J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain/Zinc-finger double-stranded RNA-binding, putative

Species:

Leishmania major

UniProt:

Q4Q9L8_LEIMA

TriTrypDb:

LmjF.25.2190 , LMJLV39_250029500 , LMJSD75_250029700

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9L8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	9
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.550
CLV_NRD_NRD_1	115	117	PF00675	0.393
CLV_NRD_NRD_1	16	18	PF00675	0.319
CLV_NRD_NRD_1	182	184	PF00675	0.435
CLV_NRD_NRD_1	213	215	PF00675	0.386
CLV_NRD_NRD_1	247	249	PF00675	0.475
CLV_PCSK_FUR_1	243	247	PF00082	0.518
CLV_PCSK_KEX2_1	182	184	PF00082	0.435
CLV_PCSK_KEX2_1	213	215	PF00082	0.386
CLV_PCSK_KEX2_1	232	234	PF00082	0.497
CLV_PCSK_KEX2_1	245	247	PF00082	0.409
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.505
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.390
CLV_PCSK_PC7_1	243	249	PF00082	0.532
CLV_PCSK_SKI1_1	116	120	PF00082	0.342
CLV_PCSK_SKI1_1	163	167	PF00082	0.534
CLV_PCSK_SKI1_1	17	21	PF00082	0.369
CLV_PCSK_SKI1_1	329	333	PF00082	0.262
CLV_Separin_Metazoa	293	297	PF03568	0.673
DOC_MAPK_gen_1	116	123	PF00069	0.461
DOC_PP4_FxxP_1	322	325	PF00568	0.511
DOC_USP7_UBL2_3	168	172	PF12436	0.441
DOC_USP7_UBL2_3	328	332	PF12436	0.452
DOC_USP7_UBL2_3	345	349	PF12436	0.462
LIG_14-3-3_CanoR_1	157	163	PF00244	0.447
LIG_14-3-3_CanoR_1	17	22	PF00244	0.306
LIG_14-3-3_CanoR_1	202	208	PF00244	0.444
LIG_deltaCOP1_diTrp_1	145	152	PF00928	0.482
LIG_FHA_1	82	88	PF00498	0.605
LIG_FHA_2	164	170	PF00498	0.533
LIG_FHA_2	18	24	PF00498	0.388
LIG_LIR_Apic_2	320	325	PF02991	0.420
LIG_LIR_Gen_1	143	153	PF02991	0.406
LIG_LIR_Gen_1	20	28	PF02991	0.366
LIG_LIR_Gen_1	305	315	PF02991	0.606
LIG_LIR_Nem_3	108	114	PF02991	0.402
LIG_LIR_Nem_3	143	149	PF02991	0.402
LIG_LIR_Nem_3	160	165	PF02991	0.401
LIG_LIR_Nem_3	20	24	PF02991	0.373
LIG_LIR_Nem_3	305	311	PF02991	0.614
LIG_Pex14_1	167	171	PF04695	0.435
LIG_Pex14_2	152	156	PF04695	0.346
LIG_SH2_CRK	115	119	PF00017	0.358
LIG_SH2_CRK	58	62	PF00017	0.303
LIG_SH2_SRC	21	24	PF00017	0.423
LIG_SH2_STAP1	129	133	PF00017	0.428
LIG_SH2_STAP1	180	184	PF00017	0.558
LIG_SH2_STAT3	41	44	PF00017	0.359
LIG_SH2_STAT5	112	115	PF00017	0.311
LIG_SH2_STAT5	200	203	PF00017	0.392
LIG_SH2_STAT5	95	98	PF00017	0.398
LIG_SUMO_SIM_par_1	11	16	PF11976	0.360
LIG_TRAF2_1	263	266	PF00917	0.501
LIG_TYR_ITSM	111	118	PF00017	0.451
LIG_UBA3_1	280	287	PF00899	0.566
LIG_WRC_WIRS_1	162	167	PF05994	0.430
MOD_CK1_1	59	65	PF00069	0.348
MOD_CK2_1	17	23	PF00069	0.337
MOD_CK2_1	276	282	PF00069	0.595
MOD_CK2_1	69	75	PF00069	0.473
MOD_GlcNHglycan	108	111	PF01048	0.478
MOD_GlcNHglycan	297	300	PF01048	0.656
MOD_GlcNHglycan	371	374	PF01048	0.756
MOD_GSK3_1	106	113	PF00069	0.475
MOD_GSK3_1	124	131	PF00069	0.411
MOD_GSK3_1	157	164	PF00069	0.412
MOD_N-GLC_1	157	162	PF02516	0.384
MOD_NEK2_1	139	144	PF00069	0.409
MOD_NEK2_1	276	281	PF00069	0.623
MOD_NEK2_1	295	300	PF00069	0.443
MOD_NEK2_2	110	115	PF00069	0.362
MOD_PKA_1	17	23	PF00069	0.303
MOD_PKA_1	29	35	PF00069	0.423
MOD_PKA_2	178	184	PF00069	0.438
MOD_PKA_2	288	294	PF00069	0.579
MOD_PKA_2	295	301	PF00069	0.616
MOD_Plk_1	157	163	PF00069	0.387
MOD_Plk_2-3	124	130	PF00069	0.439
MOD_Plk_4	110	116	PF00069	0.354
MOD_Plk_4	276	282	PF00069	0.579
MOD_Plk_4	317	323	PF00069	0.619
MOD_Plk_4	56	62	PF00069	0.370
MOD_SUMO_for_1	196	199	PF00179	0.442
MOD_SUMO_for_1	218	221	PF00179	0.518
MOD_SUMO_for_1	231	234	PF00179	0.427
MOD_SUMO_for_1	331	334	PF00179	0.388
MOD_SUMO_rev_2	11	20	PF00179	0.303
MOD_SUMO_rev_2	169	173	PF00179	0.422
TRG_ENDOCYTIC_2	115	118	PF00928	0.403
TRG_ENDOCYTIC_2	162	165	PF00928	0.514
TRG_ENDOCYTIC_2	21	24	PF00928	0.388
TRG_ENDOCYTIC_2	58	61	PF00928	0.349
TRG_ENDOCYTIC_2	9	12	PF00928	0.303
TRG_ENDOCYTIC_2	93	96	PF00928	0.390
TRG_ER_diArg_1	182	184	PF00400	0.450
TRG_ER_diArg_1	212	214	PF00400	0.413
TRG_ER_diArg_1	246	248	PF00400	0.487
TRG_NLS_Bipartite_1	17	33	PF00514	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE61	Leptomonas seymouri	86%	100%
A0A0S4J1C8	Bodo saltans	53%	81%
A0A1X0NZG6	Trypanosomatidae	62%	100%
A0A3Q8IDF1	Leishmania donovani	96%	100%
A0A422P4I6	Trypanosoma rangeli	60%	100%
A4HEC3	Leishmania braziliensis	91%	100%
A4I1R8	Leishmania infantum	97%	100%
C9ZKC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AXV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9Q8D0	Mus musculus	41%	71%
O14213	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	99%
Q0II91	Bos taurus	39%	71%
Q5F1R6	Homo sapiens	40%	71%
Q6PGY5	Danio rerio	38%	69%
V5ASJ0	Trypanosoma cruzi	59%	100%