Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9P8_LEIMA

TriTrypDb:

LmjF.25.1910 , LMJLV39_250026700 , LMJSD75_250026700

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9P8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9P8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.741
CLV_NRD_NRD_1	189	191	PF00675	0.772
CLV_NRD_NRD_1	288	290	PF00675	0.734
CLV_PCSK_KEX2_1	189	191	PF00082	0.772
CLV_PCSK_KEX2_1	288	290	PF00082	0.734
CLV_PCSK_SKI1_1	171	175	PF00082	0.746
CLV_PCSK_SKI1_1	21	25	PF00082	0.473
CLV_PCSK_SKI1_1	225	229	PF00082	0.411
CLV_PCSK_SKI1_1	34	38	PF00082	0.559
CLV_PCSK_SKI1_1	69	73	PF00082	0.568
DEG_APCC_DBOX_1	224	232	PF00400	0.530
DEG_APCC_DBOX_1	236	244	PF00400	0.540
DOC_CYCLIN_yCln2_LP_2	231	234	PF00134	0.523
DOC_MAPK_gen_1	235	242	PF00069	0.481
DOC_MAPK_MEF2A_6	117	126	PF00069	0.498
DOC_PP2B_LxvP_1	231	234	PF13499	0.523
DOC_USP7_MATH_1	176	180	PF00917	0.697
DOC_USP7_MATH_1	199	203	PF00917	0.758
DOC_USP7_MATH_1	204	208	PF00917	0.745
DOC_USP7_MATH_1	281	285	PF00917	0.635
DOC_USP7_MATH_1	3	7	PF00917	0.585
DOC_USP7_MATH_1	313	317	PF00917	0.536
DOC_USP7_UBL2_3	171	175	PF12436	0.750
DOC_WW_Pin1_4	132	137	PF00397	0.559
DOC_WW_Pin1_4	156	161	PF00397	0.758
DOC_WW_Pin1_4	194	199	PF00397	0.773
DOC_WW_Pin1_4	80	85	PF00397	0.783
LIG_14-3-3_CanoR_1	21	26	PF00244	0.515
LIG_14-3-3_CanoR_1	235	243	PF00244	0.445
LIG_14-3-3_CanoR_1	59	67	PF00244	0.494
LIG_14-3-3_CanoR_1	98	108	PF00244	0.575
LIG_Actin_WH2_2	216	232	PF00022	0.584
LIG_Actin_WH2_2	310	327	PF00022	0.561
LIG_eIF4E_1	25	31	PF01652	0.502
LIG_FHA_1	119	125	PF00498	0.541
LIG_FHA_1	133	139	PF00498	0.487
LIG_FHA_1	215	221	PF00498	0.569
LIG_FHA_1	270	276	PF00498	0.668
LIG_FHA_1	35	41	PF00498	0.546
LIG_FHA_2	146	152	PF00498	0.717
LIG_FHA_2	39	45	PF00498	0.560
LIG_FHA_2	70	76	PF00498	0.602
LIG_LIR_Gen_1	181	191	PF02991	0.738
LIG_LIR_Nem_3	181	187	PF02991	0.734
LIG_PDZ_Class_3	338	343	PF00595	0.646
LIG_Pex14_1	28	32	PF04695	0.417
LIG_SH2_NCK_1	184	188	PF00017	0.740
LIG_SH2_SRC	298	301	PF00017	0.459
LIG_SH2_STAP1	120	124	PF00017	0.588
LIG_SH2_STAT5	120	123	PF00017	0.578
LIG_SH2_STAT5	241	244	PF00017	0.540
LIG_SH3_3	195	201	PF00018	0.740
LIG_SH3_3	210	216	PF00018	0.498
LIG_SH3_3	277	283	PF00018	0.629
LIG_SH3_3	81	87	PF00018	0.761
LIG_SH3_3	88	94	PF00018	0.624
LIG_SUMO_SIM_par_1	120	125	PF11976	0.582
LIG_SUMO_SIM_par_1	276	284	PF11976	0.616
LIG_WW_1	233	236	PF00397	0.539
LIG_WW_3	232	236	PF00397	0.529
MOD_CDK_SPxxK_3	156	163	PF00069	0.593
MOD_CK1_1	103	109	PF00069	0.402
MOD_CK1_1	144	150	PF00069	0.733
MOD_CK1_1	256	262	PF00069	0.716
MOD_CK1_1	83	89	PF00069	0.731
MOD_CK2_1	139	145	PF00069	0.598
MOD_CK2_1	176	182	PF00069	0.672
MOD_CK2_1	270	276	PF00069	0.611
MOD_CK2_1	38	44	PF00069	0.531
MOD_CK2_1	69	75	PF00069	0.562
MOD_CK2_1	83	89	PF00069	0.606
MOD_GlcNHglycan	102	105	PF01048	0.539
MOD_GlcNHglycan	12	15	PF01048	0.578
MOD_GlcNHglycan	20	24	PF01048	0.504
MOD_GlcNHglycan	206	209	PF01048	0.720
MOD_GlcNHglycan	257	261	PF01048	0.750
MOD_GlcNHglycan	300	303	PF01048	0.501
MOD_GlcNHglycan	311	314	PF01048	0.367
MOD_GSK3_1	118	125	PF00069	0.503
MOD_GSK3_1	139	146	PF00069	0.656
MOD_GSK3_1	200	207	PF00069	0.797
MOD_GSK3_1	252	259	PF00069	0.620
MOD_GSK3_1	265	272	PF00069	0.736
MOD_GSK3_1	309	316	PF00069	0.493
MOD_GSK3_1	34	41	PF00069	0.469
MOD_GSK3_1	59	66	PF00069	0.533
MOD_GSK3_1	99	106	PF00069	0.400
MOD_N-GLC_2	137	139	PF02516	0.635
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_2	241	246	PF00069	0.365
MOD_PIKK_1	59	65	PF00454	0.569
MOD_PKA_2	58	64	PF00069	0.482
MOD_PKB_1	19	27	PF00069	0.515
MOD_Plk_4	103	109	PF00069	0.362
MOD_Plk_4	169	175	PF00069	0.718
MOD_Plk_4	313	319	PF00069	0.499
MOD_ProDKin_1	132	138	PF00069	0.560
MOD_ProDKin_1	156	162	PF00069	0.758
MOD_ProDKin_1	194	200	PF00069	0.773
MOD_ProDKin_1	80	86	PF00069	0.785
MOD_SUMO_rev_2	166	173	PF00179	0.765
TRG_DiLeu_BaEn_1	182	187	PF01217	0.798
TRG_DiLeu_BaEn_1	224	229	PF01217	0.567
TRG_DiLeu_BaEn_4	277	283	PF01217	0.604
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.568
TRG_ENDOCYTIC_2	184	187	PF00928	0.740
TRG_ER_diArg_1	189	191	PF00400	0.772
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I869	Leptomonas seymouri	47%	100%
A0A3Q8IFE5	Leishmania donovani	90%	99%
A0A3S5ISQ2	Trypanosoma rangeli	27%	100%
A4HE93	Leishmania braziliensis	66%	79%
A4I1N9	Leishmania infantum	90%	99%
C9ZK88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AXS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
V5BHX9	Trypanosoma cruzi	27%	100%