Putative vacuolar protein sorting-associated protein 33

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar protein sorting-associated protein 33, putative

Species:

Leishmania major

UniProt:

Q4Q9L9_LEIMA

TriTrypDb:

LmjF.25.2180 , LMJLV39_250029400 , LMJSD75_250029600

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005773	vacuole	5	2
GO:0032991	protein-containing complex	1	2
GO:0033263	CORVET complex	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0099023	vesicle tethering complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9L9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	324	326	PF00675	0.270
CLV_NRD_NRD_1	370	372	PF00675	0.294
CLV_NRD_NRD_1	398	400	PF00675	0.391
CLV_NRD_NRD_1	467	469	PF00675	0.239
CLV_PCSK_KEX2_1	324	326	PF00082	0.270
CLV_PCSK_KEX2_1	372	374	PF00082	0.268
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.369
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.288
CLV_PCSK_SKI1_1	156	160	PF00082	0.397
CLV_PCSK_SKI1_1	167	171	PF00082	0.270
CLV_PCSK_SKI1_1	183	187	PF00082	0.260
CLV_PCSK_SKI1_1	286	290	PF00082	0.311
CLV_PCSK_SKI1_1	302	306	PF00082	0.209
CLV_PCSK_SKI1_1	332	336	PF00082	0.246
CLV_PCSK_SKI1_1	373	377	PF00082	0.357
CLV_PCSK_SKI1_1	423	427	PF00082	0.411
CLV_PCSK_SKI1_1	588	592	PF00082	0.518
DEG_APCC_KENBOX_2	428	432	PF00400	0.305
DEG_SCF_FBW7_1	245	250	PF00400	0.249
DOC_CKS1_1	244	249	PF01111	0.246
DOC_CYCLIN_RxL_1	180	190	PF00134	0.305
DOC_CYCLIN_RxL_1	402	414	PF00134	0.317
DOC_CYCLIN_RxL_1	585	594	PF00134	0.405
DOC_MAPK_gen_1	399	409	PF00069	0.360
DOC_MAPK_gen_1	421	428	PF00069	0.310
DOC_MAPK_gen_1	585	593	PF00069	0.453
DOC_MAPK_gen_1	60	67	PF00069	0.310
DOC_MAPK_HePTP_8	397	409	PF00069	0.323
DOC_MAPK_JIP1_4	111	117	PF00069	0.391
DOC_MAPK_MEF2A_6	156	164	PF00069	0.391
DOC_MAPK_MEF2A_6	400	409	PF00069	0.265
DOC_PP1_RVXF_1	238	245	PF00149	0.244
DOC_PP1_RVXF_1	370	377	PF00149	0.267
DOC_PP2B_LxvP_1	115	118	PF13499	0.339
DOC_PP4_FxxP_1	244	247	PF00568	0.310
DOC_USP7_UBL2_3	335	339	PF12436	0.246
DOC_WW_Pin1_4	243	248	PF00397	0.312
DOC_WW_Pin1_4	5	10	PF00397	0.498
LIG_14-3-3_CanoR_1	106	115	PF00244	0.465
LIG_14-3-3_CanoR_1	142	147	PF00244	0.267
LIG_14-3-3_CanoR_1	563	570	PF00244	0.382
LIG_14-3-3_CanoR_1	585	591	PF00244	0.391
LIG_Actin_WH2_2	542	560	PF00022	0.339
LIG_BRCT_BRCA1_1	134	138	PF00533	0.391
LIG_BRCT_BRCA1_1	220	224	PF00533	0.279
LIG_BRCT_BRCA1_1	240	244	PF00533	0.467
LIG_Clathr_ClatBox_1	235	239	PF01394	0.261
LIG_Clathr_ClatBox_1	590	594	PF01394	0.524
LIG_eIF4E_2	493	499	PF01652	0.310
LIG_FHA_1	157	163	PF00498	0.467
LIG_FHA_1	232	238	PF00498	0.271
LIG_FHA_1	33	39	PF00498	0.423
LIG_FHA_1	5	11	PF00498	0.619
LIG_FHA_1	538	544	PF00498	0.246
LIG_FHA_1	575	581	PF00498	0.286
LIG_FHA_2	548	554	PF00498	0.261
LIG_GBD_Chelix_1	405	413	PF00786	0.373
LIG_LIR_Apic_2	241	247	PF02991	0.391
LIG_LIR_Gen_1	147	158	PF02991	0.337
LIG_LIR_Gen_1	293	304	PF02991	0.271
LIG_LIR_Gen_1	401	411	PF02991	0.316
LIG_LIR_Gen_1	462	471	PF02991	0.238
LIG_LIR_LC3C_4	95	98	PF02991	0.208
LIG_LIR_Nem_3	135	141	PF02991	0.320
LIG_LIR_Nem_3	147	153	PF02991	0.325
LIG_LIR_Nem_3	165	169	PF02991	0.171
LIG_LIR_Nem_3	190	196	PF02991	0.246
LIG_LIR_Nem_3	253	257	PF02991	0.250
LIG_LIR_Nem_3	293	299	PF02991	0.246
LIG_LIR_Nem_3	301	307	PF02991	0.246
LIG_LIR_Nem_3	401	406	PF02991	0.316
LIG_LIR_Nem_3	443	448	PF02991	0.383
LIG_LIR_Nem_3	462	467	PF02991	0.150
LIG_MYND_1	518	522	PF01753	0.267
LIG_NRBOX	408	414	PF00104	0.391
LIG_PCNA_yPIPBox_3	584	597	PF02747	0.434
LIG_Pex14_2	166	170	PF04695	0.391
LIG_Rb_pABgroove_1	256	264	PF01858	0.244
LIG_SH2_CRK	436	440	PF00017	0.253
LIG_SH2_CRK	464	468	PF00017	0.230
LIG_SH2_CRK	493	497	PF00017	0.299
LIG_SH2_NCK_1	493	497	PF00017	0.244
LIG_SH2_PTP2	150	153	PF00017	0.391
LIG_SH2_SRC	488	491	PF00017	0.255
LIG_SH2_SRC	493	496	PF00017	0.267
LIG_SH2_STAP1	103	107	PF00017	0.311
LIG_SH2_STAT3	116	119	PF00017	0.391
LIG_SH2_STAT5	103	106	PF00017	0.150
LIG_SH2_STAT5	116	119	PF00017	0.339
LIG_SH2_STAT5	150	153	PF00017	0.391
LIG_SH2_STAT5	392	395	PF00017	0.272
LIG_SH2_STAT5	76	79	PF00017	0.310
LIG_SH2_STAT5	84	87	PF00017	0.456
LIG_SH3_2	592	597	PF14604	0.521
LIG_SH3_3	266	272	PF00018	0.257
LIG_SH3_3	589	595	PF00018	0.524
LIG_SUMO_SIM_anti_2	233	239	PF11976	0.289
LIG_SUMO_SIM_par_1	233	239	PF11976	0.286
LIG_SUMO_SIM_par_1	408	414	PF11976	0.305
LIG_TRAF2_1	18	21	PF00917	0.396
LIG_TRFH_1	84	88	PF08558	0.339
LIG_TYR_ITIM	148	153	PF00017	0.355
LIG_TYR_ITIM	252	257	PF00017	0.261
LIG_UBA3_1	425	429	PF00899	0.310
MOD_CK1_1	165	171	PF00069	0.411
MOD_CK1_1	176	182	PF00069	0.449
MOD_CK1_1	24	30	PF00069	0.385
MOD_CK1_1	362	368	PF00069	0.391
MOD_CK1_1	46	52	PF00069	0.479
MOD_CK1_1	462	468	PF00069	0.380
MOD_CK1_1	552	558	PF00069	0.444
MOD_CK1_1	92	98	PF00069	0.396
MOD_CK2_1	227	233	PF00069	0.309
MOD_CK2_1	271	277	PF00069	0.339
MOD_CK2_1	474	480	PF00069	0.317
MOD_CK2_1	547	553	PF00069	0.261
MOD_GlcNHglycan	108	111	PF01048	0.223
MOD_GlcNHglycan	23	26	PF01048	0.349
MOD_GlcNHglycan	277	281	PF01048	0.391
MOD_GlcNHglycan	417	420	PF01048	0.221
MOD_GlcNHglycan	45	48	PF01048	0.420
MOD_GlcNHglycan	457	460	PF01048	0.379
MOD_GlcNHglycan	553	557	PF01048	0.279
MOD_GlcNHglycan	565	568	PF01048	0.246
MOD_GlcNHglycan	581	584	PF01048	0.201
MOD_GlcNHglycan	77	80	PF01048	0.335
MOD_GSK3_1	106	113	PF00069	0.206
MOD_GSK3_1	158	165	PF00069	0.244
MOD_GSK3_1	223	230	PF00069	0.333
MOD_GSK3_1	243	250	PF00069	0.173
MOD_GSK3_1	271	278	PF00069	0.326
MOD_GSK3_1	302	309	PF00069	0.241
MOD_GSK3_1	352	359	PF00069	0.261
MOD_GSK3_1	361	368	PF00069	0.248
MOD_GSK3_1	411	418	PF00069	0.426
MOD_GSK3_1	455	462	PF00069	0.303
MOD_GSK3_1	470	477	PF00069	0.203
MOD_GSK3_1	575	582	PF00069	0.240
MOD_GSK3_1	88	95	PF00069	0.381
MOD_N-GLC_1	176	181	PF02516	0.310
MOD_N-GLC_1	218	223	PF02516	0.168
MOD_N-GLC_1	289	294	PF02516	0.314
MOD_N-GLC_1	4	9	PF02516	0.489
MOD_N-GLC_1	474	479	PF02516	0.317
MOD_NEK2_1	101	106	PF00069	0.285
MOD_NEK2_1	132	137	PF00069	0.314
MOD_NEK2_1	158	163	PF00069	0.451
MOD_NEK2_1	275	280	PF00069	0.344
MOD_NEK2_1	415	420	PF00069	0.331
MOD_NEK2_1	500	505	PF00069	0.339
MOD_NEK2_1	586	591	PF00069	0.299
MOD_PIKK_1	101	107	PF00454	0.339
MOD_PIKK_1	247	253	PF00454	0.246
MOD_PIKK_1	362	368	PF00454	0.250
MOD_PKA_2	562	568	PF00069	0.382
MOD_PKB_1	300	308	PF00069	0.179
MOD_Plk_1	176	182	PF00069	0.319
MOD_Plk_1	238	244	PF00069	0.243
MOD_Plk_1	300	306	PF00069	0.380
MOD_Plk_1	474	480	PF00069	0.317
MOD_Plk_1	552	558	PF00069	0.246
MOD_Plk_1	88	94	PF00069	0.267
MOD_Plk_2-3	227	233	PF00069	0.391
MOD_Plk_4	110	116	PF00069	0.348
MOD_Plk_4	118	124	PF00069	0.289
MOD_Plk_4	165	171	PF00069	0.388
MOD_Plk_4	176	182	PF00069	0.285
MOD_Plk_4	231	237	PF00069	0.302
MOD_Plk_4	306	312	PF00069	0.251
MOD_Plk_4	411	417	PF00069	0.278
MOD_Plk_4	500	506	PF00069	0.357
MOD_Plk_4	516	522	PF00069	0.391
MOD_ProDKin_1	243	249	PF00069	0.312
MOD_ProDKin_1	5	11	PF00069	0.494
MOD_SUMO_for_1	18	21	PF00179	0.391
MOD_SUMO_rev_2	125	135	PF00179	0.333
MOD_SUMO_rev_2	149	158	PF00179	0.391
MOD_SUMO_rev_2	327	337	PF00179	0.260
MOD_SUMO_rev_2	519	528	PF00179	0.344
TRG_DiLeu_BaEn_1	231	236	PF01217	0.339
TRG_DiLeu_BaEn_1	346	351	PF01217	0.246
TRG_DiLeu_BaEn_1	430	435	PF01217	0.344
TRG_DiLeu_BaEn_1	449	454	PF01217	0.193
TRG_DiLeu_BaEn_1	524	529	PF01217	0.288
TRG_DiLeu_BaEn_2	332	338	PF01217	0.246
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.391
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.261
TRG_DiLeu_LyEn_5	346	351	PF01217	0.246
TRG_ENDOCYTIC_2	150	153	PF00928	0.346
TRG_ENDOCYTIC_2	254	257	PF00928	0.286
TRG_ENDOCYTIC_2	464	467	PF00928	0.282
TRG_ER_diArg_1	370	373	PF00400	0.250
TRG_NES_CRM1_1	227	239	PF08389	0.290
TRG_NES_CRM1_1	42	57	PF08389	0.301
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.250
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.239
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKV5	Leptomonas seymouri	78%	100%
A0A0S4IXS0	Bodo saltans	47%	99%
A0A1X0NZL8	Trypanosomatidae	50%	99%
A0A3Q8IDK4	Leishmania donovani	94%	100%
A0A3R7P4L0	Trypanosoma rangeli	49%	100%
A4HEC2	Leishmania braziliensis	87%	100%
A4I1R7	Leishmania infantum	94%	100%
C9ZKC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AXV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P20795	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	86%
P34260	Caenorhabditis elegans	21%	99%
P38932	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
P59016	Mus musculus	27%	97%
Q15833	Homo sapiens	21%	100%
Q18891	Caenorhabditis elegans	22%	97%
Q28288	Canis lupus familiaris	21%	100%
Q2HJ18	Bos taurus	27%	97%
Q58EN8	Danio rerio	27%	97%
Q63615	Rattus norvegicus	34%	100%
Q63616	Rattus norvegicus	27%	97%
Q64324	Mus musculus	21%	100%
Q94KJ7	Arabidopsis thaliana	31%	100%
Q96AX1	Homo sapiens	34%	100%
Q9D2N9	Mus musculus	34%	100%
Q9H267	Homo sapiens	27%	97%
Q9P7V6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9Y1I2	Drosophila melanogaster	27%	97%
V5D8I9	Trypanosoma cruzi	50%	100%