Protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein phosphatase

Gene product:

Stage II sporulation protein E (SpoIIE), putative

Species:

Leishmania major

UniProt:

Q4Q9N3_LEIMA

TriTrypDb:

LmjF.25.2060 , LMJLV39_250028200 , LMJSD75_250028200

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q9N3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9N3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004721	phosphoprotein phosphatase activity	3	13
GO:0004722	protein serine/threonine phosphatase activity	4	13
GO:0005488	binding	1	13
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0016791	phosphatase activity	5	13
GO:0017018	myosin phosphatase activity	5	13
GO:0042578	phosphoric ester hydrolase activity	4	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	352	358	PF00089	0.292
CLV_NRD_NRD_1	174	176	PF00675	0.277
CLV_NRD_NRD_1	71	73	PF00675	0.456
CLV_NRD_NRD_1	74	76	PF00675	0.430
CLV_NRD_NRD_1	80	82	PF00675	0.378
CLV_PCSK_FUR_1	72	76	PF00082	0.459
CLV_PCSK_KEX2_1	73	75	PF00082	0.439
CLV_PCSK_KEX2_1	82	84	PF00082	0.421
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.475
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.394
CLV_PCSK_SKI1_1	155	159	PF00082	0.286
CLV_PCSK_SKI1_1	311	315	PF00082	0.349
DEG_SPOP_SBC_1	164	168	PF00917	0.464
DOC_CKS1_1	30	35	PF01111	0.611
DOC_MAPK_gen_1	155	164	PF00069	0.534
DOC_MAPK_gen_1	342	351	PF00069	0.464
DOC_MAPK_gen_1	81	89	PF00069	0.415
DOC_MAPK_MEF2A_6	345	353	PF00069	0.464
DOC_PP4_FxxP_1	213	216	PF00568	0.443
DOC_USP7_MATH_1	3	7	PF00917	0.749
DOC_USP7_MATH_1	328	332	PF00917	0.439
DOC_WW_Pin1_4	277	282	PF00397	0.558
DOC_WW_Pin1_4	29	34	PF00397	0.607
DOC_WW_Pin1_4	324	329	PF00397	0.437
DOC_WW_Pin1_4	57	62	PF00397	0.449
LIG_14-3-3_CanoR_1	198	203	PF00244	0.543
LIG_14-3-3_CanoR_1	355	362	PF00244	0.367
LIG_14-3-3_CanoR_1	4	8	PF00244	0.718
LIG_14-3-3_CanoR_1	74	79	PF00244	0.435
LIG_14-3-3_CanoR_1	81	87	PF00244	0.410
LIG_BIR_III_4	340	344	PF00653	0.443
LIG_BRCT_BRCA1_1	200	204	PF00533	0.503
LIG_BRCT_BRCA1_1	50	54	PF00533	0.432
LIG_BRCT_BRCA1_2	50	56	PF00533	0.436
LIG_FHA_1	152	158	PF00498	0.549
LIG_FHA_1	166	172	PF00498	0.313
LIG_FHA_1	253	259	PF00498	0.464
LIG_FHA_1	348	354	PF00498	0.466
LIG_FHA_1	43	49	PF00498	0.527
LIG_FHA_2	30	36	PF00498	0.600
LIG_FHA_2	356	362	PF00498	0.369
LIG_LIR_Apic_2	29	33	PF02991	0.498
LIG_LIR_Apic_2	301	305	PF02991	0.492
LIG_LIR_Gen_1	150	161	PF02991	0.466
LIG_LIR_Gen_1	327	336	PF02991	0.444
LIG_LIR_Gen_1	85	93	PF02991	0.384
LIG_LIR_Nem_3	150	156	PF02991	0.466
LIG_LIR_Nem_3	85	89	PF02991	0.414
LIG_MLH1_MIPbox_1	200	204	PF16413	0.383
LIG_Pex14_2	213	217	PF04695	0.443
LIG_Pex14_2	259	263	PF04695	0.464
LIG_RPA_C_Fungi	257	269	PF08784	0.364
LIG_SH2_CRK	102	106	PF00017	0.295
LIG_SH2_CRK	153	157	PF00017	0.422
LIG_SH2_PTP2	302	305	PF00017	0.324
LIG_SH2_SRC	302	305	PF00017	0.324
LIG_SH2_STAP1	153	157	PF00017	0.444
LIG_SH2_STAT5	153	156	PF00017	0.444
LIG_SH2_STAT5	203	206	PF00017	0.404
LIG_SH2_STAT5	302	305	PF00017	0.295
LIG_SH3_3	5	11	PF00018	0.720
LIG_SH3_4	58	65	PF00018	0.639
LIG_SUMO_SIM_anti_2	191	198	PF11976	0.324
LIG_SUMO_SIM_anti_2	249	256	PF11976	0.364
LIG_SUMO_SIM_anti_2	347	354	PF11976	0.325
LIG_SUMO_SIM_par_1	347	354	PF11976	0.325
LIG_TRAF2_1	244	247	PF00917	0.366
LIG_TRAF2_1	358	361	PF00917	0.408
LIG_TRAF2_2	244	249	PF00917	0.412
MOD_CDK_SPxK_1	57	63	PF00069	0.547
MOD_CDK_SPxxK_3	277	284	PF00069	0.444
MOD_CK1_1	29	35	PF00069	0.615
MOD_CK1_1	354	360	PF00069	0.391
MOD_CK2_1	354	360	PF00069	0.391
MOD_CK2_1	82	88	PF00069	0.419
MOD_GlcNHglycan	15	18	PF01048	0.641
MOD_GlcNHglycan	191	194	PF01048	0.295
MOD_GlcNHglycan	292	295	PF01048	0.355
MOD_GSK3_1	324	331	PF00069	0.314
MOD_GSK3_1	347	354	PF00069	0.327
MOD_GSK3_1	360	367	PF00069	0.359
MOD_N-GLC_1	198	203	PF02516	0.210
MOD_N-GLC_1	363	368	PF02516	0.532
MOD_NEK2_1	135	140	PF00069	0.378
MOD_NEK2_1	189	194	PF00069	0.357
MOD_NEK2_1	290	295	PF00069	0.324
MOD_NEK2_1	362	367	PF00069	0.402
MOD_NEK2_2	170	175	PF00069	0.422
MOD_NEK2_2	92	97	PF00069	0.325
MOD_NMyristoyl	1	7	PF02799	0.617
MOD_PIKK_1	262	268	PF00454	0.298
MOD_PK_1	74	80	PF00069	0.522
MOD_PKA_1	74	80	PF00069	0.434
MOD_PKA_1	82	88	PF00069	0.405
MOD_PKA_2	239	245	PF00069	0.340
MOD_PKA_2	3	9	PF00069	0.715
MOD_PKA_2	354	360	PF00069	0.362
MOD_PKA_2	74	80	PF00069	0.434
MOD_PKA_2	82	88	PF00069	0.405
MOD_PKB_1	72	80	PF00069	0.439
MOD_Plk_1	198	204	PF00069	0.410
MOD_Plk_1	347	353	PF00069	0.295
MOD_Plk_1	92	98	PF00069	0.324
MOD_Plk_4	119	125	PF00069	0.365
MOD_Plk_4	328	334	PF00069	0.295
MOD_Plk_4	82	88	PF00069	0.426
MOD_Plk_4	92	98	PF00069	0.324
MOD_ProDKin_1	277	283	PF00069	0.456
MOD_ProDKin_1	29	35	PF00069	0.615
MOD_ProDKin_1	324	330	PF00069	0.287
MOD_ProDKin_1	57	63	PF00069	0.467
MOD_SUMO_rev_2	293	300	PF00179	0.310
MOD_SUMO_rev_2	35	44	PF00179	0.512
TRG_DiLeu_BaEn_2	92	98	PF01217	0.324
TRG_ENDOCYTIC_2	102	105	PF00928	0.335
TRG_ENDOCYTIC_2	153	156	PF00928	0.422
TRG_ER_diArg_1	197	200	PF00400	0.308
TRG_ER_diArg_1	72	75	PF00400	0.448
TRG_ER_diArg_1	80	83	PF00400	0.384
TRG_NLS_MonoExtN_4	72	77	PF00514	0.504
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Z6	Leptomonas seymouri	80%	100%
A0A0N1IH92	Leptomonas seymouri	27%	100%
A0A0S4IN49	Bodo saltans	37%	100%
A0A0S4JK95	Bodo saltans	62%	100%
A0A0S4JS91	Bodo saltans	62%	100%
A0A1X0NY52	Trypanosomatidae	61%	96%
A0A1X0P4F0	Trypanosomatidae	26%	100%
A0A1X0P973	Trypanosomatidae	28%	100%
A0A3Q8IBW1	Leishmania donovani	96%	100%
A0A3R7N5R3	Trypanosoma rangeli	28%	100%
A0A3R7RFR7	Trypanosoma rangeli	28%	100%
A0A422P4L0	Trypanosoma rangeli	66%	100%
A4HEA8	Leishmania braziliensis	92%	99%
A4I1Q4	Leishmania infantum	96%	100%
B3MTI8	Drosophila ananassae	33%	100%
B3P5D3	Drosophila erecta	37%	100%
B4G653	Drosophila persimilis	34%	100%
B4HZE7	Drosophila sechellia	37%	100%
B4JYN1	Drosophila grimshawi	35%	100%
B4K616	Drosophila mojavensis	38%	100%
B4M5T5	Drosophila virilis	37%	100%
B4NBL6	Drosophila willistoni	39%	100%
B4PPK3	Drosophila yakuba	37%	100%
B4R089	Drosophila simulans	37%	100%
C9ZKA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
C9ZN10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A5X5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AXT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O64730	Arabidopsis thaliana	30%	100%
P38797	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
Q09189	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q29AP0	Drosophila pseudoobscura pseudoobscura	36%	100%
Q339D2	Oryza sativa subsp. japonica	31%	79%
Q5U3N5	Danio rerio	37%	100%
Q6GR25	Xenopus laevis	37%	100%
Q6H7J3	Oryza sativa subsp. japonica	32%	100%
Q6H7J4	Oryza sativa subsp. japonica	28%	100%
Q6NVE9	Mus musculus	38%	100%
Q8NI37	Homo sapiens	38%	100%
Q942P9	Oryza sativa subsp. japonica	29%	100%
Q9LVQ8	Arabidopsis thaliana	34%	89%
Q9SUK9	Arabidopsis thaliana	32%	79%
Q9VAH4	Drosophila melanogaster	37%	100%
V5AT69	Trypanosoma cruzi	27%	100%
V5AUW7	Trypanosoma cruzi	31%	100%
V5BMI3	Trypanosoma cruzi	64%	85%