PHB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9N5_LEIMA

TriTrypDb:

LmjF.25.2040 , LMJLV39_250028000 , LMJSD75_250028000

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q9N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9N5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.634
CLV_C14_Caspase3-7	96	100	PF00656	0.690
CLV_NRD_NRD_1	161	163	PF00675	0.454
CLV_NRD_NRD_1	233	235	PF00675	0.406
CLV_NRD_NRD_1	317	319	PF00675	0.521
CLV_PCSK_KEX2_1	133	135	PF00082	0.472
CLV_PCSK_KEX2_1	160	162	PF00082	0.429
CLV_PCSK_KEX2_1	167	169	PF00082	0.491
CLV_PCSK_KEX2_1	233	235	PF00082	0.406
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.472
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.427
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.493
CLV_PCSK_SKI1_1	233	237	PF00082	0.430
DEG_APCC_DBOX_1	355	363	PF00400	0.622
DEG_Nend_UBRbox_3	1	3	PF02207	0.463
DOC_CYCLIN_RxL_1	230	237	PF00134	0.578
DOC_CYCLIN_yClb5_NLxxxL_5	337	343	PF00134	0.458
DOC_MAPK_DCC_7	356	366	PF00069	0.495
DOC_MAPK_gen_1	238	248	PF00069	0.581
DOC_MAPK_gen_1	55	64	PF00069	0.689
DOC_PP1_RVXF_1	218	225	PF00149	0.628
DOC_PP1_RVXF_1	342	348	PF00149	0.582
DOC_PP4_FxxP_1	236	239	PF00568	0.561
DOC_PP4_FxxP_1	53	56	PF00568	0.657
DOC_USP7_MATH_1	177	181	PF00917	0.683
DOC_USP7_MATH_1	242	246	PF00917	0.635
DOC_USP7_MATH_1	60	64	PF00917	0.596
DOC_WW_Pin1_4	62	67	PF00397	0.586
DOC_WW_Pin1_4	76	81	PF00397	0.647
LIG_14-3-3_CanoR_1	154	160	PF00244	0.542
LIG_14-3-3_CanoR_1	241	247	PF00244	0.575
LIG_14-3-3_CanoR_1	344	348	PF00244	0.585
LIG_BIR_III_4	273	277	PF00653	0.632
LIG_BRCT_BRCA1_1	9	13	PF00533	0.471
LIG_Clathr_ClatBox_1	144	148	PF01394	0.586
LIG_Clathr_ClatBox_1	221	225	PF01394	0.624
LIG_Clathr_ClatBox_1	361	365	PF01394	0.511
LIG_CtBP_PxDLS_1	363	367	PF00389	0.540
LIG_FHA_1	127	133	PF00498	0.604
LIG_FHA_1	195	201	PF00498	0.594
LIG_FHA_1	334	340	PF00498	0.577
LIG_FHA_2	261	267	PF00498	0.600
LIG_FHA_2	310	316	PF00498	0.801
LIG_FHA_2	353	359	PF00498	0.622
LIG_FXI_DFP_1	221	225	PF00024	0.405
LIG_HP1_1	39	43	PF01393	0.475
LIG_LIR_Gen_1	211	221	PF02991	0.570
LIG_LIR_Gen_1	223	232	PF02991	0.548
LIG_LIR_Gen_1	340	350	PF02991	0.604
LIG_LIR_Gen_1	69	78	PF02991	0.596
LIG_LIR_Nem_3	117	122	PF02991	0.589
LIG_LIR_Nem_3	211	216	PF02991	0.568
LIG_LIR_Nem_3	223	227	PF02991	0.504
LIG_LIR_Nem_3	290	295	PF02991	0.661
LIG_LIR_Nem_3	340	345	PF02991	0.552
LIG_LIR_Nem_3	346	350	PF02991	0.570
LIG_LIR_Nem_3	69	73	PF02991	0.584
LIG_PCNA_PIPBox_1	42	51	PF02747	0.475
LIG_Pex14_2	194	198	PF04695	0.617
LIG_Pex14_2	227	231	PF04695	0.510
LIG_SH2_CRK	292	296	PF00017	0.667
LIG_SH2_NCK_1	296	300	PF00017	0.656
LIG_SH2_PTP2	218	221	PF00017	0.605
LIG_SH2_SRC	296	299	PF00017	0.650
LIG_SH2_STAP1	196	200	PF00017	0.632
LIG_SH2_STAP1	357	361	PF00017	0.537
LIG_SH2_STAT3	196	199	PF00017	0.638
LIG_SH2_STAT5	196	199	PF00017	0.625
LIG_SH2_STAT5	218	221	PF00017	0.614
LIG_SH2_STAT5	330	333	PF00017	0.588
LIG_SH2_STAT5	342	345	PF00017	0.528
LIG_SH2_STAT5	49	52	PF00017	0.371
LIG_SH2_STAT5	72	75	PF00017	0.567
LIG_SH3_3	304	310	PF00018	0.751
LIG_SH3_3	33	39	PF00018	0.475
LIG_TYR_ITIM	216	221	PF00017	0.620
LIG_TYR_ITSM	288	295	PF00017	0.659
LIG_WRC_WIRS_1	200	205	PF05994	0.612
LIG_WRC_WIRS_1	67	72	PF05994	0.587
LIG_WW_3	238	242	PF00397	0.647
MOD_CK1_1	281	287	PF00069	0.650
MOD_CK2_1	177	183	PF00069	0.704
MOD_CK2_1	253	259	PF00069	0.620
MOD_CK2_1	309	315	PF00069	0.709
MOD_CK2_1	352	358	PF00069	0.601
MOD_CK2_1	90	96	PF00069	0.663
MOD_Cter_Amidation	316	319	PF01082	0.586
MOD_GlcNHglycan	347	350	PF01048	0.378
MOD_GSK3_1	177	184	PF00069	0.678
MOD_GSK3_1	194	201	PF00069	0.463
MOD_GSK3_1	260	267	PF00069	0.622
MOD_GSK3_1	277	284	PF00069	0.503
MOD_GSK3_1	62	69	PF00069	0.577
MOD_GSK3_1	7	14	PF00069	0.499
MOD_GSK3_1	72	79	PF00069	0.442
MOD_NEK2_1	198	203	PF00069	0.533
MOD_NEK2_1	264	269	PF00069	0.577
MOD_NEK2_1	278	283	PF00069	0.623
MOD_NEK2_1	343	348	PF00069	0.539
MOD_PKA_2	126	132	PF00069	0.587
MOD_PKA_2	16	22	PF00069	0.418
MOD_PKA_2	343	349	PF00069	0.587
MOD_PKB_1	168	176	PF00069	0.714
MOD_Plk_1	287	293	PF00069	0.612
MOD_Plk_2-3	309	315	PF00069	0.775
MOD_Plk_4	126	132	PF00069	0.594
MOD_Plk_4	16	22	PF00069	0.430
MOD_Plk_4	181	187	PF00069	0.686
MOD_Plk_4	242	248	PF00069	0.576
MOD_Plk_4	375	381	PF00069	0.659
MOD_Plk_4	66	72	PF00069	0.607
MOD_Plk_4	90	96	PF00069	0.609
MOD_ProDKin_1	62	68	PF00069	0.582
MOD_ProDKin_1	76	82	PF00069	0.642
MOD_SUMO_for_1	132	135	PF00179	0.665
TRG_AP2beta_CARGO_1	211	220	PF09066	0.658
TRG_AP2beta_CARGO_1	225	234	PF09066	0.566
TRG_DiLeu_BaEn_2	180	186	PF01217	0.694
TRG_DiLeu_BaEn_4	301	307	PF01217	0.711
TRG_DiLeu_BaLyEn_6	357	362	PF01217	0.614
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.595
TRG_ENDOCYTIC_2	218	221	PF00928	0.614
TRG_ENDOCYTIC_2	292	295	PF00928	0.649
TRG_ENDOCYTIC_2	296	299	PF00928	0.679
TRG_ENDOCYTIC_2	342	345	PF00928	0.598
TRG_ENDOCYTIC_2	49	52	PF00928	0.330
TRG_ER_diArg_1	161	163	PF00400	0.660
TRG_ER_diArg_1	232	234	PF00400	0.603
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	360	365	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I861	Leptomonas seymouri	63%	99%
A0A0S4JNZ4	Bodo saltans	29%	100%
A0A1X0NY60	Trypanosomatidae	38%	100%
A0A3R7MC60	Trypanosoma rangeli	35%	100%
A0A3S7WZB8	Leishmania donovani	96%	100%
A4HEA6	Leishmania braziliensis	88%	99%
A4I1Q2	Leishmania infantum	96%	100%
C9ZKA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AXT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BHZ5	Trypanosoma cruzi	35%	100%