75_250026400

Length:

139

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	2
GO:0016020	membrane	2	9
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q9Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Q1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0007034	vacuolar transport	4	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0032509	endosome transport via multivesicular body sorting pathway	5	2
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	2
GO:0045324	late endosome to vacuole transport	5	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0071985	multivesicular body sorting pathway	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.366
CLV_PCSK_KEX2_1	30	32	PF00082	0.336
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.336
DOC_USP7_MATH_1	118	122	PF00917	0.409
DOC_USP7_MATH_1	35	39	PF00917	0.386
LIG_BIR_II_1	1	5	PF00653	0.347
LIG_BRCT_BRCA1_1	37	41	PF00533	0.217
LIG_BRCT_BRCA1_1	57	61	PF00533	0.311
LIG_BRCT_BRCA1_1	9	13	PF00533	0.319
LIG_FHA_1	115	121	PF00498	0.134
LIG_FHA_1	72	78	PF00498	0.336
LIG_FHA_1	95	101	PF00498	0.471
LIG_FHA_2	121	127	PF00498	0.323
LIG_FXI_DFP_1	61	65	PF00024	0.464
LIG_IRF3_LxIS_1	4	10	PF10401	0.312
LIG_LIR_Gen_1	10	21	PF02991	0.342
LIG_LIR_Gen_1	58	69	PF02991	0.288
LIG_LIR_Gen_1	70	79	PF02991	0.195
LIG_LIR_Nem_3	10	15	PF02991	0.342
LIG_LIR_Nem_3	38	44	PF02991	0.217
LIG_LIR_Nem_3	58	64	PF02991	0.248
LIG_LIR_Nem_3	70	75	PF02991	0.243
LIG_MLH1_MIPbox_1	9	13	PF16413	0.350
LIG_PCNA_PIPBox_1	6	15	PF02747	0.350
LIG_PCNA_yPIPBox_3	5	13	PF02747	0.288
LIG_PDZ_Class_2	134	139	PF00595	0.417
LIG_SH2_STAT5	42	45	PF00017	0.381
LIG_SUMO_SIM_par_1	81	86	PF11976	0.348
MOD_GlcNHglycan	110	113	PF01048	0.408
MOD_GlcNHglycan	85	88	PF01048	0.381
MOD_GlcNHglycan	9	12	PF01048	0.413
MOD_GSK3_1	114	121	PF00069	0.317
MOD_NEK2_1	105	110	PF00069	0.276
MOD_NEK2_1	23	28	PF00069	0.247
MOD_NEK2_1	7	12	PF00069	0.337
MOD_NEK2_1	83	88	PF00069	0.353
MOD_NEK2_1	94	99	PF00069	0.296
MOD_Plk_4	23	29	PF00069	0.350
MOD_Plk_4	95	101	PF00069	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL8	Leptomonas seymouri	65%	100%
A0A0S4JPU8	Bodo saltans	33%	100%
A0A1X0NY46	Trypanosomatidae	41%	100%
A0A3R7KZE9	Trypanosoma rangeli	44%	100%
A0A3S7WZC0	Leishmania donovani	95%	100%
A4HE90	Leishmania braziliensis	78%	100%
A4I1N6	Leishmania infantum	95%	100%
B9TRX0	Sus scrofa	30%	100%
C9ZK85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	89%
E9AXS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O15243	Homo sapiens	30%	100%
O89013	Mus musculus	33%	100%
O95214	Homo sapiens	30%	100%
P47111	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	99%
Q32PD8	Bos taurus	30%	100%
Q3SYT0	Bos taurus	31%	100%
Q54VP1	Dictyostelium discoideum	35%	100%
Q561T9	Danio rerio	31%	100%
Q5RDE9	Pongo abelii	30%	100%
Q6PDU4	Rattus norvegicus	31%	100%
Q9CQ74	Mus musculus	31%	100%
Q9JLS8	Rattus norvegicus	31%	100%