Putative RNA triphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Capping enzyme RNA triphosphatase 1

Species:

Leishmania major

UniProt:

Q4Q9M9_LEIMA

TriTrypDb:

LmjF.25.2095 , LMJLV39_250028600 , LMJSD75_250028600

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11
GO:0005634	nucleus	5	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9

Expansion

Sequence features

Q4Q9M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9M9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0016311	dephosphorylation	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0036260	RNA capping	7	2
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0098507	polynucleotide 5' dephosphorylation	6	2
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	2
GO:0004651	polynucleotide 5'-phosphatase activity	6	12
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0042578	phosphoric ester hydrolase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	174	176	PF00675	0.339
CLV_NRD_NRD_1	215	217	PF00675	0.484
CLV_NRD_NRD_1	218	220	PF00675	0.303
CLV_PCSK_FUR_1	215	219	PF00082	0.331
CLV_PCSK_KEX2_1	173	175	PF00082	0.329
CLV_PCSK_KEX2_1	215	217	PF00082	0.331
CLV_PCSK_KEX2_1	218	220	PF00082	0.303
CLV_PCSK_KEX2_1	286	288	PF00082	0.703
CLV_PCSK_KEX2_1	81	83	PF00082	0.456
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.329
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.331
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.480
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.473
CLV_PCSK_SKI1_1	106	110	PF00082	0.178
CLV_PCSK_SKI1_1	59	63	PF00082	0.437
DEG_COP1_1	193	201	PF00400	0.200
DOC_ANK_TNKS_1	32	39	PF00023	0.523
DOC_CKS1_1	4	9	PF01111	0.587
DOC_MAPK_gen_1	106	115	PF00069	0.265
DOC_MAPK_gen_1	173	181	PF00069	0.272
DOC_MAPK_HePTP_8	171	183	PF00069	0.411
DOC_MAPK_MEF2A_6	109	117	PF00069	0.215
DOC_MAPK_MEF2A_6	174	183	PF00069	0.362
DOC_MAPK_RevD_3	272	287	PF00069	0.318
DOC_MIT_MIM_1	266	274	PF04212	0.367
DOC_USP7_MATH_1	201	205	PF00917	0.487
DOC_USP7_MATH_1	83	87	PF00917	0.373
DOC_WD40_RPTOR_TOS_1	244	249	PF00400	0.411
DOC_WW_Pin1_4	17	22	PF00397	0.593
DOC_WW_Pin1_4	3	8	PF00397	0.735
DOC_WW_Pin1_4	31	36	PF00397	0.654
DOC_WW_Pin1_4	38	43	PF00397	0.568
DOC_WW_Pin1_4	92	97	PF00397	0.402
LIG_14-3-3_CanoR_1	154	158	PF00244	0.305
LIG_14-3-3_CanoR_1	191	199	PF00244	0.296
LIG_14-3-3_CanoR_1	218	227	PF00244	0.285
LIG_BIR_II_1	1	5	PF00653	0.744
LIG_BRCT_BRCA1_1	163	167	PF00533	0.331
LIG_BRCT_BRCA1_1	223	227	PF00533	0.200
LIG_FHA_1	143	149	PF00498	0.272
LIG_FHA_1	154	160	PF00498	0.279
LIG_FHA_2	24	30	PF00498	0.707
LIG_GBD_Chelix_1	264	272	PF00786	0.318
LIG_GBD_Chelix_1	50	58	PF00786	0.408
LIG_LIR_Gen_1	122	132	PF02991	0.302
LIG_LIR_Gen_1	228	236	PF02991	0.484
LIG_LIR_Nem_3	228	234	PF02991	0.484
LIG_NRBOX	263	269	PF00104	0.392
LIG_Pex14_2	227	231	PF04695	0.331
LIG_PTAP_UEV_1	20	25	PF05743	0.612
LIG_SH2_NCK_1	157	161	PF00017	0.381
LIG_SH2_STAP1	155	159	PF00017	0.360
LIG_SH2_STAP1	188	192	PF00017	0.325
LIG_SH2_STAT5	155	158	PF00017	0.325
LIG_SH2_STAT5	213	216	PF00017	0.322
LIG_SH3_3	1	7	PF00018	0.616
LIG_SH3_3	178	184	PF00018	0.327
LIG_SH3_3	18	24	PF00018	0.615
LIG_SxIP_EBH_1	92	102	PF03271	0.265
LIG_UBA3_1	271	278	PF00899	0.462
LIG_UBA3_1	54	59	PF00899	0.446
LIG_ULM_U2AF65_1	215	221	PF00076	0.331
MOD_CK1_1	193	199	PF00069	0.285
MOD_CK1_1	200	206	PF00069	0.276
MOD_CK1_1	98	104	PF00069	0.400
MOD_CK2_1	140	146	PF00069	0.411
MOD_CK2_1	23	29	PF00069	0.734
MOD_CK2_1	5	11	PF00069	0.589
MOD_CK2_1	62	68	PF00069	0.314
MOD_GlcNHglycan	1	4	PF01048	0.740
MOD_GlcNHglycan	119	122	PF01048	0.425
MOD_GlcNHglycan	17	20	PF01048	0.759
MOD_GlcNHglycan	199	202	PF01048	0.297
MOD_GlcNHglycan	203	206	PF01048	0.298
MOD_GlcNHglycan	223	226	PF01048	0.447
MOD_GSK3_1	149	156	PF00069	0.346
MOD_GSK3_1	15	22	PF00069	0.713
MOD_GSK3_1	193	200	PF00069	0.267
MOD_GSK3_1	94	101	PF00069	0.440
MOD_NEK2_1	140	145	PF00069	0.402
MOD_NEK2_1	62	67	PF00069	0.479
MOD_PIKK_1	252	258	PF00454	0.418
MOD_PIKK_1	84	90	PF00454	0.351
MOD_PKA_1	218	224	PF00069	0.331
MOD_PKA_2	153	159	PF00069	0.285
MOD_PKA_2	190	196	PF00069	0.314
MOD_PKA_2	218	224	PF00069	0.279
MOD_PKA_2	83	89	PF00069	0.365
MOD_PKB_1	216	224	PF00069	0.331
MOD_PKB_1	82	90	PF00069	0.265
MOD_Plk_1	122	128	PF00069	0.319
MOD_Plk_4	163	169	PF00069	0.355
MOD_Plk_4	50	56	PF00069	0.540
MOD_ProDKin_1	17	23	PF00069	0.592
MOD_ProDKin_1	3	9	PF00069	0.733
MOD_ProDKin_1	31	37	PF00069	0.655
MOD_ProDKin_1	38	44	PF00069	0.559
MOD_ProDKin_1	92	98	PF00069	0.402
TRG_DiLeu_BaEn_4	133	139	PF01217	0.400
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.421
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.624
TRG_ER_diArg_1	174	176	PF00400	0.447
TRG_ER_diArg_1	214	216	PF00400	0.331
TRG_ER_diArg_1	218	220	PF00400	0.469
TRG_NLS_MonoCore_2	215	220	PF00514	0.331
TRG_NLS_MonoExtN_4	215	221	PF00514	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I3	Leptomonas seymouri	54%	100%
A0A0S4JKB2	Bodo saltans	28%	100%
A0A1X0NZM4	Trypanosomatidae	35%	100%
A0A3S7WZD5	Leishmania donovani	91%	100%
A0A422P4J1	Trypanosoma rangeli	36%	100%
A4HEB2	Leishmania braziliensis	66%	94%
A4I1Q8	Leishmania infantum	91%	100%
C9ZKB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AXU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BH28	Trypanosoma cruzi	33%	100%