Phosphopantothenate--cysteine ligase (CTP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphopantothenate--cysteine ligase, putative

Species:

Leishmania major

UniProt:

Q4Q9P9_LEIMA

TriTrypDb:

LmjF.25.1900 , LMJLV39_250026600 , LMJSD75_250026600

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9P9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006164	purine nucleotide biosynthetic process	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009117	nucleotide metabolic process	5	11
GO:0009150	purine ribonucleotide metabolic process	6	11
GO:0009152	purine ribonucleotide biosynthetic process	7	11
GO:0009165	nucleotide biosynthetic process	6	11
GO:0009259	ribonucleotide metabolic process	5	11
GO:0009260	ribonucleotide biosynthetic process	6	11
GO:0009987	cellular process	1	11
GO:0015936	coenzyme A metabolic process	6	11
GO:0015937	coenzyme A biosynthetic process	7	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019693	ribose phosphate metabolic process	4	11
GO:0033865	nucleoside bisphosphate metabolic process	5	11
GO:0033866	nucleoside bisphosphate biosynthetic process	6	11
GO:0033875	ribonucleoside bisphosphate metabolic process	6	11
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	11
GO:0034032	purine nucleoside bisphosphate metabolic process	5	11
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046390	ribose phosphate biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072521	purine-containing compound metabolic process	4	11
GO:0072522	purine-containing compound biosynthetic process	5	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901293	nucleoside phosphate biosynthetic process	5	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004632	phosphopantothenate--cysteine ligase activity	5	3
GO:0016874	ligase activity	2	3
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	3
GO:0016881	acid-amino acid ligase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.335
CLV_NRD_NRD_1	159	161	PF00675	0.325
CLV_NRD_NRD_1	328	330	PF00675	0.416
CLV_NRD_NRD_1	371	373	PF00675	0.467
CLV_NRD_NRD_1	52	54	PF00675	0.427
CLV_PCSK_KEX2_1	159	161	PF00082	0.321
CLV_PCSK_KEX2_1	328	330	PF00082	0.416
CLV_PCSK_KEX2_1	371	373	PF00082	0.551
CLV_PCSK_KEX2_1	43	45	PF00082	0.447
CLV_PCSK_KEX2_1	52	54	PF00082	0.419
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.416
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.380
CLV_PCSK_SKI1_1	121	125	PF00082	0.299
CLV_PCSK_SKI1_1	159	163	PF00082	0.375
CLV_PCSK_SKI1_1	293	297	PF00082	0.402
DEG_APCC_DBOX_1	158	166	PF00400	0.269
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DOC_CYCLIN_RxL_1	287	301	PF00134	0.333
DOC_USP7_MATH_1	175	179	PF00917	0.517
DOC_USP7_MATH_1	18	22	PF00917	0.544
DOC_USP7_MATH_1	198	202	PF00917	0.355
DOC_USP7_MATH_1	261	265	PF00917	0.279
DOC_USP7_MATH_1	271	275	PF00917	0.279
DOC_USP7_MATH_1	28	32	PF00917	0.489
DOC_USP7_MATH_1	37	41	PF00917	0.407
DOC_WW_Pin1_4	173	178	PF00397	0.305
DOC_WW_Pin1_4	193	198	PF00397	0.569
LIG_14-3-3_CanoR_1	22	26	PF00244	0.440
LIG_14-3-3_CanoR_1	38	46	PF00244	0.394
LIG_eIF4E_1	213	219	PF01652	0.256
LIG_eIF4E_1	351	357	PF01652	0.358
LIG_FHA_1	110	116	PF00498	0.402
LIG_FHA_1	165	171	PF00498	0.299
LIG_FHA_1	213	219	PF00498	0.445
LIG_FHA_1	283	289	PF00498	0.323
LIG_FHA_1	309	315	PF00498	0.308
LIG_FHA_2	224	230	PF00498	0.299
LIG_FHA_2	320	326	PF00498	0.304
LIG_IRF3_LxIS_1	382	388	PF10401	0.245
LIG_LIR_Apic_2	264	269	PF02991	0.279
LIG_LIR_Gen_1	141	149	PF02991	0.402
LIG_LIR_Gen_1	168	179	PF02991	0.301
LIG_LIR_Gen_1	229	237	PF02991	0.300
LIG_LIR_Gen_1	353	358	PF02991	0.458
LIG_LIR_LC3C_4	311	316	PF02991	0.276
LIG_LIR_Nem_3	141	147	PF02991	0.402
LIG_LIR_Nem_3	168	174	PF02991	0.286
LIG_LIR_Nem_3	229	233	PF02991	0.324
LIG_LIR_Nem_3	264	270	PF02991	0.299
LIG_LIR_Nem_3	353	357	PF02991	0.461
LIG_NRBOX	381	387	PF00104	0.239
LIG_PCNA_PIPBox_1	60	69	PF02747	0.496
LIG_PCNA_yPIPBox_3	53	67	PF02747	0.360
LIG_Pex14_1	354	358	PF04695	0.433
LIG_Pex14_2	122	126	PF04695	0.357
LIG_PTAP_UEV_1	176	181	PF05743	0.470
LIG_SH2_CRK	224	228	PF00017	0.365
LIG_SH2_PTP2	230	233	PF00017	0.403
LIG_SH2_PTP2	267	270	PF00017	0.395
LIG_SH2_STAP1	224	228	PF00017	0.383
LIG_SH2_STAP1	67	71	PF00017	0.486
LIG_SH2_STAT5	221	224	PF00017	0.330
LIG_SH2_STAT5	230	233	PF00017	0.303
LIG_SH2_STAT5	267	270	PF00017	0.304
LIG_SH2_STAT5	358	361	PF00017	0.494
LIG_SH3_1	95	101	PF00018	0.504
LIG_SH3_3	171	177	PF00018	0.351
LIG_SH3_3	265	271	PF00018	0.395
LIG_SH3_3	95	101	PF00018	0.489
LIG_SUMO_SIM_par_1	232	238	PF11976	0.362
LIG_SUMO_SIM_par_1	294	301	PF11976	0.389
LIG_SUMO_SIM_par_1	311	317	PF11976	0.409
LIG_TRAF2_1	322	325	PF00917	0.299
LIG_TYR_ITIM	222	227	PF00017	0.347
LIG_TYR_ITIM	228	233	PF00017	0.335
LIG_UBA3_1	56	61	PF00899	0.301
LIG_WRC_WIRS_1	315	320	PF05994	0.279
MOD_CK1_1	108	114	PF00069	0.317
MOD_CK1_1	178	184	PF00069	0.681
MOD_CK1_1	187	193	PF00069	0.671
MOD_CK1_1	20	26	PF00069	0.415
MOD_CK1_1	3	9	PF00069	0.562
MOD_CK2_1	198	204	PF00069	0.457
MOD_CK2_1	223	229	PF00069	0.305
MOD_CK2_1	319	325	PF00069	0.304
MOD_CK2_1	347	353	PF00069	0.416
MOD_GlcNHglycan	107	110	PF01048	0.296
MOD_GlcNHglycan	127	130	PF01048	0.119
MOD_GlcNHglycan	177	180	PF01048	0.627
MOD_GlcNHglycan	186	189	PF01048	0.693
MOD_GlcNHglycan	278	281	PF01048	0.299
MOD_GlcNHglycan	363	367	PF01048	0.498
MOD_GlcNHglycan	39	42	PF01048	0.714
MOD_GlcNHglycan	47	50	PF01048	0.524
MOD_GlcNHglycan	79	82	PF01048	0.514
MOD_GSK3_1	101	108	PF00069	0.330
MOD_GSK3_1	121	128	PF00069	0.263
MOD_GSK3_1	16	23	PF00069	0.447
MOD_GSK3_1	178	185	PF00069	0.563
MOD_GSK3_1	237	244	PF00069	0.295
MOD_GSK3_1	28	35	PF00069	0.456
MOD_GSK3_1	282	289	PF00069	0.340
MOD_GSK3_1	3	10	PF00069	0.559
MOD_GSK3_1	319	326	PF00069	0.327
MOD_N-GLC_1	124	129	PF02516	0.279
MOD_N-GLC_1	271	276	PF02516	0.206
MOD_NEK2_1	105	110	PF00069	0.272
MOD_NEK2_1	241	246	PF00069	0.364
MOD_NEK2_1	286	291	PF00069	0.386
MOD_NEK2_1	314	319	PF00069	0.435
MOD_NEK2_1	356	361	PF00069	0.464
MOD_NEK2_1	385	390	PF00069	0.379
MOD_NEK2_2	323	328	PF00069	0.246
MOD_PIKK_1	308	314	PF00454	0.429
MOD_PKA_2	21	27	PF00069	0.513
MOD_PKA_2	37	43	PF00069	0.410
MOD_Plk_1	323	329	PF00069	0.343
MOD_Plk_2-3	374	380	PF00069	0.412
MOD_Plk_4	21	27	PF00069	0.513
MOD_Plk_4	223	229	PF00069	0.324
MOD_Plk_4	82	88	PF00069	0.494
MOD_ProDKin_1	173	179	PF00069	0.305
MOD_ProDKin_1	193	199	PF00069	0.559
MOD_SUMO_for_1	318	321	PF00179	0.279
TRG_DiLeu_BaEn_1	229	234	PF01217	0.312
TRG_ENDOCYTIC_2	224	227	PF00928	0.318
TRG_ENDOCYTIC_2	230	233	PF00928	0.307
TRG_ENDOCYTIC_2	267	270	PF00928	0.404
TRG_ER_diArg_1	158	160	PF00400	0.321
TRG_ER_diArg_1	370	372	PF00400	0.456
TRG_ER_diArg_1	51	53	PF00400	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I9	Leptomonas seymouri	65%	100%
A0A0S4JKM7	Bodo saltans	36%	100%
A0A1X0NYS8	Trypanosomatidae	42%	100%
A0A3Q8ICG6	Leishmania donovani	92%	100%
A0A3R7MC75	Trypanosoma rangeli	42%	100%
A4HE92	Leishmania braziliensis	75%	100%
A4I1N8	Leishmania infantum	91%	100%
C9ZK87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AXS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
P40506	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q0J7N5	Oryza sativa subsp. japonica	36%	100%
Q69S81	Oryza sativa subsp. japonica	32%	100%
Q8GXR5	Arabidopsis thaliana	36%	100%
Q9HAB8	Homo sapiens	32%	100%
Q9LZM3	Arabidopsis thaliana	32%	100%
Q9USK7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
V5BS04	Trypanosoma cruzi	45%	100%