Acylphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Acylphosphatase

Gene product:

acylphosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q9P3_LEIMA

TriTrypDb:

LmjF.25.1960 , LMJLV39_250027200 , LMJSD75_250027200

Length:

177

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9P3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0003998	acylphosphatase activity	6	6
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	6
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.659
CLV_NRD_NRD_1	37	39	PF00675	0.519
CLV_NRD_NRD_1	88	90	PF00675	0.506
CLV_PCSK_SKI1_1	26	30	PF00082	0.580
DOC_ANK_TNKS_1	105	112	PF00023	0.506
DOC_PP4_MxPP_1	1	4	PF00568	0.468
DOC_WW_Pin1_4	12	17	PF00397	0.643
DOC_WW_Pin1_4	132	137	PF00397	0.513
DOC_WW_Pin1_4	42	47	PF00397	0.544
LIG_Actin_WH2_2	79	97	PF00022	0.506
LIG_FHA_1	100	106	PF00498	0.506
LIG_FHA_1	147	153	PF00498	0.385
LIG_FHA_1	35	41	PF00498	0.611
LIG_FHA_1	72	78	PF00498	0.506
LIG_FHA_2	139	145	PF00498	0.506
LIG_FHA_2	3	9	PF00498	0.473
LIG_FHA_2	52	58	PF00498	0.666
LIG_IRF3_LxIS_1	46	53	PF10401	0.491
LIG_LIR_Gen_1	7	17	PF02991	0.492
LIG_LIR_Nem_3	7	13	PF02991	0.496
LIG_LIR_Nem_3	74	78	PF02991	0.513
LIG_SH2_CRK	91	95	PF00017	0.506
LIG_SH2_GRB2like	34	37	PF00017	0.576
LIG_SH2_STAP1	73	77	PF00017	0.418
LIG_SH2_STAT5	34	37	PF00017	0.561
LIG_SH2_STAT5	71	74	PF00017	0.458
LIG_SH2_STAT5	91	94	PF00017	0.199
LIG_SH3_3	148	154	PF00018	0.527
LIG_SH3_3	59	65	PF00018	0.562
LIG_Sin3_3	59	66	PF02671	0.560
LIG_WRC_WIRS_1	9	14	PF05994	0.500
MOD_CDK_SPK_2	132	137	PF00069	0.418
MOD_CK1_1	135	141	PF00069	0.243
MOD_CK1_1	15	21	PF00069	0.696
MOD_CK1_1	51	57	PF00069	0.524
MOD_CK2_1	122	128	PF00069	0.261
MOD_CK2_1	50	56	PF00069	0.500
MOD_GlcNHglycan	124	127	PF01048	0.243
MOD_GlcNHglycan	154	157	PF01048	0.575
MOD_GlcNHglycan	79	82	PF01048	0.506
MOD_GSK3_1	122	129	PF00069	0.243
MOD_GSK3_1	4	11	PF00069	0.556
MOD_N-GLC_1	146	151	PF02516	0.243
MOD_NEK2_1	50	55	PF00069	0.485
MOD_NEK2_1	66	71	PF00069	0.671
MOD_NEK2_1	99	104	PF00069	0.506
MOD_PIKK_1	135	141	PF00454	0.278
MOD_PKA_1	89	95	PF00069	0.506
MOD_Plk_1	18	24	PF00069	0.520
MOD_Plk_1	66	72	PF00069	0.597
MOD_Plk_2-3	8	14	PF00069	0.499
MOD_ProDKin_1	12	18	PF00069	0.638
MOD_ProDKin_1	132	138	PF00069	0.513
MOD_ProDKin_1	42	48	PF00069	0.546
TRG_ENDOCYTIC_2	75	78	PF00928	0.506
TRG_ENDOCYTIC_2	91	94	PF00928	0.260
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDK0	Leishmania donovani	86%	100%
A4HE98	Leishmania braziliensis	71%	88%
A4I1P4	Leishmania infantum	90%	77%
E9AXS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	83%