TPR_MalT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9P7_LEIMA

TriTrypDb:

LmjF.25.1920 , LMJLV39_250026800 , LMJSD75_250026800

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	5
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0110165	cellular anatomical entity	1	5
GO:0120025	plasma membrane bounded cell projection	3	5
GO:0031514	motile cilium	5	3

Expansion

Sequence features

Q4Q9P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9P7

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.251
CLV_NRD_NRD_1	170	172	PF00675	0.449
CLV_NRD_NRD_1	195	197	PF00675	0.349
CLV_NRD_NRD_1	9	11	PF00675	0.673
CLV_PCSK_KEX2_1	195	197	PF00082	0.349
CLV_PCSK_SKI1_1	171	175	PF00082	0.430
CLV_Separin_Metazoa	192	196	PF03568	0.323
DEG_APCC_DBOX_1	482	490	PF00400	0.522
DEG_Nend_UBRbox_3	1	3	PF02207	0.642
DOC_CKS1_1	73	78	PF01111	0.567
DOC_MAPK_MEF2A_6	343	350	PF00069	0.313
DOC_MAPK_MEF2A_6	71	80	PF00069	0.482
DOC_MAPK_NFAT4_5	343	351	PF00069	0.313
DOC_PP1_RVXF_1	178	184	PF00149	0.333
DOC_PP2B_LxvP_1	403	406	PF13499	0.313
DOC_PP2B_LxvP_1	93	96	PF13499	0.582
DOC_PP4_FxxP_1	174	177	PF00568	0.330
DOC_PP4_FxxP_1	27	30	PF00568	0.517
DOC_PP4_FxxP_1	303	306	PF00568	0.378
DOC_USP7_MATH_1	13	17	PF00917	0.718
DOC_USP7_MATH_1	21	25	PF00917	0.795
DOC_USP7_MATH_1	320	324	PF00917	0.182
DOC_USP7_MATH_1	35	39	PF00917	0.504
DOC_USP7_MATH_1	419	423	PF00917	0.245
DOC_USP7_MATH_1	487	491	PF00917	0.535
DOC_WW_Pin1_4	120	125	PF00397	0.457
DOC_WW_Pin1_4	72	77	PF00397	0.670
LIG_14-3-3_CanoR_1	195	204	PF00244	0.329
LIG_14-3-3_CanoR_1	311	321	PF00244	0.270
LIG_14-3-3_CanoR_1	371	375	PF00244	0.259
LIG_14-3-3_CanoR_1	50	58	PF00244	0.710
LIG_14-3-3_CanoR_1	71	76	PF00244	0.602
LIG_Actin_WH2_2	286	304	PF00022	0.438
LIG_BIR_III_4	99	103	PF00653	0.505
LIG_BRCT_BRCA1_1	133	137	PF00533	0.351
LIG_BRCT_BRCA1_1	169	173	PF00533	0.453
LIG_BRCT_BRCA1_1	23	27	PF00533	0.520
LIG_BRCT_BRCA1_1	73	77	PF00533	0.568
LIG_BRCT_BRCA1_2	23	29	PF00533	0.521
LIG_FHA_1	113	119	PF00498	0.693
LIG_FHA_1	121	127	PF00498	0.582
LIG_FHA_1	371	377	PF00498	0.331
LIG_FHA_1	411	417	PF00498	0.267
LIG_FHA_1	449	455	PF00498	0.393
LIG_FHA_1	53	59	PF00498	0.746
LIG_FHA_1	73	79	PF00498	0.602
LIG_FHA_2	203	209	PF00498	0.421
LIG_FHA_2	250	256	PF00498	0.501
LIG_FHA_2	280	286	PF00498	0.301
LIG_FHA_2	313	319	PF00498	0.337
LIG_FHA_2	390	396	PF00498	0.382
LIG_FHA_2	82	88	PF00498	0.609
LIG_Integrin_RGD_1	343	345	PF01839	0.382
LIG_Integrin_RGD_1	460	462	PF01839	0.462
LIG_LIR_Apic_2	24	30	PF02991	0.520
LIG_LIR_Apic_2	300	306	PF02991	0.320
LIG_LIR_Gen_1	151	159	PF02991	0.334
LIG_LIR_Gen_1	198	204	PF02991	0.364
LIG_LIR_Gen_1	331	339	PF02991	0.182
LIG_LIR_Nem_3	151	155	PF02991	0.326
LIG_LIR_Nem_3	170	176	PF02991	0.496
LIG_LIR_Nem_3	198	203	PF02991	0.346
LIG_LIR_Nem_3	331	336	PF02991	0.182
LIG_LIR_Nem_3	74	80	PF02991	0.483
LIG_MAD2	116	124	PF02301	0.553
LIG_Pex14_2	200	204	PF04695	0.330
LIG_Pex14_2	433	437	PF04695	0.292
LIG_SH2_CRK	333	337	PF00017	0.327
LIG_SH2_NCK_1	220	224	PF00017	0.422
LIG_SH2_NCK_1	313	317	PF00017	0.313
LIG_SH2_SRC	220	223	PF00017	0.452
LIG_SH2_STAP1	220	224	PF00017	0.350
LIG_SH2_STAP1	267	271	PF00017	0.388
LIG_SH2_STAP1	313	317	PF00017	0.313
LIG_SH2_STAT5	213	216	PF00017	0.314
LIG_SH2_STAT5	464	467	PF00017	0.358
LIG_SH2_STAT5	474	477	PF00017	0.356
LIG_SH2_STAT5	479	482	PF00017	0.365
LIG_SH3_3	124	130	PF00018	0.505
LIG_SH3_3	27	33	PF00018	0.599
LIG_SH3_3	6	12	PF00018	0.646
LIG_SUMO_SIM_anti_2	122	129	PF11976	0.431
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.326
LIG_TRAF2_1	252	255	PF00917	0.445
LIG_TRAF2_1	84	87	PF00917	0.482
LIG_TYR_ITIM	477	482	PF00017	0.444
LIG_WRC_WIRS_1	250	255	PF05994	0.352
MOD_CK1_1	3	9	PF00069	0.700
MOD_CK1_1	331	337	PF00069	0.182
MOD_CK1_1	37	43	PF00069	0.749
MOD_CK1_1	64	70	PF00069	0.637
MOD_CK2_1	186	192	PF00069	0.325
MOD_CK2_1	195	201	PF00069	0.361
MOD_CK2_1	202	208	PF00069	0.323
MOD_CK2_1	249	255	PF00069	0.495
MOD_CK2_1	312	318	PF00069	0.297
MOD_CK2_1	389	395	PF00069	0.346
MOD_CK2_1	81	87	PF00069	0.609
MOD_GlcNHglycan	188	191	PF01048	0.325
MOD_GlcNHglycan	2	5	PF01048	0.746
MOD_GlcNHglycan	23	26	PF01048	0.799
MOD_GlcNHglycan	328	333	PF01048	0.263
MOD_GlcNHglycan	489	492	PF01048	0.546
MOD_GSK3_1	21	28	PF00069	0.755
MOD_GSK3_1	234	241	PF00069	0.474
MOD_GSK3_1	297	304	PF00069	0.301
MOD_GSK3_1	33	40	PF00069	0.700
MOD_GSK3_1	57	64	PF00069	0.709
MOD_NEK2_1	297	302	PF00069	0.315
MOD_NEK2_1	387	392	PF00069	0.382
MOD_NEK2_1	39	44	PF00069	0.671
MOD_NEK2_1	433	438	PF00069	0.313
MOD_NEK2_1	448	453	PF00069	0.249
MOD_NEK2_1	57	62	PF00069	0.689
MOD_NEK2_2	352	357	PF00069	0.461
MOD_NEK2_2	370	375	PF00069	0.278
MOD_NEK2_2	389	394	PF00069	0.148
MOD_PKA_1	195	201	PF00069	0.343
MOD_PKA_2	131	137	PF00069	0.515
MOD_PKA_2	195	201	PF00069	0.343
MOD_PKA_2	25	31	PF00069	0.697
MOD_PKA_2	370	376	PF00069	0.281
MOD_Plk_1	238	244	PF00069	0.540
MOD_Plk_1	279	285	PF00069	0.419
MOD_Plk_1	433	439	PF00069	0.313
MOD_Plk_2-3	279	285	PF00069	0.269
MOD_Plk_4	148	154	PF00069	0.296
MOD_Plk_4	86	92	PF00069	0.611
MOD_ProDKin_1	120	126	PF00069	0.453
MOD_ProDKin_1	72	78	PF00069	0.669
MOD_SUMO_for_1	385	388	PF00179	0.382
TRG_DiLeu_BaEn_4	261	267	PF01217	0.458
TRG_DiLeu_BaEn_4	380	386	PF01217	0.382
TRG_ENDOCYTIC_2	152	155	PF00928	0.450
TRG_ENDOCYTIC_2	226	229	PF00928	0.315
TRG_ENDOCYTIC_2	250	253	PF00928	0.326
TRG_ENDOCYTIC_2	267	270	PF00928	0.311
TRG_ENDOCYTIC_2	333	336	PF00928	0.302
TRG_ENDOCYTIC_2	474	477	PF00928	0.371
TRG_ENDOCYTIC_2	479	482	PF00928	0.392
TRG_ER_diArg_1	194	196	PF00400	0.360
TRG_ER_diArg_1	420	423	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG68	Leptomonas seymouri	57%	93%
A0A1X0NYE0	Trypanosomatidae	48%	97%
A0A3Q8ICL8	Leishmania donovani	95%	100%
A0A3R7MX90	Trypanosoma rangeli	50%	100%
A4HE94	Leishmania braziliensis	77%	100%
A4I1P0	Leishmania infantum	95%	100%
C9ZK89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AXS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q32NR4	Xenopus laevis	22%	100%
Q4R6M4	Macaca fascicularis	23%	100%
Q8NA56	Homo sapiens	23%	100%
V5B2E8	Trypanosoma cruzi	46%	100%