Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

STE group serine/threonine-protein kinase, putative

Species:

Leishmania major

UniProt:

Q4Q9P0_LEIMA

TriTrypDb:

LmjF.25.1990 , LMJLV39_250027500 , LMJSD75_250027500

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9P0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004672	protein kinase activity	3	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.551
CLV_NRD_NRD_1	380	382	PF00675	0.679
CLV_NRD_NRD_1	429	431	PF00675	0.785
CLV_NRD_NRD_1	503	505	PF00675	0.630
CLV_NRD_NRD_1	76	78	PF00675	0.298
CLV_NRD_NRD_1	8	10	PF00675	0.264
CLV_PCSK_KEX2_1	429	431	PF00082	0.565
CLV_PCSK_KEX2_1	503	505	PF00082	0.585
CLV_PCSK_KEX2_1	76	78	PF00082	0.252
CLV_PCSK_SKI1_1	114	118	PF00082	0.273
CLV_PCSK_SKI1_1	132	136	PF00082	0.180
CLV_PCSK_SKI1_1	430	434	PF00082	0.629
DEG_APCC_DBOX_1	113	121	PF00400	0.276
DEG_Nend_UBRbox_2	1	3	PF02207	0.391
DEG_SPOP_SBC_1	239	243	PF00917	0.469
DOC_ANK_TNKS_1	75	82	PF00023	0.316
DOC_CDC14_PxL_1	433	441	PF14671	0.591
DOC_CKS1_1	140	145	PF01111	0.334
DOC_CKS1_1	160	165	PF01111	0.218
DOC_CKS1_1	200	205	PF01111	0.252
DOC_MAPK_gen_1	132	141	PF00069	0.252
DOC_MAPK_gen_1	76	84	PF00069	0.252
DOC_MAPK_MEF2A_6	76	84	PF00069	0.252
DOC_USP7_MATH_1	239	243	PF00917	0.553
DOC_USP7_MATH_1	258	262	PF00917	0.689
DOC_USP7_MATH_1	276	280	PF00917	0.395
DOC_USP7_MATH_1	482	486	PF00917	0.703
DOC_USP7_MATH_1	512	516	PF00917	0.684
DOC_USP7_MATH_1	522	526	PF00917	0.539
DOC_USP7_MATH_1	540	544	PF00917	0.589
DOC_USP7_MATH_1	554	558	PF00917	0.614
DOC_USP7_UBL2_3	278	282	PF12436	0.651
DOC_USP7_UBL2_3	6	10	PF12436	0.276
DOC_WW_Pin1_4	139	144	PF00397	0.381
DOC_WW_Pin1_4	159	164	PF00397	0.227
DOC_WW_Pin1_4	199	204	PF00397	0.187
DOC_WW_Pin1_4	260	265	PF00397	0.670
DOC_WW_Pin1_4	333	338	PF00397	0.269
DOC_WW_Pin1_4	452	457	PF00397	0.595
DOC_WW_Pin1_4	475	480	PF00397	0.590
DOC_WW_Pin1_4	502	507	PF00397	0.701
LIG_14-3-3_CanoR_1	171	177	PF00244	0.185
LIG_14-3-3_CanoR_1	365	372	PF00244	0.369
LIG_14-3-3_CanoR_1	429	433	PF00244	0.699
LIG_14-3-3_CanoR_1	481	489	PF00244	0.682
LIG_14-3-3_CanoR_1	496	502	PF00244	0.598
LIG_Actin_WH2_2	349	367	PF00022	0.311
LIG_APCC_ABBA_1	165	170	PF00400	0.174
LIG_BRCT_BRCA1_1	240	244	PF00533	0.560
LIG_FHA_1	111	117	PF00498	0.271
LIG_FHA_1	160	166	PF00498	0.185
LIG_FHA_1	448	454	PF00498	0.677
LIG_FHA_1	65	71	PF00498	0.301
LIG_FHA_2	254	260	PF00498	0.550
LIG_FHA_2	293	299	PF00498	0.252
LIG_FHA_2	303	309	PF00498	0.263
LIG_FHA_2	365	371	PF00498	0.320
LIG_FHA_2	429	435	PF00498	0.613
LIG_FHA_2	563	569	PF00498	0.588
LIG_LIR_Apic_2	202	208	PF02991	0.252
LIG_LIR_Apic_2	270	276	PF02991	0.635
LIG_LIR_Apic_2	35	41	PF02991	0.316
LIG_LIR_Gen_1	305	315	PF02991	0.252
LIG_LIR_Gen_1	352	360	PF02991	0.287
LIG_LIR_Gen_1	525	535	PF02991	0.494
LIG_LIR_Gen_1	568	576	PF02991	0.564
LIG_LIR_Nem_3	271	277	PF02991	0.631
LIG_LIR_Nem_3	305	310	PF02991	0.261
LIG_LIR_Nem_3	352	356	PF02991	0.326
LIG_LIR_Nem_3	431	436	PF02991	0.652
LIG_LIR_Nem_3	525	531	PF02991	0.486
LIG_LIR_Nem_3	568	572	PF02991	0.541
LIG_MYND_1	375	379	PF01753	0.431
LIG_Pex14_2	244	248	PF04695	0.561
LIG_SH2_CRK	274	278	PF00017	0.617
LIG_SH2_CRK	528	532	PF00017	0.487
LIG_SH2_GRB2like	273	276	PF00017	0.627
LIG_SH2_NCK_1	307	311	PF00017	0.330
LIG_SH2_STAP1	112	116	PF00017	0.252
LIG_SH2_STAP1	293	297	PF00017	0.252
LIG_SH2_STAP1	360	364	PF00017	0.369
LIG_SH2_STAT5	112	115	PF00017	0.263
LIG_SH2_STAT5	122	125	PF00017	0.235
LIG_SH2_STAT5	195	198	PF00017	0.369
LIG_SH2_STAT5	293	296	PF00017	0.252
LIG_SH2_STAT5	88	91	PF00017	0.276
LIG_SH2_STAT5	96	99	PF00017	0.276
LIG_SH3_1	38	44	PF00018	0.185
LIG_SH3_3	157	163	PF00018	0.391
LIG_SH3_3	197	203	PF00018	0.252
LIG_SH3_3	335	341	PF00018	0.253
LIG_SH3_3	38	44	PF00018	0.274
LIG_SH3_3	442	448	PF00018	0.619
LIG_SH3_3	450	456	PF00018	0.590
LIG_SH3_4	396	403	PF00018	0.547
LIG_SUMO_SIM_par_1	551	558	PF11976	0.481
LIG_TYR_ITSM	303	310	PF00017	0.311
LIG_WRC_WIRS_1	350	355	PF05994	0.381
LIG_WW_1	265	268	PF00397	0.663
MOD_CDC14_SPxK_1	478	481	PF00782	0.598
MOD_CDK_SPxK_1	475	481	PF00069	0.593
MOD_CDK_SPxxK_3	139	146	PF00069	0.369
MOD_CK1_1	242	248	PF00069	0.543
MOD_CK1_1	455	461	PF00069	0.599
MOD_CK1_1	497	503	PF00069	0.720
MOD_CK1_1	505	511	PF00069	0.640
MOD_CK1_1	514	520	PF00069	0.566
MOD_CK1_1	543	549	PF00069	0.691
MOD_CK1_1	558	564	PF00069	0.608
MOD_CK1_1	90	96	PF00069	0.369
MOD_CK2_1	240	246	PF00069	0.679
MOD_CK2_1	302	308	PF00069	0.252
MOD_CK2_1	364	370	PF00069	0.285
MOD_CK2_1	389	395	PF00069	0.721
MOD_CK2_1	514	520	PF00069	0.605
MOD_CK2_1	562	568	PF00069	0.586
MOD_GlcNHglycan	250	253	PF01048	0.571
MOD_GlcNHglycan	259	263	PF01048	0.659
MOD_GlcNHglycan	295	298	PF01048	0.291
MOD_GlcNHglycan	323	326	PF01048	0.348
MOD_GlcNHglycan	346	349	PF01048	0.351
MOD_GlcNHglycan	385	388	PF01048	0.637
MOD_GlcNHglycan	389	392	PF01048	0.596
MOD_GlcNHglycan	466	469	PF01048	0.771
MOD_GlcNHglycan	484	487	PF01048	0.765
MOD_GlcNHglycan	491	494	PF01048	0.583
MOD_GlcNHglycan	496	499	PF01048	0.522
MOD_GlcNHglycan	542	545	PF01048	0.615
MOD_GlcNHglycan	548	551	PF01048	0.695
MOD_GlcNHglycan	557	560	PF01048	0.614
MOD_GlcNHglycan	89	92	PF01048	0.375
MOD_GSK3_1	195	202	PF00069	0.312
MOD_GSK3_1	238	245	PF00069	0.641
MOD_GSK3_1	287	294	PF00069	0.299
MOD_GSK3_1	298	305	PF00069	0.206
MOD_GSK3_1	383	390	PF00069	0.598
MOD_GSK3_1	447	454	PF00069	0.645
MOD_GSK3_1	487	494	PF00069	0.725
MOD_GSK3_1	507	514	PF00069	0.704
MOD_GSK3_1	554	561	PF00069	0.712
MOD_N-GLC_1	239	244	PF02516	0.510
MOD_NEK2_1	123	128	PF00069	0.325
MOD_NEK2_1	231	236	PF00069	0.602
MOD_NEK2_1	253	258	PF00069	0.741
MOD_NEK2_1	267	272	PF00069	0.536
MOD_NEK2_1	364	369	PF00069	0.378
MOD_NEK2_1	489	494	PF00069	0.749
MOD_NEK2_1	562	567	PF00069	0.701
MOD_NEK2_2	428	433	PF00069	0.558
MOD_PKA_2	364	370	PF00069	0.276
MOD_PKA_2	428	434	PF00069	0.588
MOD_PKA_2	482	488	PF00069	0.682
MOD_PKA_2	538	544	PF00069	0.623
MOD_Plk_1	239	245	PF00069	0.470
MOD_Plk_2-3	349	355	PF00069	0.280
MOD_Plk_4	276	282	PF00069	0.615
MOD_Plk_4	302	308	PF00069	0.258
MOD_Plk_4	349	355	PF00069	0.347
MOD_Plk_4	558	564	PF00069	0.555
MOD_ProDKin_1	139	145	PF00069	0.381
MOD_ProDKin_1	159	165	PF00069	0.227
MOD_ProDKin_1	199	205	PF00069	0.187
MOD_ProDKin_1	260	266	PF00069	0.670
MOD_ProDKin_1	333	339	PF00069	0.269
MOD_ProDKin_1	452	458	PF00069	0.596
MOD_ProDKin_1	475	481	PF00069	0.593
MOD_ProDKin_1	502	508	PF00069	0.700
MOD_SUMO_rev_2	390	397	PF00179	0.536
TRG_DiLeu_BaEn_2	348	354	PF01217	0.316
TRG_DiLeu_BaEn_2	567	573	PF01217	0.552
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.588
TRG_ENDOCYTIC_2	20	23	PF00928	0.369
TRG_ENDOCYTIC_2	274	277	PF00928	0.614
TRG_ENDOCYTIC_2	307	310	PF00928	0.311
TRG_ENDOCYTIC_2	528	531	PF00928	0.476
TRG_ER_diArg_1	185	188	PF00400	0.372
TRG_ER_diArg_1	531	534	PF00400	0.552
TRG_NES_CRM1_1	118	133	PF08389	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W2	Leptomonas seymouri	54%	96%
A0A1X0NYS1	Trypanosomatidae	40%	100%
A0A3S7WZA6	Leishmania donovani	93%	100%
A0A422P4L8	Trypanosoma rangeli	44%	100%
A4HEA1	Leishmania braziliensis	77%	100%
A4I1P7	Leishmania infantum	93%	99%
C9ZK98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AXT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q1PFB9	Arabidopsis thaliana	24%	100%