Rieske domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rieske [2Fe-2S] domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q9N2_LEIMA

TriTrypDb:

LmjF.25.2070 , LMJLV39_250028300 , LMJSD75_250028300

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q9N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9N2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051537	2 iron, 2 sulfur cluster binding	4	12
GO:0051540	metal cluster binding	2	12
GO:0003824	catalytic activity	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0008942	nitrite reductase [NAD(P)H] activity	5	1
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	3	1
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	4	1
GO:0098809	nitrite reductase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	273	275	PF00675	0.535
CLV_NRD_NRD_1	303	305	PF00675	0.400
CLV_NRD_NRD_1	364	366	PF00675	0.467
CLV_NRD_NRD_1	446	448	PF00675	0.686
CLV_PCSK_KEX2_1	14	16	PF00082	0.404
CLV_PCSK_KEX2_1	273	275	PF00082	0.720
CLV_PCSK_KEX2_1	302	304	PF00082	0.422
CLV_PCSK_KEX2_1	364	366	PF00082	0.518
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.404
CLV_PCSK_PC7_1	360	366	PF00082	0.295
CLV_PCSK_SKI1_1	431	435	PF00082	0.496
CLV_PCSK_SKI1_1	519	523	PF00082	0.323
CLV_PCSK_SKI1_1	78	82	PF00082	0.401
CLV_Separin_Metazoa	299	303	PF03568	0.427
DEG_APCC_DBOX_1	38	46	PF00400	0.343
DOC_CDC14_PxL_1	413	421	PF14671	0.452
DOC_CYCLIN_RxL_1	9	22	PF00134	0.343
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.502
DOC_MAPK_gen_1	110	118	PF00069	0.371
DOC_MAPK_gen_1	148	156	PF00069	0.452
DOC_MAPK_gen_1	447	457	PF00069	0.528
DOC_MAPK_JIP1_4	150	156	PF00069	0.458
DOC_MAPK_MEF2A_6	148	156	PF00069	0.452
DOC_MAPK_MEF2A_6	451	459	PF00069	0.469
DOC_PP1_RVXF_1	12	19	PF00149	0.343
DOC_PP1_RVXF_1	367	373	PF00149	0.395
DOC_PP2B_LxvP_1	163	166	PF13499	0.593
DOC_PP2B_LxvP_1	266	269	PF13499	0.377
DOC_PP2B_LxvP_1	341	344	PF13499	0.525
DOC_USP7_MATH_1	330	334	PF00917	0.416
DOC_USP7_MATH_1	495	499	PF00917	0.552
DOC_USP7_MATH_1	527	531	PF00917	0.542
DOC_USP7_MATH_1	73	77	PF00917	0.415
DOC_USP7_MATH_2	211	217	PF00917	0.602
DOC_WW_Pin1_4	220	225	PF00397	0.759
DOC_WW_Pin1_4	377	382	PF00397	0.420
DOC_WW_Pin1_4	469	474	PF00397	0.723
DOC_WW_Pin1_4	91	96	PF00397	0.475
LIG_14-3-3_CanoR_1	150	155	PF00244	0.590
LIG_14-3-3_CanoR_1	198	204	PF00244	0.610
LIG_14-3-3_CanoR_1	217	224	PF00244	0.698
LIG_14-3-3_CanoR_1	227	235	PF00244	0.485
LIG_Actin_WH2_2	241	258	PF00022	0.521
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BRCT_BRCA1_1	313	317	PF00533	0.581
LIG_FHA_1	223	229	PF00498	0.454
LIG_FHA_1	28	34	PF00498	0.343
LIG_FHA_1	372	378	PF00498	0.464
LIG_FHA_1	523	529	PF00498	0.479
LIG_FHA_2	294	300	PF00498	0.551
LIG_FHA_2	304	310	PF00498	0.326
LIG_LIR_Gen_1	122	133	PF02991	0.384
LIG_LIR_Gen_1	137	146	PF02991	0.349
LIG_LIR_Gen_1	262	270	PF02991	0.566
LIG_LIR_Gen_1	314	324	PF02991	0.387
LIG_LIR_Gen_1	380	390	PF02991	0.323
LIG_LIR_Gen_1	456	465	PF02991	0.533
LIG_LIR_Nem_3	122	128	PF02991	0.355
LIG_LIR_Nem_3	262	266	PF02991	0.543
LIG_LIR_Nem_3	314	320	PF02991	0.377
LIG_LIR_Nem_3	380	386	PF02991	0.367
LIG_LIR_Nem_3	456	461	PF02991	0.354
LIG_LIR_Nem_3	85	91	PF02991	0.372
LIG_MYND_3	416	420	PF01753	0.396
LIG_Pex14_1	425	429	PF04695	0.518
LIG_PTB_Apo_2	389	396	PF02174	0.362
LIG_PTB_Apo_2	44	51	PF02174	0.263
LIG_PTB_Phospho_1	389	395	PF10480	0.353
LIG_PTB_Phospho_1	44	50	PF10480	0.262
LIG_SH2_CRK	383	387	PF00017	0.349
LIG_SH2_PTP2	125	128	PF00017	0.395
LIG_SH2_PTP2	263	266	PF00017	0.482
LIG_SH2_STAT5	11	14	PF00017	0.415
LIG_SH2_STAT5	125	128	PF00017	0.370
LIG_SH2_STAT5	263	266	PF00017	0.465
LIG_SH2_STAT5	395	398	PF00017	0.647
LIG_SH2_STAT5	453	456	PF00017	0.396
LIG_SH2_STAT5	504	507	PF00017	0.501
LIG_SH2_STAT5	513	516	PF00017	0.463
LIG_SH2_STAT5	88	91	PF00017	0.530
LIG_SH3_3	340	346	PF00018	0.360
LIG_SH3_3	511	517	PF00018	0.355
LIG_SUMO_SIM_par_1	126	131	PF11976	0.379
LIG_SUMO_SIM_par_1	54	60	PF11976	0.343
LIG_UBA3_1	316	322	PF00899	0.361
MOD_CDK_SPK_2	96	101	PF00069	0.396
MOD_CDK_SPxxK_3	220	227	PF00069	0.545
MOD_CK1_1	131	137	PF00069	0.420
MOD_CK1_1	2	8	PF00069	0.661
MOD_CK1_1	216	222	PF00069	0.788
MOD_CK1_1	223	229	PF00069	0.600
MOD_CK1_1	288	294	PF00069	0.693
MOD_CK1_1	409	415	PF00069	0.603
MOD_CK1_1	441	447	PF00069	0.634
MOD_CK1_1	472	478	PF00069	0.731
MOD_CK2_1	184	190	PF00069	0.720
MOD_CK2_1	293	299	PF00069	0.587
MOD_Cter_Amidation	12	15	PF01082	0.415
MOD_GlcNHglycan	1	4	PF01048	0.693
MOD_GlcNHglycan	129	133	PF01048	0.478
MOD_GlcNHglycan	177	180	PF01048	0.531
MOD_GlcNHglycan	290	293	PF01048	0.663
MOD_GlcNHglycan	330	333	PF01048	0.439
MOD_GlcNHglycan	397	400	PF01048	0.575
MOD_GlcNHglycan	431	434	PF01048	0.509
MOD_GlcNHglycan	440	443	PF01048	0.547
MOD_GlcNHglycan	497	500	PF01048	0.532
MOD_GSK3_1	212	219	PF00069	0.644
MOD_GSK3_1	311	318	PF00069	0.408
MOD_GSK3_1	386	393	PF00069	0.435
MOD_GSK3_1	429	436	PF00069	0.527
MOD_GSK3_1	437	444	PF00069	0.528
MOD_GSK3_1	468	475	PF00069	0.649
MOD_GSK3_1	533	540	PF00069	0.499
MOD_N-GLC_1	19	24	PF02516	0.415
MOD_N-GLC_1	312	317	PF02516	0.529
MOD_N-GLC_1	386	391	PF02516	0.488
MOD_N-GLC_1	409	414	PF02516	0.532
MOD_N-GLC_1	495	500	PF02516	0.397
MOD_N-GLC_2	47	49	PF02516	0.271
MOD_NEK2_1	1	6	PF00069	0.590
MOD_NEK2_1	16	21	PF00069	0.333
MOD_NEK2_1	228	233	PF00069	0.411
MOD_NEK2_1	286	291	PF00069	0.582
MOD_NEK2_1	371	376	PF00069	0.382
MOD_NEK2_1	386	391	PF00069	0.319
MOD_NEK2_1	528	533	PF00069	0.479
MOD_PIKK_1	325	331	PF00454	0.466
MOD_PKA_1	303	309	PF00069	0.372
MOD_PKA_2	216	222	PF00069	0.704
MOD_PKA_2	272	278	PF00069	0.448
MOD_PKA_2	303	309	PF00069	0.372
MOD_PKA_2	359	365	PF00069	0.448
MOD_PKB_1	148	156	PF00069	0.452
MOD_Plk_1	312	318	PF00069	0.406
MOD_Plk_1	337	343	PF00069	0.584
MOD_Plk_1	386	392	PF00069	0.506
MOD_Plk_1	409	415	PF00069	0.450
MOD_Plk_4	312	318	PF00069	0.443
MOD_Plk_4	390	396	PF00069	0.616
MOD_Plk_4	449	455	PF00069	0.485
MOD_ProDKin_1	220	226	PF00069	0.747
MOD_ProDKin_1	377	383	PF00069	0.420
MOD_ProDKin_1	469	475	PF00069	0.724
MOD_ProDKin_1	91	97	PF00069	0.478
MOD_SUMO_for_1	417	420	PF00179	0.464
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.535
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.271
TRG_ENDOCYTIC_2	125	128	PF00928	0.363
TRG_ENDOCYTIC_2	140	143	PF00928	0.324
TRG_ENDOCYTIC_2	263	266	PF00928	0.465
TRG_ENDOCYTIC_2	383	386	PF00928	0.322
TRG_ENDOCYTIC_2	88	91	PF00928	0.404
TRG_ER_diArg_1	301	304	PF00400	0.407
TRG_ER_diArg_1	363	365	PF00400	0.475
TRG_ER_diArg_1	489	492	PF00400	0.447
TRG_NES_CRM1_1	259	272	PF08389	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I7	Leptomonas seymouri	58%	100%
A0A0S4JP70	Bodo saltans	38%	100%
A0A1X0NYR2	Trypanosomatidae	37%	100%
A0A3S5ISQ1	Trypanosoma rangeli	34%	100%
A0A3S7WZH8	Leishmania donovani	92%	100%
A4HEA9	Leishmania braziliensis	72%	99%
A4I1Q5	Leishmania infantum	91%	100%
C9ZKA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AXT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BS23	Trypanosoma cruzi	35%	100%