PHB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9N5_LEIMA

TriTrypDb:

LmjF.25.2040 , LMJLV39_250028000 , LMJSD75_250028000

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

Q4Q9N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9N5

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.634
CLV_C14_Caspase3-7	96	100	PF00656	0.690
CLV_NRD_NRD_1	161	163	PF00675	0.454
CLV_NRD_NRD_1	233	235	PF00675	0.406
CLV_NRD_NRD_1	317	319	PF00675	0.521
CLV_PCSK_KEX2_1	133	135	PF00082	0.472
CLV_PCSK_KEX2_1	160	162	PF00082	0.429
CLV_PCSK_KEX2_1	167	169	PF00082	0.491
CLV_PCSK_KEX2_1	233	235	PF00082	0.406
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.472

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I861	Leptomonas seymouri	63%	99%
A0A0S4JNZ4	Bodo saltans	29%	100%
A0A1X0NY60	Trypanosomatidae	38%	100%
A0A3R7MC60	Trypanosoma rangeli	35%	100%
A0A3S7WZB8	Leishmania donovani	96%	100%
A4HEA6	Leishmania braziliensis	88%	99%
A4I1Q2	Leishmania infantum	96%	100%
C9ZKA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AXT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BHZ5	Trypanosoma cruzi	35%	100%

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