Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9L5_LEIMA

TriTrypDb:

LmjF.25.2220 , LMJLV39_250029800 , LMJSD75_250030000

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q9L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9L5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.511
CLV_C14_Caspase3-7	505	509	PF00656	0.627
CLV_C14_Caspase3-7	61	65	PF00656	0.531
CLV_MEL_PAP_1	218	224	PF00089	0.487
CLV_NRD_NRD_1	166	168	PF00675	0.531
CLV_NRD_NRD_1	32	34	PF00675	0.533
CLV_NRD_NRD_1	381	383	PF00675	0.483
CLV_NRD_NRD_1	435	437	PF00675	0.734
CLV_NRD_NRD_1	488	490	PF00675	0.631
CLV_NRD_NRD_1	493	495	PF00675	0.636
CLV_NRD_NRD_1	521	523	PF00675	0.537
CLV_PCSK_KEX2_1	166	168	PF00082	0.529
CLV_PCSK_KEX2_1	32	34	PF00082	0.533
CLV_PCSK_KEX2_1	488	490	PF00082	0.610
CLV_PCSK_KEX2_1	521	523	PF00082	0.544
CLV_PCSK_SKI1_1	227	231	PF00082	0.421
CLV_PCSK_SKI1_1	320	324	PF00082	0.400
CLV_PCSK_SKI1_1	565	569	PF00082	0.567
CLV_PCSK_SKI1_1	627	631	PF00082	0.449
DEG_APCC_DBOX_1	273	281	PF00400	0.522
DOC_CKS1_1	294	299	PF01111	0.488
DOC_MAPK_gen_1	326	334	PF00069	0.466
DOC_MAPK_gen_1	606	616	PF00069	0.570
DOC_MAPK_MEF2A_6	326	334	PF00069	0.457
DOC_MAPK_MEF2A_6	577	585	PF00069	0.546
DOC_PP1_RVXF_1	611	617	PF00149	0.574
DOC_USP7_MATH_1	117	121	PF00917	0.465
DOC_USP7_MATH_1	412	416	PF00917	0.762
DOC_USP7_MATH_1	421	425	PF00917	0.738
DOC_USP7_MATH_1	524	528	PF00917	0.512
DOC_USP7_UBL2_3	403	407	PF12436	0.799
DOC_WW_Pin1_4	293	298	PF00397	0.423
DOC_WW_Pin1_4	366	371	PF00397	0.565
DOC_WW_Pin1_4	394	399	PF00397	0.746
DOC_WW_Pin1_4	417	422	PF00397	0.741
DOC_WW_Pin1_4	473	478	PF00397	0.634
LIG_14-3-3_CanoR_1	173	183	PF00244	0.385
LIG_14-3-3_CanoR_1	192	197	PF00244	0.298
LIG_14-3-3_CanoR_1	257	261	PF00244	0.514
LIG_14-3-3_CanoR_1	320	325	PF00244	0.451
LIG_14-3-3_CanoR_1	627	632	PF00244	0.566
LIG_Actin_WH2_2	582	600	PF00022	0.583
LIG_APCC_ABBA_1	72	77	PF00400	0.458
LIG_BRCT_BRCA1_1	194	198	PF00533	0.418
LIG_BRCT_BRCA1_1	43	47	PF00533	0.464
LIG_BRCT_BRCA1_1	75	79	PF00533	0.456
LIG_CaM_IQ_9	100	115	PF13499	0.294
LIG_EH1_1	464	472	PF00400	0.638
LIG_FHA_1	121	127	PF00498	0.485
LIG_FHA_1	174	180	PF00498	0.422
LIG_FHA_1	257	263	PF00498	0.459
LIG_FHA_1	598	604	PF00498	0.563
LIG_FHA_2	239	245	PF00498	0.554
LIG_FHA_2	474	480	PF00498	0.612
LIG_FHA_2	521	527	PF00498	0.612
LIG_FHA_2	532	538	PF00498	0.580
LIG_FHA_2	586	592	PF00498	0.570
LIG_LIR_Apic_2	291	297	PF02991	0.398
LIG_LIR_Gen_1	228	238	PF02991	0.570
LIG_LIR_Gen_1	296	307	PF02991	0.508
LIG_LIR_Gen_1	48	59	PF02991	0.407
LIG_LIR_Gen_1	534	542	PF02991	0.532
LIG_LIR_Nem_3	195	199	PF02991	0.403
LIG_LIR_Nem_3	208	213	PF02991	0.314
LIG_LIR_Nem_3	228	233	PF02991	0.233
LIG_LIR_Nem_3	296	302	PF02991	0.405
LIG_LIR_Nem_3	313	319	PF02991	0.371
LIG_LIR_Nem_3	48	54	PF02991	0.407
LIG_LIR_Nem_3	534	539	PF02991	0.530
LIG_MLH1_MIPbox_1	43	47	PF16413	0.523
LIG_NRBOX	340	346	PF00104	0.547
LIG_PCNA_PIPBox_1	258	267	PF02747	0.515
LIG_PCNA_PIPBox_1	457	466	PF02747	0.638
LIG_PCNA_yPIPBox_3	367	375	PF02747	0.544
LIG_Pex14_2	147	151	PF04695	0.482
LIG_Pex14_2	68	72	PF04695	0.393
LIG_Pex14_2	75	79	PF04695	0.413
LIG_Rb_LxCxE_1	208	231	PF01857	0.404
LIG_SH2_CRK	316	320	PF00017	0.421
LIG_SH2_GRB2like	159	162	PF00017	0.564
LIG_SH2_GRB2like	454	457	PF00017	0.573
LIG_SH2_PTP2	299	302	PF00017	0.448
LIG_SH2_PTP2	51	54	PF00017	0.508
LIG_SH2_SRC	299	302	PF00017	0.495
LIG_SH2_STAP1	604	608	PF00017	0.558
LIG_SH2_STAT3	357	360	PF00017	0.536
LIG_SH2_STAT3	454	457	PF00017	0.573
LIG_SH2_STAT3	635	638	PF00017	0.639
LIG_SH2_STAT5	294	297	PF00017	0.355
LIG_SH2_STAT5	299	302	PF00017	0.343
LIG_SH2_STAT5	454	457	PF00017	0.717
LIG_SH2_STAT5	51	54	PF00017	0.502
LIG_SH2_STAT5	604	607	PF00017	0.351
LIG_SH3_2	2	7	PF14604	0.722
LIG_SH3_3	13	19	PF00018	0.529
LIG_SH3_3	389	395	PF00018	0.715
LIG_SH3_4	403	410	PF00018	0.797
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.445
LIG_SUMO_SIM_par_1	258	263	PF11976	0.520
LIG_SUMO_SIM_par_1	300	305	PF11976	0.459
LIG_TRAF2_1	241	244	PF00917	0.554
LIG_TRAF2_1	359	362	PF00917	0.573
LIG_TRAF2_1	523	526	PF00917	0.392
LIG_TRAF2_1	588	591	PF00917	0.469
LIG_TYR_ITIM	314	319	PF00017	0.381
LIG_UBA3_1	179	187	PF00899	0.406
LIG_UBA3_1	99	108	PF00899	0.515
LIG_WRC_WIRS_1	363	368	PF05994	0.555
MOD_CDC14_SPxK_1	369	372	PF00782	0.510
MOD_CDK_SPxK_1	366	372	PF00069	0.516
MOD_CK1_1	120	126	PF00069	0.491
MOD_CK1_1	256	262	PF00069	0.496
MOD_CK1_1	397	403	PF00069	0.721
MOD_CK1_1	415	421	PF00069	0.603
MOD_CK1_1	82	88	PF00069	0.491
MOD_CK2_1	157	163	PF00069	0.482
MOD_CK2_1	238	244	PF00069	0.574
MOD_CK2_1	421	427	PF00069	0.796
MOD_CK2_1	473	479	PF00069	0.612
MOD_CK2_1	520	526	PF00069	0.555
MOD_CK2_1	531	537	PF00069	0.472
MOD_CK2_1	585	591	PF00069	0.486
MOD_CK2_1	81	87	PF00069	0.524
MOD_GlcNHglycan	119	122	PF01048	0.486
MOD_GlcNHglycan	20	23	PF01048	0.518
MOD_GlcNHglycan	446	449	PF01048	0.718
MOD_GlcNHglycan	60	63	PF01048	0.534
MOD_GSK3_1	282	289	PF00069	0.501
MOD_GSK3_1	362	369	PF00069	0.403
MOD_GSK3_1	412	419	PF00069	0.735
MOD_GSK3_1	422	429	PF00069	0.697
MOD_GSK3_1	520	527	PF00069	0.515
MOD_GSK3_1	623	630	PF00069	0.456
MOD_GSK3_1	95	102	PF00069	0.481
MOD_N-GLC_1	310	315	PF02516	0.397
MOD_N-GLC_1	623	628	PF02516	0.659
MOD_N-GLC_1	95	100	PF02516	0.500
MOD_NEK2_1	220	225	PF00069	0.412
MOD_NEK2_1	233	238	PF00069	0.411
MOD_NEK2_1	287	292	PF00069	0.468
MOD_NEK2_1	343	348	PF00069	0.580
MOD_NEK2_1	416	421	PF00069	0.803
MOD_NEK2_1	46	51	PF00069	0.501
MOD_NEK2_1	99	104	PF00069	0.450
MOD_PK_1	541	547	PF00069	0.365
MOD_PKA_2	172	178	PF00069	0.444
MOD_PKA_2	220	226	PF00069	0.414
MOD_PKA_2	256	262	PF00069	0.510
MOD_PKA_2	520	526	PF00069	0.546
MOD_PKA_2	597	603	PF00069	0.550
MOD_PKB_1	625	633	PF00069	0.444
MOD_Plk_1	283	289	PF00069	0.525
MOD_Plk_1	310	316	PF00069	0.381
MOD_Plk_1	47	53	PF00069	0.414
MOD_Plk_1	82	88	PF00069	0.492
MOD_Plk_1	95	101	PF00069	0.487
MOD_Plk_4	250	256	PF00069	0.417
MOD_Plk_4	350	356	PF00069	0.473
MOD_Plk_4	41	47	PF00069	0.397
MOD_Plk_4	531	537	PF00069	0.495
MOD_Plk_4	541	547	PF00069	0.405
MOD_Plk_4	627	633	PF00069	0.475
MOD_Plk_4	95	101	PF00069	0.448
MOD_ProDKin_1	293	299	PF00069	0.421
MOD_ProDKin_1	366	372	PF00069	0.572
MOD_ProDKin_1	394	400	PF00069	0.747
MOD_ProDKin_1	417	423	PF00069	0.741
MOD_ProDKin_1	473	479	PF00069	0.653
MOD_SUMO_for_1	339	342	PF00179	0.605
TRG_DiLeu_BaEn_4	243	249	PF01217	0.545
TRG_ENDOCYTIC_2	299	302	PF00928	0.388
TRG_ENDOCYTIC_2	316	319	PF00928	0.381
TRG_ENDOCYTIC_2	51	54	PF00928	0.510
TRG_ER_diArg_1	31	33	PF00400	0.503
TRG_ER_diArg_1	487	489	PF00400	0.617
TRG_ER_diArg_1	625	628	PF00400	0.657
TRG_NES_CRM1_1	537	551	PF08389	0.552
TRG_NES_CRM1_1	572	584	PF08389	0.573
TRG_NES_CRM1_1	97	112	PF08389	0.462
TRG_NLS_MonoExtC_3	435	440	PF00514	0.665
TRG_NLS_MonoExtN_4	436	441	PF00514	0.705
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P623	Leptomonas seymouri	78%	98%
A0A0N0P6N7	Leptomonas seymouri	24%	94%
A0A1X0NY32	Trypanosomatidae	44%	100%
A0A3Q8IDH9	Leishmania donovani	95%	100%
A0A422NY96	Trypanosoma rangeli	25%	100%
A0A422P4I7	Trypanosoma rangeli	45%	100%
A4HEC6	Leishmania braziliensis	89%	99%
A4I1S1	Leishmania infantum	95%	100%
C9ZKC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AXV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5D5U6	Trypanosoma cruzi	26%	100%
V5D8I6	Trypanosoma cruzi	41%	100%