BRO1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BRO1-like domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q9M3_LEIMA

TriTrypDb:

LmjF.25.2150 , LMJLV39_250029200 , LMJSD75_250029300

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9M3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.397
CLV_C14_Caspase3-7	84	88	PF00656	0.362
CLV_NRD_NRD_1	54	56	PF00675	0.384
CLV_NRD_NRD_1	59	61	PF00675	0.404
CLV_PCSK_KEX2_1	187	189	PF00082	0.425
CLV_PCSK_KEX2_1	276	278	PF00082	0.370
CLV_PCSK_KEX2_1	43	45	PF00082	0.439
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.425
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.370
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.448
CLV_PCSK_SKI1_1	232	236	PF00082	0.278
CLV_PCSK_SKI1_1	277	281	PF00082	0.382
CLV_PCSK_SKI1_1	77	81	PF00082	0.426
CLV_PCSK_SKI1_1	8	12	PF00082	0.358
DEG_APCC_DBOX_1	126	134	PF00400	0.329
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DOC_MAPK_DCC_7	8	16	PF00069	0.435
DOC_MAPK_gen_1	187	193	PF00069	0.390
DOC_MAPK_gen_1	320	328	PF00069	0.294
DOC_MAPK_gen_1	42	50	PF00069	0.479
DOC_MAPK_MEF2A_6	322	330	PF00069	0.288
DOC_MAPK_MEF2A_6	378	385	PF00069	0.345
DOC_MAPK_MEF2A_6	8	16	PF00069	0.480
DOC_MAPK_RevD_3	28	44	PF00069	0.334
DOC_PP2B_LxvP_1	326	329	PF13499	0.370
DOC_PP2B_LxvP_1	369	372	PF13499	0.331
DOC_USP7_MATH_1	194	198	PF00917	0.455
DOC_USP7_UBL2_3	38	42	PF12436	0.505
DOC_WW_Pin1_4	387	392	PF00397	0.522
LIG_14-3-3_CanoR_1	152	156	PF00244	0.415
LIG_14-3-3_CanoR_1	17	24	PF00244	0.486
LIG_14-3-3_CanoR_1	240	248	PF00244	0.361
LIG_14-3-3_CanoR_1	344	353	PF00244	0.315
LIG_14-3-3_CanoR_1	60	66	PF00244	0.382
LIG_APCC_ABBA_1	206	211	PF00400	0.370
LIG_APCC_ABBAyCdc20_2	262	268	PF00400	0.214
LIG_BRCT_BRCA1_1	172	176	PF00533	0.415
LIG_BRCT_BRCA1_1	223	227	PF00533	0.407
LIG_BRCT_BRCA1_1	289	293	PF00533	0.329
LIG_BRCT_BRCA1_1	381	385	PF00533	0.538
LIG_BRCT_BRCA1_2	289	295	PF00533	0.475
LIG_EH1_1	134	142	PF00400	0.304
LIG_FHA_1	236	242	PF00498	0.351
LIG_FHA_1	269	275	PF00498	0.415
LIG_FHA_1	331	337	PF00498	0.454
LIG_FHA_1	345	351	PF00498	0.356
LIG_FHA_1	393	399	PF00498	0.548
LIG_FHA_1	88	94	PF00498	0.348
LIG_FHA_2	259	265	PF00498	0.318
LIG_LIR_Gen_1	125	135	PF02991	0.358
LIG_LIR_Gen_1	264	274	PF02991	0.312
LIG_LIR_Gen_1	49	58	PF02991	0.348
LIG_LIR_Nem_3	120	126	PF02991	0.246
LIG_LIR_Nem_3	164	169	PF02991	0.285
LIG_LIR_Nem_3	173	178	PF02991	0.285
LIG_LIR_Nem_3	264	269	PF02991	0.329
LIG_LIR_Nem_3	278	283	PF02991	0.276
LIG_LIR_Nem_3	333	338	PF02991	0.382
LIG_LIR_Nem_3	49	54	PF02991	0.357
LIG_MLH1_MIPbox_1	172	176	PF16413	0.415
LIG_Pex14_2	50	54	PF04695	0.412
LIG_SH2_CRK	166	170	PF00017	0.285
LIG_SH2_CRK	9	13	PF00017	0.419
LIG_SH2_GRB2like	134	137	PF00017	0.329
LIG_SH2_NCK_1	281	285	PF00017	0.214
LIG_SH2_STAP1	281	285	PF00017	0.337
LIG_SH2_STAP1	89	93	PF00017	0.285
LIG_SH2_STAT5	147	150	PF00017	0.377
LIG_SH2_STAT5	175	178	PF00017	0.297
LIG_SH2_STAT5	317	320	PF00017	0.439
LIG_SH2_STAT5	78	81	PF00017	0.469
LIG_SH2_STAT5	89	92	PF00017	0.319
LIG_SH3_1	9	15	PF00018	0.476
LIG_SH3_2	12	17	PF14604	0.484
LIG_SH3_3	193	199	PF00018	0.415
LIG_SH3_3	27	33	PF00018	0.435
LIG_SH3_3	368	374	PF00018	0.413
LIG_SH3_3	9	15	PF00018	0.440
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.374
LIG_SUMO_SIM_anti_2	395	400	PF11976	0.505
LIG_SUMO_SIM_par_1	197	203	PF11976	0.469
LIG_SUMO_SIM_par_1	394	400	PF11976	0.502
LIG_TYR_ITIM	247	252	PF00017	0.370
MOD_CK1_1	113	119	PF00069	0.438
MOD_CK1_1	392	398	PF00069	0.521
MOD_CK2_1	156	162	PF00069	0.349
MOD_CK2_1	23	29	PF00069	0.533
MOD_CK2_1	258	264	PF00069	0.324
MOD_Cter_Amidation	40	43	PF01082	0.539
MOD_GlcNHglycan	172	175	PF01048	0.397
MOD_GlcNHglycan	33	36	PF01048	0.529
MOD_GlcNHglycan	401	404	PF01048	0.625
MOD_GlcNHglycan	71	74	PF01048	0.371
MOD_GSK3_1	109	116	PF00069	0.331
MOD_GSK3_1	235	242	PF00069	0.402
MOD_GSK3_1	251	258	PF00069	0.173
MOD_GSK3_1	89	96	PF00069	0.314
MOD_N-GLC_1	330	335	PF02516	0.463
MOD_N-GLC_1	339	344	PF02516	0.399
MOD_NEK2_1	209	214	PF00069	0.351
MOD_NEK2_1	318	323	PF00069	0.370
MOD_NEK2_1	330	335	PF00069	0.237
MOD_NEK2_1	338	343	PF00069	0.150
MOD_NEK2_1	399	404	PF00069	0.465
MOD_NEK2_1	69	74	PF00069	0.423
MOD_NEK2_1	93	98	PF00069	0.404
MOD_NEK2_2	339	344	PF00069	0.292
MOD_PIKK_1	23	29	PF00454	0.580
MOD_PIKK_1	302	308	PF00454	0.334
MOD_PK_1	102	108	PF00069	0.214
MOD_PK_1	61	67	PF00069	0.415
MOD_PKA_2	151	157	PF00069	0.415
MOD_PKA_2	16	22	PF00069	0.467
MOD_PKA_2	239	245	PF00069	0.351
MOD_Plk_1	189	195	PF00069	0.306
MOD_Plk_1	267	273	PF00069	0.350
MOD_Plk_1	339	345	PF00069	0.240
MOD_Plk_1	379	385	PF00069	0.394
MOD_Plk_4	156	162	PF00069	0.377
MOD_Plk_4	352	358	PF00069	0.315
MOD_ProDKin_1	387	393	PF00069	0.530
MOD_SUMO_rev_2	224	234	PF00179	0.350
MOD_SUMO_rev_2	31	40	PF00179	0.537
MOD_SUMO_rev_2	64	70	PF00179	0.363
TRG_DiLeu_BaEn_2	204	210	PF01217	0.381
TRG_ENDOCYTIC_2	128	131	PF00928	0.309
TRG_ENDOCYTIC_2	134	137	PF00928	0.286
TRG_ENDOCYTIC_2	166	169	PF00928	0.285
TRG_ENDOCYTIC_2	175	178	PF00928	0.285
TRG_ENDOCYTIC_2	249	252	PF00928	0.489
TRG_NES_CRM1_1	205	219	PF08389	0.407
TRG_NES_CRM1_1	264	278	PF08389	0.264

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN4	Leptomonas seymouri	67%	100%
A0A0S4JPD3	Bodo saltans	25%	93%
A0A1X0NY42	Trypanosomatidae	38%	100%
A0A3Q8ICM9	Leishmania donovani	92%	100%
A0A422P4K0	Trypanosoma rangeli	36%	97%
A4HEB8	Leishmania braziliensis	81%	95%
A4I1R3	Leishmania infantum	92%	100%
C9ZKB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AXU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%