Parkin coregulated gene protein homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

parkin co-regulated protein, putative

Species:

Leishmania major

UniProt:

Q4Q9L7_LEIMA

TriTrypDb:

LmjF.25.2200 , LMJLV39_250029600 , LMJSD75_250029800

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 17
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q9L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9L7

Function

Biological processes
Term	Name	Level	Count
GO:0010941	regulation of cell death	4	3
GO:0048519	negative regulation of biological process	3	3
GO:0048523	negative regulation of cellular process	4	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0060548	negative regulation of cell death	5	3
GO:0065007	biological regulation	1	3

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0030544	Hsp70 protein binding	4	3
GO:0031072	heat shock protein binding	3	3
GO:0051087	protein-folding chaperone binding	3	3
GO:0051879	Hsp90 protein binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.410
CLV_C14_Caspase3-7	55	59	PF00656	0.501
CLV_C14_Caspase3-7	91	95	PF00656	0.523
CLV_NRD_NRD_1	124	126	PF00675	0.300
CLV_NRD_NRD_1	19	21	PF00675	0.628
CLV_NRD_NRD_1	256	258	PF00675	0.252
CLV_NRD_NRD_1	84	86	PF00675	0.651
CLV_PCSK_KEX2_1	115	117	PF00082	0.400
CLV_PCSK_KEX2_1	124	126	PF00082	0.252
CLV_PCSK_KEX2_1	14	16	PF00082	0.532
CLV_PCSK_KEX2_1	255	257	PF00082	0.252
CLV_PCSK_KEX2_1	74	76	PF00082	0.467
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.416
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.529
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.252
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.467
CLV_PCSK_SKI1_1	204	208	PF00082	0.268
CLV_PCSK_SKI1_1	241	245	PF00082	0.305
CLV_PCSK_SKI1_1	42	46	PF00082	0.645
DEG_APCC_DBOX_1	240	248	PF00400	0.390
DOC_CDC14_PxL_1	193	201	PF14671	0.268
DOC_CYCLIN_yCln2_LP_2	117	120	PF00134	0.535
DOC_MAPK_DCC_7	191	201	PF00069	0.268
DOC_MAPK_DCC_7	241	249	PF00069	0.390
DOC_MAPK_MEF2A_6	129	136	PF00069	0.268
DOC_MAPK_MEF2A_6	241	249	PF00069	0.390
DOC_PP2B_LxvP_1	117	120	PF13499	0.535
DOC_PP2B_LxvP_1	199	202	PF13499	0.268
DOC_USP7_MATH_1	80	84	PF00917	0.546
DOC_USP7_UBL2_3	100	104	PF12436	0.630
DOC_USP7_UBL2_3	251	255	PF12436	0.303
LIG_14-3-3_CanoR_1	256	265	PF00244	0.345
LIG_APCC_ABBA_1	159	164	PF00400	0.268
LIG_BIR_II_1	1	5	PF00653	0.486
LIG_EVH1_2	119	123	PF00568	0.260
LIG_FHA_1	216	222	PF00498	0.251
LIG_FHA_1	278	284	PF00498	0.285
LIG_FHA_2	11	17	PF00498	0.491
LIG_Integrin_RGD_1	129	131	PF01839	0.216
LIG_LIR_Gen_1	170	177	PF02991	0.308
LIG_LIR_Gen_1	290	301	PF02991	0.266
LIG_LIR_Nem_3	154	158	PF02991	0.288
LIG_LIR_Nem_3	170	176	PF02991	0.312
LIG_LIR_Nem_3	290	296	PF02991	0.266
LIG_PTB_Apo_2	292	299	PF02174	0.268
LIG_PTB_Phospho_1	292	298	PF10480	0.268
LIG_SH2_CRK	173	177	PF00017	0.246
LIG_SH2_CRK	240	244	PF00017	0.278
LIG_SH2_CRK	298	302	PF00017	0.278
LIG_SH2_GRB2like	293	296	PF00017	0.278
LIG_SH2_NCK_1	22	26	PF00017	0.535
LIG_SH2_PTP2	293	296	PF00017	0.278
LIG_SH2_SRC	158	161	PF00017	0.290
LIG_SH2_SRC	293	296	PF00017	0.278
LIG_SH2_STAP1	303	307	PF00017	0.290
LIG_SH2_STAT3	239	242	PF00017	0.279
LIG_SH2_STAT3	4	7	PF00017	0.526
LIG_SH2_STAT5	158	161	PF00017	0.300
LIG_SH2_STAT5	293	296	PF00017	0.256
LIG_SH2_STAT5	70	73	PF00017	0.620
LIG_SH3_1	191	197	PF00018	0.268
LIG_SH3_3	191	197	PF00018	0.268
LIG_SH3_3	63	69	PF00018	0.523
LIG_UBA3_1	199	204	PF00899	0.268
LIG_UBA3_1	243	251	PF00899	0.227
MOD_CK1_1	140	146	PF00069	0.272
MOD_CK1_1	302	308	PF00069	0.380
MOD_CK1_1	37	43	PF00069	0.675
MOD_GlcNHglycan	104	107	PF01048	0.534
MOD_GlcNHglycan	42	45	PF01048	0.688
MOD_GlcNHglycan	47	50	PF01048	0.693
MOD_GSK3_1	202	209	PF00069	0.294
MOD_N-GLC_1	277	282	PF02516	0.351
MOD_NEK2_1	45	50	PF00069	0.652
MOD_NEK2_2	80	85	PF00069	0.526
MOD_PKA_1	255	261	PF00069	0.383
MOD_PKA_2	140	146	PF00069	0.262
MOD_PKA_2	166	172	PF00069	0.281
MOD_PKA_2	255	261	PF00069	0.400
MOD_Plk_1	277	283	PF00069	0.267
MOD_SUMO_rev_2	140	148	PF00179	0.262
TRG_DiLeu_BaEn_1	279	284	PF01217	0.246
TRG_DiLeu_BaEn_3	170	176	PF01217	0.278
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.540
TRG_ENDOCYTIC_2	158	161	PF00928	0.292
TRG_ENDOCYTIC_2	173	176	PF00928	0.301
TRG_ENDOCYTIC_2	240	243	PF00928	0.278
TRG_ENDOCYTIC_2	293	296	PF00928	0.278
TRG_ER_diArg_1	123	125	PF00400	0.292
TRG_ER_diArg_1	256	259	PF00400	0.252
TRG_NLS_Bipartite_1	74	89	PF00514	0.468
TRG_NLS_MonoExtC_3	254	259	PF00514	0.252
TRG_NLS_MonoExtC_3	84	89	PF00514	0.641
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N4	Leptomonas seymouri	83%	100%
A0A0N0P9H6	Leptomonas seymouri	59%	97%
A0A0S4IYX0	Bodo saltans	56%	100%
A0A0S4J0U8	Bodo saltans	62%	100%
A0A1X0NY39	Trypanosomatidae	73%	100%
A0A1X0P4X2	Trypanosomatidae	59%	100%
A0A3S7WZF1	Leishmania donovani	98%	100%
A0A3S7XA05	Leishmania donovani	59%	99%
A0A422P182	Trypanosoma rangeli	58%	98%
A0A422P4M1	Trypanosoma rangeli	71%	100%
A4HEC4	Leishmania braziliensis	90%	76%
A4HND5	Leishmania braziliensis	50%	99%
A4I1R9	Leishmania infantum	98%	100%
A4IC08	Leishmania infantum	59%	99%
A5PK71	Bos taurus	57%	100%
C9ZKC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AFU6	Leishmania major	54%	100%
E9AXV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B6Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	99%
Q96M98	Homo sapiens	47%	100%
Q9D3X5	Mus musculus	29%	100%
Q9DAK2	Mus musculus	56%	100%
V5B824	Trypanosoma cruzi	73%	100%
V5BXN2	Trypanosoma cruzi	52%	97%