RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9P6_LEIMA

TriTrypDb:

LmjF.25.1930 , LMJLV39_250026900 , LMJSD75_250026900

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9P6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.457
CLV_NRD_NRD_1	215	217	PF00675	0.491
CLV_NRD_NRD_1	225	227	PF00675	0.523
CLV_PCSK_KEX2_1	132	134	PF00082	0.434
CLV_PCSK_KEX2_1	217	219	PF00082	0.497
CLV_PCSK_KEX2_1	225	227	PF00082	0.523
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.434
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.497
CLV_PCSK_SKI1_1	129	133	PF00082	0.509
CLV_PCSK_SKI1_1	37	41	PF00082	0.433
DOC_CYCLIN_RxL_1	193	203	PF00134	0.623
DOC_CYCLIN_yCln2_LP_2	123	126	PF00134	0.466
DOC_PP2B_LxvP_1	123	126	PF13499	0.471
DOC_PP2B_LxvP_1	198	201	PF13499	0.659
DOC_USP7_MATH_1	101	105	PF00917	0.651
DOC_USP7_MATH_1	106	110	PF00917	0.595
DOC_USP7_MATH_1	8	12	PF00917	0.478
DOC_USP7_MATH_1	89	93	PF00917	0.700
LIG_14-3-3_CanoR_1	37	44	PF00244	0.481
LIG_14-3-3_CanoR_1	9	18	PF00244	0.371
LIG_Actin_WH2_2	113	131	PF00022	0.506
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_FHA_1	17	23	PF00498	0.472
LIG_FHA_1	28	34	PF00498	0.519
LIG_FHA_1	48	54	PF00498	0.408
LIG_FHA_1	79	85	PF00498	0.608
LIG_FHA_2	103	109	PF00498	0.610
LIG_HCF-1_HBM_1	137	140	PF13415	0.398
LIG_IRF3_LxIS_1	18	24	PF10401	0.459
LIG_LIR_Apic_2	51	57	PF02991	0.485
LIG_LIR_Apic_2	69	73	PF02991	0.444
LIG_LIR_Gen_1	137	147	PF02991	0.458
LIG_LIR_Nem_3	137	143	PF02991	0.464
LIG_SH2_CRK	54	58	PF00017	0.460
LIG_SH2_CRK	70	74	PF00017	0.408
LIG_SH2_GRB2like	54	57	PF00017	0.450
LIG_SH2_NCK_1	140	144	PF00017	0.446
LIG_SH2_NCK_1	54	58	PF00017	0.460
LIG_SH2_NCK_1	70	74	PF00017	0.408
LIG_SH2_STAP1	140	144	PF00017	0.453
LIG_SH2_STAT5	144	147	PF00017	0.365
LIG_SH2_STAT5	150	153	PF00017	0.357
LIG_SH2_STAT5	38	41	PF00017	0.422
LIG_SH2_STAT5	54	57	PF00017	0.390
LIG_SH3_3	161	167	PF00018	0.460
LIG_SUMO_SIM_anti_2	19	24	PF11976	0.433
LIG_SUMO_SIM_par_1	18	24	PF11976	0.403
LIG_TRAF2_1	105	108	PF00917	0.507
LIG_TRFH_1	70	74	PF08558	0.524
MOD_CK1_1	92	98	PF00069	0.700
MOD_CK2_1	102	108	PF00069	0.627
MOD_GlcNHglycan	11	14	PF01048	0.509
MOD_GlcNHglycan	110	113	PF01048	0.694
MOD_GlcNHglycan	222	225	PF01048	0.612
MOD_GlcNHglycan	227	230	PF01048	0.657
MOD_GlcNHglycan	23	26	PF01048	0.357
MOD_GlcNHglycan	231	234	PF01048	0.630
MOD_GlcNHglycan	75	78	PF01048	0.613
MOD_GlcNHglycan	81	84	PF01048	0.645
MOD_GSK3_1	102	109	PF00069	0.713
MOD_GSK3_1	151	158	PF00069	0.528
MOD_GSK3_1	225	232	PF00069	0.693
MOD_GSK3_1	48	55	PF00069	0.443
MOD_GSK3_1	85	92	PF00069	0.567
MOD_N-GLC_1	89	94	PF02516	0.592
MOD_NEK2_1	21	26	PF00069	0.403
MOD_NEK2_1	219	224	PF00069	0.615
MOD_NEK2_1	79	84	PF00069	0.648
MOD_PIKK_1	151	157	PF00454	0.438
MOD_PKA_1	225	231	PF00069	0.643
MOD_PKA_2	155	161	PF00069	0.557
MOD_PKA_2	219	225	PF00069	0.637
MOD_PKA_2	8	14	PF00069	0.568
MOD_PKB_1	216	224	PF00069	0.553
MOD_Plk_4	16	22	PF00069	0.379
TRG_DiLeu_BaLyEn_6	1	6	PF01217	0.522
TRG_ENDOCYTIC_2	140	143	PF00928	0.514
TRG_ENDOCYTIC_2	144	147	PF00928	0.357
TRG_ER_diArg_1	175	178	PF00400	0.604
TRG_ER_diArg_1	215	218	PF00400	0.493
TRG_NLS_MonoExtC_3	215	220	PF00514	0.494
TRG_NLS_MonoExtN_4	214	221	PF00514	0.555
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I303	Leptomonas seymouri	64%	100%
A0A1X0NZI8	Trypanosomatidae	43%	92%
A0A3R7P4N9	Trypanosoma rangeli	44%	100%
A0A3S7WZA1	Leishmania donovani	94%	100%
A4HE95	Leishmania braziliensis	82%	100%
A4I1P1	Leishmania infantum	94%	100%
C9ZK90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AXS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%