Proteasome assembly chaperone 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9Q0_LEIMA

TriTrypDb:

LmjF.25.1890 , LMJLV39_250026500 , LMJSD75_250026500

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9Q0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0043248	proteasome assembly	6	7
GO:0043933	protein-containing complex organization	4	7
GO:0065003	protein-containing complex assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.311
CLV_PCSK_FUR_1	168	172	PF00082	0.310
CLV_PCSK_KEX2_1	170	172	PF00082	0.311
CLV_PCSK_SKI1_1	176	180	PF00082	0.310
CLV_PCSK_SKI1_1	197	201	PF00082	0.427
CLV_PCSK_SKI1_1	60	64	PF00082	0.427
CLV_PCSK_SKI1_1	93	97	PF00082	0.468
DEG_APCC_DBOX_1	175	183	PF00400	0.310
DOC_CYCLIN_RxL_1	194	203	PF00134	0.469
DOC_MAPK_FxFP_2	64	67	PF00069	0.474
DOC_MAPK_MEF2A_6	176	184	PF00069	0.310
DOC_MAPK_MEF2A_6	93	100	PF00069	0.422
DOC_MAPK_NFAT4_5	93	101	PF00069	0.425
DOC_PP1_RVXF_1	58	65	PF00149	0.476
DOC_PP4_FxxP_1	64	67	PF00568	0.497
DOC_USP7_MATH_1	26	30	PF00917	0.628
DOC_USP7_MATH_1	67	71	PF00917	0.609
DOC_WW_Pin1_4	138	143	PF00397	0.412
DOC_WW_Pin1_4	214	219	PF00397	0.596
DOC_WW_Pin1_4	42	47	PF00397	0.640
DOC_WW_Pin1_4	8	13	PF00397	0.717
LIG_14-3-3_CanoR_1	27	33	PF00244	0.641
LIG_14-3-3_CanoR_1	60	65	PF00244	0.397
LIG_BRCT_BRCA1_1	142	146	PF00533	0.310
LIG_FHA_1	139	145	PF00498	0.434
LIG_FHA_1	156	162	PF00498	0.310
LIG_FHA_1	173	179	PF00498	0.383
LIG_FHA_1	9	15	PF00498	0.612
LIG_LIR_Apic_2	61	67	PF02991	0.485
LIG_LIR_Gen_1	105	111	PF02991	0.349
LIG_LIR_Gen_1	143	152	PF02991	0.310
LIG_LIR_Nem_3	105	109	PF02991	0.353
LIG_LIR_Nem_3	143	149	PF02991	0.310
LIG_SH2_CRK	125	129	PF00017	0.421
LIG_SH2_NCK_1	125	129	PF00017	0.494
LIG_SH2_PTP2	106	109	PF00017	0.324
LIG_SH2_STAT5	106	109	PF00017	0.376
LIG_SH2_STAT5	15	18	PF00017	0.509
LIG_SH3_3	212	218	PF00018	0.470
LIG_SH3_3	29	35	PF00018	0.576
LIG_SH3_3	43	49	PF00018	0.551
LIG_TYR_ITIM	104	109	PF00017	0.366
LIG_UBA3_1	1	9	PF00899	0.560
MOD_CDC14_SPxK_1	217	220	PF00782	0.604
MOD_CDK_SPxK_1	214	220	PF00069	0.575
MOD_CK1_1	203	209	PF00069	0.297
MOD_CK1_1	42	48	PF00069	0.562
MOD_CK1_1	71	77	PF00069	0.604
MOD_GlcNHglycan	162	165	PF01048	0.470
MOD_GlcNHglycan	202	205	PF01048	0.423
MOD_GSK3_1	109	116	PF00069	0.368
MOD_GSK3_1	180	187	PF00069	0.310
MOD_GSK3_1	22	29	PF00069	0.713
MOD_GSK3_1	36	43	PF00069	0.595
MOD_GSK3_1	67	74	PF00069	0.532
MOD_N-GLC_1	191	196	PF02516	0.385
MOD_NEK2_1	1	6	PF00069	0.560
MOD_NEK2_1	160	165	PF00069	0.499
MOD_NEK2_1	180	185	PF00069	0.310
MOD_NEK2_1	191	196	PF00069	0.410
MOD_NEK2_1	200	205	PF00069	0.231
MOD_NEK2_1	28	33	PF00069	0.645
MOD_NEK2_1	72	77	PF00069	0.481
MOD_NEK2_1	96	101	PF00069	0.340
MOD_PIKK_1	13	19	PF00454	0.500
MOD_PKA_2	26	32	PF00069	0.611
MOD_PKB_1	58	66	PF00069	0.439
MOD_Plk_1	88	94	PF00069	0.447
MOD_Plk_2-3	140	146	PF00069	0.310
MOD_Plk_4	1	7	PF00069	0.534
MOD_Plk_4	180	186	PF00069	0.320
MOD_Plk_4	68	74	PF00069	0.434
MOD_ProDKin_1	138	144	PF00069	0.412
MOD_ProDKin_1	214	220	PF00069	0.575
MOD_ProDKin_1	42	48	PF00069	0.637
MOD_ProDKin_1	8	14	PF00069	0.719
TRG_DiLeu_LyEn_5	174	179	PF01217	0.310
TRG_ENDOCYTIC_2	106	109	PF00928	0.340
TRG_ER_diArg_1	168	171	PF00400	0.310
TRG_ER_diArg_1	57	60	PF00400	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W5	Leptomonas seymouri	65%	100%
A0A3Q8IGP4	Leishmania donovani	96%	100%
A4HE91	Leishmania braziliensis	75%	88%
A4I1N7	Leishmania infantum	96%	100%
E9AXS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%