FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial import inner membrane translocase subunit TIM50, putative

Species:

Leishmania major

UniProt:

Q4Q9N6_LEIMA

TriTrypDb:

LmjF.25.2030 , LMJLV39_250027900 , LMJSD75_250027900

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9N6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004721	phosphoprotein phosphatase activity	3	3
GO:0016787	hydrolase activity	2	16
GO:0016788	hydrolase activity, acting on ester bonds	3	16
GO:0016791	phosphatase activity	5	16
GO:0042578	phosphoric ester hydrolase activity	4	16
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.571
CLV_C14_Caspase3-7	344	348	PF00656	0.397
CLV_Separin_Metazoa	325	329	PF03568	0.342
DEG_Nend_UBRbox_2	1	3	PF02207	0.693
DEG_SCF_FBW7_1	75	80	PF00400	0.496
DEG_SPOP_SBC_1	38	42	PF00917	0.656
DOC_CDC14_PxL_1	327	335	PF14671	0.331
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.486
DOC_MAPK_gen_1	178	187	PF00069	0.278
DOC_MAPK_MEF2A_6	178	187	PF00069	0.276
DOC_MAPK_MEF2A_6	201	210	PF00069	0.217
DOC_MAPK_MEF2A_6	212	220	PF00069	0.212
DOC_MAPK_NFAT4_5	180	188	PF00069	0.265
DOC_MAPK_RevD_3	167	181	PF00069	0.357
DOC_USP7_MATH_1	165	169	PF00917	0.491
DOC_USP7_MATH_1	30	34	PF00917	0.625
DOC_USP7_MATH_1	313	317	PF00917	0.229
DOC_USP7_MATH_1	37	41	PF00917	0.598
DOC_WW_Pin1_4	156	161	PF00397	0.433
DOC_WW_Pin1_4	297	302	PF00397	0.290
DOC_WW_Pin1_4	47	52	PF00397	0.629
DOC_WW_Pin1_4	59	64	PF00397	0.658
DOC_WW_Pin1_4	67	72	PF00397	0.720
DOC_WW_Pin1_4	7	12	PF00397	0.617
DOC_WW_Pin1_4	73	78	PF00397	0.467
LIG_APCC_ABBA_1	266	271	PF00400	0.282
LIG_BRCT_BRCA1_1	131	135	PF00533	0.471
LIG_FHA_1	140	146	PF00498	0.486
LIG_FHA_1	156	162	PF00498	0.359
LIG_FHA_1	241	247	PF00498	0.263
LIG_FHA_1	276	282	PF00498	0.356
LIG_FHA_1	70	76	PF00498	0.558
LIG_FHA_2	246	252	PF00498	0.235
LIG_FHA_2	339	345	PF00498	0.328
LIG_LIR_Apic_2	247	252	PF02991	0.282
LIG_LIR_Gen_1	340	351	PF02991	0.293
LIG_LIR_Nem_3	12	18	PF02991	0.475
LIG_LIR_Nem_3	340	346	PF02991	0.297
LIG_LIR_Nem_3	347	352	PF02991	0.260
LIG_MYND_1	167	171	PF01753	0.436
LIG_REV1ctd_RIR_1	12	20	PF16727	0.463
LIG_SH2_CRK	349	353	PF00017	0.281
LIG_SH2_GRB2like	196	199	PF00017	0.213
LIG_SH2_STAP1	202	206	PF00017	0.342
LIG_SH2_STAT3	304	307	PF00017	0.288
LIG_SH2_STAT5	150	153	PF00017	0.478
LIG_SH2_STAT5	219	222	PF00017	0.290
LIG_SH2_STAT5	249	252	PF00017	0.263
LIG_SH2_STAT5	280	283	PF00017	0.263
LIG_SH2_STAT5	304	307	PF00017	0.251
LIG_SH3_2	48	53	PF14604	0.544
LIG_SH3_3	201	207	PF00018	0.342
LIG_SH3_3	45	51	PF00018	0.595
LIG_SUMO_SIM_anti_2	283	288	PF11976	0.215
LIG_SUMO_SIM_anti_2	292	298	PF11976	0.215
LIG_SUMO_SIM_par_1	183	190	PF11976	0.292
LIG_SUMO_SIM_par_1	206	211	PF11976	0.295
LIG_UBA3_1	253	259	PF00899	0.342
MOD_CDC14_SPxK_1	50	53	PF00782	0.546
MOD_CDK_SPxK_1	47	53	PF00069	0.543
MOD_CK1_1	109	115	PF00069	0.705
MOD_CK1_1	245	251	PF00069	0.235
MOD_CK1_1	40	46	PF00069	0.601
MOD_CK1_1	65	71	PF00069	0.699
MOD_CK1_1	73	79	PF00069	0.483
MOD_CK2_1	318	324	PF00069	0.366
MOD_GlcNHglycan	108	112	PF01048	0.680
MOD_GlcNHglycan	113	117	PF01048	0.666
MOD_GlcNHglycan	162	166	PF01048	0.532
MOD_GlcNHglycan	32	35	PF01048	0.775
MOD_GlcNHglycan	360	364	PF01048	0.517
MOD_GlcNHglycan	65	68	PF01048	0.662
MOD_GlcNHglycan	97	100	PF01048	0.686
MOD_GSK3_1	126	133	PF00069	0.637
MOD_GSK3_1	161	168	PF00069	0.514
MOD_GSK3_1	187	194	PF00069	0.275
MOD_GSK3_1	240	247	PF00069	0.247
MOD_GSK3_1	271	278	PF00069	0.353
MOD_GSK3_1	59	66	PF00069	0.608
MOD_GSK3_1	67	74	PF00069	0.684
MOD_GSK3_1	76	83	PF00069	0.439
MOD_N-GLC_1	156	161	PF02516	0.375
MOD_N-GLC_1	7	12	PF02516	0.665
MOD_NEK2_1	191	196	PF00069	0.296
MOD_NEK2_1	242	247	PF00069	0.263
MOD_PIKK_1	80	86	PF00454	0.481
MOD_PKA_2	211	217	PF00069	0.318
MOD_PKA_2	4	10	PF00069	0.726
MOD_Plk_1	187	193	PF00069	0.290
MOD_Plk_1	282	288	PF00069	0.268
MOD_Plk_2-3	338	344	PF00069	0.328
MOD_Plk_4	10	16	PF00069	0.456
MOD_Plk_4	165	171	PF00069	0.410
MOD_Plk_4	187	193	PF00069	0.288
MOD_Plk_4	271	277	PF00069	0.248
MOD_Plk_4	282	288	PF00069	0.247
MOD_Plk_4	313	319	PF00069	0.283
MOD_Plk_4	338	344	PF00069	0.321
MOD_Plk_4	77	83	PF00069	0.514
MOD_ProDKin_1	156	162	PF00069	0.438
MOD_ProDKin_1	297	303	PF00069	0.290
MOD_ProDKin_1	47	53	PF00069	0.632
MOD_ProDKin_1	59	65	PF00069	0.658
MOD_ProDKin_1	67	73	PF00069	0.717
MOD_ProDKin_1	7	13	PF00069	0.615
TRG_DiLeu_BaEn_1	325	330	PF01217	0.271
TRG_DiLeu_LyEn_5	325	330	PF01217	0.249
TRG_ENDOCYTIC_2	219	222	PF00928	0.275
TRG_ENDOCYTIC_2	343	346	PF00928	0.311
TRG_ENDOCYTIC_2	349	352	PF00928	0.278
TRG_ER_diArg_1	135	138	PF00400	0.562
TRG_ER_diArg_1	147	150	PF00400	0.392
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG96	Leptomonas seymouri	68%	100%
A0A0S4IJH3	Bodo saltans	46%	100%
A0A1X0NYI7	Trypanosomatidae	44%	91%
A0A3Q8IDG4	Leishmania donovani	96%	99%
A0A3S7WZH2	Leishmania donovani	51%	100%
A0A422P4K3	Trypanosoma rangeli	41%	89%
A4HEA5	Leishmania braziliensis	86%	99%
A4HEM1	Leishmania braziliensis	50%	100%
A4I1Q1	Leishmania infantum	96%	99%
A4I1V3	Leishmania infantum	51%	100%
A4ICB8	Leishmania infantum	27%	100%
C9ZKA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	86%
E9AXT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
E9AXZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
Q4Q9H6	Leishmania major	51%	100%
Q6NWD4	Danio rerio	26%	94%
V5BAV0	Trypanosoma cruzi	24%	100%