Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9P5_LEIMA

TriTrypDb:

LmjF.25.1940 , LMJLV39_250027000 , LMJSD75_250027000

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9P5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.571
CLV_C14_Caspase3-7	56	60	PF00656	0.296
CLV_NRD_NRD_1	323	325	PF00675	0.400
CLV_NRD_NRD_1	419	421	PF00675	0.608
CLV_NRD_NRD_1	487	489	PF00675	0.467
CLV_NRD_NRD_1	84	86	PF00675	0.403
CLV_PCSK_FUR_1	420	424	PF00082	0.553
CLV_PCSK_KEX2_1	104	106	PF00082	0.277
CLV_PCSK_KEX2_1	323	325	PF00082	0.427
CLV_PCSK_KEX2_1	419	421	PF00082	0.608
CLV_PCSK_KEX2_1	422	424	PF00082	0.601
CLV_PCSK_KEX2_1	487	489	PF00082	0.467
CLV_PCSK_KEX2_1	62	64	PF00082	0.437
CLV_PCSK_KEX2_1	84	86	PF00082	0.403
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.406
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.553
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.437
CLV_PCSK_SKI1_1	113	117	PF00082	0.375
CLV_PCSK_SKI1_1	166	170	PF00082	0.431
CLV_PCSK_SKI1_1	227	231	PF00082	0.576
CLV_PCSK_SKI1_1	382	386	PF00082	0.567
CLV_PCSK_SKI1_1	452	456	PF00082	0.427
CLV_PCSK_SKI1_1	55	59	PF00082	0.405
CLV_PCSK_SKI1_1	575	579	PF00082	0.504
CLV_PCSK_SKI1_1	84	88	PF00082	0.427
CLV_Separin_Metazoa	146	150	PF03568	0.386
DEG_APCC_DBOX_1	165	173	PF00400	0.426
DEG_APCC_DBOX_1	451	459	PF00400	0.434
DEG_APCC_DBOX_1	520	528	PF00400	0.421
DEG_APCC_DBOX_1	83	91	PF00400	0.459
DEG_Nend_UBRbox_3	1	3	PF02207	0.520
DOC_CKS1_1	172	177	PF01111	0.518
DOC_CYCLIN_RxL_1	149	163	PF00134	0.446
DOC_CYCLIN_RxL_1	50	59	PF00134	0.302
DOC_CYCLIN_yClb5_NLxxxL_5	71	80	PF00134	0.343
DOC_CYCLIN_yCln2_LP_2	279	285	PF00134	0.502
DOC_CYCLIN_yCln2_LP_2	316	322	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.434
DOC_MAPK_gen_1	104	111	PF00069	0.447
DOC_MAPK_MEF2A_6	104	111	PF00069	0.458
DOC_MAPK_MEF2A_6	521	529	PF00069	0.473
DOC_MAPK_MEF2A_6	651	659	PF00069	0.460
DOC_PP2B_LxvP_1	316	319	PF13499	0.501
DOC_PP2B_LxvP_1	431	434	PF13499	0.613
DOC_PP2B_LxvP_1	655	658	PF13499	0.416
DOC_PP2B_LxvP_1	76	79	PF13499	0.424
DOC_USP7_MATH_1	204	208	PF00917	0.413
DOC_USP7_MATH_1	274	278	PF00917	0.566
DOC_USP7_MATH_1	299	303	PF00917	0.583
DOC_USP7_MATH_1	401	405	PF00917	0.611
DOC_USP7_MATH_1	439	443	PF00917	0.552
DOC_USP7_MATH_1	500	504	PF00917	0.769
DOC_USP7_MATH_1	516	520	PF00917	0.415
DOC_USP7_MATH_1	658	662	PF00917	0.552
DOC_WW_Pin1_4	171	176	PF00397	0.479
DOC_WW_Pin1_4	502	507	PF00397	0.652
LIG_14-3-3_CanoR_1	117	123	PF00244	0.464
LIG_14-3-3_CanoR_1	338	342	PF00244	0.406
LIG_14-3-3_CanoR_1	521	525	PF00244	0.401
LIG_14-3-3_CanoR_1	560	566	PF00244	0.494
LIG_14-3-3_CterR_2	660	663	PF00244	0.506
LIG_BRCT_BRCA1_1	393	397	PF00533	0.484
LIG_Clathr_ClatBox_1	562	566	PF01394	0.479
LIG_FHA_1	118	124	PF00498	0.426
LIG_FHA_1	303	309	PF00498	0.690
LIG_FHA_1	34	40	PF00498	0.470
LIG_FHA_1	356	362	PF00498	0.464
LIG_FHA_1	520	526	PF00498	0.433
LIG_FHA_1	576	582	PF00498	0.381
LIG_FHA_1	654	660	PF00498	0.482
LIG_FHA_1	95	101	PF00498	0.519
LIG_FHA_2	184	190	PF00498	0.541
LIG_FHA_2	503	509	PF00498	0.633
LIG_FHA_2	54	60	PF00498	0.301
LIG_FHA_2	545	551	PF00498	0.380
LIG_FHA_2	94	100	PF00498	0.512
LIG_GBD_Chelix_1	482	490	PF00786	0.478
LIG_LIR_Gen_1	139	148	PF02991	0.374
LIG_LIR_Gen_1	362	373	PF02991	0.486
LIG_LIR_Gen_1	43	53	PF02991	0.394
LIG_LIR_Nem_3	139	144	PF02991	0.373
LIG_LIR_Nem_3	163	168	PF02991	0.411
LIG_LIR_Nem_3	287	291	PF02991	0.447
LIG_LIR_Nem_3	362	368	PF02991	0.476
LIG_LIR_Nem_3	41	45	PF02991	0.471
LIG_LIR_Nem_3	74	80	PF02991	0.444
LIG_NRBOX	19	25	PF00104	0.339
LIG_NRBOX	53	59	PF00104	0.444
LIG_PCNA_yPIPBox_3	386	397	PF02747	0.404
LIG_Pex14_2	364	368	PF04695	0.456
LIG_SH2_GRB2like	388	391	PF00017	0.580
LIG_SH2_NCK_1	45	49	PF00017	0.470
LIG_SH2_STAP1	263	267	PF00017	0.382
LIG_SH2_STAP1	596	600	PF00017	0.383
LIG_SH2_STAT5	291	294	PF00017	0.522
LIG_SH3_3	169	175	PF00018	0.493
LIG_SH3_3	503	509	PF00018	0.512
LIG_SUMO_SIM_anti_2	522	531	PF11976	0.338
LIG_SUMO_SIM_par_1	233	240	PF11976	0.455
LIG_TRAF2_1	249	252	PF00917	0.575
LIG_TRAF2_1	540	543	PF00917	0.474
LIG_UBA3_1	53	62	PF00899	0.445
LIG_UBA3_1	76	81	PF00899	0.434
LIG_WRC_WIRS_1	361	366	PF05994	0.446
LIG_WRC_WIRS_1	600	605	PF05994	0.455
MOD_CK1_1	240	246	PF00069	0.583
MOD_CK1_1	302	308	PF00069	0.609
MOD_CK1_1	360	366	PF00069	0.462
MOD_CK1_1	402	408	PF00069	0.602
MOD_CK1_1	519	525	PF00069	0.437
MOD_CK1_1	544	550	PF00069	0.475
MOD_CK1_1	643	649	PF00069	0.379
MOD_CK2_1	158	164	PF00069	0.509
MOD_CK2_1	183	189	PF00069	0.533
MOD_CK2_1	204	210	PF00069	0.396
MOD_CK2_1	281	287	PF00069	0.424
MOD_CK2_1	40	46	PF00069	0.474
MOD_CK2_1	502	508	PF00069	0.642
MOD_CK2_1	642	648	PF00069	0.392
MOD_CK2_1	93	99	PF00069	0.511
MOD_CMANNOS	514	517	PF00535	0.485
MOD_Cter_Amidation	417	420	PF01082	0.615
MOD_GlcNHglycan	124	127	PF01048	0.501
MOD_GlcNHglycan	160	163	PF01048	0.534
MOD_GlcNHglycan	239	242	PF01048	0.555
MOD_GlcNHglycan	246	249	PF01048	0.493
MOD_GlcNHglycan	276	279	PF01048	0.523
MOD_GlcNHglycan	283	286	PF01048	0.457
MOD_GlcNHglycan	302	305	PF01048	0.577
MOD_GlcNHglycan	401	404	PF01048	0.655
MOD_GlcNHglycan	407	410	PF01048	0.639
MOD_GlcNHglycan	427	431	PF01048	0.633
MOD_GlcNHglycan	445	448	PF01048	0.423
MOD_GlcNHglycan	538	541	PF01048	0.595
MOD_GlcNHglycan	543	546	PF01048	0.437
MOD_GlcNHglycan	582	585	PF01048	0.466
MOD_GlcNHglycan	631	634	PF01048	0.536
MOD_GSK3_1	113	120	PF00069	0.342
MOD_GSK3_1	198	205	PF00069	0.565
MOD_GSK3_1	240	247	PF00069	0.646
MOD_GSK3_1	360	367	PF00069	0.461
MOD_GSK3_1	401	408	PF00069	0.635
MOD_GSK3_1	435	442	PF00069	0.572
MOD_GSK3_1	516	523	PF00069	0.405
MOD_GSK3_1	575	582	PF00069	0.386
MOD_GSK3_1	94	101	PF00069	0.442
MOD_NEK2_1	16	21	PF00069	0.395
MOD_NEK2_1	230	235	PF00069	0.513
MOD_NEK2_1	237	242	PF00069	0.527
MOD_NEK2_1	244	249	PF00069	0.646
MOD_NEK2_1	364	369	PF00069	0.460
MOD_NEK2_1	396	401	PF00069	0.493
MOD_NEK2_1	478	483	PF00069	0.457
MOD_NEK2_1	53	58	PF00069	0.390
MOD_NEK2_1	536	541	PF00069	0.624
MOD_NEK2_1	580	585	PF00069	0.409
MOD_PIKK_1	133	139	PF00454	0.398
MOD_PIKK_1	176	182	PF00454	0.539
MOD_PIKK_1	302	308	PF00454	0.629
MOD_PKA_2	116	122	PF00069	0.539
MOD_PKA_2	183	189	PF00069	0.557
MOD_PKA_2	308	314	PF00069	0.474
MOD_PKA_2	337	343	PF00069	0.405
MOD_PKA_2	520	526	PF00069	0.543
MOD_PKA_2	570	576	PF00069	0.397
MOD_Plk_1	113	119	PF00069	0.387
MOD_Plk_1	230	236	PF00069	0.496
MOD_Plk_1	426	432	PF00069	0.693
MOD_Plk_1	653	659	PF00069	0.512
MOD_Plk_1	98	104	PF00069	0.447
MOD_Plk_2-3	357	363	PF00069	0.469
MOD_Plk_4	360	366	PF00069	0.463
MOD_Plk_4	40	46	PF00069	0.474
MOD_Plk_4	509	515	PF00069	0.530
MOD_Plk_4	520	526	PF00069	0.357
MOD_Plk_4	53	59	PF00069	0.311
MOD_Plk_4	544	550	PF00069	0.466
MOD_ProDKin_1	171	177	PF00069	0.481
MOD_ProDKin_1	502	508	PF00069	0.651
TRG_DiLeu_BaEn_1	164	169	PF01217	0.398
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.492
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.393
TRG_ENDOCYTIC_2	165	168	PF00928	0.398
TRG_ENDOCYTIC_2	322	325	PF00928	0.469
TRG_ENDOCYTIC_2	353	356	PF00928	0.592
TRG_ENDOCYTIC_2	45	48	PF00928	0.405
TRG_ER_diArg_1	322	324	PF00400	0.406
TRG_ER_diArg_1	486	488	PF00400	0.455
TRG_ER_diArg_1	494	497	PF00400	0.557
TRG_ER_diArg_1	83	85	PF00400	0.476
TRG_NES_CRM1_1	557	570	PF08389	0.407
TRG_Pf-PMV_PEXEL_1	155	160	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9N5	Leptomonas seymouri	39%	100%
A0A3Q8INM1	Leishmania donovani	92%	100%
A4HE96	Leishmania braziliensis	76%	100%
A4I1P2	Leishmania infantum	91%	100%
E9AXS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%