PHD-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q9L3_LEIMA

TriTrypDb:

LmjF.25.2235 , LMJLV39_250030000 , LMJSD75_250030200

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q9L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9L3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.459
CLV_NRD_NRD_1	117	119	PF00675	0.497
CLV_NRD_NRD_1	321	323	PF00675	0.620
CLV_PCSK_KEX2_1	117	119	PF00082	0.497
CLV_PCSK_KEX2_1	321	323	PF00082	0.623
CLV_PCSK_SKI1_1	117	121	PF00082	0.609
CLV_PCSK_SKI1_1	322	326	PF00082	0.483
DEG_APCC_DBOX_1	251	259	PF00400	0.490
DEG_Nend_Nbox_1	1	3	PF02207	0.543
DEG_SPOP_SBC_1	226	230	PF00917	0.460
DOC_CKS1_1	36	41	PF01111	0.533
DOC_CYCLIN_RxL_1	114	124	PF00134	0.608
DOC_CYCLIN_RxL_1	74	87	PF00134	0.446
DOC_MAPK_gen_1	22	30	PF00069	0.545
DOC_MAPK_gen_1	74	83	PF00069	0.532
DOC_MAPK_JIP1_4	77	83	PF00069	0.528
DOC_MAPK_MEF2A_6	156	163	PF00069	0.591
DOC_MAPK_MEF2A_6	77	85	PF00069	0.448
DOC_PP2B_LxvP_1	83	86	PF13499	0.430
DOC_USP7_MATH_1	111	115	PF00917	0.476
DOC_USP7_MATH_1	121	125	PF00917	0.512
DOC_USP7_MATH_1	193	197	PF00917	0.580
DOC_WW_Pin1_4	162	167	PF00397	0.580
DOC_WW_Pin1_4	2	7	PF00397	0.464
DOC_WW_Pin1_4	35	40	PF00397	0.574
DOC_WW_Pin1_4	84	89	PF00397	0.511
LIG_14-3-3_CanoR_1	106	110	PF00244	0.552
LIG_14-3-3_CanoR_1	129	134	PF00244	0.549
LIG_14-3-3_CanoR_1	187	192	PF00244	0.562
LIG_14-3-3_CanoR_1	298	304	PF00244	0.594
LIG_14-3-3_CanoR_1	79	84	PF00244	0.518
LIG_BRCT_BRCA1_1	44	48	PF00533	0.564
LIG_FHA_1	229	235	PF00498	0.477
LIG_FHA_1	241	247	PF00498	0.399
LIG_FHA_1	291	297	PF00498	0.435
LIG_FHA_2	153	159	PF00498	0.552
LIG_FHA_2	264	270	PF00498	0.454
LIG_FHA_2	3	9	PF00498	0.465
LIG_IRF3_LxIS_1	88	95	PF10401	0.391
LIG_LIR_Apic_2	305	311	PF02991	0.601
LIG_LIR_Gen_1	45	56	PF02991	0.524
LIG_LIR_Nem_3	114	119	PF02991	0.487
LIG_LIR_Nem_3	45	51	PF02991	0.736
LIG_LIR_Nem_3	53	59	PF02991	0.556
LIG_LIR_Nem_3	69	75	PF02991	0.574
LIG_LYPXL_S_1	71	75	PF13949	0.578
LIG_LYPXL_yS_3	72	75	PF13949	0.577
LIG_MYND_1	253	257	PF01753	0.478
LIG_SH2_CRK	300	304	PF00017	0.340
LIG_SH2_STAP1	56	60	PF00017	0.567
LIG_SH2_STAT5	240	243	PF00017	0.453
LIG_SH2_STAT5	309	312	PF00017	0.349
LIG_SH3_3	160	166	PF00018	0.738
LIG_SH3_3	206	212	PF00018	0.554
LIG_SH3_3	33	39	PF00018	0.543
LIG_SUMO_SIM_anti_2	87	93	PF11976	0.393
LIG_SUMO_SIM_par_1	89	95	PF11976	0.444
LIG_TRAF2_1	181	184	PF00917	0.606
LIG_UBA3_1	255	262	PF00899	0.469
LIG_WRC_WIRS_1	258	263	PF05994	0.526
MOD_CK1_1	152	158	PF00069	0.477
MOD_CK1_1	228	234	PF00069	0.468
MOD_CK1_1	304	310	PF00069	0.427
MOD_CK1_1	44	50	PF00069	0.458
MOD_CK2_1	2	8	PF00069	0.465
MOD_CK2_1	263	269	PF00069	0.457
MOD_GlcNHglycan	151	154	PF01048	0.498
MOD_GlcNHglycan	200	203	PF01048	0.590
MOD_GlcNHglycan	99	102	PF01048	0.379
MOD_GSK3_1	121	128	PF00069	0.583
MOD_GSK3_1	129	136	PF00069	0.547
MOD_GSK3_1	183	190	PF00069	0.615
MOD_GSK3_1	193	200	PF00069	0.598
MOD_GSK3_1	299	306	PF00069	0.575
MOD_N-GLC_1	197	202	PF02516	0.620
MOD_NEK2_1	105	110	PF00069	0.464
MOD_NEK2_1	191	196	PF00069	0.518
MOD_NEK2_1	303	308	PF00069	0.530
MOD_NEK2_1	49	54	PF00069	0.691
MOD_NEK2_1	92	97	PF00069	0.476
MOD_NEK2_1	99	104	PF00069	0.404
MOD_NEK2_2	257	262	PF00069	0.467
MOD_PIKK_1	217	223	PF00454	0.497
MOD_PKA_2	105	111	PF00069	0.392
MOD_PKA_2	186	192	PF00069	0.638
MOD_PKA_2	198	204	PF00069	0.647
MOD_PKB_1	127	135	PF00069	0.545
MOD_PKB_1	77	85	PF00069	0.521
MOD_Plk_2-3	205	211	PF00069	0.565
MOD_Plk_4	111	117	PF00069	0.455
MOD_Plk_4	292	298	PF00069	0.480
MOD_Plk_4	304	310	PF00069	0.461
MOD_Plk_4	44	50	PF00069	0.610
MOD_Plk_4	79	85	PF00069	0.613
MOD_Plk_4	99	105	PF00069	0.411
MOD_ProDKin_1	162	168	PF00069	0.576
MOD_ProDKin_1	2	8	PF00069	0.465
MOD_ProDKin_1	35	41	PF00069	0.573
MOD_ProDKin_1	84	90	PF00069	0.507
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.622
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.577
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.420
TRG_ENDOCYTIC_2	300	303	PF00928	0.435
TRG_ENDOCYTIC_2	56	59	PF00928	0.629
TRG_ENDOCYTIC_2	72	75	PF00928	0.761
TRG_ER_diArg_1	116	118	PF00400	0.496
TRG_ER_diArg_1	252	255	PF00400	0.511
TRG_ER_diArg_1	320	322	PF00400	0.617
TRG_ER_diArg_1	76	79	PF00400	0.537
TRG_PTS2	1	32	PF00400	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGR6	Leishmania donovani	83%	100%
A4I1S3	Leishmania infantum	83%	98%
E9AXV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%