Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9M1_LEIMA

TriTrypDb:

LmjF.25.2160 , LMJSD75_250029400

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q9M1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9M1

PDB structure(s): 7ane_av

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.348
CLV_NRD_NRD_1	2	4	PF00675	0.554
CLV_NRD_NRD_1	34	36	PF00675	0.463
CLV_PCSK_KEX2_1	2	4	PF00082	0.552
CLV_PCSK_KEX2_1	34	36	PF00082	0.459
CLV_PCSK_SKI1_1	34	38	PF00082	0.488
CLV_PCSK_SKI1_1	47	51	PF00082	0.376
DEG_Nend_UBRbox_1	1	4	PF02207	0.537
DOC_MAPK_gen_1	2	9	PF00069	0.585
DOC_MAPK_gen_1	89	98	PF00069	0.450
DOC_MAPK_MEF2A_6	2	9	PF00069	0.644
DOC_MAPK_NFAT4_5	2	10	PF00069	0.644
DOC_PP1_RVXF_1	87	93	PF00149	0.344
DOC_USP7_MATH_1	29	33	PF00917	0.579
DOC_WW_Pin1_4	129	134	PF00397	0.377
DOC_WW_Pin1_4	196	201	PF00397	0.431
DOC_WW_Pin1_4	47	52	PF00397	0.413
LIG_14-3-3_CanoR_1	2	6	PF00244	0.574
LIG_14-3-3_CanoR_1	34	43	PF00244	0.637
LIG_14-3-3_CanoR_1	91	96	PF00244	0.507
LIG_FHA_2	116	122	PF00498	0.476
LIG_FHA_2	152	158	PF00498	0.391
LIG_FHA_2	176	182	PF00498	0.535
LIG_FHA_2	48	54	PF00498	0.419
LIG_LIR_Apic_2	39	45	PF02991	0.458
LIG_LIR_Gen_1	162	169	PF02991	0.567
LIG_LIR_Nem_3	162	166	PF02991	0.571
LIG_LIR_Nem_3	94	98	PF02991	0.404
LIG_MYND_1	210	214	PF01753	0.503
LIG_SH2_NCK_1	163	167	PF00017	0.426
LIG_SH2_STAP1	25	29	PF00017	0.446
LIG_SH2_STAT5	134	137	PF00017	0.373
LIG_SH3_3	74	80	PF00018	0.500
LIG_TRAF2_1	168	171	PF00917	0.427
LIG_WRC_WIRS_1	92	97	PF05994	0.400
MOD_CDC14_SPxK_1	199	202	PF00782	0.401
MOD_CDK_SPxK_1	196	202	PF00069	0.410
MOD_CK1_1	60	66	PF00069	0.432
MOD_CK2_1	115	121	PF00069	0.252
MOD_CK2_1	175	181	PF00069	0.534
MOD_CK2_1	20	26	PF00069	0.559
MOD_CK2_1	97	103	PF00069	0.352
MOD_DYRK1A_RPxSP_1	47	51	PF00069	0.413
MOD_GlcNHglycan	17	20	PF01048	0.531
MOD_GlcNHglycan	228	232	PF01048	0.495
MOD_GlcNHglycan	59	62	PF01048	0.509
MOD_GlcNHglycan	99	102	PF01048	0.464
MOD_GSK3_1	34	41	PF00069	0.443
MOD_GSK3_1	47	54	PF00069	0.369
MOD_N-GLC_1	129	134	PF02516	0.377
MOD_NEK2_1	1	6	PF00069	0.570
MOD_NEK2_1	135	140	PF00069	0.432
MOD_NEK2_1	36	41	PF00069	0.464
MOD_NEK2_1	9	14	PF00069	0.545
MOD_NEK2_2	136	141	PF00069	0.442
MOD_PIKK_1	20	26	PF00454	0.572
MOD_PIKK_1	36	42	PF00454	0.505
MOD_PKA_1	34	40	PF00069	0.403
MOD_PKA_2	1	7	PF00069	0.604
MOD_PKA_2	114	120	PF00069	0.385
MOD_PKA_2	34	40	PF00069	0.483
MOD_PKB_1	89	97	PF00069	0.397
MOD_Plk_1	115	121	PF00069	0.371
MOD_Plk_1	161	167	PF00069	0.409
MOD_Plk_2-3	151	157	PF00069	0.431
MOD_Plk_4	60	66	PF00069	0.419
MOD_Plk_4	91	97	PF00069	0.399
MOD_ProDKin_1	129	135	PF00069	0.370
MOD_ProDKin_1	196	202	PF00069	0.433
MOD_ProDKin_1	47	53	PF00069	0.408
MOD_SUMO_rev_2	139	149	PF00179	0.385
MOD_SUMO_rev_2	150	155	PF00179	0.364
TRG_DiLeu_BaEn_1	171	176	PF01217	0.474
TRG_ENDOCYTIC_2	163	166	PF00928	0.573
TRG_ENDOCYTIC_2	201	204	PF00928	0.422
TRG_ENDOCYTIC_2	229	232	PF00928	0.438
TRG_ER_diArg_1	1	3	PF00400	0.564
TRG_ER_diArg_1	34	36	PF00400	0.427
TRG_ER_diArg_1	88	91	PF00400	0.320
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IST6	Bodo saltans	48%	98%
A0A1X0NY44	Trypanosomatidae	67%	100%
A0A3R7MC48	Trypanosoma rangeli	68%	100%
A0A3S7WZF0	Leishmania donovani	95%	100%
A4HEC0	Leishmania braziliensis	90%	78%
A4I1R5	Leishmania infantum	95%	100%
C9ZKC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AXV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%