Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinyl-CoA synthetase alpha subunit, putative

Species:

Leishmania major

UniProt:

Q4Q9M4_LEIMA

TriTrypDb:

LmjF.25.2130 , LMJLV39_250029000 , LMJSD75_250029200

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0009361	succinate-CoA ligase complex (ADP-forming)	5	2
GO:0032991	protein-containing complex	1	2
GO:0042709	succinate-CoA ligase complex	4	2
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0045239	tricarboxylic acid cycle enzyme complex	3	2
GO:0110165	cellular anatomical entity	1	12
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4Q9M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9M4

Function

Biological processes
Term	Name	Level	Count
GO:0006099	tricarboxylic acid cycle	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004774	succinate-CoA ligase activity	5	12
GO:0004775	succinate-CoA ligase (ADP-forming) activity	6	12
GO:0004776	succinate-CoA ligase (GDP-forming) activity	6	2
GO:0005488	binding	1	12
GO:0016874	ligase activity	2	12
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	12
GO:0016878	acid-thiol ligase activity	4	12
GO:0036094	small molecule binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.446
CLV_C14_Caspase3-7	90	94	PF00656	0.309
CLV_NRD_NRD_1	251	253	PF00675	0.273
CLV_NRD_NRD_1	8	10	PF00675	0.533
CLV_PCSK_KEX2_1	251	253	PF00082	0.288
CLV_PCSK_KEX2_1	8	10	PF00082	0.533
CLV_PCSK_PC7_1	4	10	PF00082	0.516
CLV_PCSK_SKI1_1	115	119	PF00082	0.383
CLV_PCSK_SKI1_1	200	204	PF00082	0.403
CLV_PCSK_SKI1_1	271	275	PF00082	0.357
DEG_Nend_Nbox_1	1	3	PF02207	0.513
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.252
DOC_MAPK_gen_1	235	241	PF00069	0.273
DOC_PP2B_LxvP_1	55	58	PF13499	0.273
DOC_PP2B_LxvP_1	77	80	PF13499	0.357
DOC_USP7_MATH_1	237	241	PF00917	0.292
DOC_USP7_MATH_1	258	262	PF00917	0.309
DOC_USP7_MATH_1	72	76	PF00917	0.403
DOC_WW_Pin1_4	229	234	PF00397	0.357
DOC_WW_Pin1_4	281	286	PF00397	0.385
DOC_WW_Pin1_4	43	48	PF00397	0.357
LIG_14-3-3_CanoR_1	113	118	PF00244	0.377
LIG_AP2alpha_2	188	190	PF02296	0.273
LIG_DLG_GKlike_1	113	121	PF00625	0.355
LIG_FHA_1	101	107	PF00498	0.298
LIG_FHA_1	122	128	PF00498	0.337
LIG_FHA_1	13	19	PF00498	0.275
LIG_FHA_1	191	197	PF00498	0.299
LIG_FHA_1	206	212	PF00498	0.273
LIG_FHA_1	37	43	PF00498	0.279
LIG_FHA_1	50	56	PF00498	0.273
LIG_FHA_1	71	77	PF00498	0.435
LIG_FHA_2	170	176	PF00498	0.309
LIG_FHA_2	218	224	PF00498	0.349
LIG_FHA_2	278	284	PF00498	0.495
LIG_FHA_2	60	66	PF00498	0.281
LIG_LIR_Gen_1	163	174	PF02991	0.273
LIG_LIR_LC3C_4	95	100	PF02991	0.273
LIG_LIR_Nem_3	163	169	PF02991	0.280
LIG_SH2_NCK_1	166	170	PF00017	0.273
LIG_SH2_SRC	78	81	PF00017	0.273
LIG_SH2_STAP1	166	170	PF00017	0.273
LIG_SH2_STAT5	78	81	PF00017	0.273
LIG_SH3_3	126	132	PF00018	0.311
LIG_SH3_3	76	82	PF00018	0.292
LIG_SUMO_SIM_anti_2	207	216	PF11976	0.295
LIG_SUMO_SIM_par_1	207	216	PF11976	0.275
LIG_SUMO_SIM_par_1	97	104	PF11976	0.285
LIG_TRAF2_1	220	223	PF00917	0.273
LIG_TRAF2_1	87	90	PF00917	0.273
LIG_TYR_ITIM	164	169	PF00017	0.273
LIG_WRC_WIRS_1	238	243	PF05994	0.271
MOD_CDC14_SPxK_1	232	235	PF00782	0.357
MOD_CDC14_SPxK_1	46	49	PF00782	0.357
MOD_CDK_SPK_2	43	48	PF00069	0.357
MOD_CDK_SPxK_1	229	235	PF00069	0.357
MOD_CDK_SPxK_1	43	49	PF00069	0.357
MOD_CDK_SPxxK_3	229	236	PF00069	0.357
MOD_CK2_1	169	175	PF00069	0.309
MOD_CK2_1	217	223	PF00069	0.305
MOD_CK2_1	59	65	PF00069	0.320
MOD_CK2_1	84	90	PF00069	0.357
MOD_Cter_Amidation	249	252	PF01082	0.273
MOD_Cter_Amidation	268	271	PF01082	0.138
MOD_GlcNHglycan	160	163	PF01048	0.273
MOD_GlcNHglycan	260	263	PF01048	0.273
MOD_GlcNHglycan	4	7	PF01048	0.540
MOD_GSK3_1	113	120	PF00069	0.361
MOD_GSK3_1	156	163	PF00069	0.274
MOD_GSK3_1	277	284	PF00069	0.562
MOD_N-GLC_1	121	126	PF02516	0.363
MOD_N-GLC_1	190	195	PF02516	0.300
MOD_NEK2_1	117	122	PF00069	0.364
MOD_NEK2_1	177	182	PF00069	0.273
MOD_NEK2_1	190	195	PF00069	0.273
MOD_NEK2_1	2	7	PF00069	0.512
MOD_PIKK_1	117	123	PF00454	0.366
MOD_Plk_1	121	127	PF00069	0.358
MOD_Plk_4	113	119	PF00069	0.376
MOD_Plk_4	237	243	PF00069	0.273
MOD_Plk_4	72	78	PF00069	0.292
MOD_ProDKin_1	229	235	PF00069	0.357
MOD_ProDKin_1	281	287	PF00069	0.386
MOD_ProDKin_1	43	49	PF00069	0.357
TRG_DiLeu_BaEn_1	209	214	PF01217	0.292
TRG_DiLeu_BaEn_3	223	229	PF01217	0.292
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.356
TRG_ENDOCYTIC_2	166	169	PF00928	0.275
TRG_ER_diArg_1	251	253	PF00400	0.273
TRG_ER_diArg_1	7	9	PF00400	0.571
TRG_NES_CRM1_1	110	121	PF08389	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JKD5	Bodo saltans	75%	100%
A0A1X0NY43	Trypanosomatidae	83%	99%
A0A3Q8IFF5	Leishmania donovani	100%	100%
A0A3R7N4H2	Trypanosoma rangeli	80%	100%
A4HEB6	Leishmania braziliensis	96%	100%
A4I1R2	Leishmania infantum	100%	100%
B3FHT4	Blastocystis sp. subtype 1 (strain ATCC 50177 / NandII)	68%	94%
C9ZKB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	99%
E9AXU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AXU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O08371	Rickettsia prowazekii (strain Madrid E)	66%	100%
O13750	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	66%	90%
O19069	Sus scrofa	67%	86%
O26663	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	51%	100%
O28098	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	52%	100%
O28733	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	52%	100%
O67547	Aquifex aeolicus (strain VF5)	56%	98%
P09143	Thermus thermophilus	55%	100%
P0AGE9	Escherichia coli (strain K12)	62%	100%
P0AGF0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	62%	100%
P0AGF1	Escherichia coli O157:H7	62%	100%
P13086	Rattus norvegicus	69%	86%
P36967	Dictyostelium discoideum	66%	95%
P45102	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	62%	100%
P53399	Trichomonas vaginalis	57%	97%
P53400	Trichomonas vaginalis	57%	97%
P53401	Trichomonas vaginalis	57%	97%
P53591	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	61%	100%
P53595	Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)	52%	100%
P53596	Caenorhabditis elegans	71%	93%
P53597	Homo sapiens	67%	86%
P53598	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	59%	91%
P66866	Staphylococcus aureus (strain Mu50 / ATCC 700699)	59%	99%
P68209	Arabidopsis thaliana	69%	86%
P80865	Bacillus subtilis (strain 168)	61%	100%
P99070	Staphylococcus aureus (strain N315)	59%	99%
P9WGC6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	49%	99%
P9WGC7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	49%	99%
Q1RH56	Rickettsia bellii (strain RML369-C)	69%	100%
Q4ULQ8	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	67%	100%
Q51567	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	65%	100%
Q58643	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	50%	100%
Q58DR8	Bos taurus	66%	86%
Q5HGI6	Staphylococcus aureus (strain COL)	59%	99%
Q5HPU4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	59%	99%
Q6DQL1	Solanum lycopersicum	70%	89%
Q6G9W7	Staphylococcus aureus (strain MSSA476)	59%	99%
Q6GHI9	Staphylococcus aureus (strain MRSA252)	59%	99%
Q6ZL94	Oryza sativa subsp. japonica	69%	90%
Q7U0Z0	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	49%	99%
Q8CPH4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	58%	99%
Q8GTQ9	Solanum lycopersicum	69%	90%
Q8LAD2	Arabidopsis thaliana	70%	88%
Q8NX01	Staphylococcus aureus (strain MW2)	59%	99%
Q92I22	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	66%	100%
Q94522	Drosophila melanogaster	67%	91%
Q9AKE1	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	66%	100%
Q9P727	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	67%	90%
Q9WUM5	Mus musculus	68%	86%
Q9YGD2	Columba livia	65%	98%
V5B829	Trypanosoma cruzi	79%	100%