TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania major

UniProt:

Q4Q9M8_LEIMA

TriTrypDb:

LmjF.25.2100 , LMJLV39_250028700 , LMJSD75_250028700

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9M8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	14
GO:0009987	cellular process	1	14

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	16
GO:0005515	protein binding	2	14
GO:0030544	Hsp70 protein binding	4	14
GO:0031072	heat shock protein binding	3	14
GO:0051879	Hsp90 protein binding	4	14
GO:0003676	nucleic acid binding	3	8
GO:0008270	zinc ion binding	6	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.387
CLV_C14_Caspase3-7	49	53	PF00656	0.563
CLV_NRD_NRD_1	121	123	PF00675	0.301
CLV_NRD_NRD_1	135	137	PF00675	0.345
CLV_NRD_NRD_1	2	4	PF00675	0.461
CLV_NRD_NRD_1	282	284	PF00675	0.491
CLV_NRD_NRD_1	346	348	PF00675	0.495
CLV_PCSK_FUR_1	346	350	PF00082	0.506
CLV_PCSK_KEX2_1	121	123	PF00082	0.532
CLV_PCSK_KEX2_1	135	137	PF00082	0.345
CLV_PCSK_KEX2_1	2	4	PF00082	0.461
CLV_PCSK_KEX2_1	27	29	PF00082	0.379
CLV_PCSK_KEX2_1	346	348	PF00082	0.497
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.364
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.497
CLV_PCSK_SKI1_1	11	15	PF00082	0.438
CLV_PCSK_SKI1_1	257	261	PF00082	0.416
CLV_PCSK_SKI1_1	295	299	PF00082	0.584
DEG_Nend_UBRbox_1	1	4	PF02207	0.478
DEG_SPOP_SBC_1	125	129	PF00917	0.297
DOC_CYCLIN_RxL_1	179	191	PF00134	0.481
DOC_MAPK_gen_1	81	89	PF00069	0.281
DOC_USP7_MATH_1	125	129	PF00917	0.325
DOC_USP7_MATH_1	279	283	PF00917	0.586
DOC_USP7_MATH_1	309	313	PF00917	0.598
DOC_USP7_MATH_1	321	325	PF00917	0.511
DOC_USP7_UBL2_3	242	246	PF12436	0.396
DOC_USP7_UBL2_3	260	264	PF12436	0.396
LIG_14-3-3_CanoR_1	295	304	PF00244	0.561
LIG_14-3-3_CanoR_1	3	13	PF00244	0.418
LIG_14-3-3_CanoR_1	318	326	PF00244	0.499
LIG_Actin_WH2_2	231	248	PF00022	0.357
LIG_FHA_1	170	176	PF00498	0.556
LIG_FHA_1	254	260	PF00498	0.407
LIG_FHA_1	292	298	PF00498	0.564
LIG_FHA_1	299	305	PF00498	0.435
LIG_FHA_2	127	133	PF00498	0.345
LIG_FHA_2	191	197	PF00498	0.550
LIG_FHA_2	283	289	PF00498	0.470
LIG_LIR_Gen_1	250	259	PF02991	0.303
LIG_LIR_Gen_1	327	334	PF02991	0.544
LIG_LIR_Gen_1	43	51	PF02991	0.478
LIG_LIR_Gen_1	67	78	PF02991	0.437
LIG_LIR_Gen_1	7	14	PF02991	0.414
LIG_LIR_Nem_3	250	255	PF02991	0.331
LIG_LIR_Nem_3	327	331	PF02991	0.517
LIG_LIR_Nem_3	43	48	PF02991	0.469
LIG_LIR_Nem_3	67	73	PF02991	0.437
LIG_LIR_Nem_3	7	12	PF02991	0.420
LIG_RPA_C_Fungi	199	211	PF08784	0.314
LIG_RPA_C_Fungi	278	290	PF08784	0.561
LIG_SH2_CRK	252	256	PF00017	0.303
LIG_SH2_CRK	70	74	PF00017	0.281
LIG_SH2_NCK_1	110	114	PF00017	0.368
LIG_SH2_NCK_1	45	49	PF00017	0.366
LIG_SH2_SRC	130	133	PF00017	0.338
LIG_SH2_SRC	174	177	PF00017	0.353
LIG_SH2_STAP1	158	162	PF00017	0.394
LIG_SH2_STAT5	130	133	PF00017	0.449
LIG_SH2_STAT5	174	177	PF00017	0.421
LIG_SH2_STAT5	208	211	PF00017	0.424
LIG_SH2_STAT5	328	331	PF00017	0.412
LIG_TRAF2_1	102	105	PF00917	0.471
LIG_TRAF2_1	285	288	PF00917	0.476
MOD_CK1_1	111	117	PF00069	0.423
MOD_CK1_1	190	196	PF00069	0.465
MOD_CK1_1	202	208	PF00069	0.343
MOD_CK1_1	282	288	PF00069	0.550
MOD_CK1_1	324	330	PF00069	0.626
MOD_CK1_1	340	346	PF00069	0.364
MOD_CK1_1	43	49	PF00069	0.468
MOD_CK2_1	126	132	PF00069	0.333
MOD_CK2_1	170	176	PF00069	0.596
MOD_CK2_1	190	196	PF00069	0.558
MOD_CK2_1	282	288	PF00069	0.497
MOD_CK2_1	335	341	PF00069	0.431
MOD_CK2_1	43	49	PF00069	0.392
MOD_GlcNHglycan	117	120	PF01048	0.387
MOD_GlcNHglycan	148	151	PF01048	0.480
MOD_GlcNHglycan	204	207	PF01048	0.312
MOD_GlcNHglycan	215	219	PF01048	0.327
MOD_GlcNHglycan	323	326	PF01048	0.592
MOD_GlcNHglycan	33	36	PF01048	0.462
MOD_GlcNHglycan	42	45	PF01048	0.418
MOD_GlcNHglycan	66	69	PF01048	0.272
MOD_GSK3_1	111	118	PF00069	0.508
MOD_GSK3_1	187	194	PF00069	0.489
MOD_GSK3_1	291	298	PF00069	0.638
MOD_GSK3_1	317	324	PF00069	0.725
MOD_LATS_1	293	299	PF00433	0.415
MOD_N-GLC_1	125	130	PF02516	0.319
MOD_N-GLC_1	202	207	PF02516	0.308
MOD_N-GLC_1	332	337	PF02516	0.520
MOD_N-GLC_1	64	69	PF02516	0.249
MOD_N-GLC_2	330	332	PF02516	0.524
MOD_NEK2_1	115	120	PF00069	0.540
MOD_NEK2_1	169	174	PF00069	0.499
MOD_NEK2_1	307	312	PF00069	0.444
MOD_PIKK_1	4	10	PF00454	0.412
MOD_PKA_1	347	353	PF00069	0.527
MOD_PKA_2	282	288	PF00069	0.520
MOD_PKA_2	302	308	PF00069	0.540
MOD_PKA_2	317	323	PF00069	0.588
MOD_PKB_1	289	297	PF00069	0.467
MOD_Plk_1	111	117	PF00069	0.414
MOD_Plk_1	125	131	PF00069	0.323
MOD_Plk_1	158	164	PF00069	0.459
MOD_Plk_1	227	233	PF00069	0.399
MOD_Plk_1	340	346	PF00069	0.404
MOD_Plk_4	111	117	PF00069	0.508
MOD_Plk_4	126	132	PF00069	0.441
MOD_Plk_4	170	176	PF00069	0.355
MOD_Plk_4	196	202	PF00069	0.459
MOD_Plk_4	340	346	PF00069	0.599
MOD_SUMO_rev_2	149	155	PF00179	0.514
MOD_SUMO_rev_2	21	29	PF00179	0.442
TRG_DiLeu_BaEn_1	196	201	PF01217	0.479
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.344
TRG_ENDOCYTIC_2	252	255	PF00928	0.344
TRG_ENDOCYTIC_2	328	331	PF00928	0.555
TRG_ENDOCYTIC_2	45	48	PF00928	0.348
TRG_ENDOCYTIC_2	70	73	PF00928	0.326
TRG_ER_diArg_1	1	3	PF00400	0.491
TRG_ER_diArg_1	121	123	PF00400	0.301
TRG_ER_diArg_1	345	347	PF00400	0.486
TRG_ER_diArg_1	349	352	PF00400	0.506
TRG_ER_diArg_1	58	61	PF00400	0.348
TRG_NLS_MonoExtC_3	346	351	PF00514	0.496
TRG_NLS_MonoExtN_4	346	352	PF00514	0.493
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBD2	Leptomonas seymouri	64%	100%
A0A0S4JRK3	Bodo saltans	33%	100%
A0A1X0NZH9	Trypanosomatidae	37%	96%
A0A3Q8IJP8	Leishmania donovani	24%	100%
A0A3R7LE97	Trypanosoma rangeli	40%	99%
A0A3S7WZC1	Leishmania donovani	95%	100%
A4HEB3	Leishmania braziliensis	82%	98%
A4I1Q9	Leishmania infantum	95%	100%
A4ICY0	Leishmania infantum	24%	100%
C9ZKB4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ASC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AXU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q271	Leishmania major	24%	100%
V5BCJ3	Trypanosoma cruzi	40%	99%