(d)CMP kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

(d)CMP kinase

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9N7_LEIMA

TriTrypDb:

LmjF.25.2020 , LMJLV39_250027800 , LMJSD75_250027800

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9N7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	3
GO:0004127	cytidylate kinase activity	6	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	3
GO:0017076	purine nucleotide binding	4	3
GO:0019205	nucleobase-containing compound kinase activity	5	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0050145	nucleoside monophosphate kinase activity	5	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.586
CLV_NRD_NRD_1	189	191	PF00675	0.382
CLV_NRD_NRD_1	268	270	PF00675	0.433
CLV_NRD_NRD_1	60	62	PF00675	0.570
CLV_PCSK_KEX2_1	169	171	PF00082	0.578
CLV_PCSK_KEX2_1	189	191	PF00082	0.572
CLV_PCSK_KEX2_1	268	270	PF00082	0.433
CLV_PCSK_KEX2_1	43	45	PF00082	0.603
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.578
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.651
CLV_PCSK_SKI1_1	121	125	PF00082	0.501
CLV_PCSK_SKI1_1	126	130	PF00082	0.429
CLV_PCSK_SKI1_1	152	156	PF00082	0.586
CLV_PCSK_SKI1_1	169	173	PF00082	0.363
CLV_PCSK_SKI1_1	3	7	PF00082	0.403
DEG_Nend_UBRbox_3	1	3	PF02207	0.698
DEG_SCF_FBW7_1	198	205	PF00400	0.491
DOC_AGCK_PIF_1	136	141	PF00069	0.427
DOC_CKS1_1	199	204	PF01111	0.512
DOC_MAPK_DCC_7	254	264	PF00069	0.564
DOC_MAPK_MEF2A_6	51	60	PF00069	0.485
DOC_MAPK_RevD_3	255	269	PF00069	0.438
DOC_PP1_RVXF_1	124	131	PF00149	0.452
DOC_PP1_RVXF_1	167	174	PF00149	0.462
DOC_PP2B_LxvP_1	257	260	PF13499	0.580
DOC_USP7_MATH_1	15	19	PF00917	0.499
DOC_USP7_MATH_1	94	98	PF00917	0.606
DOC_USP7_UBL2_3	293	297	PF12436	0.473
DOC_WW_Pin1_4	198	203	PF00397	0.493
DOC_WW_Pin1_4	248	253	PF00397	0.472
DOC_WW_Pin1_4	69	74	PF00397	0.646
LIG_14-3-3_CanoR_1	137	142	PF00244	0.406
LIG_14-3-3_CanoR_1	170	174	PF00244	0.524
LIG_14-3-3_CanoR_1	242	247	PF00244	0.434
LIG_BIR_III_2	122	126	PF00653	0.528
LIG_FHA_1	158	164	PF00498	0.477
LIG_FHA_1	186	192	PF00498	0.581
LIG_FHA_1	199	205	PF00498	0.437
LIG_FHA_1	86	92	PF00498	0.493
LIG_FHA_2	181	187	PF00498	0.581
LIG_FHA_2	213	219	PF00498	0.489
LIG_LIR_Gen_1	138	147	PF02991	0.397
LIG_LIR_Gen_1	178	185	PF02991	0.525
LIG_LIR_Gen_1	233	239	PF02991	0.505
LIG_LIR_Gen_1	29	37	PF02991	0.420
LIG_LIR_Nem_3	138	142	PF02991	0.385
LIG_LIR_Nem_3	233	238	PF02991	0.506
LIG_LIR_Nem_3	29	33	PF02991	0.422
LIG_SH2_CRK	139	143	PF00017	0.419
LIG_SH2_CRK	235	239	PF00017	0.434
LIG_SH2_STAT5	139	142	PF00017	0.446
LIG_SH2_STAT5	248	251	PF00017	0.521
LIG_SUMO_SIM_anti_2	261	266	PF11976	0.488
LIG_TRAF2_1	287	290	PF00917	0.662
LIG_TRAF2_1	83	86	PF00917	0.538
LIG_UBA3_1	104	113	PF00899	0.568
MOD_CDC14_SPxK_1	251	254	PF00782	0.435
MOD_CDK_SPxK_1	248	254	PF00069	0.422
MOD_CDK_SPxxK_3	69	76	PF00069	0.620
MOD_CK2_1	162	168	PF00069	0.584
MOD_CK2_1	212	218	PF00069	0.460
MOD_CK2_1	284	290	PF00069	0.652
MOD_CK2_1	31	37	PF00069	0.490
MOD_CK2_1	80	86	PF00069	0.524
MOD_GlcNHglycan	108	111	PF01048	0.480
MOD_GlcNHglycan	230	233	PF01048	0.597
MOD_GlcNHglycan	283	287	PF01048	0.688
MOD_GlcNHglycan	65	68	PF01048	0.583
MOD_GlcNHglycan	82	85	PF01048	0.437
MOD_GSK3_1	108	115	PF00069	0.459
MOD_GSK3_1	194	201	PF00069	0.481
MOD_GSK3_1	203	210	PF00069	0.503
MOD_N-GLC_1	26	31	PF02516	0.487
MOD_NEK2_1	1	6	PF00069	0.523
MOD_NEK2_1	108	113	PF00069	0.466
MOD_NEK2_1	180	185	PF00069	0.562
MOD_NEK2_1	203	208	PF00069	0.659
MOD_NEK2_1	282	287	PF00069	0.681
MOD_PIKK_1	212	218	PF00454	0.460
MOD_PIKK_1	240	246	PF00454	0.521
MOD_PKA_1	169	175	PF00069	0.581
MOD_PKA_2	169	175	PF00069	0.581
MOD_Plk_1	155	161	PF00069	0.517
MOD_Plk_1	26	32	PF00069	0.380
MOD_Plk_2-3	157	163	PF00069	0.610
MOD_Plk_2-3	284	290	PF00069	0.606
MOD_Plk_4	1	7	PF00069	0.636
MOD_Plk_4	137	143	PF00069	0.427
MOD_Plk_4	169	175	PF00069	0.551
MOD_Plk_4	180	186	PF00069	0.524
MOD_Plk_4	194	200	PF00069	0.423
MOD_ProDKin_1	198	204	PF00069	0.486
MOD_ProDKin_1	248	254	PF00069	0.466
MOD_ProDKin_1	69	75	PF00069	0.646
MOD_SUMO_for_1	174	177	PF00179	0.489
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.598
TRG_ENDOCYTIC_2	139	142	PF00928	0.401
TRG_ENDOCYTIC_2	235	238	PF00928	0.433
TRG_ER_diArg_1	189	191	PF00400	0.382
TRG_NES_CRM1_1	247	263	PF08389	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1G0	Leptomonas seymouri	78%	100%
A0A0S4IKR6	Bodo saltans	56%	100%
A0A1X0NZI5	Trypanosomatidae	59%	100%
A0A3S7WZD1	Leishmania donovani	98%	99%
A0A422P4M6	Trypanosoma rangeli	59%	100%
A4HEA4	Leishmania braziliensis	86%	100%
A4I1Q0	Leishmania infantum	98%	99%
C9ZKA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	98%
E9AXT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
V5BMH9	Trypanosoma cruzi	57%	100%