COP9 signalosome complex subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9L6_LEIMA

TriTrypDb:

LmjF.25.2210 , LMJLV39_250029700 , LMJSD75_250029900

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0008180	COP9 signalosome	3	12
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0000502	proteasome complex	3	3
GO:0140535	intracellular protein-containing complex	2	3
GO:1902494	catalytic complex	2	3
GO:1905368	peptidase complex	3	3
GO:1905369	endopeptidase complex	4	3

Expansion

Sequence features

Q4Q9L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9L6

Function

Biological processes
Term	Name	Level	Count
GO:0000338	protein deneddylation	6	2
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070646	protein modification by small protein removal	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.447
CLV_NRD_NRD_1	153	155	PF00675	0.379
CLV_NRD_NRD_1	204	206	PF00675	0.454
CLV_NRD_NRD_1	214	216	PF00675	0.197
CLV_NRD_NRD_1	404	406	PF00675	0.341
CLV_PCSK_KEX2_1	153	155	PF00082	0.379
CLV_PCSK_KEX2_1	214	216	PF00082	0.437
CLV_PCSK_SKI1_1	108	112	PF00082	0.417
CLV_PCSK_SKI1_1	153	157	PF00082	0.329
CLV_PCSK_SKI1_1	405	409	PF00082	0.324
CLV_PCSK_SKI1_1	68	72	PF00082	0.349
CLV_PCSK_SKI1_1	78	82	PF00082	0.445
DEG_COP1_1	141	151	PF00400	0.424
DEG_Nend_UBRbox_2	1	3	PF02207	0.603
DOC_CYCLIN_RxL_1	194	202	PF00134	0.496
DOC_CYCLIN_RxL_1	400	414	PF00134	0.532
DOC_MAPK_DCC_7	222	232	PF00069	0.571
DOC_MAPK_gen_1	125	133	PF00069	0.505
DOC_MAPK_gen_1	153	159	PF00069	0.358
DOC_MAPK_MEF2A_6	125	133	PF00069	0.486
DOC_MAPK_MEF2A_6	313	320	PF00069	0.393
DOC_PP1_RVXF_1	404	411	PF00149	0.570
DOC_PP2B_LxvP_1	327	330	PF13499	0.547
DOC_PP2B_LxvP_1	368	371	PF13499	0.519
DOC_PP4_FxxP_1	96	99	PF00568	0.531
DOC_USP7_MATH_1	226	230	PF00917	0.575
DOC_USP7_MATH_1	236	240	PF00917	0.319
DOC_USP7_MATH_1	256	260	PF00917	0.463
DOC_USP7_MATH_1	57	61	PF00917	0.469
DOC_USP7_UBL2_3	108	112	PF12436	0.401
LIG_14-3-3_CanoR_1	125	130	PF00244	0.493
LIG_14-3-3_CanoR_1	153	158	PF00244	0.492
LIG_14-3-3_CanoR_1	64	68	PF00244	0.394
LIG_Actin_WH2_2	20	35	PF00022	0.645
LIG_Actin_WH2_2	216	233	PF00022	0.517
LIG_APCC_ABBA_1	342	347	PF00400	0.516
LIG_APCC_ABBAyCdc20_2	154	160	PF00400	0.477
LIG_BRCT_BRCA1_1	361	365	PF00533	0.560
LIG_deltaCOP1_diTrp_1	247	257	PF00928	0.382
LIG_FHA_1	126	132	PF00498	0.470
LIG_FHA_1	154	160	PF00498	0.392
LIG_FHA_1	183	189	PF00498	0.561
LIG_FHA_1	19	25	PF00498	0.623
LIG_FHA_1	196	202	PF00498	0.450
LIG_FHA_1	315	321	PF00498	0.450
LIG_FHA_1	353	359	PF00498	0.570
LIG_FHA_1	365	371	PF00498	0.423
LIG_FHA_1	387	393	PF00498	0.541
LIG_FHA_1	429	435	PF00498	0.584
LIG_FHA_1	89	95	PF00498	0.510
LIG_IRF3_LxIS_1	316	321	PF10401	0.446
LIG_LIR_Gen_1	321	330	PF02991	0.495
LIG_LIR_Gen_1	88	97	PF02991	0.434
LIG_LIR_Nem_3	10	16	PF02991	0.597
LIG_LIR_Nem_3	141	146	PF02991	0.462
LIG_LIR_Nem_3	202	207	PF02991	0.452
LIG_LIR_Nem_3	321	326	PF02991	0.495
LIG_LIR_Nem_3	339	345	PF02991	0.394
LIG_LIR_Nem_3	362	368	PF02991	0.498
LIG_LIR_Nem_3	66	70	PF02991	0.343
LIG_LIR_Nem_3	88	93	PF02991	0.424
LIG_Rb_pABgroove_1	77	85	PF01858	0.449
LIG_RPA_C_Fungi	250	262	PF08784	0.508
LIG_SH2_CRK	204	208	PF00017	0.413
LIG_SH2_CRK	273	277	PF00017	0.477
LIG_SH2_CRK	90	94	PF00017	0.391
LIG_SH2_GRB2like	17	20	PF00017	0.682
LIG_SH2_PTP2	278	281	PF00017	0.445
LIG_SH2_PTP2	345	348	PF00017	0.454
LIG_SH2_SRC	164	167	PF00017	0.400
LIG_SH2_SRC	17	20	PF00017	0.722
LIG_SH2_SRC	34	37	PF00017	0.282
LIG_SH2_SRC	345	348	PF00017	0.428
LIG_SH2_SRC	357	360	PF00017	0.364
LIG_SH2_STAP1	164	168	PF00017	0.465
LIG_SH2_STAP1	361	365	PF00017	0.399
LIG_SH2_STAP1	83	87	PF00017	0.356
LIG_SH2_STAP1	90	94	PF00017	0.359
LIG_SH2_STAT3	89	92	PF00017	0.431
LIG_SH2_STAT5	278	281	PF00017	0.335
LIG_SH2_STAT5	34	37	PF00017	0.456
LIG_SH2_STAT5	345	348	PF00017	0.392
LIG_SH2_STAT5	357	360	PF00017	0.282
LIG_SH2_STAT5	90	93	PF00017	0.507
LIG_SH3_3	143	149	PF00018	0.511
LIG_SUMO_SIM_anti_2	420	426	PF11976	0.642
LIG_SUMO_SIM_par_1	131	137	PF11976	0.514
LIG_SUMO_SIM_par_1	315	322	PF11976	0.221
LIG_SUMO_SIM_par_1	366	372	PF11976	0.389
LIG_TRAF2_1	294	297	PF00917	0.541
LIG_TYR_ITIM	276	281	PF00017	0.343
LIG_WRC_WIRS_1	320	325	PF05994	0.420
MOD_CK1_1	181	187	PF00069	0.648
MOD_CK1_1	364	370	PF00069	0.406
MOD_CK1_1	428	434	PF00069	0.554
MOD_CK2_1	232	238	PF00069	0.440
MOD_CK2_1	366	372	PF00069	0.428
MOD_CK2_1	40	46	PF00069	0.450
MOD_GlcNHglycan	234	237	PF01048	0.450
MOD_GlcNHglycan	238	241	PF01048	0.396
MOD_GlcNHglycan	258	261	PF01048	0.403
MOD_GlcNHglycan	266	269	PF01048	0.483
MOD_GlcNHglycan	331	334	PF01048	0.260
MOD_GSK3_1	125	132	PF00069	0.395
MOD_GSK3_1	178	185	PF00069	0.583
MOD_GSK3_1	195	202	PF00069	0.422
MOD_GSK3_1	232	239	PF00069	0.468
MOD_GSK3_1	314	321	PF00069	0.318
MOD_GSK3_1	357	364	PF00069	0.440
MOD_GSK3_1	36	43	PF00069	0.446
MOD_GSK3_1	425	432	PF00069	0.517
MOD_N-GLC_1	18	23	PF02516	0.628
MOD_NEK2_1	199	204	PF00069	0.420
MOD_NEK2_1	232	237	PF00069	0.484
MOD_NEK2_1	318	323	PF00069	0.410
MOD_NEK2_1	40	45	PF00069	0.488
MOD_NEK2_2	63	68	PF00069	0.376
MOD_PIKK_1	114	120	PF00454	0.509
MOD_PIKK_1	88	94	PF00454	0.449
MOD_PKA_1	153	159	PF00069	0.381
MOD_PKA_2	153	159	PF00069	0.498
MOD_PKA_2	411	417	PF00069	0.605
MOD_PKA_2	63	69	PF00069	0.386
MOD_Plk_1	178	184	PF00069	0.529
MOD_Plk_1	295	301	PF00069	0.519
MOD_Plk_1	318	324	PF00069	0.422
MOD_Plk_1	45	51	PF00069	0.519
MOD_Plk_2-3	18	24	PF00069	0.649
MOD_Plk_4	147	153	PF00069	0.456
MOD_Plk_4	189	195	PF00069	0.474
MOD_Plk_4	280	286	PF00069	0.392
MOD_Plk_4	319	325	PF00069	0.442
MOD_Plk_4	36	42	PF00069	0.421
MOD_SUMO_for_1	162	165	PF00179	0.413
MOD_SUMO_rev_2	26	35	PF00179	0.528
TRG_ENDOCYTIC_2	143	146	PF00928	0.491
TRG_ENDOCYTIC_2	204	207	PF00928	0.403
TRG_ENDOCYTIC_2	210	213	PF00928	0.311
TRG_ENDOCYTIC_2	217	220	PF00928	0.440
TRG_ENDOCYTIC_2	273	276	PF00928	0.384
TRG_ENDOCYTIC_2	278	281	PF00928	0.314
TRG_ENDOCYTIC_2	83	86	PF00928	0.372
TRG_ENDOCYTIC_2	90	93	PF00928	0.376
TRG_ER_diArg_1	124	127	PF00400	0.465
TRG_ER_diArg_1	152	154	PF00400	0.385
TRG_ER_diArg_1	213	215	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKE5	Leptomonas seymouri	65%	98%
A0A0S4J4F8	Bodo saltans	27%	96%
A0A1X0NY12	Trypanosomatidae	32%	99%
A0A3S7WZD2	Leishmania donovani	92%	100%
A0A422P4P2	Trypanosoma rangeli	32%	99%
A4HEC5	Leishmania braziliensis	85%	100%
A4I1S0	Leishmania infantum	92%	100%
C9ZKC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	99%
E9AXV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O01422	Caenorhabditis elegans	21%	88%
P61201	Homo sapiens	23%	99%
P61202	Mus musculus	23%	99%
P61203	Rattus norvegicus	23%	99%
Q54HL6	Dictyostelium discoideum	22%	97%
Q5B3U7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	21%	86%
Q6IQT4	Danio rerio	23%	99%
Q6IR75	Xenopus laevis	23%	99%
Q7SI58	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	22%	89%
Q8W207	Arabidopsis thaliana	22%	100%
Q94899	Drosophila melanogaster	22%	98%
Q9HFR0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
V5BH20	Trypanosoma cruzi	31%	99%