Putative helicase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

helicase-like protein, putative

Species:

Leishmania major

UniProt:

Q4Q9N4_LEIMA

TriTrypDb:

LmjF.25.2050 , LMJLV39_250028100 , LMJSD75_250028100

Length:

1043

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	2
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9N4

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	2
GO:0006338	chromatin remodeling	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003682	chromatin binding	2	2
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	9
GO:0005488	binding	1	12
GO:0005515	protein binding	2	2
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016462	pyrophosphatase activity	5	2
GO:0016491	oxidoreductase activity	2	11
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0042393	histone binding	3	2
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0051213	dioxygenase activity	3	11
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:0140658	ATP-dependent chromatin remodeler activity	3	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1004	1008	PF00656	0.654
CLV_C14_Caspase3-7	1020	1024	PF00656	0.738
CLV_C14_Caspase3-7	1039	1043	PF00656	0.452
CLV_C14_Caspase3-7	138	142	PF00656	0.729
CLV_C14_Caspase3-7	646	650	PF00656	0.476
CLV_C14_Caspase3-7	765	769	PF00656	0.535
CLV_NRD_NRD_1	380	382	PF00675	0.319
CLV_NRD_NRD_1	411	413	PF00675	0.291
CLV_NRD_NRD_1	438	440	PF00675	0.276
CLV_NRD_NRD_1	500	502	PF00675	0.276
CLV_NRD_NRD_1	741	743	PF00675	0.450
CLV_NRD_NRD_1	977	979	PF00675	0.554
CLV_PCSK_KEX2_1	120	122	PF00082	0.787
CLV_PCSK_KEX2_1	380	382	PF00082	0.382
CLV_PCSK_KEX2_1	408	410	PF00082	0.301
CLV_PCSK_KEX2_1	413	415	PF00082	0.262
CLV_PCSK_KEX2_1	500	502	PF00082	0.276
CLV_PCSK_KEX2_1	583	585	PF00082	0.612
CLV_PCSK_KEX2_1	907	909	PF00082	0.620
CLV_PCSK_KEX2_1	977	979	PF00082	0.519
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.787
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.301
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.258
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.633
CLV_PCSK_PC1ET2_1	907	909	PF00082	0.635
CLV_PCSK_PC7_1	409	415	PF00082	0.381
CLV_PCSK_SKI1_1	147	151	PF00082	0.666
CLV_PCSK_SKI1_1	17	21	PF00082	0.724
CLV_PCSK_SKI1_1	273	277	PF00082	0.568
CLV_PCSK_SKI1_1	372	376	PF00082	0.294
CLV_PCSK_SKI1_1	408	412	PF00082	0.297
CLV_PCSK_SKI1_1	439	443	PF00082	0.287
CLV_PCSK_SKI1_1	781	785	PF00082	0.559
CLV_PCSK_SKI1_1	831	835	PF00082	0.584
DEG_APCC_DBOX_1	780	788	PF00400	0.629
DEG_Nend_UBRbox_3	1	3	PF02207	0.633
DEG_SPOP_SBC_1	126	130	PF00917	0.799
DEG_SPOP_SBC_1	194	198	PF00917	0.743
DEG_SPOP_SBC_1	208	212	PF00917	0.561
DOC_CKS1_1	38	43	PF01111	0.569
DOC_CKS1_1	398	403	PF01111	0.487
DOC_MAPK_FxFP_2	467	470	PF00069	0.476
DOC_MAPK_gen_1	390	398	PF00069	0.487
DOC_MAPK_gen_1	408	419	PF00069	0.405
DOC_MAPK_gen_1	500	510	PF00069	0.487
DOC_MAPK_MEF2A_6	366	373	PF00069	0.476
DOC_MAPK_MEF2A_6	412	421	PF00069	0.560
DOC_MAPK_MEF2A_6	501	510	PF00069	0.491
DOC_PP1_RVXF_1	236	243	PF00149	0.466
DOC_PP1_RVXF_1	618	625	PF00149	0.476
DOC_PP1_SILK_1	659	664	PF00149	0.414
DOC_PP2B_LxvP_1	508	511	PF13499	0.476
DOC_PP4_FxxP_1	467	470	PF00568	0.476
DOC_USP7_MATH_1	1021	1025	PF00917	0.754
DOC_USP7_MATH_1	133	137	PF00917	0.743
DOC_USP7_MATH_1	194	198	PF00917	0.697
DOC_USP7_MATH_1	295	299	PF00917	0.540
DOC_USP7_MATH_1	329	333	PF00917	0.562
DOC_USP7_MATH_1	385	389	PF00917	0.562
DOC_USP7_MATH_1	433	437	PF00917	0.562
DOC_USP7_MATH_1	44	48	PF00917	0.746
DOC_USP7_MATH_1	667	671	PF00917	0.537
DOC_USP7_MATH_1	814	818	PF00917	0.676
DOC_USP7_MATH_1	976	980	PF00917	0.552
DOC_USP7_UBL2_3	790	794	PF12436	0.717
DOC_USP7_UBL2_3	9	13	PF12436	0.626
DOC_WW_Pin1_4	129	134	PF00397	0.676
DOC_WW_Pin1_4	189	194	PF00397	0.668
DOC_WW_Pin1_4	196	201	PF00397	0.656
DOC_WW_Pin1_4	37	42	PF00397	0.736
DOC_WW_Pin1_4	397	402	PF00397	0.487
DOC_WW_Pin1_4	449	454	PF00397	0.470
DOC_WW_Pin1_4	62	67	PF00397	0.729
DOC_WW_Pin1_4	77	82	PF00397	0.538
DOC_WW_Pin1_4	801	806	PF00397	0.678
DOC_WW_Pin1_4	856	861	PF00397	0.683
LIG_14-3-3_CanoR_1	414	420	PF00244	0.565
LIG_14-3-3_CanoR_1	439	447	PF00244	0.487
LIG_14-3-3_CanoR_1	641	646	PF00244	0.537
LIG_14-3-3_CanoR_1	908	913	PF00244	0.466
LIG_14-3-3_CanoR_1	977	983	PF00244	0.517
LIG_Actin_WH2_2	259	275	PF00022	0.568
LIG_BIR_III_2	934	938	PF00653	0.467
LIG_BRCT_BRCA1_1	46	50	PF00533	0.684
LIG_BRCT_BRCA1_1	668	672	PF00533	0.476
LIG_BRCT_BRCA1_1	938	942	PF00533	0.425
LIG_Clathr_ClatBox_1	403	407	PF01394	0.581
LIG_deltaCOP1_diTrp_1	460	467	PF00928	0.476
LIG_DLG_GKlike_1	641	648	PF00625	0.537
LIG_FHA_1	1001	1007	PF00498	0.761
LIG_FHA_1	144	150	PF00498	0.731
LIG_FHA_1	326	332	PF00498	0.476
LIG_FHA_1	359	365	PF00498	0.489
LIG_FHA_1	398	404	PF00498	0.480
LIG_FHA_1	416	422	PF00498	0.425
LIG_FHA_1	517	523	PF00498	0.504
LIG_FHA_1	626	632	PF00498	0.476
LIG_FHA_1	690	696	PF00498	0.487
LIG_FHA_1	718	724	PF00498	0.410
LIG_FHA_1	845	851	PF00498	0.671
LIG_FHA_2	1018	1024	PF00498	0.672
LIG_FHA_2	500	506	PF00498	0.537
LIG_FHA_2	627	633	PF00498	0.562
LIG_FHA_2	686	692	PF00498	0.476
LIG_FHA_2	729	735	PF00498	0.413
LIG_FHA_2	774	780	PF00498	0.615
LIG_LIR_Apic_2	466	470	PF02991	0.537
LIG_LIR_Gen_1	249	258	PF02991	0.518
LIG_LIR_Gen_1	4	11	PF02991	0.568
LIG_LIR_Gen_1	460	470	PF02991	0.467
LIG_LIR_Gen_1	644	649	PF02991	0.556
LIG_LIR_Gen_1	669	680	PF02991	0.476
LIG_LIR_Gen_1	939	950	PF02991	0.444
LIG_LIR_Nem_3	249	254	PF02991	0.445
LIG_LIR_Nem_3	4	10	PF02991	0.564
LIG_LIR_Nem_3	466	472	PF02991	0.515
LIG_LIR_Nem_3	644	648	PF02991	0.556
LIG_LIR_Nem_3	669	675	PF02991	0.476
LIG_LIR_Nem_3	939	945	PF02991	0.408
LIG_LYPXL_S_1	468	472	PF13949	0.301
LIG_LYPXL_yS_3	469	472	PF13949	0.537
LIG_NRBOX	161	167	PF00104	0.544
LIG_NRBOX	529	535	PF00104	0.581
LIG_PCNA_yPIPBox_3	520	534	PF02747	0.565
LIG_Pex14_2	254	258	PF04695	0.516
LIG_Pex14_2	467	471	PF04695	0.537
LIG_Pex14_2	696	700	PF04695	0.537
LIG_REV1ctd_RIR_1	255	265	PF16727	0.437
LIG_REV1ctd_RIR_1	408	418	PF16727	0.470
LIG_SH2_NCK_1	664	668	PF00017	0.581
LIG_SH2_PTP2	496	499	PF00017	0.537
LIG_SH2_STAT3	89	92	PF00017	0.666
LIG_SH2_STAT5	235	238	PF00017	0.535
LIG_SH2_STAT5	496	499	PF00017	0.537
LIG_SH2_STAT5	6	9	PF00017	0.627
LIG_SH2_STAT5	606	609	PF00017	0.562
LIG_SH2_STAT5	745	748	PF00017	0.574
LIG_SH2_STAT5	949	952	PF00017	0.425
LIG_SH2_STAT5	982	985	PF00017	0.383
LIG_SH3_3	188	194	PF00018	0.734
LIG_SH3_3	35	41	PF00018	0.735
LIG_SH3_3	395	401	PF00018	0.501
LIG_SH3_3	511	517	PF00018	0.501
LIG_SH3_3	799	805	PF00018	0.673
LIG_SH3_3	873	879	PF00018	0.479
LIG_SH3_3	896	902	PF00018	0.587
LIG_SUMO_SIM_anti_2	155	166	PF11976	0.654
LIG_SUMO_SIM_anti_2	628	635	PF11976	0.488
LIG_SUMO_SIM_anti_2	658	663	PF11976	0.414
LIG_SUMO_SIM_par_1	279	287	PF11976	0.549
LIG_SUMO_SIM_par_1	417	423	PF11976	0.488
LIG_SUMO_SIM_par_1	529	535	PF11976	0.584
LIG_SUMO_SIM_par_1	628	635	PF11976	0.537
LIG_SUMO_SIM_par_1	691	697	PF11976	0.476
LIG_TRAF2_1	538	541	PF00917	0.581
LIG_TRAF2_1	731	734	PF00917	0.376
LIG_TYR_ITIM	494	499	PF00017	0.537
LIG_UBA3_1	403	408	PF00899	0.581
LIG_UBA3_1	610	615	PF00899	0.562
LIG_UBA3_1	783	790	PF00899	0.638
LIG_UBA3_1	880	888	PF00899	0.471
LIG_WRC_WIRS_1	464	469	PF05994	0.521
LIG_WW_3	510	514	PF00397	0.487
LIG_WW_3	898	902	PF00397	0.655
MOD_CDC14_SPxK_1	859	862	PF00782	0.634
MOD_CDK_SPxK_1	856	862	PF00069	0.672
MOD_CK1_1	1000	1006	PF00069	0.642
MOD_CK1_1	15	21	PF00069	0.775
MOD_CK1_1	196	202	PF00069	0.724
MOD_CK1_1	225	231	PF00069	0.577
MOD_CK1_1	282	288	PF00069	0.533
MOD_CK1_1	355	361	PF00069	0.507
MOD_CK1_1	463	469	PF00069	0.519
MOD_CK1_1	532	538	PF00069	0.562
MOD_CK1_1	577	583	PF00069	0.645
MOD_CK1_1	625	631	PF00069	0.485
MOD_CK1_1	77	83	PF00069	0.729
MOD_CK1_1	800	806	PF00069	0.768
MOD_CK1_1	817	823	PF00069	0.737
MOD_CK1_1	993	999	PF00069	0.583
MOD_CK2_1	728	734	PF00069	0.392
MOD_CK2_1	995	1001	PF00069	0.619
MOD_GlcNHglycan	137	140	PF01048	0.777
MOD_GlcNHglycan	14	17	PF01048	0.754
MOD_GlcNHglycan	211	214	PF01048	0.618
MOD_GlcNHglycan	225	228	PF01048	0.446
MOD_GlcNHglycan	246	249	PF01048	0.590
MOD_GlcNHglycan	30	33	PF01048	0.680
MOD_GlcNHglycan	315	318	PF01048	0.301
MOD_GlcNHglycan	331	334	PF01048	0.209
MOD_GlcNHglycan	387	390	PF01048	0.336
MOD_GlcNHglycan	435	438	PF01048	0.369
MOD_GlcNHglycan	599	603	PF01048	0.388
MOD_GlcNHglycan	764	767	PF01048	0.596
MOD_GlcNHglycan	819	822	PF01048	0.710
MOD_GlcNHglycan	954	957	PF01048	0.647
MOD_GlcNHglycan	997	1000	PF01048	0.689
MOD_GSK3_1	1017	1024	PF00069	0.718
MOD_GSK3_1	11	18	PF00069	0.607
MOD_GSK3_1	115	122	PF00069	0.643
MOD_GSK3_1	125	132	PF00069	0.573
MOD_GSK3_1	143	150	PF00069	0.550
MOD_GSK3_1	189	196	PF00069	0.704
MOD_GSK3_1	21	28	PF00069	0.574
MOD_GSK3_1	221	228	PF00069	0.616
MOD_GSK3_1	325	332	PF00069	0.512
MOD_GSK3_1	352	359	PF00069	0.478
MOD_GSK3_1	40	47	PF00069	0.746
MOD_GSK3_1	429	436	PF00069	0.519
MOD_GSK3_1	622	629	PF00069	0.513
MOD_GSK3_1	685	692	PF00069	0.487
MOD_GSK3_1	794	801	PF00069	0.737
MOD_GSK3_1	815	822	PF00069	0.738
MOD_GSK3_1	97	104	PF00069	0.727
MOD_GSK3_1	990	997	PF00069	0.531
MOD_LATS_1	113	119	PF00433	0.727
MOD_LATS_1	639	645	PF00433	0.525
MOD_LATS_1	792	798	PF00433	0.664
MOD_N-GLC_1	625	630	PF02516	0.276
MOD_N-GLC_1	952	957	PF02516	0.476
MOD_NEK2_1	103	108	PF00069	0.791
MOD_NEK2_1	11	16	PF00069	0.606
MOD_NEK2_1	127	132	PF00069	0.583
MOD_NEK2_1	165	170	PF00069	0.661
MOD_NEK2_1	195	200	PF00069	0.801
MOD_NEK2_1	306	311	PF00069	0.452
MOD_NEK2_1	325	330	PF00069	0.358
MOD_NEK2_1	334	339	PF00069	0.471
MOD_NEK2_1	499	504	PF00069	0.476
MOD_NEK2_1	539	544	PF00069	0.544
MOD_NEK2_1	622	627	PF00069	0.482
MOD_NEK2_1	648	653	PF00069	0.501
MOD_NEK2_1	674	679	PF00069	0.484
MOD_NEK2_1	952	957	PF00069	0.530
MOD_NEK2_1	991	996	PF00069	0.570
MOD_NEK2_2	667	672	PF00069	0.537
MOD_NEK2_2	976	981	PF00069	0.538
MOD_OFUCOSY	980	985	PF10250	0.498
MOD_PIKK_1	165	171	PF00454	0.645
MOD_PIKK_1	56	62	PF00454	0.739
MOD_PIKK_1	574	580	PF00454	0.673
MOD_PIKK_1	819	825	PF00454	0.627
MOD_PK_1	657	663	PF00069	0.414
MOD_PKA_1	439	445	PF00069	0.501
MOD_PKA_2	228	234	PF00069	0.575
MOD_PKA_2	379	385	PF00069	0.510
MOD_PKA_2	499	505	PF00069	0.468
MOD_PKA_2	808	814	PF00069	0.794
MOD_PKA_2	962	968	PF00069	0.581
MOD_PKA_2	976	982	PF00069	0.402
MOD_Plk_1	657	663	PF00069	0.468
MOD_Plk_2-3	1005	1011	PF00069	0.680
MOD_Plk_4	415	421	PF00069	0.538
MOD_Plk_4	463	469	PF00069	0.519
MOD_Plk_4	529	535	PF00069	0.537
MOD_Plk_4	606	612	PF00069	0.516
MOD_Plk_4	657	663	PF00069	0.484
MOD_Plk_4	689	695	PF00069	0.487
MOD_Plk_4	803	809	PF00069	0.799
MOD_ProDKin_1	129	135	PF00069	0.674
MOD_ProDKin_1	189	195	PF00069	0.672
MOD_ProDKin_1	196	202	PF00069	0.656
MOD_ProDKin_1	37	43	PF00069	0.739
MOD_ProDKin_1	397	403	PF00069	0.487
MOD_ProDKin_1	449	455	PF00069	0.470
MOD_ProDKin_1	62	68	PF00069	0.730
MOD_ProDKin_1	77	83	PF00069	0.536
MOD_ProDKin_1	801	807	PF00069	0.678
MOD_ProDKin_1	856	862	PF00069	0.672
TRG_DiLeu_BaEn_1	161	166	PF01217	0.552
TRG_DiLeu_BaEn_1	460	465	PF01217	0.487
TRG_DiLeu_BaEn_2	301	307	PF01217	0.457
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.752
TRG_DiLeu_BaLyEn_6	563	568	PF01217	0.451
TRG_DiLeu_BaLyEn_6	876	881	PF01217	0.603
TRG_ENDOCYTIC_2	469	472	PF00928	0.501
TRG_ENDOCYTIC_2	496	499	PF00928	0.537
TRG_ENDOCYTIC_2	645	648	PF00928	0.562
TRG_ENDOCYTIC_2	949	952	PF00928	0.418
TRG_ENDOCYTIC_2	966	969	PF00928	0.478
TRG_ER_diArg_1	380	383	PF00400	0.581
TRG_ER_diArg_1	411	414	PF00400	0.492
TRG_ER_diArg_1	478	481	PF00400	0.525
TRG_ER_diArg_1	499	501	PF00400	0.476
TRG_ER_diArg_1	976	978	PF00400	0.561
TRG_NLS_MonoExtN_4	409	416	PF00514	0.581
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE28	Leptomonas seymouri	65%	100%
A0A0S4JP66	Bodo saltans	41%	94%
A0A1X0NY53	Trypanosomatidae	55%	100%
A0A3S7WZF4	Leishmania donovani	93%	100%
A0A422P4R6	Trypanosoma rangeli	57%	100%
A4HEA7	Leishmania braziliensis	83%	100%
A4I1Q3	Leishmania infantum	93%	100%
C9ZKA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AXT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DIY2	Trypanosoma cruzi	56%	100%